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Publications

Total: 737 results
  • Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus

    October 31, 2019
    Author(s): Gang Fu, Lei Zhao, Erin Dymek, Yuqing Hou, Kangkang Song, Nhan Phan, Zhiguo Shang, Elizabeth F. Smith, George B. Witman, Daniela Nicastro
    Source: The Journal of cell biology
    Nearly all motile cilia contain a central apparatus (CA) composed of two connected singlet microtubules with attached projections that play crucial roles in regulating ciliary motility. Defects in CA assembly usually result in motility-impaired or paralyzed cilia, which in humans causes disease. Despite their importance, the protein composition and functions of the CA projections are largely unknown. Here, we integrated bioc...
  • Dense motion propagation from sparse samples

    October 21, 2019
    Author(s): Rhodri L. Smith, Paul K. R. Dasari, Clifford Lindsay, Michael A. King, Kevin Wells
    Source: Physics in medicine and biology
    There are many applications for which sparse, or partial sampling of dynamic image data can be used for articulating or estimating motion within the medical imaging area. In this new work, we propose a generalized framework for dense motion propagation from sparse samples which represents an example of transfer learning and manifold alignment, allowing the transfer of knowledge across imaging sources of different domains whi...
  • Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy

    October 08, 2019
    Author(s): Ju-Yu Chueh, Dong-Hun Kang, Byung Moon Kim, Matthew J. Gounis
    Source: Journal of Korean Neurosurgical Society
    Proximal flow control achieved with a balloon guide catheter (BGC) during endovascular treatment of acute ischemic stroke is reviewed in this article. In clinical practice, BGCs offer a multi-faceted approach for clot retrieval by creating proximal flow arrest, reducing embolic burden, and shortening procedure time. Evaluation of frontline thrombectomy procedures with BGCs revealed advantages of combined use over the convent...
  • Flow Diversion for Treatment of Intracranial Aneurysms in Pediatric Patients: Multicenter Case Series

    September 26, 2019
    Author(s): Jacob Cherian, Ajit S. Puri, Peter Kan
    Source: Neurosurgery
    BACKGROUND: Though the Pipeline Embolization Device (Medtronic) is approved for use in adults 22 yr and older, the high efficacy and long-term durability of the device is attractive for treatment of intracranial aneurysms in younger patients who often have aneurysms less amenable to traditional endovascular treatments. OBJECTIVE: To report technical, angiographic, and clinical outcomes in patients aged 21 or below undergoing...
  • The central role of the tail in switching off 10S myosin II activity

    September 02, 2019
    Author(s): Shixin Yang, Kyounghwan Lee, John L. Woodhead, Osamu Sato, Mitsuo Ikebe, Roger Craig
    Source: The Journal of general physiology
    Myosin II is a motor protein with two heads and an extended tail that plays an essential role in cell motility. Its active form is a polymer (myosin filament) that pulls on actin to generate motion. Its inactive form is a monomer with a compact structure (10S sedimentation coefficient), in which the tail is folded and the two heads interact with each other, inhibiting activity. This conformation is thought to function in cel...
  • Opioid Use and Respiratory Compromise in the Interventional Suite: A Wake-up Call

    September 01, 2019
    Author(s): Max P. Rosen, J. Matthias Walz
    Source: Radiology
    The study by Urman et al (1) in this issue of Radiology addresses the effect of respiratory compromise among inpatients undergoing interventional radiology (IR) procedures performed with moderate sedation. The study was conducted by using a national all-payer database and included data from over 500 000 patients across 853 hospitals, collected during a 3-year period. The results demonstrated that, among a wide range of varia...
  • Site Experience and Outcomes in the Trevo Acute Ischemic Stroke (TRACK) Multicenter Registry

    September 01, 2019
    Author(s): Raul G. Nogueira, Ajit S. Puri
    Source: Stroke
    Background and Purpose- It remains unclear how experience influences outcomes after the advent of stent retriever technology. We studied the relationship between site experience and outcomes in the Trevo Acute Ischemic Stroke multicenter registry. Methods- The 24 sites that enrolled patients in the Trevo Acute Ischemic Stroke registry were trichotomized into low-volume ( 4 cases/month). Baseline features, imaging, and clini...
  • Abbreviated MRI of the foot in patients with suspected osteomyelitis

    August 28, 2019
    Author(s): Hemang M. Kotecha, Hao S. Lo, Srinivasan Vedantham, Heeseop Shin, Christopher Cerniglia
    Source: Emergency radiology
    PURPOSE: To determine the diagnostic accuracy of an abbreviated magnetic resonance imaging (MRI) protocol of the foot for the diagnosis of osteomyelitis in patients with acute foot infection. METHODS: This retrospective study evaluated adult patients (age 18 and over) visiting an academic medical center from 1 January 2013 to 31 December 2015 who were imaged with MRI for suspected acute pedal osteomyelitis. Examinations were...
  • A Program Director's Guide to Cultivating Diversity and Inclusion in Radiology Residency Recruitment

    August 28, 2019
    Author(s): Carolynn M. DeBenedectis, Darel E. Heitkamp, Eric England, Glenn C. Gaviola, Joshua A. Hirsch, Christopher P. Ho, Ann K. Jay, Nolan Kagetsu, Vivek Kalia, James Milburn, Seng Ong, Angelisa M. Paladin, Maitray D. Patel, Jonathan Swanson, David S. Sarkany
    Source: Academic radiology
    Diversity and inclusion are vital elements to the success of any group. Indeed, evidence from the business world indicates that a group's overall talent level is a function of its collective cognitive diversity. The ability to effectively problem solve, innovate, and adapt to change all depend to a large degree on the biases and life experiences of an organization's constituent members. As other industries have come to embra...
  • Metastatic Signet Ring Cell Carcinoma of the Ampulla of Vater with an Unusually Prolonged Survival

    August 27, 2019
    Author(s): Chandana Javvaji, Jacob R. Bledsoe, Lloyd Hutchinson, Ediz F. Cosar, Lacey J. McIntosh, Venu G. Bathini
    Source: Journal of gastrointestinal cancer
    Ampulla of Vater tumors are uncommon, with an incidence of approximately four to six cases per million population. Incidence of ampullary cancer is higher in Caucasian and African-American men than in women [Fig. 1]. Among the periampullary tumors, they account for around 6% of lesions. Signet ring cell pathology is a rare finding in ampulla of Vater carcinoma.
  • Flow diversion treatment for acutely ruptured aneurysms

    August 24, 2019
    Author(s): Michelle F. M. Ten Brinck, Maike Jager, Joost de Vries, J. Andre Grotenhuis, Rene Aquarius, Svein H. Morkve, Riitta Rautio, Jussi Numminen, Rahul Raj, Ajay K. Wakhloo, Ajit S. Puri, Christian A. Taschner, Hieronymus D. Boogaarts
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Flow diverters are sometimes used in the setting of acutely ruptured aneurysms. However, thromboembolic and hemorrhagic complications are feared and evidence regarding safety is limited. Therefore, in this multicenter study we evaluated complications, clinical, and angiographic outcomes of patients treated with a flow diverter for acutely ruptured aneurysms. METHODS: We conducted a retrospective obser...
  • Overview on Percutaneous Therapies of Disc Diseases

    August 12, 2019
    Author(s): Salvatore Masala, Fabio Salimei, Adriano Lacche, Stefano Marcia, Francesco Massari
    Source: Medicina (Kaunas, Lithuania)
    Low back pain is an extremely common pathology affecting a great share of the population, in particular, young adults. Many structures can be responsible for pain such as intervertebral discs, facet joints, nerve roots, and sacroiliac joints. This review paper focuses on disc pathology and the percutaneous procedures available to date for its treatment. For each option, we will assess the indications, technical aspects, adva...
  • Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation

    August 09, 2019
    Author(s): Aurora Rodriguez-Rodriguez, Sergey Shuvaev, Nicholas Rotile, Chloe M. Jones, Clemens K. Probst, Diego Dos Santos Ferreira, Katherine Graham-O Regan, Eszter Boros, Rachel S. Knipe, Jason W. Griffith, Andrew M. Tager, Alexei A. Bogdanov Jr., Peter Caravan
    Source: ACS sensors
    An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of...
  • Intraoperative Aneurysm Rupture during Resection for Presumed Metastasis

    August 09, 2019
    Author(s): Anna L. Kuhn, Katyucia de Macedo Rodrigues, Ajit S. Puri
    Source: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    A 54-year-old male with metastatic melanoma, including a presumed brain metastasis underwent elective surgery when there was sudden onset of extensive bleeding upon resection. An emergent cerebral angiogram revealed a fusiform left posterior cerebral artery aneurysm. Malignant melanoma commonly metastasizes to the brain and has shown to assume a wide variety of appearances with involvement of almost any intracranial structur...
  • A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

    August 02, 2019
    Author(s): Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aro...
    Source: Nature biotechnology
    Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent, sustained gene silencing in the central nervous system (CNS) of mice and nonhuman primates following a single injection into the cerebrospinal fluid. Di-siRNAs are composed of two fully chemically modified, phosphoroth...
  • Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept

    July 30, 2019
    Author(s): Jildaz Caroff, Robert M. King, Jennifer E. Mitchell, Miklos G. Marosfoi, Joseph R. Licwinko, Heather L. Gray-Edwards, Ajit S. Puri, Thomas L. Merrill, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    INTRODUCTION: The neuroprotective benefit of therapeutic hypothermia (TH) has been demonstrated, but systemic side effects and time required to achieve effective TH in acute ischemic stroke (AIS) care limits clinical use. We investigate rapid and localized cooling using a novel insulated catheter in an ischemia-reperfusion model. METHODS: In phase I (n=4), cold saline was delivered to the canine internal carotid artery via a...
  • Prospective study on embolization of intracranial aneurysms with the pipeline device: the PREMIER study 1 year results

    July 15, 2019
    Author(s): Ricardo A. Hanel, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Preliminary clinical studies on the safety and efficacy of the pipeline embolization device (PED) for the treatment of small/medium aneurysms have demonstrated high occlusion rates with low complications. OBJECTIVE: To evaluate the safety and effectiveness of the PED for treatment of wide necked small and medium intracranial aneurysms. METHODS: PREMIER is a prospective, multicenter, single arm trial. Patients wer...
  • The Association of Program Directors in Radiology Well-Being 2019 Survey: Identifying Residency Gaps and Offering Solutions

    July 11, 2019
    Author(s): Sheryl G. Jordan, Jessica B. Robbins, David Sarkany, Eric England, Vivek Kalia, Maitray D. Patel, Kamran Ali, Carolynn M. DeBenedectis, Christopher P. Ho, James M. Milburn, Seng Ong, Ann K. Jay, Glenn C. Gaviola, Darel E. Heitkamp
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: The Well-Being subcommittee of the Association of Program Directors in Radiology (APDR) Common Program Requirements (CPR) Ad Hoc Committee and the APDR Academic Output Task Force jointly conducted a study of APDR members' current level of understanding and implementation of the 2017 ACGME CPR regarding well-being. METHODS: A survey instrument consisting of 10 multiple-choice and open-ended questions was distributed ...
  • Still Coming Out of the Dark: Enduring Effects of Simulation-Based Communication Skills Training for Radiology Residents-Four-Year Follow-Up

    July 09, 2019
    Author(s): Sana Majid, Jean-Marc Gauguet, Lacey J. McIntosh, George Watts, Max P. Rosen, Carolynn M. DeBenedectis
    Source: Current problems in diagnostic radiology
    PURPOSE: To evaluate the long-term efficacy of simulation-based communication skills training for radiology residents. METHOD AND MATERIALS: The simulation-based communication skills training curriculum was developed in 2014. The curriculum included a teaching module based on the essential elements of communication. Two sets of 6 communication scenarios encountered by radiologist were created. First and fourth year radiology...
  • TARGET(R) Intracranial Aneurysm Coiling Prospective Multicenter Registry: Final Analysis of Peri-Procedural and Long-Term Safety and Efficacy Results

    July 09, 2019
    Author(s): Osama O. Zaidat, Ajit S. Puri
    Source: Frontiers in neurology
    Background and Purpose: To describe the final results of the TARGET Registry, a multicenter, real-world study of patients with intracranial aneurysms treated with new generation TARGET Coils. . Methods: The TARGET Registry is a prospective, single-arm study with independent medical event monitoring and core-lab adjudication. Patients with de novo intracranial aneurysms were embolized with either TARGET-360 degrees or helical...
  • Sarcopenia in lung cancer: Could chest imaging help?

    July 02, 2019
    Author(s): Jennifer Baima, Elke Sarah Schipani, Wasih Kamran, John M. Varlotto, Lacey J. McIntosh, Karl Uy, Isabel Emmerick, Mathew J. Most
    Source: Prehabilitation World Congress 2019
    Introduction: Fifteen to seventy percent of cancer patients demonstrate sarcopenia.1-6,[i],[ii],[iii],[iv],[v],[vi],[vii],[viii],[ix],[x],[xi],[xii],[xiii] Analysis of iliopsoas cross-sectional area, a non-invasive surrogate measure for sarcopenia in patients with cancer has been associated with survival.[xiv],[xv],[xvi],[xvii] The pectoralis muscle may be a more accessible target for measuring sarcopenia in lung cancer pati...
  • Impact of age on cerebral aneurysm occlusion after flow diversion

    July 01, 2019
    Author(s): Anna Luisa Kuhn, Peter Kan, Nils Henninger, Visish Srinivasan, Katyucia de Macedo Rodrigues, Ajay K. Wakhloo, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
    The purpose of this study was to evaluate safety and efficacy of the pipeline embolization device (PED) in different patient age groups with unruptured intracranial aneurysms (UIA). All patients with UIA treated with the PED between 2011 and 2017 were included. Based on their age, patients were trichotomized to: young ( /=65years) groups. Patient's vascular risk factors, presenting symptoms and mRS on admission were collect...
  • Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source

    July 01, 2019
    Author(s): Sean Fitzgerald, Matthew J. Gounis, Juyu Chueh, Ajit S. Puri, Waleed Brinjikji
    Source: Stroke
    Background and Purpose- Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source. We assessed histological clot composition in a series of patients with large vessel occlusion and investigated correlations between clot composition and stroke pathogenesis. Methods- As part of the multi-institutional STRIP registry (Stroke Thromboembolism Registry of Imaging and Pathology), consecutive emboli...
  • Introduction. Formation, growth, and rupture: the biology and physics of cerebral aneurysms

    July 01, 2019
    Author(s): Charles J. Prestigiacomo, Matthew J. Gounis, L. Fernando Gonzalez, Juhana Frosen
    Source: Neurosurgical focus
    his issue of Neurosurgical Focus addresses several of the important biological and genetic aspects of aneurysm formation. The reader will be exposed to the latest theories of aneurysm formation that invoke genetic predispositions and the role of inflammation and matrix metalloproteinases in the genesis of a cerebral aneurysm. Observational studies provide additional insight into the role of estrogen and other female sex ster...
  • Shortened cataract surgery by standardisation of the perioperative protocol according to the Joint Commission International accreditation: a retrospective observational study

