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USMLE | Male Reproductive System

Normal Processes

Embryonic development, fetal maturation, and neonatal changes, gametogenesis

Organ structure and function

    • structure, male genitalia and prostate
    • function, male genitalia and prostate (eg, spermatogenesis, puberty)
    • intercourse, orgasm, erection

Cell/tissue structure and function, including hypothalamic-pituitary-gonadal axis, sex steroids, and gestational hormones

Reproductive system defense mechanisms and normal flora

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Infectious, immunologic, and inflammatory disorders

    • infectious disorders: balanitis; epididymitis; orchitis; prostatitis; sexually transmitted infections and exposure; chancroid (Haemophilus ducreyi); genital herpes; gonorrhea (Neisseria gonorrhoeae); human papillomavirus infection, genital/venereal/anal warts, condylomata acuminata; lymphogranuloma venereum (Chlamydia trachomatis); syphilis (Treponema pallidum); trichomoniasis (Trichomonas vaginalis); urethritis, chlamydial and nonchlamydial, nongonococcal
    • immunologic and inflammatory disorders: autoimmune hypogonadism

Neoplasms: malignant neoplasms, penile, prostate, testicular, breast

Metabolic and regulatory disorders, including sexual dysfunction: erectile dysfunction, impotence; infertility, male factor; male sexual dysfunction; premature ejaculation

Traumatic and mechanical disorders: benign prostatic hyperplasia/hypertrophy; circumcision, including complications; epididymal cyst; hydrocele; injuries, wounds, and burns to male genitalia, including blast injuries; penile laceration, penile fracture, Peyronie disease; phimosis; scrotal laceration; spermatocele; testicular rupture/avulsion/laceration; torsion of testis; urethral laceration/disruption; varicocele

Congenital disorders of the male reproductive system: hypospadias; Klinefelter syndrome; undescended testicle

Adverse effects of drugs on the male reproductive system: alcohol; androgens, testosterone; antipsychotics, antidepressants including selective serotonin reuptake inhibitors; beta- adrenergic blockers; diuretic including thiazides; drug-induced priapism (eg, trazodone); finasteride, dutasteride; sildenafil, tadalafil, vardenafil; marijuana; nitric oxide reductase inhibitors


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