Center for Psychopharmacologic Research and Treatment In The News.....
Treating Bipolar – I and II – Disorders
Michael Schroeder staff reporter and health editor at U.S. News
While there are similarities, the type of bipolar disorder a person has can influence treatment
"Bipolar I disorder is what used to be called classic manic depressive illness," says Dr. Anthony Rothschild, a professor of psychiatry at the University of Massachusetts Medical School. Those who have it experience periods of mania – that is, "of increased energy, not needing to sleep…
To ready more on this topic please see https://health.usnews.com/health-care/patient-advice/articles/2018-05-29/treating-bipolar-i-and-ii-disorders
Dr. Anthony J. Rothschild, MD has been appointed Vice Chair for Research in the Department of Psychiatry. Dr. Rothschild is a proud Princeton Alumnus who attended the University of Pennsylvania School of Medicine. He was a resident in Psychiatry and Chief Resident in Psychopharmacology at McLean Hospital. At McLean he went on to become a Research Fellow in Neurochemistry and a CIBA-Geigy Fellow in Affective Disorders as he laid the groundwork for what would become a career-long focus in mood disorders, publishing 5 books and over 140 peer-reviewed papers to date. Dr. Rothschild came to UMass in 1996 and became a tenured professor of Psychiatry and the occupant of the Irving S. and Betty Brudnick Endowed Chair of Psychiatry.
Dr. Rothschild is widely known as a leading international expert on psychotic depression. He is a sought-after mentor who has helped a large number of medical students, residents, and faculty members launch their academic careers. Dr. Rothschild does a spectacular job of providing continuing education to all of us by carefully leading the planning of and curating the grand rounds series. As Vice Chair for Research, Dr. Rothschild will oversee our department’s research efforts, making sure we are well-represented on medical school research committees, looking for ways to mentor trainees and junior faculty seeking research careers, and helping the department strategically grow its research efforts.
What is Seasonal Affective Disorder?
July 31, 2017
Vitamin D supplementation in bipolar depression: A double blind placebo controlled trial
Study conducted by Wendy Marsh, MD, MSc et al., to explore whether vitamin D supplementation reduces bipolar depression, shows there was no significant difference lessening depressive symptoms. Read the summary in MDLinx Journal of Psychiatric Research.
June 26, 2017
UMASS study of 30 patients with multiple sclerosis and depression cited (Drs. Anthony Rothschild and Nancy Byatt)
Read full article here:
June 1, 2016
In Defense of Antidepressants
Though recent studies have questioned the drugs’ effectiveness, psychiatrist Peter D. Kramer has seen real benefits
Further testimony comes from a psychiatrist at the University of Massachusetts, Anthony Rothschild—arguably our premier expert on psychotic depression, which includes hallucinations or delusions. In 2014, I asked him if he was seeing classic, immobilizing melancholy—in the absence of psychosis. No, he said. There’s much less of it. His thought was that primary-care doctors nip progressive mood disorders in the bud. People used to move from depression to severe depression to paralyzing melancholy. Since the 1980s, with the advent of easier-to-use antidepressants, often the slide is interrupted.
See http://www.wsj.com/articles/in-defense-of-antidepressants-1464360915 for full article.
May 16, 2016
|Congratulations to Dr. Anthnoy Rothschild who has been inducted as a Distinguished Life Fellow of the American Psychiatric Association at the 60th Convocation of Distinguished Fellows at the APA Annual Meeting on May 16, 2016.|
May 13, 2016
May 13, 2016 5:33 PM By Dr. Mallika Marshall
Kristina Deligiannidis MD, a reproductive psychiatrist asks:
Are Hormones Or Genes To Blame For Peripartum Depression?
BOSTON (CBS) — About one in eight women suffer from peripartum depression and it is often passed from mother to daughter to daughter. Local researchers are trying to figure out how a woman’s DNA affects her risk.