    June 14, 2019
    Author(s): Yuichi Okumura, Takenori Inomata, Masao Iwagami, Atsuko Eguchi, Ju Mizuno, Tina Shiang, Shiori Kawasaki, Akie Shimada, Eiichi Inada, Atsushi Amano, Akira Murakami
    Source: BMJ open
    OBJECTIVES: To investigate the impact of standardisation of the perioperative protocol based on the Joint Commission International (JCI) accreditation guidelines for operating time in cataract surgery. DESIGN: Retrospective observational study. SETTING: Single centre in Japan. PARTICIPANTS: Between March 2014 and June 2016, 3127 patients underwent cataract surgery under topical anaesthesia including 2581 and 546 patients bef...
  • Proteome of the central apparatus of a ciliary axoneme

    June 03, 2019
    Author(s): Lei Zhao, Yuqing Hou, Tyler Picariello, Branch Craige, George B. Witman
    Source: The Journal of cell biology
    Nearly all motile cilia have a "9+2" axoneme containing a central apparatus (CA), consisting of two central microtubules with projections, that is essential for motility. To date, only 22 proteins are known to be CA components. To identify new candidate CA proteins, we used mass spectrometry to compare axonemes of wild-type Chlamydomonas and a CA-less mutant. We identified 44 novel candidate CA proteins, of which 13 are cons...
  • Lithium-Induced Chronic Kidney Disease in a Pediatric Patient

    June 03, 2019
    Author(s): Neena Gupta, Meghan Gibson, Ellen C. Wallace
    Source: Case reports in pediatrics
    Lithium-induced nephropathy usually manifests in adulthood as it develops slowly after many years of cumulative exposure. There is very limited information available in pediatric patients. Renal function monitoring and timely intervention is the key in preventing lithium-induced chronic kidney disease in these patients. We report a case of a 14-year-old boy who was on lithium for almost 9 years for his complex psychiatric il...
  • Benign Breast Cyst in a Young Male

    June 03, 2019
    Author(s): Nima Azimi, Azniv Azar, Ashraf Khan, Carolynn M. DeBenedectis
    Source: Cureus
    Simple benign breast cysts are commonly diagnosed in female breasts and may present as palpable masses. However, they are extremely uncommon in the male breast and are rarely reported in the literature. Here, we report a case of a simple benign cyst of the breast in a relatively healthy 37-year-old man. The patient initially presented with a palpable 2-3 mm tender left breast lump. Further evaluation with mammography and ult...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria ((R)): Radiologic Management of Central Venous Access

    May 28, 2019
    Author(s): Roberta Savo, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Venous access is a procedure in which a catheter is placed into a vein for medical diagnosis or therapy. The type of device used depends on the patient and the type of illness being treated. There are two main types of venous access devices: peripheral and central catheters. A peripheral catheter is usually placed into a small vein, often in the arm, and is usually used up to 96 hours. A central catheter can be placed into a...
  • A canine model of mechanical thrombectomy in stroke

    May 18, 2019
    Author(s): Olivia W. Brooks, Robert M. King, Erez Nossek, Miklos G. Marosfoi, Jildaz Caroff, Juyu Chueh, Ajit S. Puri, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    PURPOSE: To develop a preclinical model of stroke with a large vessel occlusion treated with mechanical thrombectomy. MATERIALS AND METHODS: An ischemic stroke model was created in dogs by the introduction of an autologous clot into the middle cerebral artery (MCA). A microcatheter was navigated to the clot and a stent retriever thrombectomy was performed with the goal to achieve Thrombolysis in Cerebral Ischemia (TICI) 2b/3...
  • Retrospective fractional dose reduction in Tc-99m cardiac perfusion SPECT/CT patients: A human and model observer study

    May 10, 2019
    Author(s): P. Hendrik Pretorius, Albert Juan Ramon, Michael A. King, Arda Konik, Seth T. Dahlberg, Matthew Parker, Naomi F. Botkin, Karen L. Johnson, Yongyi Yang, Miles N. Wernick
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: In the ongoing efforts to reduce cardiac perfusion dose (injected radioactivity) for conventional SPECT/CT systems, we performed a human observer study to confirm our clinical model observer findings that iterative reconstruction employing OSEM (ordered-subset expectation-maximization) at 25% of the full dose (quarter-dose) has a similar performance for detection of hybrid cardiac perfusion defects as FBP at full...
  • Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy

    May 03, 2019
    Author(s): Diederik W.D. Kuster, Thomas L. Lynch, David Y. Barefield, Mayandi Sivaguru, Gina Kuffel, Michael J. Zilliox, Kyounghwan Lee, Roger Craig, Rajasekaran Namakkal-Soorappan, Sakthivel Sadayappan
    Source: Cardiovascular research
    AIMS: A 25-base pair (bp) deletion in the cardiac myosin binding protein-C (cMyBP-C) gene (MYBPC3), proposed to skip exon 33, modifies the C10 domain (cMyBP-CDeltaC10mut) and is associated with hypertrophic cardiomyopathy (HCM) and heart failure, affecting approximately 100 million South Asians. However, the molecular mechanisms underlying the pathogenicity of cMyBP-CDeltaC10mutin vivo are unknown. We hypothesized that expre...
  • Unconventional myosins muscle into myofibrils

    May 03, 2019
    Author(s): Elizabeth J. Luna
    Source: The Journal of biological chemistry
    "Myosin" is famous as a component of muscle fibrils, but the majority of myosin family members act elsewhere with roles unrelated to muscle contraction. The biological functions of a relatively new family of these unconventional myosins, myosins 18A and 18B, are poorly understood. New research from Horsthemke et al. describes a new isoform (Myo18Agamma) that is essential for heart function and viability in mice. Their findin...
  • Segmental Distribution of Hepatocellular Carcinoma Correlates with Microvascular Invasion in Liver Explants Undergoing Transplantation

    May 02, 2019
    Author(s): Yasir Al-Azzawai, Eva Rouanet, Ryan J. Hendrix, Lidia Spaho, Hesham Malik, Deepika Devuni, Gyongyi Szabo, Graham Barnard
    Source: Journal of cancer epidemiology
    Introduction: Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients is a poor prognostic factor after liver transplantation and/or resection. Any correlation between MVI and segmental location of HCC has yet to be studied. Our aim is to evaluate the segmental location of HCC and any correlation with the presence of MVI, portal vein thrombosis (PVT) in explanted livers, and the recurrence of HCC after transp...
  • ACR Appropriateness Criteria ((R)) Jaundice

    May 01, 2019
    Author(s): Expert Panel on Gastrointestinal Imaging, Nicole M. Hindman, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Jaundice is the end result of myriad causes, which makes the role of imaging in this setting particularly challenging. In the United States, the most common causes of all types of jaundice fall into four categories including hepatitis, alcoholic liver disease, blockage of the common bile duct by a gallstone or tumor, and toxic reaction to a drug or medicinal herb. Clinically, differentiating between the various potential eti...
  • ACR Appropriateness Criteria ((R)) Nonatherosclerotic Peripheral Arterial Disease

    May 01, 2019
    Author(s): Expert Panels on Vascular Imaging, Christopher J. Francois, Erik P. Skulborstad, Sanjeeva P. Kalva, Bill S. Majdalany, Jeremy D. Collins, Jens Eldrup-Jorgensen, Maros Ferencik, Suvranu Ganguli, A. Tuba Kendi, Minhajuddin S. Khaja, Piotr Obara, Thomas Ptak, Stephen P. Reis, Patrick D. Sutphin, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    A broad range of nonatherosclerotic diseases affect the peripheral arteries. The appropriate initial diagnostic imaging studies vary, depending upon the clinical presentation and suspicion of disease. Accurate vascular imaging relies upon visualization of the vessel lumen, vessel wall, and surrounding soft-tissue structures, with some modalities also offering the ability to characterize blood flow direction and velocity. Fur...
  • ACR Appropriateness Criteria ((R)) Right Upper Quadrant Pain

    May 01, 2019
    Author(s): Expert Panel on Gastrointestinal Imaging, Christine M. Peterson, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Although right upper quadrant pain is a very common clinical presentation, it can be nonspecific. However, acute cholecystitis is very often the diagnosis of exclusion. This review focuses on the recommended imaging evaluation in the most commonly encountered clinical scenarios presenting with right upper quadrant abdominal pain, including suspected biliary disease, suspected acute cholecystitis, and suspected acalculous cho...
  • ACR Appropriateness Criteria ((R)) Abdominal Aortic Aneurysm Follow-up (Without Repair)

    May 01, 2019
    Author(s): Expert Panel on Vascular Imaging, Michael Collard, Patrick D. Sutphin, Sanjeeva P. Kalva, Bill S. Majdalany, Jeremy D. Collins, Jens Eldrup-Jorgensen, Christopher J. Francois, Suvranu Ganguli, Andrew J. Gunn, A. Tuba Kendi, Minhajuddin S. Khaja, Piotr Obara, Stephen P. Reis, Kanupriya Vijay, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Abdominal aortic aneurysm (AAA) is defined as aneurysmal dilation of the abdominal aorta to 3 cm or greater. A high degree of morbidity and mortality is associated with AAA rupture, and imaging surveillance plays an essential role in mitigating the risk of rupture. Aneurysm size and growth rate are factors associated with the risk of rupture, thus surveillance imaging studies must be accurate and reproducible to characterize...
  • Should Radiology Delay the Start of Fellowships? A Survey of the APDR

    April 29, 2019
    Author(s): James Michael Milburn, Darel E. Heitkamp, Ann K. Jay, David Sarkany, Kamran Ali, Carolynn M. DeBenedectis, Eric England, Christopher P. Ho, Vivek Kalia, Todd R. Kumm, Seng Ong, Angelisa M. Paladin, Maitray D. Patel, Jonathan O. Swanson, Joshua A. Hirsch
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: Several major medical specialties have recently considered delaying the start date of their fellowship training programs to allow for completion of their trainees' residency obligations. Radiology program directors (PDs) have voiced the need for a similar solution, as fellowship start dates at some institutions now occur well before the end of residency training. The objectives of this study are to ...
  • High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion

    April 29, 2019
    Author(s): Robert M. King, Miklos G. Marosfoi, Jildaz Caroff, Giovanni J. Ughi, Dale M. Groth, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: High frequency optical coherence tomography (HF-OCT) is a novel intravascular imaging technology developed for use in the cerebral vasculature. We hypothesize that HF-OCT characterization of intrasaccular device neck coverage can prognosticate exclusion of the aneurysm from the circulation. METHODS: Bifurcation and sidewall aneurysms were made in six dogs. Seven aneurysms were treated with next generation intrasa...
  • Microaggression in Radiology

    April 08, 2019
    Author(s): Carolynn M. Debenedictis, Ann K. Jay, James Milburn, Judy Yee, Nolan J. Kagetsu
    Source: Journal of the American College of Radiology : JACR
    A microaggression is a comment or an action that subtly and often unconsciously or unintentionally expresses a prejudiced attitude toward a member of a marginalized group (such as a racial minority). Microaggressions can be seen in all aspects of society in everyday life. As members of the Association of Program Directors in Radiology and/or the ACR Diversity Committee, we want to raise awareness about microaggressions in ev...
  • Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT

    April 05, 2019
    Author(s): Sean T. Fitzgerald, Matthew J. Gounis, Juyu Chueh, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize clot composition using the Martius Scarlet Blue stain and assess associations between platelet density and CT density. MATERIALS AND METHOD: Histopathological analysis of the clots collected as part of the m...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Staging of Pancreatic Ductal Adenocarcinoma

    April 01, 2019
    Author(s): Frank J. Rybicki Jr., Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Pancreatic ductal adenocarcinoma, cancer of the pancreas, usually causes only vague symptoms until the pancreatic duct is blocked. Surgery with complete removal of the tumor is curative. Thus, it is important to find out if the tumor has spread outside of the pancreas or whether it remains confined to the pancreas and can be completely resected (surgically removed).
  • Antiretroviral Hydrophobic Core Graft-Copolymer Nanoparticles: The Effectiveness against Mutant HIV-1 Strains and in Vivo Distribution after Topical Application

    March 27, 2019
    Author(s): Anita M. Leporati, Suresh Gupta, Elijah Bolotin, Gerardo Castillo, Joshua Alfaro, Marina B. Gottikh, Alexei A. Bogdanov Jr.
    Source: Pharmaceutical research
    PURPOSE: Developing and testing of microbicides for pre-exposure prophylaxis and post-exposure protection from HIV are on the list of major HIV/AIDS research priorities. To improve solubility and bioavailability of highly potent anti-retroviral drugs, we explored the use of a nanoparticle (NP) for formulating a combination of two water-insoluble HIV inhibitors. METHODS: The combination of a non-nucleoside HIV reverse transcr...
  • Transitioning from Radiology Training to Academic Faculty: Defining Your Role and Interests

    March 07, 2019
    Author(s): Joseph R. Grajo, Michele Retrouvey, Omer Awan, Tara Catanzano, Li Hsia Cheong Alicia, David Mankoff, Jonathan H. Burdette, Mishal Mendiratta-Lala, Lucy B. Spalluto, Richard A. Bronen, Carolynn M. DeBenedectis
    Source: Current problems in diagnostic radiology
    Transitioning from radiology training to academic faculty presents many challenges. In this review, we discuss strategies to navigate this process and to facilitate success through appropriate selection of career tracks. Various modern avenues include roles as a Clinician-Educator, Clinician-Investigator, and Clinician-Administrator. Selection of the appropriate career track based on personal interests and institutional cult...
  • Impact of Balloon Guide Catheter Use on Clinical and Angiographic Outcomes in the STRATIS Stroke Thrombectomy Registry

    March 01, 2019
    Author(s): Osama O. Zaidat, Ajit S. Puri
    Source: Stroke
    Background and Purpose- Mechanical thrombectomy has been shown to improve clinical outcomes in patients with acute ischemic stroke. However, the impact of balloon guide catheter (BGC) use is not well established. Methods- STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter study of patients with large vessel occlusion treated with the Sol...
  • Transitioning From Radiology Training to Academic Faculty: The Importance of Mentorship

    February 27, 2019
    Author(s): Michele Retrouvey, Joseph R. Grajo, Omer Awan, Tara Catanzano, Li Hsia Cheong Alicia, David Mankoff, Jonathan H. Burdette, Mishal Mendiratta-Lala, Lucy B. Spalluto, Richard A. Bronen, Carolynn M. DeBenedectis
    Source: Current problems in diagnostic radiology
    Transitioning from radiology residency to academic faculty presents many challenges. In this review, we discuss the importance of introspection and mentorship to successfully navigate this process. Key points include alignment of goals with those of the institution, formation of a mentorship program, and periodic reassessment of career goals. These tips and tools can help make the transition from residency to academic facult...
  • Getting into the thick (and thin) of it

    February 21, 2019
    Author(s): Thomas C. Irving, Roger Craig
    Source: The Journal of general physiology
    The heart is a highly regulated system in which a combination of mechanisms work together to match cardiac output to the needs of the body. Loss of this regulation characterizes many cardiomyopathies, where muscle is either hypo- or hypercontractile. For many years, x-ray diffraction has been used to study the structural basis of myofilament length-dependent activation...
  • Cardiac motion correction for improving perfusion defect detection in cardiac SPECT at standard and reduced doses of activity

