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Healthier Immune System in Infants Born to Mothers with Crohn’s Disease

Accumulating evidence suggests that maternal health and diet during pregnancy and early life have an impact on the baby's microbiome composition and immune system development, with long-term health consequences, including establishing predisposition to Crohn' s disease and other immune-mediated diseases.

By modulating the maternal microbiome during pregnancy through diet, researchers at the UMass Medical School, hope to promote healthier immune system development in infants born to mothers with Crohn's disease.

The MELODY Trial, conducted by the University of Massachusetts Medical School and the Icahn School of Medicine at Mount Sinai, will test whether a non­invasive diet intervention implemented during the third trimester of pregnancy can beneficially shift the microbiome, in patients with Crohn' s disease and in their babies.

Help us learn more about Crohn's disease during pregnancy

We are seeking pregnant women to participate in a trial that will evaluate the efficacy of diet intervention during the third trimester of pregnancy. This study's goal is to determine if manipulation of the mothers microbiome, through diet, would benefit their baby. The diet aims to promote a healthier immune system during a critical time of immune system development.

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