March 24, 2016
Women’s depression expert Kristina Deligiannidis encourages women to participate in PACT for the Cure
By Sandra Gray
UMass Medical School Communications
May 14, 2015
Society of Biological Psychiatry (SOBP) 2015 Top Poster Finalist in Clinical/Translational Research for its 70th Annual Meeting, Toronto, Canada
Dr. Kristina Deligiannidis' poster abstract entitled “Plasma Neuroactive Steroids and GABA Concentrations in Peripartum Women At-risk for Postpartum Depression” was designated a Top Poster Finalist for the SOBP 70th Annual Meeting. The poster abstract was 1 of 45 abstracts chosen as a top poster finalist out of a total of 823 scientific poster abstracts, representing the top 5% of all accepted poster abstracts for presentation. Co-authors on the poster included: Aimee Kroll-Desrosiers, Shunyan Mo, Hien P. Nguyen, Abby Svenson,Nina Jaitly, Janet Hall, Bruce Barton,Anthony Rothschild and Scott Shaffer. The study was funded by the CCTS Pilot Program Project grant (KMD) provided by UMMS CTSA grant UL1TR000161 (KMD) and NIMH 5K23MH097794 (KMD).
May 21, 2015
Faculty Scholar Award Winner - May 2015
Wendy Marsh, MD MS is the recipient of the 2015 UMass Medical School Faculty Scholar Award recently selected from a pool of competitive applications. The award will provide funding for her project: "Novel Biomarker for Bipolar Disorder: Sonic Hedgehog Protein."
December 9, 2014
Dr. Anthony Rothschild has been quoted in the New York Times regarding
Some see ketamine as an effective drug for some
patients and others see it as a dangerous hallucinogenic that has not been
July 17, 2014
American College of Neuropsychopharmacology (ACNP) 2014 ACNP Travel Award
After reviewing the nearly 300 submissions, the American College of Neuropsychopharmacology (ACNP) Education & Training Committee has selected Dr. Kristina M. Deligiannidis as a Travel Awardee for the 2014 ACNP Annual Meeting being held in Phoenix, Arizona from December 7-11, 2014. The ACNP annually selects distinguished young scientists in the field of neuropsychopharmacology to be a part of their Travel Award program. These awards offer an opportunity to attend an outstanding scientific program in clinical and basic research on brain-behavior-drug interactions; become aware of the most recent, and often unpublished, advances in psychopharmacology; and meet and interact with internationally distinguished researchers and scientists. Each Travel Awardee receives roundtrip coach air fare to attend the ACNP Annual Meeting; up to 5 nights lodging in the meeting hotel; paid Annual Meeting registration fee for recipient and his/her spouse; the opportunity to present a poster at the meeting; an allowance for other expenses; and an invitation to attend and present posters at the next four Annual Meetings. Congrats!
WCVB-TV interviewed post-partum depression study participant Nicole Caligiuri and UMMS psychiatrist Kristina Deligiannidis about post-partum depression, and Caligiuri’s participation in Dr. Deligiannidis’ clinical study trying to identify the neurochemical sources of the disorder.
Newsmaker: Rothschild dispels antidepressant myths
Psychiatric News features APA annual meeting highlights
In a special issue rounding up highlights from the recent annual meeting of the American Psychiatric Association (APA), Psychiatric News featured UMass Medical School depression expert Anthony Rothschild, MD. Dr. Rothschild, the Irving S. and Betty Brudnick Chair in Psychiatry and professor of psychiatry, led a workshop focused on debunking common myths surrounding antidepressants.
Antidepressants “really work” and do not “cause suicide,” said Rothschild. He referred clinicians to his most recent book, The Evidence-based Guide to Antidepressant Medications, for further details on the benefits and risks of antidepressants, including guidelines for prescribing to special populations such as children and adolescents, geriatric patients, and pregnant and lactating women.
Read the full story, “Expert Sets Record Straight on Antidepressant Myths,” in the May 18 issue of Psychiatric News.
Early Career Achievement in Science and Health Award
Kristina Deligiannidis, MD, Assistant Professor of Psychiatry
Seven women were honored at the 13th Annual Women’s Faculty Awards Luncheon, celebrating excellence in community service, education, science and health, patient care and mentorship. The event was held May 20 at UMass Medical School.
The Women’s Faculty Committee sponsors the awards, which were presented following the keynote presentation “Mentoring and Leadership on the Journey” from Jean King, PhD, professor of psychiatry.