    February 20, 2019
    Author(s): Chao Song, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Piotr J. Slomka, Michael A. King
    Source: Physics in medicine and biology
    In cardiac SPECT perfusion imaging, cardiac motion can lead to motion blurring of anatomical detail and perfusion defects in the reconstructed myocardium. In this study, we investigated the potential benefit of cardiac motion correction for improving the detectability of perfusion defects. We considered a post-reconstruction motion correction (PMC) approach in which the image motion between two cardiac gates is obtained with...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria Imaging After Total Knee Arthroplasty

    February 18, 2019
    Author(s): Casey Quinlan, Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Knee replacement, or total knee arthroplasty, is the most common joint replacement procedure in the United States. Most patients do not require any imaging after discharge other than the x-rays at the first postoperative follow-up appointment.
  • Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

    February 13, 2019
    Author(s): Anne-Laure Papa, Amanda Jiang, Netanel Korin, Michelle B. Chen, Erin T. Langan, Anna Waterhouse, Emma Nash, Jildaz Caroff, Amanda Graveline, Andyna Vernet, Akiko Mammoto, Tadanori Mammoto, Abhishek Jain, Roger D. Kamm, Matthew J. Gounis, Donald E. Ingber
    Source: Science translational medicine
    Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation and activation capacity could act as reversible inhibitors of platelet activation cascades. Here, we describe the development of detergent-extracted human modified platelets (pl...
  • A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia

    February 11, 2019
    Author(s): Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, George B. Witman
    Source: Journal of cell science
    Intraflagellar transport (IFT), which is essential for the formation and function of cilia in most organisms, is the trafficking of IFT trains (i.e. assemblies of IFT particles) that carry cargo within the cilium. Defects in IFT cause several human diseases. IFT trains contain the complexes IFT-A and IFT-B. To dissect the functions of these complexes, we studied a Chlamydomonas mutant that is null for the IFT-A protein IFT14...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Lower Extremity Arterial Revascularization-Post-Therapy Imaging

    February 11, 2019
    Author(s): Frank Jr. Rybicki, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    The goal of endovascular angioplasty and of surgical bypass is to restore normal blood flow to the diseased arteries in the legs for individuals with peripheral artery disease. Both procedures need imaging follow-up to check for lesions, typically narrowing of arteries that may come back and cause symptoms. Often, noninvasive testing is done first to help choose the appropriate imaging test. The first test is usually measure...
  • Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

    February 07, 2019
    Author(s): Andrea M. Herrmann, Stephan Meckel, Matthew J. Gounis, Leona Kringe, Edith Motschall, Christoph Mulling, Johannes Boltze
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular...
  • Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization

    February 04, 2019
    Author(s): Rose Arslanian, Miklos G. Marosfoi, Jildaz Caroff, Robert M. King, Christopher M. Raskett, Ajit S. Puri, Matthew J. Gounis, Juyu Chueh
    Source: Journal of neurointerventional surger
    BACKGROUND: Evidence is mounting that first-pass complete recanalization during mechanical thrombectomy is associated with better clinical outcomes in patients presenting with an emergent large vessel occlusion. We hypothesize that aspiration achieving complete clot ingestion results in higher first-pass successful recanalization with quantitative reduction in distal emboli. METHODS: A patient-specific cerebrovascular replic...
  • Effect of balloon guide catheter on clinical outcomes and reperfusion in Trevo thrombectomy

    February 02, 2019
    Author(s): Thanh N. Nguyen, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    INTRODUCTION: The Solitaire stent retriever registry showed improved reperfusion, faster procedure times, and better outcome in acute stroke patients with large vessel occlusion treated with a balloon guide catheter (BGC) and Solitaire stent retriever compared with a conventional guide catheter. The goal of this study was to evaluate whether use of a BGC with the Trevo stent retriever improves outcomes compared with a conven...
  • Mortality Associated With Opioid Overdose: A Review of Clinical Characteristics and Health Services Received in the Year Prior to Death

    February 01, 2019
    Author(s): Christian Rose, Abtin Shahanaghi, Mauricio Romero-Gonzalez, Jorge Yarzebski, Michael Andre, Gregory J. DiGirolamo, Alan P. Brown, Gerardo Gonzalez
    Source: Psychiatric services (Washington, D.C.)
    OBJECTIVE:: To assess missed opportunities for reducing fatal opioid overdoses, characteristics of decedents by opioid overdose with and without problematic opioid use who received health care services within one year of death were examined. METHODS:: Of 157 decedents in the Worcester, Massachusetts, area between 2008 and 2012, 112 had contact with the health care system. Electronic medical records were reviewed for clinical...
  • A2, M2, P2 aneurysms and beyond: results of treatment with pipeline embolization device in 65 patients

    January 23, 2019
    Author(s): Christopher T. Primiani, Ajit S. Puri, Maxim Mokin
    Source: Journal of neurointerventional surgery
    BACKGROUND: Intracranial aneurysms located in the distal vessels are rare and remain a challenge to treat through surgical or endovascular interventions. OBJECTIVE: To describe a multicenter approach with flow diversion using the pipeline embolization device (PED) for treatment of distal intracranial aneurysms. METHODS: Cases of distal intracranial aneurysms defined as starting on or beyond the A2 anterior cerebral artery, M...
  • Neuroform Atlas Stent System for the treatment of intracranial aneurysm: primary results of the Atlas Humanitarian Device Exemption cohort

    January 22, 2019
    Author(s): Brian T. Jankowitz, Ricardo Hanel, Ashutosh P. Jadhav, David N. Loy, Donald Frei, Adnan H. Siddiqui, Ajit S. Puri, Ahmad Khaldi, Aquilla S. Turk, Adel M. Malek, Eric Sauvageau, Steven W. Hetts, Osama O. Zaidat
    Source: Journal of neurointerventional surgery
    BACKGROUND AND OBJECTIVE: Stent-assisted coil embolization is a well-established treatment of intracranial wide-necked aneurysms. The Neuroform Atlas Stent System is a new generation microstent designed to enhance coil support, conformability, deliverability, and improve deployment accuracy. We present the 1-year efficacy and angiographic results of the Humanitarian Device Exemption (HDE) cohort from the Atlas Investigationa...
  • Towards Drug Safety Surveillance and Pharmacovigilance: Current Progress in Detecting Medication and Adverse Drug Events from Electronic Health Records

    January 16, 2019
    Author(s): Feifan Liu, Abhyuday Jagannatha, Hong Yu
    Source: Drug safety
    Large-scale drug safety surveillance and pharmacovigilance are key components of effective drug regulation systems, clinical practice, and public health programs. Although the efficacy and safety of a drug must be demonstrated in a series of clinical trials prior to approval, many adverse drug events (ADEs) are detected only after a drug has been marketed when it is used by a larger and more diverse population than during cl...
  • Overview of the First Natural Language Processing Challenge for Extracting Medication, Indication, and Adverse Drug Events from Electronic Health Record Notes (MADE 1.0)

    January 16, 2019
    Author(s): Abhyuday Jagannatha, Feifan Liu, Weisong Liu, Hong Yu
    Source: Drug safety
    INTRODUCTION: This work describes the Medication and Adverse Drug Events from Electronic Health Records (MADE 1.0) corpus and provides an overview of the MADE 1.0 2018 challenge for extracting medication, indication, and adverse drug events (ADEs) from electronic health record (EHR) notes. OBJECTIVE: The goal of MADE is to provide a set of common evaluation tasks to assess the state of the art for natural language processing...
  • Outcomes after coverage of lenticulostriate vessels by flow diverters: a multicenter experience

    January 11, 2019
    Author(s): Kathryn M. Wagner, Visish M. Srinivasan, Aditya Srivatsan, Michael G. Ghali Z, Ajith J. Thomas, Alejandro Enriquez-Marulanda, Abdulrahman Y. Alturki, Christopher S. Ogilvy, Maxim Mokin, Anna L. Kuhn, Ajit Puri, Ramesh Grandhi, Stephen Chen, Jeremiah Johnson, Peter Kan
    Source: Journal of neurosurgery
    OBJECTIVE: With the increasing use of flow diversion as treatment for intracranial aneurysms, there is a concomitant increased vigilance in monitoring complications. The low porosity of flow diverters is concerning when the origins of vessels are covered, whether large circle of Willis branches or critical perforators. In this study, the authors report their experience with flow diverter coverage of the lenticulostriate vess...
  • Incorporating Patient- and Family-Centered Care Into Radiology Residency Training Through an Experiential Curriculum

    January 08, 2019
    Author(s): Carolynn M. DeBenedectis, David Sarkany, Michael Morrow, Danielle Del Re, Devon DiVito, Stephen D. Brown, Priscilla J. Slanetz
    Source: Journal of the American College of Radiology : JACR
    The intention of this article is to introduce the Communication Curriculum for Radiology Residents developed by the ACR PFCC Committee, as well as to describe the research behind it and how radiology residency program directors can use it.
  • Improving Communication of Actionable Findings in Radiology Imaging Studies and Procedures Using an EMR-Independent System

    January 05, 2019
    Author(s): Steven J. Baccei, Cole DiRoberto, Janet Greene, Max P. Rosen
    Source: Journal of medical systems
    The primary purpose of this study is to determine if the implementation of an actionable findings communication system (PeerVue) with explicitly defined criteria for the classification of critical results, leads to an increase in the number of actionable findings reported by radiologists. Secondary goals are to 1) analyze the adoption rate of PeerVue and 2) assess the accuracy of the classification of actionable findings wit...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Prostate Cancer-Pretreatment Detection, Surveillance, and Staging

    January 01, 2019
    Author(s): David B. Andrews, Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Regular screening is recommended for men beginning about age 55. The first sign of cancer comes from either a blood test for a protein specific to prostate cancer (PSA) or by a digital examination of the prostate through the rectum to assess enlargement or firmness. Neither of these is perfectly accurate. Suspicion of cancer warrants additional testing.
  • Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human Diseases

    January 01, 2019
    Author(s): Alexei A. Bogdanov Jr., I. D. Solovyev, A P. Savitsky
    Source: Biochemistry. Biokhimiia
    Various sensors designed for optical and photo(opto)acoustic imaging in living systems are becoming essential components of basic and applied biomedical research. Some of them including those developed for determining enzyme activity in vivo are becoming commercially available. These sensors can be used for various fluorescent signal detection methods: from whole body tomography to endoscopy with miniature cameras. Sensor mo...
  • 19F MRI Imaging of Polymer Nanogels Aided by Improved Segmental Mobility of Embedded Fluorine Moieties

    December 18, 2018
    Author(s): Oyuntuya Munkhbat, Mine Canakci, Shaokuan Zheng, Weiguo Hu, Barbara Osborne, Alexei A. Bogdanov, S. Thayumanavan
    Source: Biomacromolecules
    Using fluorinated probes for 19F MRI imaging is an emerging field with potential utility in cellular imaging and cell tracking in vivo, which complements conventional 1H MRI. An attractive feature of 19F-based imaging is that this is a bio-orthogonal nucleus and the naturally abundant isotope is NMR active. A significant hurdle however in the 19F MRI arises from the tendency of organic macromolecules, with multiple fluorocar...
  • A Revisit to the Pretargeting Concept - A Target Conversion

    December 17, 2018
    Author(s): Guozheng Liu
    Source: Frontiers in pharmacology
    Pretargeting is often used as a tumor targeting strategy that provides much higher tumor to non-tumor ratios than direct-targeting using radiolabeled antibody. Due to the multiple injections, pretargeting is investigated less than direct targeting, but the high T/NT ratios have rendered it more useful for therapy. While the progress in using this strategy for tumor therapy has been regularly reviewed in the literature, this ...
  • Personalized Models for Injected Activity Levels in SPECT Myocardial Perfusion Imaging

    December 06, 2018
    Author(s): Albert Juan Ramon, Yongyi Yang, P. Hendrik Pretorius, Karen L. Johnson, Michael A. King, Miles N. Wernick
    Source: IEEE transactions on medical imaging
    We propose a patient-specific ("personalized") approach for tailoring the injected activities to individual patients in order to achieve dose reduction in SPECT-myocardial perfusion imaging (MPI). First, we develop a strategy to determine the minimum dose levels required for each patient in a large set of clinical acquisitions (857 subjects) such that the reconstructed images are sufficiently similar to that obtained at conv...
  • Intravascular Optical Coherence Tomography for Neurointerventional Surgery

    November 29, 2018
    Author(s): Matthew J. Gounis, Giovanni J. Ughi, Miklos G. Marosfoi, Demetrius K. Lopes, David Fiorella, Hiram G. Bezerra, Conrad W. Liang, Ajit S. Puri
    Source: Stroke
    Optical coherence tomography (OCT) is a high-resolution imaging modality that uses backscattered light to produce cross-sectional images of biological tissue with micrometer resolution. The first publication using the term OCT appeared in 1991 and arose as a collaboration between the Massachusetts Institute of Technology (MIT) and Harvard University. The high-spatial resolution makes it an optimal modality for imaging pathol...
  • Endovascular techniques for achievement of better flow diverter wall apposition

    November 28, 2018
    Author(s): Anna L. Kuhn, Katyucia de Macedo Rodrigues, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Flow diverter malapposition has been described as a technical complication during endovascular procedures and can be associated with, potentially delayed, life-threatening aneurysm rupture or ischemic events. We performed a retrospective review of our flow diverter database to identify all patients in whom device malapposition was detected on follow-up angiogram immediately after device deployment. Feasibility and technical ...
  • Performance analysis of a high-sensitivity multi-pinhole cardiac SPECT system with hemi-ellipsoid detectors

    November 08, 2018
    Author(s): Narayan Bhusal, Joyoni Dey, Jingzhu Xu, Kesava S. Kalluri, Arda Konik, Joyeeta M. Mukherjee, P. Hendrik Pretorius
    Source: Medical physics
    PURPOSE: Single-photon emission computed tomography (SPECT) is a noninvasive imaging modality, used in myocardial perfusion imaging. The challenges facing the majority of clinical SPECT systems are low sensitivity, poor resolution, and the relatively high radiation dose to the patient. New generation systems (GE Discovery, DSPECT) dedicated to cardiac imaging improve sensitivity by a factor of 5-8. This improvement can be us...
  • Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT

    November 07, 2018
    Author(s): Albert Juan Ramon, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Karen L. Johnson, Piotr J. Slomka, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function. METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with...
  • Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation

    November 01, 2018
    Author(s): Yumi Uetake, Greenfield Sluder
    Source: Molecular biology of the cell
    When untransformed human cells spend 1.5 hr. in prometaphase under standard culture conditions, all daughters arrest in G1 despite normal division of their mothers. We investigate what happens during prolonged prometaphase that leads to daughter cell arrest in the absence of DNA damage. We find that progressive loss of anti-apoptotic MCL-1 activity and oxidative stress act in concert to partially activate the apoptosis pathw...
  • ACR Appropriateness Criteria((R)) Imaging of Mesenteric Ischemia

