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Recent Publications

Teaching cancer imaging in the era of precision medicine: Looking at the big picture.  Lacey J.McIntosh and Ryan Tai for their work co-authoring this article in the European Journal of Radiology Open which provides the framework to teach cancer imaging in the era of genomic oncology. Available online 15 March 2022

Anagnostakou FigureThe New England Center for Stroke Research team led by Dr. Anagnostakou publishes the first in vivo imaging of the subarachnoid trabeculae using intravascular high-frequency optical coherence tomography. This could represent transformation in our understanding of brain trauma, hydrocephalous, and brain aneurysm pathophysiology. Anagnostakou V, Epshtein M, Ughi GJ, King R, Valavanis A, Puri A, Gounis M. Transvascular in vivo microscopy of the subarachnoid space.

Cheers to the successful collaboration supported by the U.S. – Israel Binational Science Foundation between UMass Chan Medical School and the Technion recently published jointly in Bioengineering & Translational Medicine! The project was the doctoral thesis for Mark Epshtein, who joined the New England Center for Stroke Research as a postdoctoral fellow. Biophysical targeting of high-risk cerebral aneurysms

Tay-Sachs Nature FigureAAV gene therapy for Tay-Sachs Disease. T Flotte, O Cataltepe, A Puri, A Batista, R Moser, D McKenna-Yasek, C Douthwright, G Gernoux, M Blackwood, C Mueller, PWL Tai, X Jiang, S Bateman, SG Spanakis, J Parzych, AM Keeler, A Abayazeed, S Rohatgi, L Gibson, R Finberg, BA Barton, Z Vardar, MS Shazeeb, M Gounis, CJ Tifft, FS Eichler, RH Brown Jr., DR Martin, Heather L. Gray-Edwards & Miguel Sena-Esteves. Nature Medicine volume 28, pages 251–259 (2022). A wonderful cross department collaboration for the first ever gene therapy of TaySachs disease.

Health Care Disparities in Radiology-A Review of the Current Literature.
Carolynn M DeBenedectisLucy B SpallutoLisa Americo, Casey Bishop, Asim Mian, David SarkanyNolan J KagetsuPriscilla J Slanetz. JAM Coll Radiol. 2022 Jan;19(1 Pt B):101-111. doi: 10.1016/j.jacr.2021.08.024. PMID: 35033297

Impaired pulmonary ventilation beyond pneumonia in COVID-19: A preliminary observation

January 25, 2022 Author(s): Shohei Inui, Soon Ho Yoon, Ozkan Doganay, Fergus V. Gleeson, Minsuok Kim
Source: PloS one

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

December 23, 2021 Author(s): Helene Tran, Michael P. Moazami, Huiya Yang, Diane Mckenna-Yasek, Catherine Douthwright, Courtney Pinto, Jake P. Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley, Ajit S. Puri, Alexandra Weiss, Nicholas Wightman, Heather L. Gray-Edwards, Miklos G. Marosfoi, Robert M. King, Jonathan K. Watts, Robert H. Brown Jr. Source: Nature medicine

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

December 22, 2021 Author(s): Chantal M. Ferguson, Bruno M. D. C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew R. Hassler, Dimas Echeverria, James W. Gilbert, Emily G. Knox, Jillian Caiazzi, Reka A. Haraszti, Robert M. King, Toloo Taghian, Ajit S. Puri, Richard P. Moser, Matthew J. Gounis, Neil Aronin, Heather L. Gray-Edwards, Anastasia Khvorova. Source: JCI insight

International Study of Intracranial Aneurysm Treatment Using Woven EndoBridge: Results of the WorldWideWEB Consortium

December 17, 2021. Author(s): Adam A. Dmytriw, Anna L. Kuhn, Ajit S. Puri. Source: Stroke

Quantification of clot spatial heterogeneity and its impact on thrombectomy

December 15, 2021. Author(s): Yang Liu, Matthew J. Gounis, Ajit S. Puri. Source: Journal of neurointerventional surgery

Data-driven respiratory signal estimation from temporally finely sampled projection data in conventional cardiac perfusion SPECT imaging

December 13, 2021. Author(s): P. Hendrik Pretorius, Michael A. King. Source: Medical physics

Structural basis of the super- and hyper-relaxed states of myosin II

December 10, 2021. Author(s): Roger W. Craig, Raul A. Padron. Source: The Journal of general physiology