Expert Sets Record Straight on Antidepressant Myths
Antidepressants do “really work” and do not “cause suicide,” said Anthony Rothschild, M.D., at APA’s 2013 annual meeting today during a discussion of his second book in the Evidence-Based Guides series, The Evidence-Based Guide to Antidepressant Medications (American Psychiatric Publishing, 2012). Rothschild is the Irving S. and Betty Brudnick Endowed Chair and Professor of Psychiatry at the University of Massachusetts Medical School.
For more on this please see http://www.psychnews.org/update/report2_AM13_8.html
Rothschild compares unblinded and double-blinded studies for treatment-resistant depression
|By Sandra Gray||April 19, 2013|
|UMass Medical School Communications|
For more information please see http://www.umassmed.edu/news/2013/research/depression-expert-calls-deep-brain-stimulation-results-promising.aspx
Kristina Deligiannidis, MD, Assistant Professor of Psychiatry and Obstetrics & Gynecology and Director, Depression Specialty Clinic, was recently awarded a prestigious NIH mentored research career development award (K23) from the NIH/NIMH. In 2012 the NIH reviewed 555 K23 career development award applications, of which 35 were awarded by the NIH/NIMH.
The five year award of approx. $1 million will investigate potential neuroendocrine and neuroimaging endophenotypes in postpartum depression. As part of the K23 award, Dr. Deligiannidis will acquire advanced training (UMMS Graduate School of Biomedical Sciences, NIMH, and Harvard) which will focus on reproductive and behavioral endocrinology and neuroimaging to study interactions of the reproductive endocrine system on neural circuitry in depression.
Kristina Deligiannidis, MD, Assistant Professor of Psychiatry and Obstetrics & Gynecology and Director, Depression Specialty Clinic,will present on “Nutriceuticals in the Treatment of Perinatal Depression” at the American Psychiatric Association’s 166th Annual Meeting in San Francisco, CA on May 18, 2013. Her presentation is part of the Symposium “Non-pharmacological Treatment Interventions for Perinatal Depression” chaired by Dr. Katherine Wisner and whose focus is the safety and efficacy of three commonly available nutriceuticals: omega-3 fatty acids, folate and S-Adenosylmethionine (SAMe). Other topics to be presented as part of this Symposium include psychotherapy, sleep and wake therapies and acupuncture in the treatment of perinatal depression. Dr. Deligiannidis is a perinatal psychiatrist who conducts translational perinatal depression research in the Center for Psychopharmacologic Research & Treatment (CPRT).
Dr Kristina Deligiannidis was recently invited to join the trainee advisory board (junior editorial board) of the Scandinavian peer-reviewed Journal, Acta Psychiatrica Scandinavica. Her three-year term will begin January 1, 2013. As a member of this internationally-based board she will participate in editorial training activities and participate in the annual Editorial Board meeting in Denmark.
Dr. Anthony Rothschild has been invited to join the Editorial Board of Comprehensive Psychiatry . Dr.Rothschild is also on the Editorial Board of the Journal of Clinical Psychiatry, Depression and Anxiety and Current Psychiatry as well as a reviewer for 26 jounals.
Can Vitamin D help chase away depression?
Wendy K. Marsh, M.D., M.S., assistant professor of psychiatry, UMass Medical School and UMass Memorial Health Care, is trying to find out.
Marsh is among an elite group of researchers chosen to receive prestigious 2012 Young Investigator Grants from the Brain & Behavior Research Foundation. The grants are said to be among the most competitive in biomedical research: Marsh’s was one of only 202 awarded from some 1,030 applications this year. Funding for the grants totals $11.9 million.
Marsh will use her award for a randomized double-blind, placebo-controlled pilot trial to examine the effect of Vitamin D supplementation on bipolar depression. She believes there is a link; that Vitamin D may help to safely reduce depression symptoms in bipolar disorders.
Trial participants with bipolar depression and low Vitamin D levels will receive either Vitamin D or a placebo and see if an increase in their Vitamin D levels can be associated with improved mood and, in particular, less depression.
Marsh’s research interests include mood and reproductive phases as well as alternative treatments for depression. She sees patients with a focus on mood disorders in relation to reproductive phases.