    November 01, 2018
    Author(s): Michael Ginsburg, Piotr Obara, Drew L. Lambert, Michael Hanley, Michael L. Steigner, Marc A. Camacho, Ankur Chandra, Kevin J. Chang, Kenneth L. Gage, Christine M. Peterson, Thomas Ptak, Nupur Verma, David H. Kim, Laura R. Carucci, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Mesenteric ischemia is an uncommon condition resulting from decreased blood flow to the small or large bowel in an acute or chronic setting. Acute ischemia is associated with high rates of morbidity and mortality; however, it is difficult to diagnose clinically. Therefore, a high degree of suspicion and prompt imaging evaluation are necessary. Chronic mesenteric ischemia is less common and typically caused by atherosclerotic...
  • ACR Appropriateness Criteria((R)) Suspected Lower Extremity Deep Vein Thrombosis

    November 01, 2018
    Author(s): Michael Hanley, Michael L. Steigner, Osmanuddin Ahmed, Ezana M. Azene, Shelby J. Bennett, Ankur Chandra, Benoit Desjardins, Kenneth L. Gage, Michael Ginsburg, David M. Mauro, Isabel B. Oliva, Thomas Ptak, Richard Strax, Nupur Verma, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Suspected lower extremity deep venous thrombosis is a common clinical scenario which providers seek a reliable test to guide management. The importance of confidently making this diagnosis lies in the 50% to 60% risk of pulmonary embolism with untreated deep vein thrombosis and subsequent mortality of 25% to 30%, balanced with the risks of anticoagulation. The ACR Appropriateness Criteria Expert Panel on Vascular Imaging rev...
  • Name That Nephrogram: Asymmetric Renal Enhancement in the Acute Care Setting

    October 19, 2018
    Author(s): Staci M. Gagne, Alex Newbury, Kristina M. Nowitzki, Byron Y. Chen, Hao S. Lo
    Source: Current problems in diagnostic radiology
    Disorders of the kidney and urinary collecting system are common encountered in the acute care setting. Computed tomography has progressively replaced intravenous pyelography for the evaluation of most urinary tract pathology including acute flank pain, suspected malignancy, congenital abnormalities, anatomical variants, and inflammatory/vascular conditions through evaluation of the "nephrogram" produced by intravenous contr...
  • Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms

    October 17, 2018
    Author(s): Tara C. Smith, Richard G. Saul, Elisabeth R. Barton, Elizabeth J. Luna
    Source: PloS one
    Supervillin isoforms have been implicated in cell proliferation, actin filament-based motile processes, vesicle trafficking, and signal transduction. However, an understanding of the roles of these proteins in cancer metastasis and physiological processes has been limited by the difficulty of obtaining specific antibodies against these highly conserved membrane-associated proteins. To facilitate research into the biological ...
  • Association Between Sarcopenia and Functional Status in Liver Transplant Patients

    October 05, 2018
    Author(s): Natasha H. Dolgin, Andrew J. Smith, Samantha G. Harrington, Babak Movahedi, Paulo N.A. Martins, Adel Bozorgzadeh
    Source: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
    OBJECTIVES: A growing body of evidence shows that frailty and functional performance predict liver transplant outcomes. The Organ Procurement and Transplant Network uses the Karnofsky Performance Status scale to adjust for transplant center case mix in assessing quality measures. This study explores the strength of the relationship between Karnofsky Performance Status scores and objective measures of frailty. MATERIALS AND M...
  • Creating a Radiology Quality and Safety Program: Principles and Pitfalls

    October 01, 2018
    Author(s): Jennifer C. Broder, Scott F. Cameron, William T. Korn, Steven J. Baccei
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    All radiology departments are now expected to create organized and comprehensive quality and safety (QS) programs. No matter the department size, there are fundamental principles that should be at the core of each program. "Just culture" and culture of safety are essential principles in establishing effective programs. Physician leaders of QS programs must involve stakeholders, define program goals, and develop an effective ...
  • Advances in Breast Localization Techniques: An Opportunity to Improve Quality of Care and Patient Satisfaction

    October 01, 2018
    Author(s): Lucy B. Spalluto, Carolynn M. Debenedectis, Michael Morrow, Ana P. Lourenco
    Source: Seminars in roentgenology
    We will review imaging modalities used for localization in addition to current localization techniques for nonpalpable breast lesions.
  • Women's response to state-mandated language in dense breast notification

    September 25, 2018
    Author(s): Lucy B. Spalluto, Christianne L. Roumie, Kemberlee R. Bonnett, David G. Schlundt, Carolynn M. Debenedectis, Consuelo H. Wilkins
    Source: The breast journal
    Many states require radiologists to notify women of dense breast status. Our aim was to elicit women's response to state-mandated dense breast notification language. Of respondents, 82% report that current notification does not inform them of additional screening studies available, and 41% report notification does not inform them of next steps. Open-ended responses indicate three main areas of patient concern: Decisional Nee...
  • The impact of Joint Commission International accreditation on time periods in the operating room: A retrospective observational study

    September 21, 2018
    Author(s): Takenori Inomata, Ju Mizuno, Masao Iwagami, Shiori Kawasaki, Akie Shimada, Eiichi Inada, Tina Shiang, Atsushi Amano
    Source: PloS one
    The Joint Commission International (JCI) is responsible for upholding standards in healthcare and organizations in compliance receive accreditation. JCI requires quality improvement on patient safety goals, but requirements may prolong the total procedure/surgery time and reduce efficiency. Here, we evaluate the impact of JCI requirements on time periods in the operating room. We included patients who received elective and e...
  • Validation of Adult Relative Radiation Levels Using the ACR Dose Index Registry: Report of the ACR Appropriateness Criteria Radiation Exposure Subcommittee

    September 20, 2018
    Author(s): David W. Jordan, Murray D. Becker, Samuel Brady, Mary Ann Keenan, Max P. Rosen, Debapriya Sengupta, Keith J. Strauss, Dianna D. Cody, Subcommittee on Appropriateness Criteria Radiation Exposure
    Source: Journal of the American College of Radiology : JACR
    The ACR Dose Index Registry (DIR) provides a new source of clinical radiation exposure data that has not been used previously to establish or update the relative radiation level (RRL) values in the ACR Appropriateness Criteria (AC). The results of a recent review of DIR data for 10 common CT examinations were compared with current ACR AC RRL values for the same procedures. The AC RRL values were previously determined by cons...
  • Maximum blink interval is associated with tear film breakup time: A new simple, screening test for dry eye disease

    September 07, 2018
    Author(s): Takenori Inomata, Masao Iwagami, Yoshimune Hiratsuka, Keiichi Fujimoto, Yuichi Okumura, Tina Shiang, Akira Murakami
    Source: Scientific reports
    The prevalence of dry eye disease (DED) is increasing worldwide, and its diagnosis often needs dedicated reagents and machines. We investigated the usefulness of maximum blink interval (MBI) (the length of time that participants could keep their eyes open) in screening for DED. This cross-sectional study included 292 patients (194 with DED and 98 without DED) recruited between September 2016 and September 2017. We compared t...
  • Microcatheter navigation through the clot: does size matter

    September 03, 2018
    Author(s): Jildaz Caroff, Robert M. King, Rose Arslanian, Miklos G. Marosfoi, Erin T. Langan, Matthew J. Gounis, Juyu Chueh
    Source: Journal of neurointerventional surgery
    BACKGROUND: Despite high recanalization rates achieved with endovascular treatment of acute ischemic strokes, around 50% of eligible patients will not achieve a good outcome. Parameters that may determine patient outcomes include: time from puncture to recanalization, the collateral status, the anesthesia regimen, blood pressure management, and distal emboli. Characterization of distal emboli generated during mechanical thro...
  • Spinal cord involvement in adult-onset metabolic and genetic diseases

    August 27, 2018
    Author(s): Cecilia Marelli, Ettore Salsano, Letterio S. Politi, Pierre Labauge
    Source: Journal of neurology, neurosurgery, and psychiatry
    In adulthood, spinal cord MRI abnormalities such as T2-weighted hyperintensities and atrophy are commonly associated with a large variety of causes (inflammation, infections, neoplasms, vascular and spondylotic diseases). Occasionally, they can be due to rare metabolic or genetic diseases, in which the spinal cord involvement can be a prominent or even predominant feature, or a secondary one. This review focuses on these rar...
  • Evaluation of different respiratory gating schemes for cardiac SPECT

    August 07, 2018
    Author(s): Duo Zhang, P. Hendrik Pretorius, Michael Ghaly, Qi Zhang, Michael A. King, Greta S. P. Mok
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: Respiratory gating reduces motion blurring in cardiac SPECT. Here we aim to evaluate the performance of three respiratory gating strategies using a population of digital phantoms with known truth and clinical data. METHODS: We analytically simulated 60 projections for 10 XCAT phantoms with (99m)Tc-sestamibi distributions using three gating schemes: equal amplitude gating (AG), equal count gating (CG), and equal t...
  • Flow diverter for endovascular treatment of intracranial mirror segment internal carotid artery aneurysms

    August 06, 2018
    Author(s): Anna L. Kuhn, Peter Kan, Visish Srinivasan, David E. Rex, Katyucia de Macedo Rodrigues, Mary Howk, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background: To evaluate the feasibility and efficacy of the pipeline embolization device in the treatment of unruptured intracranial mirror segment aneurysms. Methods: Out of a total of 338 subjects, 14 were identified harboring a total of 32 internal carotid artery mirror segment aneurysms that were treated with the pipeline embolization device and were consecutively enrolled into our study. We collected data on patient dem...
  • Bypass for Innominate artery occlusive disease

    August 01, 2018
    Author(s): Anna L. Kuhn, Ajit S. Puri, David E. Rex
    Source: World neurosurgery
    The innominate artery, also known as the brachiocephalic artery, is the first vessel off the aortic arch and provides blood to the right arm, neck and head. Occlusion of the innominate artery can be treated with endarterectomy, angioplasty and stenting as well as bypass grafting. Bypass grafting describes a surgical procedure during which a bypass from the ascending aorta to the innominate artery is created. Our case depicts...
  • Imaging of Spine Fractures With Emphasis on the Craniocervical Junction

    August 01, 2018
    Author(s): Gabriela Santos-Nunez, Hao S. Lo, Hemang Kotecha, Joe Jose, Aly Abayazeed
    Source: Seminars in ultrasound, CT, and MR
    Spinal cord injury often times is a catastrophic result of trauma. Delay in diagnosis may result in increased morbidity and mortality. Cross-sectional imaging is now increasingly used as a first-line diagnostic modality in the setting of trauma for recognition of spine fractures and ligamentous injuries that might be missed on routine radiographs. The learning objectives of this article are to review the anatomy of the spine...
  • Imaging and Management of Thoracic Trauma

    August 01, 2018
    Author(s): Alex Newbury, Jon D. Dorfman, Hao S. Lo
    Source: Seminars in ultrasound, CT, and MR
    Thoracic injury results from penetrating and blunt trauma and is a major contributor to overall trauma morbidity and mortality in the United States. Modern imaging algorithms utilize ultrasound, chest radiograph, and computed tomography with intravenous contrast to accurately diagnose and effectively treat patients with acute thoracic trauma. This review focuses on the etiologies, signs and symptoms, imaging, and management ...
  • Pancreaticobiliary Trauma: A Multimodality Imaging Update

    August 01, 2018
    Author(s): Staci M. Gagne, Bryan O'Sullivan-Murphy, Hao S. Lo, Lacey J. McIntosh
    Source: Seminars in ultrasound, CT, and MR
    Pancreaticobiliary injury is an uncommon entity which more often occurs in the setting of blunt than penetrating trauma. We present cases of pancreaticobiliary traumatic injuries from our Level 1 trauma center to illustrate an imaging update on the spectrum of injuries and correlation with current grading systems.
  • Pediatric Elbow Injuries

    August 01, 2018
    Author(s): Helen H. R. Kim, Jean-Marc Gauguet
    Source: Seminars in ultrasound, CT, and MR
    Elbow trauma in children is one of the most commonly encountered musculoskeletal injuries in pediatric radiology. However, elbow injuries in children can be misdiagnosed due to secondary ossification centers unique to pediatric patients. Familiarity of the normal elbow anatomy in children is crucial for an accurate diagnosis. This article seeks to improve diagnostic accuracy of these elbow injuries by reviewing the secondary...
  • Soft Tissue Injuries of the Finger and Thumb

    August 01, 2018
    Author(s): Juliann Giese, Christopher Cerniglia
    Source: Seminars in ultrasound, CT, and MR
    Soft tissue digital injury of the hand is a common presenting complaint in the emergency setting. Although initial work-up requires physical examination and radiographs, many of these entities may be radiographically occult and solely appreciated on ultrasound (US) or magnetic resonance imaging (MRI). If undiagnosed, these conditions may lead to sequela of untreated disease including early osteoarthritis, pain, permanent def...
  • Improving perfusion defect detection with respiratory motion correction in cardiac SPECT at standard and reduced doses

    July 30, 2018
    Author(s): Chao Song, Yongyi Yang, Albert Juan Ramon, Miles N. Wernick, P. Hendrik Pretorius, Karen L. Johnson, Piotr J. Slomka, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: In cardiac SPECT perfusion imaging, respiratory motion can cause non-uniform blurring in the reconstructed myocardium. We investigate the potential benefit of respiratory correction with respiratory-binned acquisitions, both at standard dose and at reduced dose, for defect detection and for left ventricular (LV) wall resolution. METHODS: We applied two reconstruction methods for respiratory motion correction: pos...
  • Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology

    July 27, 2018
    Author(s): Gopal Vijayaraghavan, Srinivasan Vedantham, Gabriela Santos-Nunez, Rebecca Hultman
    Source: Clinical breast cancer
    BACKGROUND: We systematically analyzed the extent of disease in unifocal invasive lobular carcinoma (ILC) using ultrasonography, with the histopathologic findings as the reference standard. PATIENTS AND METHODS: In the present single-institution retrospective study, 128 cases of ILC were identified during a 5-year period. After exclusions, the analyzed cohort included 66 cases. Ultrasound measurements of the tumor extent alo...
  • Size matters... but how do I know what size it is

    July 24, 2018
    Author(s): Patrick A. Brouwer, Leonard L. Yeo, Matthew J. Gounis, Vamsi Krishna Gontu
    Source: Journal of neurointerventional surgery
    One of the challenges that doctors, nurses, and technologists in the field of neurointervention face is the differing definitions regarding the sizes of the materials we use, or more specifically the nomenclature by which these sizes are communicated. In this field, where practitioners have grown accustomed to ‘odd’ units of measurement, such as mm Hg for blood pressure and cm H2O for intracranial pressure, the neurovascular...
  • Development and validation of a new MRI simulation technique that can reliably estimate optimal in vivo scanning parameters in a glioblastoma murine model

    July 23, 2018
    Author(s): Andrea Protti, Kristen L. Jones, Dennis M. Bonal, Lei Qin, Letterio S. Politi, Sasha Kravets, Quang-De Nguyen, Annick D. Van den Abbeele
    Source: PloS one
    BACKGROUND: Magnetic Resonance Imaging (MRI) relies on optimal scanning parameters to achieve maximal signal-to-noise ratio (SNR) and high contrast-to-noise ratio (CNR) between tissues resulting in high quality images. The optimization of such parameters is often laborious, time consuming, and user-dependent, making harmonization of imaging parameters a difficult task. In this report, we aim to develop and validate a compute...
  • Teaching Radiologists Who Perform Image Guided Interventions Effective Communication Skills Through Simulation