Preclinical modeling of mechanical thrombectomy

December 08, 2021. Author(s): Vania Anagnostakou, Mark Epshtein, Anna L. Kuhn, Robert M. King, Ajit S. Puri, Matthew J. Gounis. Source: Journal of biomechanics

American Association for Women in Radiology

December 01, 2021. Author(s): Carolynn M. DeBenedectis, Chelsea Schmitt, Kristin K. Porter, Carol Rumack. Source: Clinical imaging

Paramagnetic Rim Lesions in Multiple Sclerosis: Comparison of Visualization at 1.5-T and 3-T MRI

December 01, 2021. Author(s): Christopher C. Hemond, Daniel S. Reich, Sathish Kumar Dundamadappa. Source: AJR. American journal of roentgenology

ACR Appropriateness Criteria(R) Epigastric Pain

November 15, 2021. Author(s): Abhinav Vij, Alan J. Goldstein. Source: Journal of the American College of Radiology : JACR

Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

November 08, 2021. Author(s): Thanh N. Nguyen, Ajit S. Puri, Anna L. Kuhn, Raul G. Nogueira. Source: JAMA neurology

Endoluminal flow diverting stents for middle cerebral artery bifurcation aneurysms: multicenter cohort

November 03, 2021. Author(s): Mohamed M. Salem, Anna L. Kuhn, Francesco Massari, Ajit S. Puri, Ajith J. Thomas. Source: Journal of neurointerventional surgery

Structural organization of the C1b projection within the ciliary central apparatus

November 01, 2021. Author(s): Kai Cai, Yanhe Zhao, Lei Zhao, Nhan Phan, Yuqing Hou, Xi Cheng, George B. Witman, Daniela Nicastro, Source: Journal of cell science

Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing

November 01, 2021. Author(s): Arda Konik, Navid Zeraatkar, Kesava S. Kalluri, Benjamin Auer, Timothy J. Fromme, Yulun He, Micaehla May, Lars R. Furenlid, Phillip H. Kuo, Michael A. King. Source: IEEE transactions on radiation and plasma medical sciences

Disability: An Important Dimension of Diversity

November 01, 2021. Author(s): Juan D. Guerrero-Calderon, Kay Lozano, Carolynn M. DeBenedectis, LeAnn Shannon, Chitra Viswanathan, Nolan J. Kagetsu. Source: Journal of the American College of Radiology : JACR

Carotid artery revascularization using the Walrus balloon guide catheter: safety and feasibility from a US multicenter experience

October 22, 2021. Author(s): Mohamed M. Salem, Anna L. Kuhn, Ajit S. Puri, Jan-Karl Burkhardt. Source: Journal of neurointerventional surgery

Repeat Flow Diversion for Cerebral Aneurysms Failing Prior Flow Diversion: Safety and Feasibility From Multicenter Experience

October 12, 2021. Author(s): Mohamed M. Salem, Anna L. Kuhn, Ajit S. Puri, Ajith J. Thomas. Source: Stroke

A clinical perspective on endovascular stroke treatment biomechanics

October 11, 2021. Author(s): Johanna M. Ospel, Aad van der Lugt, Matthew J. Gounis, Mayank Goyal, Charles B. L. M. Majoie. Source: Journal of biomechanics

Artificial Intelligence in Healthcare Explained for Computer-Non-Experts

October 06, 2021. Author(s): Sarwat Hussain. Source: Annals of King Edward Medical University

The Lancet Commission on diagnostics: transforming access to diagnostics

October 06, 2021. Author(s): Kenneth A. Fleming, Susan Horton, Sarwat Hussain. Source: Lancet (London, England)

Qualifying Certainty in Radiology Reports through Deep Learning-Based Natural Language Processing

October 01, 2021. Author(s): Feifan Liu, Peng Zhou, Steven J. Baccei, Mark J. Masciocchi, Nita Amornsiripanitch, Catarina I. Kiefe, Max P. Rosen. Source: AJNR. American journal of neuroradiology

Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner

September 22, 2021. Author(s): Navid Zeraatkar, Kesava S. Kalluri, Benjamin Auer, Micaehla May, R. Garrett Richards, Lars R. Furenlid, Phillip H. Kuo, Michael A. King. Source: Biomedical physics and engineering express