August 16, 2012 -
Dr. Søren Dinesen Østergaard, a visiting professor from the Aalborg Psychiatric Hospital and Aarhus University Hospital in Denmark, recently spoke to a UMMS Psychiatry audience about the evolving study of psychotic depression and the diagnoses and treatment of the disorder.
Østergaard, who is working on a clinical study to construct a rating scale for all of the symptoms of psychotic depression, said there is evidence that severe depression has “specific heritability” – meaning that it is passed down through generations of families.
Østergaard spoke at the Biological Psychiatry Seminar Aug. 16 at the invitation of Dr. Anthony Rothschild, whom Østergaard described as, “one of the most famous researchers in the field.” Rothschild, who holds the Irving S. and Betty Brudnick Endowed Chair of Psychiatry at UMMS, directs the UMass Medical Depression Center. He also serves as Program Director for the Mood Disorders Comprehensive Consultation Clinic at UMass Memorial Medical Center, and directs the Center for Psychopharmacologic Research and Treatment.
August 1, 2012
Clinical Manual for Diagnosis and Treatment of Psychotic Depression
"Anthony J. Rothschild, M.D."
In attendance were physicians, nurses, midwives, mental health providers and other professionals working with women and families in the perinatal period.
Kristina M. Deligiannidis, M.D. was elected to the national Board of Directors of the American Society of Clinical Psychopharmacology (ASCP) and installed at the 52nd Annual NCDEU meeting. The ASCP was founded in 1992 to advance the science and practice of clinical psychopharmacology. Its nearly 800 members are physicians who study and practice psychopharmacology, as well as doctoral level investigators of clinical psychopharmacology or of pharmacology. ASCP members are advocates for clinical psychopharmacology and for clinical research. She serves on the Model Curriculum Committee which develops psychopharmacology curricula for use in psychiatry residency training programs in the US and internationally.
May 6, 2012
Antidepressants do “really work” and do not “cause suicide,” said Anthony Rothschild, M.D., at APA’s 2012 annual meeting today during a discussion of his second book in the American Psychiatric Publishing’s Evidence-Based Guides series, The Evidence-Based Guide to Antidepressant Medications.
Child Psychiatry Interdisciplinary Annual Conference, Baystate Medical Center/Tufts University School of Medicine, Springfield, MA
Kristina M. Deligiannidis, M.D. gave a presentation for Baystate Health in Western Massachusetts on: -Perinatal Depression: Addressing the needs of mother and child.In attendance were physicians, nurses, midwives, mental health providers and other professionals working with women and families in the perinatal period.
March 12, 2012
Expert's Corner: Anthony Rothschild on depression
By Lisa M. Larson and Bryan Goodchild
UMass Medical School Communications
Anthony Rothschild, MD, the Irving S. and Betty Brudnick Chair in Psychiatry and professor of psychiatry, has been studying the pathophysiology and treatment of depression for approximately 30 years. In this Expert’s Corner video, Dr. Rothschild outlines the symptoms of a major depressive episode. He also explains different types of depression and talks about current research.See: http://umassmed.edu/news/2012/experts-corner/rothschild-anthony.aspx
At UMass Medical, brain ‘pacemaker’ targets depression
Kristina Deligiannidis, MD, assistant professor of psychiatry and director, Depression Specialty Clinic, will be giving a webinar about depression treatment in primary care settings, Wednesday, February 22, 12:20 to 12:50 pm. This monthly webinar series of Prime Time Conversations is presented by the Center for the Advancement of Primary Care (CAPC) for primary care physicians. Dr. Deligiannidis presents “When First-step Treatments for Depression Fail: Tips for Depression Treatment in the Primary Care Setting.” Understand how to treat the patient whose depression has failed to respond to an antidepressant trial and learn about the Depression Specialty Clinic. All Prime Time Conversations webinars are archived on the CAPC website.
New hope for treatment-resistant depression
Small pulses sent deep within the brain show great promise
By Sandra Gray
UMass Medical School Communications
January 19, 2012
Antidepressant expert creates user-friendly book
Rothschild editor of ‘The Evidence-Based Guide to Antidepressant Medications’
By Sandra Gray
UMass Medical School Communications
From the experts...