    July 05, 2018
    Author(s): Carolynn M. DeBenedectis, Max P. Rosen
    Source: Current Problems in Diagnostic Radiology
    The purpose of this project is to teach radiologists who perform image guided interventions effective communication skills. Complaints related to communication errors between Radiologists and patients during interventional procedures are not uncommon. Communication for Radiologists performing IR procedures can be challenging since they are meeting the patient for the first time on the day of the procedure. Good communication...
  • The Association of Program Directors in Radiology Academic Output Task Force: Assisting Today's Busy Radiology Educators

    July 01, 2018
    Author(s): Darel E. Heitkamp, Kamran Ali, Carolynn M. Debenedectis, Eric England, Glenn C. Gaviola, Christopher P. Ho, Vivek Kalia, James M. Milburn, Seng Ong, Maitray D. Patel, Mary H. Scanlon, David S. Sarkany
    Source: Journal of the American College of Radiology : JACR
    This report describes the mission and structure of the Academic Output Task Force (AOTF) so that APDR (Association of Program Directors in Radiology) members and radiology educators can use this new resource to its fullest potential.
  • Metachromatic Leukodystrophy: Too Frequent (Mis)Diagnosis

    June 18, 2018
    Author(s): Letterio S. Politi, Ettore Salsano, Alessandra Biffi
    Source: JAMA neurology
    Recently, Wu et al1 reported the case of an adult patient with late-onset cobalamin C disease who received an incorrect diagnosis of adult metachromatic leukodystrophy (MLD). In this patient, the disease onset was characterized by acute psychiatric symptoms and spastic paraparesis. A brain magnetic resonance imagining (MRI) scan performed 2 months after the onset showed an area of hyperintensity on fluid-attenuated inversion...
  • A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

    June 18, 2018
    Author(s): Young C. Shin, Georg F. Bischof, William A. Lauer, Lucas Gonzalez-Nieto, Eva G. Rakasz, Gregory M. Hendricks, David I. Watkins, Mauricio A. Martins, Ronald C. Desrosiers
    Source: PLoS pathogens
    The properties of the human immunodeficiency virus (HIV) pose serious difficulties for the development of an effective prophylactic vaccine. Here we describe the construction and characterization of recombinant (r), replication-competent forms of rhesus monkey rhadinovirus (RRV), a gamma-2 herpesvirus, containing a near-full-length (nfl) genome of the simian immunodeficiency virus (SIV). A 306-nucleotide deletion in the pol ...
  • Robotic Assisted MRI-Guided Interventional Interstitial MR Guided Focused Ultrasound Ablation in a Swine Model

    June 14, 2018
    Author(s): Jacquelyn MacDonell, Matthew J. Gounis, Robert M. King, Gene Bogdanov, Olivia W. Brooks, Erin T. Langan, Julie G. Pilitsis
    Source: Neurosurgery
    BACKGROUND: Ablative lesions are current treatments for epilepsy and brain tumors. Interstitial magnetic resonance (MR) guided focused ultrasound (iMRgFUS) may be an alternate ablation technique which limits thermal tissue charring as compared to laser therapy (LITT) and can produce larger ablation patterns nearer the surface than transcranial MR guided focused ultrasound (tcMRgFUS). OBJECTIVE: To describe our experience wit...
  • Varicosities affecting the lower limb veins consequent to a unique variant drainage pattern of the small saphenous vein

    June 06, 2018
    Author(s): Shauna Mary Rice, Elke Sarah Schipani, Ana Maleesa Rae Santos, Katherine Anais Sadaniantz, Prithwijit Roychowdhury, Eustathia Lela Giannaris, Manas Das
    Source: International Journal of Anatomical Variations
    We report varicosities affecting the right deep femoral vein and the right femoral vein consequent to a unique unilateral variation in the course of the small saphenous vein. The right small saphenous vein, instead of draining into the popliteal vein at the popliteal fossa, expanded considerably in girth and thickness and continued as the deep femoral vein. The deep femoral vein then pierced the adductor magnus muscle, appea...
  • Educating Radiology Residents About Patient- and Family-Centered Care: The Time Has Come

    June 01, 2018
    Author(s): David Sarkany, Carolynn M. Debenedectis, Michael Morrow, Susan Sotardi, Danielle Del Re, Devon DiVito, Priscilla J. Slanetz
    Source: Journal of the American College of Radiology : JACR
    Introduction: Patient- and family-centered care (PFCC) has gained increased attention in recent years, especially with the current focus on value over volume and improving the patient experience, but it is not a new concept in medicine or radiology. After a recent New York Times article highlighted how a radiology department failed to provide a radiologist’s husband timely results, it is more critical than ever that radiolog...
  • Health Care Disparities in Radiology: A Primer for Resident Education

    May 31, 2018
    Author(s): Lisa Americo, Amit Ramjit, Michelle Wu, Leif Jensen, Drew Caplin, Joseph Mazzie, Glenn C. Gaviola, James Milburn, Christopher P. Ho, Maitray D. Patel, Carolynn M. Debenedectis, Darel E. Heitkamp, David Sarkany
    Source: Current problems in diagnostic radiology
    As the population of the United States grows increasingly diverse, health care disparities become vital to understand and mitigate. The ethical and financial implications of how groups of Americans gain access to health care have evolved into some of today's most challenging socioeconomic problems. Educators in radiology are just beginning to tackle the concepts of health care disparities, unconscious bias, and cultural comp...
  • High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease

    May 16, 2018
    Author(s): Youssef Z. Wadghiri, Dung Minh. Hoang, Anita M. Leporati, Matthew J. Gounis, Aurora Rodriguez-Rodriguez, Mary L. Mazzanti, John P. Weaver, Ajay K. Wakhloo, Peter Caravan, Alexei A. Bogdanov Jr
    Source: Scientific reports
    Progress in clinical development of magnetic resonance imaging (MRI) substrate-sensors of enzymatic activity has been slow partly due to the lack of human efficacy data. We report here a strategy that may serve as a shortcut from bench to bedside. We tested ultra high-resolution 7T MRI (microMRI) of human surgical histology sections in a 3-year IRB approved, HIPAA compliant study of surgically clipped brain aneurysms. microM...
  • A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1)

    May 01, 2018
    Author(s): Tomohiro Kubo, Yuqing Hou, Deborah A. Cochran, George B. Witman, Toshiyuki Oda
    Source: Molecular biology of the cell
    Motility of cilia/flagella is generated by a coordinated activity of thousands of dyneins. Inner dynein arms (IDAs) are particularly important for the formation of ciliary/flagellar waveforms, but the molecular mechanism of IDA regulation is poorly understood. Here, we show using cryo-electron tomography and biochemical analyses of Chlamydomonas flagella that a conserved protein FAP44 forms a complex that tethers IDA f (I1 d...
  • ACR Appropriateness Criteria((R)) Suspected Thoracic Aortic Aneurysm

    May 01, 2018
    Author(s): Shelby J. Bennett, Karin E. Dill, Michael Hanley, Osmanuddin Ahmed, Benoit Desjardins, Kenneth L. Gage, Michael Ginsburg, Ali Khoynezhad, Isabel B. Oliva, Michael L. Steigner, Richard Strax, Nupur Verma, Frank J. Rybicki
    Source: Journal of the American College of Radiology : JACR
    Although the incidence of thoracic aortic aneurysm is on the rise, initial imaging diagnosis can present a challenge for many clinicians. Providers are faced with many imaging choices as part of the initial workup. Considering level of invasiveness, relative radiation level, and quality of associated diagnostic data, CT angiography and MR angiography are believed to be the most appropriate options for radiological diagnosis ...
  • Motion-compensated image reconstruction vs postreconstruction correction in respiratory-binned SPECT with standard and reduced-dose acquisitions

    April 21, 2018
    Author(s): Chao Song, Yongyi Yang, Wenyuan Qi, Miles N. Wernick, P. Hendrik Pretorius, Michael A. King
    Source: Medical physics
    PURPOSE: Cardiac perfusion images in single-photon emission computed tomography (SPECT) can suffer from respiratory motion blur. We investigated a reconstruction approach for correcting respiratory motion in respiratory-binned acquisitions and assessed the benefit of this approach in both standard dose and reduced dose. METHODS: We modeled the acquired data from different respiratory bins by a joint probability distribution ...
  • The Importance of Wall Apposition in Flow Diverters

    April 04, 2018
    Author(s): Rene Aquarius, Antonius de Korte, Debby Smits, Matthew J. Gounis, Kiek Verrijp, Leon Driessen, William Leenders, Joost de Vries
    Source: Neurosurgery
    BACKGROUND: It is assumed that high pore densities in flow diverters (FDs) are beneficial for intracranial aneurysm (IA) healing. However, various animal studies are not conclusive on the issue, suggesting that other factors are in play. One important factor might be wall apposition. OBJECTIVE: To (1) determine the relationship between FD pore density and aneurysm occlusion, and (2) determine the relationship between FD wall...
  • To be or not 2b? To see or not 2c? Alas, the clock is ticking on TICI

    April 01, 2018
    Author(s): David F. Kallmes, Alejandro A. Rabinstein, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    The time has come to throw the flag on the Thrombolysis in Cerebral Infarction (TICI) scale. Conceived in surrogacy from our cardiology brethren and sistren’s Thrombolysis in Myocardial Infarction (TIMI) score,1 TICI’s birth was anything but smooth. However, even though plagued by internal inconsistencies,2 confusing nomenclature,3 unclear pronunciation (are you a ‘tissy’ or ‘tiki’ person?), and modifications and more modifi...
  • Population-based differences in the outcome and presentation of lung cancer patients based upon racial, histologic, and economic factors in all lung patients and those with metastatic disease

    April 01, 2018
    Author(s): John M. Varlotto, Richard Voland, Kerrie McKie, John C. Flickinger, Malcolm M. DeCamp, Debra Maddox, Paul Rava, Thomas J. Fitzgerald, Geoffrey Graeber, Negar Rassaei, Paulo Oliveira, Suhail Ali, Chandra Belani, Jonathan Glanzman, Heather A. Wakelee, Manali Patel, Jennifer Baima, Jianying Zhang, William Walsh
    Source: Cancer medicine
    To investigate the interrelation between economic, marital, and known histopathologic/therapeutic prognostic factors in presentation and survival of patients with lung cancer in nine different ethnic groups. A retrospective review of the SEER database was conducted through the years 2007-2012. Population differences were assessed via chi-square testing. Multivariable analyses (MVA) were used to detect overall survival (OS) d...
  • Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia

    March 06, 2018
    Author(s): Jildaz Caroff, Takamitsu Tamura, Robert M. King, Pedro N. Lylyk, Erin T. Langan, Olivia W. Brooks, Frederic Clarencon, John Michael. Wainwright, Laurent Spelle, Miklos G. Marosfoi, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Optical coherence tomography (OCT) is a high-resolution, intra-vascular diagnostic technique widely used for the characterization of vascular pathologies and optimization of stent implantation during percutaneous coronary intervention. OCT was used to investigate the in vivo vascular response to a new phosphorylcholine surface modified flow diverter (sPED). METHODS: In an in vivo rabbit aneurysmal model, we used ...
  • Treatment of blood blister aneurysms of the internal carotid artery with flow diversion

    February 24, 2018
    Author(s): Maxim Mokin, Ajit S. Puri, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND: Blood blister aneurysms (BBA) are a rare subset of intracranial aneurysms that represent a therapeutic challenge from both a surgical and endovascular perspective. OBJECTIVE: To report multicenter experience with flow diversion exclusively for BBA, located at non-branching segments along the anteromedial wall of the supraclinoidal internal carotid artery (ICA). METHODS: Consecutive cases of BBA located at non-bra...
  • Flow-diverter stents for endovascular management of non-fetal posterior communicating artery aneurysms-analysis on aneurysm occlusion, vessel patency, and patient outcome

    February 22, 2018
    Author(s): Anna L. Kuhn, Guilherme Dabus, Peter Kan, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background Use of flow-diversion technology in the treatment of incidental and recanalized posterior communicating artery (PComA) aneurysms. Methods Patients treated with the Pipeline embolization device (PED) for PComA aneurysms were identified and included in our retrospective analysis. We evaluated aneurysm characteristics, modified Rankin Scale score (mRS) on admission, angiography follow-up, and patient clinical outcome...
  • Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca(2+)-dependent manner

    February 08, 2018
    Author(s): Brian Leei Lin, Amy Li, Ji Young Mun, Michael J. Previs, Samantha Beck. Previs, Stuart G. Campbell, Cristobal G. Dos Remedios, Pieter de P. Tombe, Roger Craig, David M. Warshaw, Sakthivel Sadayappan
    Source: Scientific reports
    Muscle contraction, which is initiated by Ca(2+), results in precise sliding of myosin-based thick and actin-based thin filament contractile proteins. The interactions between myosin and actin are finely tuned by three isoforms of myosin binding protein-C (MyBP-C): slow-skeletal, fast-skeletal, and cardiac (ssMyBP-C, fsMyBP-C and cMyBP-C, respectively), each with distinct N-terminal regulatory regions. The skeletal MyBP-C is...
  • (18)F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

    February 05, 2018
    Author(s): Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio S. Politi, Rosa Maria Moresco
    Source: Journal of neuroinflammation
    BACKGROUND: Positron emission tomography (PET) using translocator protein (TSPO) ligands has been used to detect neuroinflammatory processes in neurological disorders, including multiple sclerosis (MS). The aim of this study was to evaluate neuroinflammation in a mouse MS model (EAE) using TSPO-PET with (18)F-VC701, in combination with magnetic resonance imaging (MRI). METHODS: MOG35-55/CFA and pertussis toxin protocol was u...
  • Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

    February 01, 2018
    Author(s): Kyounghwan Lee, Guidenn Sulbaran, Shixin Yang, Ji Young Mun, Lorenzo Alamo, Antonio Pinto, Osamu Sato, Mitsuo Ikebe, Xiong Liu, Edward D. Korn, Floyd Sarsoza, Sanford I. Bernstein, Raul Padron, Roger Craig
    Source: Proceedings of the National Academy of Sciences of the United States of America
    Electron microscope studies have shown that the switched-off state of myosin II in muscle involves intramolecular interaction between the two heads of myosin and between one head and the tail. The interaction, seen in both myosin filaments and isolated molecules, inhibits activity by blocking actin-binding and ATPase sites on myosin. This interacting-heads motif is highly conserved, occurring in invertebrates and vertebrates...
  • Letter from the Guest Editor

    February 01, 2018
    Author(s): Gopal Vijayaraghavan
    Source: Seminars in ultrasound, CT, and MR
    The field of breast imaging is constantly evolving and has seen rapid advances in technology over the last 2 decades. Controversies surrounding breast cancer screening have also been gaining ground, despite unequivocal benefits and a decline in mortality of nearly 30%. There is talk of a paradigm shift in thinking from “population-based” screening to “personalized risk based” screening.
  • A Prospective Multicenter Trial of the TransForm Occlusion Balloon Catheter: Trial Design and Results

    February 01, 2018
    Author(s): M. Asif Taqi, Syed A. Quadri, Ajit S. Puri, Brian F. Fitzsimmons, Jianhua Nancy Jin, Ansaar T. Rai, Curtis A. Given 2nd, Javier Masso, Ciaran J. Powers, Joey D. English, Osama O. Zaidat
    Source: Interventional neurology
    Background and Purpose: Adjunctive treatments like balloon-assisted coil embolization (BACE) and stent-assisted coil embolization play a major role in the treatment of wide-neck and large intracranial aneurysms. The TransForm Occlusion Balloon Catheter (TOBC) registry is intended to evaluate the safety, efficacy, and efficiency of BACE using the TOBC. Method and Study Design: The TOBC registry is a prospective multicenter re...
  • A stereotaxic breed-averaged, symmetric T2w canine brain atlas including detailed morphological and volumetrical data sets

    January 31, 2018
    Author(s): Bjorn Nitzsche, Johannes Boltze, Eberhard Ludewig, Thomas Flegel, Martin J. Schmidt, Johannes Seeger, Henryk Barthel, Olivia W. Brooks, Matthew J. Gounis, Michael H. Stoffel, Sabine Schulze
    Source: NeuroImage
    Stereotaxic systems and automatic tissue segmentation routines enable neuronavigation as well as reproducible processing of neuroimage datasets. Such systems have been developed for humans, non-human-primates, sheep, and rodents, but not for dogs. Although dogs share important neurofunctional and -anatomical features with humans, and in spite of their importance in translational neuroscience, little is known about the variab...
  • A Review of Resources and Methodologies Available for Teaching and Assessing Patient-Related Communication Skills in Radiology

    January 18, 2018
    Author(s): David Sarkany, Carolynn M. Debenedectis, Stephen D. Brown
    Source: Academic radiology
    ACGME expectations for radiology trainees' proficiencies in communication skills pose a challenge to program directors who wish to develop curricula addressing these competencies. Numerous educational resources and pedagogical approaches have emerged to address such competencies specifically for radiology, but have yet to be systematically catalogued. In this paper, we review and compile these resources into a toolkit that w...
  • Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model

    January 15, 2018
    Author(s): Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei A. Bogdanov Jr., Friederike Lammer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S. Gersing
    Source: Scientific reports
    After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obta...
  • System-Level Process Change Improves Communication and Follow-Up for Emergency Department Patients With Incidental Radiology Findings

    January 03, 2018
    Author(s): Steven J. Baccei, Sneha A. Chinai, Martin A. Reznek, Scott Henderson, Kevin Reynolds, David Eric Brush
    Source: Journal of the American College of Radiology : JACR
    The appropriate communication and management of incidental findings on emergency department (ED) radiology studies is an important component of patient safety. Guidelines have been issued by the ACR and other medical associations that best define incidental findings across various modalities and imaging studies. However, there are few examples of health care facilities designing ways to manage incidental findings. Our instit...
  • Fostering Patient- and Family-Centered Care in Radiology Practice

    January 02, 2018
    Author(s): Priscilla J. Slanetz, Cheri L. Canon, Lucy Spalluto, Carolynn M. Debenedectis, Andrea Borondy-Kitts, Lori A. Deitte
    Source: Journal of the American College of Radiology : JACR
    Patient- and family-centered care (PFCC) is “a model of providing care in which the patient and family are partners with the provider and care team”. With reimbursement linked to health care outcomes and patient satisfaction, radiology has an opportunity to add value to the health care system by fostering partnerships with patients and families.
  • Clinical Applications of 3D Printing: Primer for Radiologists

    January 01, 2018
    Author(s): David H. Ballard, Anthony Paul Trace, Sayed Ali, Taryn Hodgdon, Matthew E. Zygmont, Carolynn M. Debenedectis, Stacy E. Smith, Michael L. Richardson, Midhir J. Patel, Summer J. Decker, Leon Lenchik
    Source: Academic radiology
    Three-dimensional (3D) printing refers to a number of manufacturing technologies that create physical models from digital information. Radiology is poised to advance the application of 3D printing in health care because our specialty has an established history of acquiring and managing the digital information needed to create such models. The 3D Printing Task Force of the Radiology Research Alliance presents a review of the ...
  • Logistics of Three-dimensional Printing: Primer for Radiologists

    January 01, 2018
    Author(s): Taryn Hodgdon, Raman Danrad, Midhir J. Patel, Stacy E. Smith, Michael L. Richardson, David H. Ballard, Sayed Ali, Anthony Paul Trace, Carolynn M. Debenedectis, Matthew E. Zygmont, Leon Lenchik, Summer J. Decker
    Source: Academic radiology
    The Association of University Radiologists Radiology Research Alliance Task Force on three-dimensional (3D) printing presents a review of the logistic considerations for establishing a clinical service using this new technology, specifically focused on implications for radiology. Specific topics include printer selection for 3D printing, software selection, creating a 3D model for printing, providing a 3D printing service, r...
  • Pediatric intracranial aneurysms: considerations and recommendations for follow-up imaging

    January 01, 2018
    Author(s): Michael George Zaki Ghali, Visish M. Srinivasan, Jacob Cherian, Louis Kim, Adnan Siddiqui, M. Ali Aziz-Sultan, Michael Froehler, Ajay K. Wakhloo, Eric Savageau, Ansaar Rai, Stephen R. Chen, Jeremiah Johnson, Sandi K. Lam, Peter Kan
    Source: World neurosurgery
    BACKGROUND: Pediatric intracranial aneurysms (IAs) are rare. Compared to adult IAs, they are more commonly giant, fusiform, or dissecting. Their treatment often proves more complex and recurrence rate and de novo aneurysmogenesis incidence is higher. A consensus regarding the most appropriate algorithm for following pediatric IAs is lacking. METHODS: We thus sought to generate recommendations based on the reported experience...
  • Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review

    January 01, 2018
    Author(s): An Tang, Adib R. Karam, LI-RADS Evidence Working Group
    Source: Radiology
    The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability of HCC to imaging-detected liver observations based on major and ancillary imaging features. LI-RADS also includes imaging features suggesting malignancy other than HCC. S...
  • Increased signal intensity within glioblastoma resection cavities on fluid-attenuated inversion recovery imaging to detect early progressive disease in patients receiving radiotherapy with concomitant temozolomide therapy

    January 01, 2018
    Author(s): Luke A. Perry, Panagiotis Korfiatis, Jay P. Agrawal, Bradley J. Erickson
    Source: Neuroradiology
    PURPOSE: Our study tested the diagnostic accuracy of increased signal intensity (SI) within FLAIR MR images of resection cavities in differentiating early progressive disease (ePD) from pseudoprogression (PsP) in patients with glioblastoma treated with radiotherapy with concomitant temozolomide therapy. METHODS: In this retrospective study approved by our Institutional Review Board, we evaluated the records of 122 consecutiv...
  • Dual radiosensitization and anti-STAT3 anti-proliferative strategy based on delivery of gold nanoparticle - oligonucleotide nanoconstructs to head and neck cancer cells

    January 01, 2018
    Author(s): Surong Zhang, Suresh Gupta, Thomas J. Fitzgerald, Alexei A. Bogdanov Jr.
    Source: Nanotheranostics
    Constitutively activated signal transducer and activator of transcription 3 (STAT3) factor is an important therapeutic target in head and neck cancer (HNC). Despite early promising results, a reliable systemic delivery system for STAT3- targeted oligonucleotide (ODN) drugs is still needed for future clinical translation of anti-STAT3 therapies. We engineered and tested a novel ODN duplex/gold nanoparticle (AuNP)-based system...
  • 4D non-local means post-filtering for cardiac gated SPECT

    December 28, 2017
    Author(s): Chao Song, Yongyi Yang, P. Hendrik Pretorius, Michael A. King
    Source: Physics in medicine and biology
    Cardiac gated images often suffer from increased noise in single photon emission computed tomography (SPECT) due to reduced data counts compared to non-gated studies. We investigate a spatiotemporal post-processing approach based on a non-local means (NLM) filter for suppressing the noise in gated SPECT images. In this filter, the output at a voxel location is computed from a weighted average of voxels in its 4D neighborhood...
  • Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research

    December 19, 2017
    Author(s): Robert J. Duronio, Patrick H. O'Farrell, Greenfield Sluder, Tin Tin Su
    Source: Disease models and mechanisms
    For hundreds of years, biologists have studied accessible organisms such as garden peas, sea urchins collected at low tide, newt eggs, and flies circling rotten fruit. These organisms help us to understand the world around us, attracting and inspiring each new generation of biologists with the promise of mystery and discovery. Time and time again, what we learn from such simple organisms has emphasized our common biological ...
  • Population representation among anatomical donors and the implication for medical student education

    December 06, 2017
    Author(s): Amanda J. Collins, Whitney Smith, Eustathia Lela Giannaris, Elizabeth Aaker Orvek, Peter Lazar, Jan K. Carney, Anne M. Gilroy, Max P. Rosen
    Source: Clinical anatomy (New York, N.Y.)
    Dissection provides a unique opportunity to integrate anatomical and clinical education. Commonly, cadavers are randomly assigned to courses, which may result in skewed representation of patient populations. The primary aim of this study was to determine if the anatomical donors studied by students at the University of Massachusetts Medical School (UMMS) accurately represent the disease burden of the local patient population...
  • Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models

    December 06, 2017
    Author(s): Silvia Valtorta, Alessia Lo. Dico, Isabella Raccagni, Daniela Gaglio, Sara Belloli, Letterio S. Politi, Cristina Martelli, Cecilia Diceglie, Marcella Bonanomi, Giulia Ercoli, Valentina Vaira, Luisa Ottobrini, Rosa Maria Moresco
    Source: Oncotarget
    Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor survival. Cytoreduction in association with radiotherapy and temozolomide (TMZ) is the standard therapy, but response is heterogeneous and life expectancy is limited. The combined use of chemotherapeutic agents with drugs targeting cell metabolism is becoming an interesting therapeutic option for cancer treatment. Here, we found that metformin...
  • Use of the Pipeline embolization device for recurrent and residual cerebral aneurysms: a safety and efficacy analysis with short-term follow-up

    December 01, 2017
    Author(s): Anna L. Kuhn, Katyucia de Macedo Rodrigues, Juan Diego Lozano, David E. Rex, Francesco Massari, Takamitsu Tamura, Mary Howk, Christopher Brooks, Jenna L'Heureux, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    OBJECTIVE: Evaluation of the safety and efficacy of the Pipeline embolization device (PED) when used as second-line treatment for recurrent or residual, pretreated ruptured and unruptured intracranial aneurysms (IAs). METHODS: Retrospective review of our database to include all patients who were treated with a PED for recurrent or residual IAs following surgical clipping or coiling. We evaluated neurological outcome and angi...
  • Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion

    November 10, 2017
    Author(s): Robert M. King, Olivia W. Brooks, Erin T. Langan, Jildaz Caroff, Frederic Clarencon, Takamitsu Tamura, John Michael Wainwright, Matthew J. Gounis, Miklos G. Marosfoi, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Optical coherence tomography (OCT) is a high resolution intravascular imaging method that allows visualization of flow diverter struts and the vessel wall. In this study, malapposition of the flow diverter that continues into the neck of the aneurysm, named communicating malapposition (CM), was investigated as a potential factor for delayed aneurysm healing. METHODS: 40 New Zealand White rabbits underwent elastas...
  • Increased Depression and Anxiety Symptoms are Associated with More Breakdowns in Cognitive Control to Cocaine Cues in Veterans with Cocaine Use Disorder

    November 09, 2017
    Author(s): Gregory J. DiGirolamo, Gerardo Gonzalez, David A. Smelson, Nathan Guevremont, Michael I. Andre, Pooja O. Patnaik, Zachary R. Zaniewski
    Source: Journal of dual diagnosis
    OBJECTIVE: Cue-elicited craving is a clinically important aspect of cocaine addiction directly linked to cognitive control breakdowns and relapse to cocaine-taking behavior. However, whether craving drives breakdowns in cognitive control toward cocaine cues in veterans, who experience significantly more co-occurring mood disorders, is unknown. The present study tests whether veterans have breakdowns in cognitive control beca...
  • ACR Appropriateness Criteria((R)) Thoracic Aorta Interventional Planning and Follow-Up

    November 01, 2017
    Author(s): Expert Panels on Vascular Imaging and Interventional Radiology, Gregory Bonci, Michael L. Steigner, Michael Hanley, Aaron R. Braun, Benoit Desjardins, Ron C. Gaba, Kenneth L. Gage, Jon S. Matsumura, Eric E. Roselli, David M. Sella, Richard Strax, Nupur Verma, Clifford R. Weiss, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Thoracic endovascular aortic repair (TEVAR) has undergone rapid evolution and is now applied to a range of aortic pathologies. Imaging plays a vital role in the pre- and postintervention assessment of TEVAR patients. Accurate characterization of pathology and evaluation for high-risk anatomic features are necessary in the planning phase, and careful assessment for graft stability, aortic lumen diameter, and presence of endol...
  • ACR Appropriateness Criteria((R)) Renovascular Hypertension

    November 01, 2017
    Author(s): Expert Panels on Urologic Imaging and Vascular Imaging, Howard J. Harvin, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Renovascular hypertension is the most common type of secondary hypertension and is estimated to have a prevalence between 0.5% and 5% of the general hypertensive population, and an even higher prevalence among patients with severe hypertension and end-stage renal disease, approaching 25% in elderly dialysis patients. Investigation for renal artery stenosis is appropriate when clinical presentation suggests secondary hyperten...
  • ACR Appropriateness Criteria((R)) Penetrating Neck Injury

    November 01, 2017
    Author(s): Expert Panels on Neurologic and Vascular Imaging, Jason W. Schroeder, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    In patients with penetrating neck injuries with clinical soft injury signs, and patients with hard signs of injury who do not require immediate surgery, CT angiography of the neck is the preferred imaging procedure to evaluate extent of injury. Other modalities, such as radiography and fluoroscopy, catheter-based angiography, ultrasound, and MR angiography have their place in the evaluation of the patient, depending on the s...
  • ACR Appropriateness Criteria((R)) Imaging of Deep Inferior Epigastric Arteries for Surgical Planning (Breast Reconstruction Surgery)

    November 01, 2017
    Author(s): Expert Panel on Vascular Imaging, Isabel B. Oliva, Kevin Day, Karin E. Dill, Michael Hanley, Osmanuddin Ahmed, Shelby J. Bennett, Benoit Desjardins, Kenneth L. Gage, Michael Ginsburg, Adam H. Hamawy, Michael L. Steigner, Richard Strax, Nupur Verma, Frank J. Rybicki
    Source: Journal of the American College of Radiology : JACR
    Breast cancer is the most common malignancy in women in the United States. Breast reconstruction surgery is a commonly used therapy for patients with breast cancer. The technique for the deep inferior epigastric perforator flap uses a preserved rectus muscle, which decreases donor site morbidity. Accurate identification and measurement of the perforator branches of the deep inferior epigastric artery is pivotal during pre-op...
  • ACR Appropriateness Criteria((R)) Imaging for Transcatheter Aortic Valve Replacement

    November 01, 2017
    Author(s): Expert Panel on Cardiac Imaging and Vascular Imaging, Jonathon A. Leipsic, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Aortic stenosis is a common valvular condition with increasing prevalence in aging populations. When severe and symptomatic, the downstream prognosis is poor without surgical or transcatheter aortic valve replacement. Transcatheter aortic valve replacement is now considered a viable alternative to surgical aortic valve replacement in patients considered high and intermediate risk for surgery. Pre-intervention imaging with ec...
  • Flow diversion for anterior choroidal artery (AChA) aneurysms: a multi-institutional experience