Do Antidepressants Cause Suicide?
Anthony J. Rothschild
In this article, I provide a brief outline of the discussion of two timely topics: whether antidepressants "really work" and whether antidepressants "can cause suicide".
October 4, 2011
Wendy Marsh MD MS and her co-authors awarded a top 2011 Poster Prize at the 22nd Annual North American Menopause Society (NAMS) Meeting in Washington DC, Sep. 24. Using the SWAN (Study of Women's health Across the Nation) database, Dr. Marsh and colleagues' study found that a longer duration of estradiol exposure, measured by years from menarche to menopause, prior to entering the menopausal transition was protective against depression during the menopausal transition. Read what Dr. Marsh says in the Reuters Health article, Oct. 4.
Efforts to fight depression earn national recognition
Center of Excellence advances collaborative work in prevention, treatment and advocacy
UMass Medical School and clinical partner UMass Memorial Health Care have been invited to join the National Network of Depression Centers (NNDC) as a Center of Excellence.
An elite network comprising 22 academic medical institutions, the NNDC was founded in 2007 to advance comprehensive, multidisciplinary collaboration and networking of resources on a national scale. “Our acceptance into this network of prestigious institutions is recognition of the collaborative work in the areas of depression treatment, research and advocacy underway at UMass Medical School and UMass Memorial,” said Anthony Rothschild, MD, the Irving S. and Betty Brudnick Chair in Psychiatry and professor of psychiatry.
For more information go to
By Sera Congi, WBZ-TV
Findings may help identify women who are at high risk
“Using new methods of imaging and measuring the brain’s chemistry, we can look at specific neurotransmitters in the brain involved in depression and see if there are any differences between women who develop postpartum depression and those who don’t,” said Kristina Deligiannidis, MD, assistant professor of psychiatry and principal investigator on the study.
For the full article and video please see:
May 11, 2011
66th SOBP Annual Meeting
Dr. Kristina Deligiannidis recently returned from San Francisco where she received a Society of Biological Psychiatry (SOBP) Travel Fellowship Award to attend the 66th SOBP Annual Meeting, President's reception (Helen Mayberg, MD) and an Awards Reception.
Six junior investigators in biological psychiatry research were awarded from the US, and six were awarded internationally to receive this fellowship award.
2010 Pilot Project Program Awardee
Kristina Deligiannidis, MD (T1)
The World Health Organization reports that depression is the leading cause of disease burden and years loss to disability for women in their childbearing years(1). The perinatal (i.e. antenatal and postpartum) period is a time of elevated risk for depression; approximately 1 in 8 women are diagnosed with postpartum depression (PPD) annually. PPD is marked by feelings of hopelessness, suicidal ideation, guilty ruminations, loss of interest and energy, loss of appetite, dysregulated sleep and poor daily functioning. To read more please see http://www.umassmed.edu/Content.aspx?id=126098.
Best Doctors 2011
Best Doctors®, Inc. continuously surveys specialists worldwide to ask which doctors they would choose for treatment in their own specialty. Less than five percent of U.S. doctors are named to the list. UMass Memorial Health Care is proud that more than 10 percent of our doctors at our five hospitals were named to this prestigious list
UMMS psychiatrists shed light on pervasive but treatable medical condition
UMass Medical School Communications
Launched last fall, Be Mentally Well is a series of informational lectures that are free and open to the public. At “Understanding and Treating Depression,” UMMS psychiatrists Anthony Rothschild, MD, Gary Moak, MD, and Kristina Deligiannidis, MD, clarified the signs and symptoms of depression, discussed the great variety of effective treatments already available and those under development, and explained the exceptional challenges of recognizing and treating depression in the elderly.
For more on this article please visit:
To find out when “Understanding and Treating Depression” will be broadcast by Worcester local access cable station WCAA-TV13, visit their website at http://www.wccatv.com/schedule.
EXPERT’S CORNER: Winter’s dark makes some especially SAD
According to Assistant Professor of Psychiatry Kristina Deligiannidis, MD, while genetic predisposition and preexisting depressive disorders can contribute to SAD, it is widely believed to result from the decrease in natural sunlight that occurs during the winter months, with the greatest incidence in northerly climes like ours.