    October 31, 2017
    Author(s): Visish M. Srinivasan, Michael George Zaki Ghali, Jacob Cherian, Maxim Mokin, Ajit S. Puri, Ramesh Grandhi, Stephen R. Chen, Jeremiah N. Johnson, Peter Kan
    Source: Journal of neurointerventional surgery
    BACKGROUND: Anterior choroidal artery (AChA) aneurysms represent a small subset of cerebral aneurysms. The Pipeline Embolization Device (PED) has been successfully applied to various aneurysms of the supraclinoid internal carotid artery (ICA). The treatment of these aneurysms requires special attention due to the eloquent territory supplied by the AChA. We report the largest and first dedicated series of flow diversion treat...
  • Flow diversion for the treatment of posterior inferior cerebellar artery aneurysms: a novel classification and strategies

    October 20, 2017
    Author(s): Visish M. Srinivasan, Michael George Zaki Ghali, Oleg E. Reznik, Jacob Cherian, Maxim Mokin, Travis M. Dumont, John R. Gaughen, Ramesh Grandhi, Ajit S. Puri, Stephen R. Chen, Jeremiah N. Johnson, Peter Kan
    Source: Journal of neurointerventional surgery
    BACKGROUND: The pipeline embolization device (PED) is frequently used in the treatment of anterior circulation aneurysms, especially around the carotid siphon, with generally excellent results. However, treatment of posterior inferior cerebellar artery (PICA) aneurysms with flow diversion (FD) has not been specifically described or discussed. While there are reports of treating PICA aneurysms using placement of FD stents in ...
  • Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

    October 20, 2017
    Author(s): Julia C. Meier, Hanna Witwicka, Sung-Yong Hwang, Mark J. Birnbaum, Stefan Knapp
    Source: ACS chemical biology
    Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1-3 in bone maintenance. We report three potent and selective inhibitors: one (PFI-4) with high selectivity for the BRPF1B isoform and two pan-BRPF bromo...
  • Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke: Primary Results of the STRATIS Registry

    October 01, 2017
    Author(s): Nils H. Mueller-Kronast, Ajit S. Puri, STRATIS Investigators
    Source: Stroke
    BACKGROUND AND PURPOSE: Mechanical thrombectomy with stent retrievers has become standard of care for treatment of acute ischemic stroke patients because of large vessel occlusion. The STRATIS registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) aimed to assess whether similar process timelines, technical, and functional outcomes could be achieved in a large real world...
  • Novel Distal Emboli Protection Technology: The EmboTrap

    October 01, 2017
    Author(s): Juyu Chueh, Miklos G. Marosfoi, Olivia W. Brooks, Robert M. King, Ajit S. Puri, Matthew J. Gounis
    Source: Interventional neurology
    Background: Over the course of the thrombectomy procedure, clot fragments may become dislodged and lead to downstream emboli due to manipulation of an endovascular device. The EmboTrap thrombectomy system features an inner stent channel with an outer stent trap design that may potentially reduce the risk of distal clot fragmentation during clot removal. We tested the hypothesis that distal emboli to both the same and new ter...
  • In situ tissue engineering: endothelial growth patterns as a function of flow diverter design

    October 01, 2017
    Author(s): Miklos G. Marosfoi, Erin T. Langan, Lara Strittmatter, Kajo van der Marel, Srinivasan Vedantham, Jennifer Arends, Ivan R. Lylyk, Siddharth Loganathan, Gregory M. Hendricks, Istvan Szikora, Ajit S. Puri, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: Vascular remodeling in response to implantation of a tissue engineering scaffold such as a flow diverter (FD) leads to the cure of intracranial aneurysms. We hypothesize that the vascular response is dependent on FD design, and CD34+ progenitor cells play an important role in the endothelialization of the implant. METHODS: Sixteen rabbit aneurysms were randomly treated with two different single-layer braided FDs ...
  • TREVO stent-retriever mechanical thrombectomy for acute ischemic stroke secondary to large vessel occlusion registry

    September 29, 2017
    Author(s): Osama O. Zaidat, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Recent randomized clinical trials (RCTs) demonstrated the efficacy of mechanical thrombectomy using stent-retrievers in patients with acute ischemic stroke (AIS) with large vessel occlusions; however, it remains unclear if these results translate to a real-world setting. The TREVO Stent-Retriever Acute Stroke (TRACK) multicenter Registry aimed to evaluate the use of the Trevo device in everyday clinical practice....
  • Interhospital Transfer Prior to Thrombectomy is Associated with Delayed Treatment and Worse Outcome in the STRATIS Registry

    September 24, 2017
    Author(s): Michael T. Froehler, Ajit S. Puri, STRATIS Investigators
    Source: Circulation
    Background -Endovascular treatment with mechanical thrombectomy (MT) is beneficial for acute stroke patients suffering a large vessel occlusion, though treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared to direct presentation. Methods -STRATIS was a prospective, multicenter, observationa...
  • Do Interventions Intended to Increase Female Medical Student Interest in Radiology Work? Preliminary Findings

    September 12, 2017
    Author(s): Elizabeth D. Yuan, Joseph Makris, Carolynn M. Debenedectis
    Source: Current problems in diagnostic radiology
    PURPOSE: The purpose of this study is to share the preliminary findings after initiation of interventions at the medical school level, which have been suggested by the literature to increase female medical student interest in radiology at one institution. Additionally, the paper provides discussion of how to better future interventions for increasing female medical student interest. METHODS: Interventions to increase medical...
  • Live Cell Imaging: Assessing the Phototoxicity of 488 and 546 nm Light and Methods to Alleviate it

    September 01, 2017
    Author(s): Stephen Douthwright, Greenfield Sluder
    Source: Journal of cellular physiology
    In live cell imaging of fluorescent proteins, phototoxicity of the excitation light can be problematical. Cell death is obvious, but reduced cell viability can make the interpretation of observations error prone. We characterized the phototoxic consequences of 488 and 546 nm light on untransformed human cells and tested methods that have or could be used to alleviate photodamage. Unlabeled RPE1 cells were given single 0.5-2....
  • Pancreatic Imaging

    September 01, 2017
    Author(s): Mark Masciocchi
    Source: Endocrinology and metabolism clinics of North America
    Imaging of the endocrine pancreas is dominated by neuroendocrine tumors, a diverse category of neoplasms that may or may not cause symptoms from hormone hypersecretion. These tumors may also be evidence of several different genetic syndromes. Understanding the usefulness of different imaging modalities and entities that simulate neuroendocrine tumors is key for both radiologists and referring physicians.
  • The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16

    September 01, 2017
    Author(s): Yuqing Hou, George B. Witman
    Source: Molecular biology of the cell
    Cilia are assembled via intraflagellar transport (IFT). The IFT machinery is composed of motors and multi-subunit particles, termed IFT-A and IFT-B, that carry cargo into the cilium. Knowledge of how the IFT subunits interact with their cargo is of critical importance for understanding how the unique ciliary domain is established. We previously reported a Chlamydomonas mutant, ift46-1, that fails to express the IFT-B protein...
  • Diagnosing ectopic pregnancy in the emergency setting

    August 19, 2017
    Author(s): Robert Lee, Carolyn S. Dupuis, Byron Y. Chen, Andrew Smith, Young H. Kim
    Source: Ultrasonography (Seoul, Korea)
    Ectopic pregnancy is the implantation of a fertilized egg outside the uterine endometrial cavity. For women presenting to the emergency department with abdominal pain and/or vaginal bleeding, ectopic pregnancy is an important diagnostic consideration. The diagnosis is made based on laboratory values and ultrasound imaging findings. The ultrasound appearance of both normal early pregnancy and ectopic pregnancy are variable an...
  • Fluorocarbons Enhance Intracellular Delivery of Short STAT3-sensors and Enable Specific Imaging

    August 03, 2017
    Author(s): Valeriy G. Metelev, Surong Zhang, Shaokuan Zheng, Anand T. N. Kumar, Alexei A. Bogdanov
    Source: Theranostics
    Short oligonucleotide sequences are now being widely investigated for their potential therapeutic properties. The modification of oligonucleotide termini with short fluorinated residues is capable of drastically altering their behavior in complex in vitro and in vivo systems, and thus may serve to greatly enhance their therapeutic potential. The main goals of our work were to explore: 1) how modification of STAT3 transcripti...
  • Development of a Standardized Kalamazoo Communication Skills Assessment Tool for Radiologists: Validation, Multisource Reliability, and Lessons Learned

    August 01, 2017
    Author(s): Stephen D. Brown, Elizabeth A. Rider, Katherine Jamieson, Elaine C. Meyer, Michael J. Callahan, Carolynn M. Debenedectis, Sarah D. Bixby, Michele Walters, Sara F. Forman, Pamela H. Varrin, Peter Forbes, Christopher J. Roussin
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to develop and test a standardized communication skills assessment instrument for radiology. MATERIALS AND METHODS: The Delphi method was used to validate the Kalamazoo Communication Skills Assessment instrument for radiology by revising and achieving consensus on the 43 items of the preexisting instrument among an interdisciplinary team of experts consisting of five radiologists and ...
  • 4D Reconstruction with Respiratory Correction for Gated Myocardial Perfusion SPECT

    August 01, 2017
    Author(s): Wenyuan Qi, Yongyi Yang, Chao Song, Miles Wernick, P. Hendrik Pretorius, Michael A. King
    Source: IEEE transactions on medical imaging
    Cardiac SPECT images are known to suffer from both cardiac and respiratory motion blur. In this work, we investigate a 4D reconstruction approach to suppress the effect of respiratory motion in gated cardiac SPECT imaging. In this approach, the sequence of cardiac gated images is reconstructed with respect to a reference respiratory amplitude bin in the respiratory cycle. To combat the challenge of inherent high imaging nois...
  • Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions

    August 01, 2017
    Author(s): Matthew J. Gounis, Simon De Meyer
    Source: International journal of stroke : official journal of the International Stroke Society
    Limited data exist on clot composition and detailed characteristics of arterial thrombi associated with large vessel occlusion in acute ischemic stroke. Advances in endovascular thrombectomy and related imaging modalities have created a unique opportunity to analyze thrombi removed from cerebral arteries. Insights into thrombus composition, etiology, physical properties and neurovascular interactions may lead to future advan...
  • Histological Composition and the Origin of the Thrombus: A New Diagnostic Assay for Secondary Stroke Prevention?

    August 01, 2017
    Author(s): Matthew J. Gounis, Rene Chapot
    Source: Stroke
  • Use of a pressure sensing sheath: comparison with standard means of blood pressure monitoring in catheterization procedures

    August 01, 2017
    Author(s): Phillip D. Purdy, Charles South, Richard P. Klucznik, Kenneth C. Liu, Robin L. Novakovic, Ajit S. Puri, G. Lee Pride, Beverly Aagaard-Kienitz, Abishek Ray, Alan C. Elliott
    Source: Journal of neurointerventional surgery
    PURPOSE: Monitoring of blood pressure (BP) during procedures is variable, depending on multiple factors. Common methods include sphygmomanometer (BP cuff), separate radial artery catheterization, and side port monitoring of an indwelling sheath. Each means of monitoring has disadvantages, including time consumption, added risk, and signal dampening due to multiple factors. We sought an alternative approach to monitoring duri...
  • Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort

    August 01, 2017
    Author(s): Muhib A. Khan, Grayson L. Baird, David Miller, Anand Patel, Shawn Tsekhan, Shadi Yaghi, Ajit S. Puri, Mahesh Jayaraman, Nils Henninger, Brian Silver
    Source: Journal of neurointerventional surgery
    BACKGROUND: Recent studies have demonstrated the superiority of endovascular therapy (EVT) for emergent large vessel occlusion. OBJECTIVE: To determine the effectiveness of EVT in nonagenarians, for whom data are limited. METHODS: We retrospectively reviewed clinical and imaging data of all patients who underwent EVT at two stroke centers between January 2012 and August 2014. The 90-day functional outcome (modified Rankin Sc...
  • Acute thrombus formation on phosphorilcholine surface modified flow diverters

    July 08, 2017
    Author(s): Miklos G. Marosfoi, Frederic Clarencon, Erin T. Langan, Robert M. King, Olivia W. Brooks, Takamitsu Tamura, John M. Wainwright, Matthew J. Gounis, Srinivasan Vedantham, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    PURPOSE: Thromboembolic complications remain a limitation of flow diverting stents. We hypothesize that phosphorilcholine surface modified flow diverters (Pipeline Flex with Shield Technology, sPED) would have less acute thrombus formation on the device surface compared with the classic Pipeline Embolization device (cPED). METHODS: Elastase-induced aneurysms were created in 40 rabbits and randomly assigned to receive cPED or...
  • In vitro activity of a novel compound, Mul-1867, against clinically significant fungi Candida spp. and Aspergillus spp

    July 01, 2017
    Author(s): George Tetz, Michael Cynamon, Gregory M. Hendricks, Daria Vikina, Victor Tetz
    Source: International journal of antimicrobial agents
    There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as ...
  • Results of the ANSWER Trial Using the PulseRider for the Treatment of Broad-Necked, Bifurcation Aneurysms

    July 01, 2017
    Author(s): Alejandro M. Spiotta, Ajit S. Puri
    Source: Neurosurgery
    BACKGROUND: The safety and probable benefit of the PulseRider (Pulsar Vascular, Los Gatos, California) for the treatment of broad-necked, bifurcation aneurysms was studied in the context of the prospective, nonrandomized, single arm clinical trial-the Adjunctive Neurovascular Support of Wide-neck aneurysm Embolization and Reconstruction (ANSWER) Trial. OBJECTIVE: To present the results of the United States cases employing th...
  • Apocrine Metaplasia Found at MR Biopsy: Is There Something to be Learned

    July 01, 2017
    Author(s): Yiming Gao, Vandana Dialani, Carolynn M. Debenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
    Source: The breast journal
    The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast l...
  • Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity

    June 28, 2017
    Author(s): A. M. Ashique, L. S. Hart, C. D. L. Thomas, J. G. Clement, P. Pivonka, Yasmin Carter, D. D. Mousseau, D. M. L. Cooper
    Source: Bone reports
    The lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic extensions, which allow for intercellular communication, and are believed to serve as the mechanosensors that coordinate the processes of bone modeling and remodeling. Imbalances in remodeling, for example, are linked to bone disease, including fragility associated with aging. We have reported that there is a reduction in scale for one comp...
  • Two-year single-center experience with the 'Baby Trevo' stent retriever for mechanical thrombectomy in acute ischemic stroke

    June 01, 2017
    Author(s): Anna L. Kuhn, Ajay K. Wakhloo, Juan Diego Lozano, Francesco Massari, Katyucia De Macedo Rodrigues, Miklos G. Marosfoi, Mary Perras, Christopher Brooks, Mary Howk, David E. Rex, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    OBJECTIVE: To evaluate the safety and efficacy of the 'Baby Trevo' (Trevo XP ProVue 3x20 mm Retriever) stent retriever for large vessel occlusions (LVOs) in acute ischemic stroke (AIS). MATERIALS AND METHODS: We retrospectively analyzed our stroke database and included all patients treated with the Baby Trevo for distal LVOs in AIS. Patient gender, mean age, vascular risk factors, National Institutes of Health Stroke Scale (...
  • Aneurysms with persistent patency after treatment with the Pipeline Embolization Device