Women’s mental health focus of sixth annual Psychiatry Research Day
|Dr. Kristina Deligiannidis discusses her research||
Among many distinguished guests at the event were Betty Brudnick and Shirley Siff, EdD, who
June 17, 2010
The latest round of Worcester Foundation for Biomedical Science (WFBR) Annual Research Grants, awarded to 13 UMass Medical School investigators, is continuing the tradition of sowing seeds for innovative research across a broad array of disciplines.
WFBR Annual Research Grants allow recipients to produce preliminary data needed to secure grants from the National Institutes of Health. Among the projects funded this year with $35,000 in seed grants are those of Kristina Deligiannidis, MD, assistant professor of psychiatry; Jeffrey Jensen, PhD, assistant professor of bioinformatics & integrated biology and molecular medicine; and Laura Lambert, MD, assistant professor of surgery.
Dr. Deligiannidis’s lab will obtain pilot data to establish a neurochemical biosignature (or marker) to identify pregnant women at risk for developing post-partum depression (PPD), a disorder which afflicts one in eight new mothers, so that a potential screening test may be developed. To investigate emerging pre-clinical and clinical evidence suggesting that dysregulation of neuroactive steroids and interrelated neurochemical systems contribute to the development of PPD, her lab will analyze blood levels of neuroactive steroids during and post pregnancy. In addition, they will measure women’s brain levels of specific neurochemicals that have been implicated in the development of PPD with magnetic resonance spectroscopy, a sophisticated neuroimaging technique. A School of Medicine and UMMS psychiatry residency graduate, Deligiannidis recently joined the faculty and is the medical director of the Depression Specialty Clinic at UMass Memorial Medical Center.
May 4, 2010
Senior Scholars Day
Senior Scholars Day 2010 was held Monday, May 3rd in the Faculty Conference Room. Students presented their research posters from 11-12noon. Senior Scholars Day keynote speaker, Dr. Anthony Rothschild, spoke about his career in research following the poster session. Students individually recieved certificates for completing their research project.
Saturday, May 22 – Wednesday, May 26
Psychopharmacologic, ECT, and Psychotherapeutic Treatment of Psychotic (Delusional) Depression
Monday, May 24 1:00pm-5:00pm
Presented by Anthony J. Rothschild, M.D.,with Brandon Guadiano, Ph.D.
This course will focus on how to accurately diagnose and assess patients with psychotic depression, identify the difficult differential diagnoses between psychotic depression and other psychiatric disorders, understand the use of adjunctive psychotherapy in patients with psychotic depression, and treat patients with psychotic depression with somatic therapies including medications or referral to electroconvulsive therapy.
The price includes a copy of Clinical Manual for the Diagnosis and Treatment of Psychotic Depression.
Advances in the Use of Antipsychotic Medications
Tuesday, May 25 9:00am-12:00pm
Co-Chairpersons: Anthony J. Rothschild, M.D., Kristina Deligiannidis, M.D.
This session is based, and all the speakers are authors from, the recently published Evidence Based Guide To Antipsychotic Medications. Each speaker will review both FDA-approved and off-label uses of antipsychotic medications (both first generation and second generation) and the evidence base that supports (or does not support) their use. Each of the speakers has taken a large amount of medical literature and synthesized it into a comprehensive and understandable formfor the practicing clinician. This session will focus on the use of antipsychotic medications in schizophrenia, schizoaffective disorder, personality disorders, mood and anxiety disorders, and in the medically ill.
MARCH 22, 2010
KRISTINA DELIGIANNIDIS MD has been selected to participate in the 2010 Career Development Institute (CDI) for Psychiatry, a career enhancement opportunity that provides support around launching and maintaining a career in mental health research. 15-20 participants were chosen nationally to attend the CDI this year.
UMass Memorial congratulates its physicians named to the 2010 list of
Best Doctors 2010
Best Doctors®, Inc. continuously surveys specialists worldwide to ask which doctors they would choose for treatment in their own specialty. Less than five percent of U.S. doctors are named to the list. UMass Memorial Health Care is proud that more than 10 percent of our doctors at our five hospitals were named to this prestigious list.