    June 01, 2017
    Author(s): Peter Kan, Visish M. Srinivasan, Nnenna Mbabuike, Rabih G. Tawk, Vin Shen Ban, Babu G. Welch, Maxim Mokin, Bartley D. Mitchell, Ajit S. Puri, Mandy J. Binning, Edward Duckworth
    Source: Journal of neurosurgery
    The Pipeline Embolization Device (PED) was approved for the treatment of intracranial aneurysms from the petrous to the superior hypophyseal segment of the internal carotid artery. However, since its approval, its use for treatment of intracranial aneurysms in other locations and non-sidewall aneurysms has grown tremendously. The authors report on a cohort of 15 patients with 16 cerebral aneurysms that incorporated an end ve...
  • Prolapse of the Pipeline embolization device in aneurysms: incidence, management, and outcomes

    June 01, 2017
    Author(s): Visish M. Srinivasan, Andrew P. Carlson, Maxim Mokin, Jacob Cherian, Stephen R. Chen, Ajit S. Puri, Peter Kan
    Source: Neurosurgical focus
    OBJECTIVE: The Pipeline embolization device (PED) is frequently used in the treatment of anterior circulation aneurysms, especially around the carotid siphon, with generally excellent results. However, the PED has its own unique technical challenges, including the occurrence of device foreshortening or migration leading to prolapse into the aneurysm. The authors sought to determine the incidence of this phenomenon, the rescu...
  • Direct Intracranial Injection of AAVrh8 Encoding Monkey beta-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain

    June 01, 2017
    Author(s): Diane Golebiowski, Imramsjah M. J. van der Bom, Churl-Su Kwon, Andrew D. Miller, Keiko Petrosky, Allison M. Bradbury, Stacy A. Maitland, Anna L. Kuhn, Nina Bishop, Elizabeth Curran, Nilsa Silva, Dwijit Guhasarkar, Susan V. Westmoreland, Douglas R. Martin, Matthew J. Gounis, Wael F. Asaad, Miguel Sena-Esteves
    Source: Human gene therapy
    GM2 gangliosidoses, including Tay-Sachs disease and Sandhoff disease, are lysosomal storage disorders caused by deficiencies in beta-N-acetylhexosaminidase (Hex). Patients are afflicted primarily with progressive central nervous system (CNS) dysfunction. Studies in mice, cats, and sheep have indicated safety and widespread distribution of Hex in the CNS after intracranial vector infusion of AAVrh8 vectors encoding species-sp...
  • IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

    May 31, 2017
    Author(s): Jason M. Brown, Tyler Picariello, Deborah A. Cochran, George B. Witman, Karl Lechtreck
    Source: eLife
    Intraflagellar transport (IFT) trains, multimegadalton assemblies of IFT proteins and motors, traffic proteins in cilia. To study how trains assemble, we employed fluorescence protein-tagged IFT proteins in Chlamydomonas reinhardtii. IFT-A and motor proteins are recruited from the cell body to the basal body pool, assembled into trains, move through the cilium, and disperse back into the cell body. In contrast to this 'open'...
  • Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy

    May 23, 2017
    Author(s): Albert Juan Ramon, Yongyi Yang, P. Hendrik Pretorius, Piotr J. Slomka, Karen L. Johnson, Michael A. King, Miles N. Wernick
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: We investigated the extent to which the administered dose (activity) level can be reduced without sacrificing diagnostic accuracy for three reconstruction strategies for SPECT-myocardial perfusion imaging (MPI). METHODS: We optimized the parameters of the three reconstruction strategies for perfusion-defect detection over a range of simulated administered dose levels using a set of hybrid studies (derived from 19...
  • Pipeline Embolization Device for Pericallosal Artery Aneurysms: A Retrospective Single Center Safety and Efficacy Study

    May 17, 2017
    Author(s): Katyucia De Macedo Rodrigues, Anna L. Kuhn, Takamitsu Tamura, Guilherme Dabus, Peter Kan, Miklos G. Marosfoi, Juan Diego Lozano, Mary Perras, Christopher Brooks, Mary Howk, Samuel Y. Hou, David E. Rex, Francesco Massari, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Operative neurosurgery (Hagerstown, Md.)
    BACKGROUND: Pericallosal artery aneurysm treatment may be challenging using traditional endovascular techniques. OBJECTIVE: To demonstrate the feasibility, efficacy, and safety of endovascular treatment of pericallosal artery aneurysm using flow diverters. METHODS: We performed a retrospective review of our institutional database from July 2013 through July 2016 and identified 7 subjects with a pericallosal artery aneurysm t...
  • The Relevance of Readmissions after Common IR Procedures: Readmission Rates and Association with Early Mortality

    May 01, 2017
    Author(s): Ammar Sarwar, Lujia Zhou, Nihara Chakrala, Olga R. Brook, Jeffrey L. Weinstein, Max P. Rosen, Muneeb Ahmed
    Source: Journal of vascular and interventional radiology : JVIR
    PURPOSE: To determine all-cause readmission rates for 12 IR procedures and association of time to readmission with risk-adjusted 90-day mortality. MATERIALS AND METHODS: Patients discharged after 12 inpatient IR procedures at a tertiary-care hospital between June 2008 and May 2013 (N = 4,163) were categorized as no readmission (n = 1,479; 40.5%) or readmission between 0 and 7 (n = 379; 10.4%), 8 and 30 (n = 650; 17.8%), 31 a...
  • A Private Investigation: Radiologic-Pathologic Correlation of Testicular Tumors

    May 01, 2017
    Author(s): Arash Bedayat, Byron Y. Chen, Morris Hayim, Larry Zheng, Staci M. Gagne, Lacey J. Mcintosh, April C. Deng, Hao S. Lo
    Source: Current problems in diagnostic radiology
    To review the classification of testicular tumors, describe the sonographic and pathologic features of each tumor type, and discuss the mimics, diagnostic pitfalls, and management of testicular tumors. Method consists of pictorial review. We review sonographic and pathologic findings of several testicular tumors and tumorlike entities. Although ultrasound is the first-line imaging modality to differentiate between intratesti...
  • ACR Appropriateness Criteria(R) Chronic Hip Pain

    May 01, 2017
    Author(s): Douglas N. Mintz, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Chronic hip pain is a common clinical problem whose cause is often elucidated by imaging. The ACR Appropriateness Criteria for chronic hip pain define best practices of image ordering. Clinical scenarios are followed by the imaging choices and their appropriateness. The information is in ordered tables with an accompanying narrative explanation to guide physicians to order the right test. The American College of Radiology Ap...
  • ACR Appropriateness Criteria(R) Chronic Extremity Joint Pain-Suspected Inflammatory Arthritis

    May 01, 2017
    Author(s): Jon A. Jacobson, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Evaluation for suspected inflammatory arthritis as a cause for chronic extremity joint pain often relies on imaging. This review first discusses the characteristic osseous and soft tissue abnormalities seen with inflammatory arthritis and how they may be imaged. It is essential that imaging results are interpreted in the context of clinical and serologic results to add specificity as there is significant overlap of imaging f...
  • ACR Appropriateness Criteria(R) Vascular Claudication-Assessment for Revascularization

    May 01, 2017
    Author(s): Osmanuddin Ahmed, Michael Hanley, Shelby J. Bennett, Ankur Chandra, Benoit Desjardins, Kenneth L. Gage, Marie D. Gerhard-Herman, Michael Ginsburg, Heather L. Gornik, Isabel B. Oliva, Michael L. Steigner, Richard Strax, Nupur Verma, Frank J. Rybicki, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Vascular claudication is a symptom complex characterized by reproducible pain and weakness in an active muscle group due to peripheral arterial disease. Noninvasive hemodynamic tests such as the ankle brachial index, toe brachial index, segmental pressures, and pulse volume recordings are considered the first imaging modalities necessary to reliably establish the presence and severity of arterial obstructions. Vascular imagi...
  • ACR Appropriateness Criteria(R) Stress (Fatigue/Insufficiency) Fracture, Including Sacrum, Excluding Other Vertebrae

    May 01, 2017
    Author(s): Jenny T. Bencardino, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Stress fractures, including both fatigue and insufficiency types, are frequently encountered in clinical practice as a source of pain in both athletes and patients with predisposing conditions. Radiography is the imaging modality of choice for baseline diagnosis. MRI has greatly improved our ability to diagnose radiographically occult stress fractures. Tc-99m bone scan and CT may also be useful as diagnostic tools. Although ...
  • ACR Appropriateness Criteria(R) Osteoporosis and Bone Mineral Density

    May 01, 2017
    Author(s): Robert J. Ward, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Osteoporosis is a considerable public health risk, with 50% of women and 20% of men 50 years of age experiencing fracture, with mortality rates of 20% within the first year. Dual x-ray absorptiometry (DXA) is the primary diagnostic modality by which to screen women 65 years of age and men 70 years of age for osteoporosis. In postmenopausal women fracture, DXA is recommended. Some patients with bone mineral density above t...
  • ACR Appropriateness Criteria(R) Nonvariceal Upper Gastrointestinal Bleeding

    May 01, 2017
    Author(s): Nimarta Singh-Bhinder, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Upper gastrointestinal bleeding (UGIB) remains a significant cause of morbidity and mortality with mortality rates as high as 14%. This document addresses the indications for imaging UGIB that is nonvariceal and unrelated to portal hypertension. The four variants are derived with respect to upper endoscopy. For the first three, it is presumed that upper endoscopy has been performed, with three potential initial outcomes: end...
  • Evaluation of the utility of 99m Tc-MDP bone scintigraphy versus MIBG scintigraphy and cross-sectional imaging for staging patients with neuroblastoma

    April 27, 2017
    Author(s): Jean-Marc Gauguet, Tamara Pace-Emerson, Frederick D. Grant, Suzanne Shusterman, Steven G. DuBois, A. Lindsay Frazier, Stephan D. Voss
    Source: Pediatric blood and cancer
    PURPOSE: Accurate staging of neuroblastoma requires multiple imaging examinations. The purpose of this study was to determine the relative contribution of 99m Tc-methylene diphosphonate (MDP) bone scintigraphy (bone scan) versus metaiodobenzylguanidine scintigraphy (MIBG scan) for accurate staging of neuroblastoma. METHODS: A medical record search by the identified patients with neuroblastoma from 1993 to 2012 who underwent ...
  • Investigation of the physical effects of respiratory motion compensation in a large population of patients undergoing Tc-99m cardiac perfusion SPECT/CT stress imaging

    April 21, 2017
    Author(s): P. Hendrik Pretorius, Karen L. Johnson, Seth T. Dahlberg, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: Respiratory motion can deteriorate image fidelity in cardiac perfusion SPECT. We determined the extent of respiratory motion, assessed its impact on image fidelity, and investigated the existence of gender differences, thereby examining the influence of respiratory motion in a large population of patients. METHODS: One thousand one hundred and three SPECT/CT patients underwent visual tracking of markers on their ...
  • Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration

    April 14, 2017
    Author(s): Jillian N. Pearring, Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, Lara Strittmatter, Samer M. Jaber, Vadim Y. Arshavsky, Gregory J. Pazour
    Source: PLoS genetics
    Arf4 is proposed to be a critical regulator of membrane protein trafficking in early secretory pathway. More recently, Arf4 was also implicated in regulating ciliary trafficking, however, this has not been comprehensively tested in vivo. To directly address Arf4's role in ciliary transport, we deleted Arf4 specifically in either rod photoreceptor cells, kidney, or globally during the early postnatal period. Arf4 deletion in ...
  • Rosai-Dorfman Disease of the Breast

    April 11, 2017
    Author(s): Eileen E. Delaney, Anne C. Larkin, Sue MacMaster, Ali Sakhdari, Carolynn M. Debenedectis
    Source: Cureus
    Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented with a palpable breast lump tha...
  • Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming

    April 04, 2017
    Author(s): Jeffrey A. Nickerson, Qiong Wu, Anthony N. Imbalzano
    Source: Frontiers in oncology
    Tumor cells reprogram their metabolism to survive and grow in a challenging microenvironment. Some of this reprogramming is performed by epigenetic mechanisms. Epigenetics is in turn affected by metabolism; chromatin modifying enzymes are dependent on substrates that are also key metabolic intermediates. We have shown that the chromatin remodeling enzyme Brahma-related gene 1 (BRG1), an epigenetic regulator, is necessary for...
  • Revisiting the indirect signs of a temporal bone fracture: air, air, everywhere

    April 03, 2017
    Author(s): Adam C. Ulano, Srinivasan Vedantham, Deepak Takhtani
    Source: Emergency radiology
    BACKGROUND AND PURPOSE: The standard head CT protocol makes detection of a temporal bone fracture difficult. The purposes of our study are to revisit the finding of air in various locations around the temporal bone as an indirect sign of fracture and determine if findings could predict fracture pattern. MATERIALS AND METHODS: We searched the radiology reports for the keyword "temporal bone fracture." We recorded the presence...
  • Gallbladder opacification on gadoxetate disodium-enhanced CT scan

    April 01, 2017
    Author(s): Adib R. Karam, Eduardo Scortegagna, Byron Y. Chen, Carolyn S. Dupuis, Dennis D. Coughlin
    Source: Emergency radiology
    This study aimed to evaluate the radiologist's ability to identify excreted gadoxetate disodium within the gallbladder on CT scan. Thirty three healthy adults underwent imaging of the liver during work-up for potential liver donation. Three patients had undergone prior cholecystectomy and therefore were excluded. Imaging consisted of gadoxetate disodium-enhanced magnetic resonance cholangiography (MRC) and multiphase contras...
  • Use of Morpholino Oligomers for Pretargeting

    April 01, 2017
    Author(s): Guozheng Liu
    Source: Methods in molecular biology (Clifton, N.J.)
    Differing from the conventional direct-targeting strategy in which a probe or payload is directly loaded onto a targeting molecule that binds to the native target, pretargeting is an improved targeting strategy. It converts the native target to an artificial target specific for a secondary targeting molecule loaded with the probe or payload (effector). The effector is small and does not accumulate in normal tissues, which ac...
  • Use of self-expanding stents for better intracranial flow diverter wall apposition

    April 01, 2017
    Author(s): Anna L. Kuhn, Ajay K. Wakhloo, Matthew J. Gounis, Peter Kan, Katyucia de Macedo Rodrigues, Juan Diego Lozano, Miklos G. Marosfoi, Mary Perras, Christopher Brooks, Mary Howk, David E. Rex, Francesco Massari, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background Flow diverter (FD) malapposition is associated with stroke-related complications. We document the use of self-expanding nitinol stents to remove/reduce the ledge of a FD deployed for aneurysm treatment. Methods We identified five patients who were treated with the Pipeline embolization device (PED) in conjunction with a Neuroform EZ stent for inadequate wall apposition of the ends of the FD at our institution betw...
  • Characterization of a new oda3 allele, oda3-6, defective in assembly of the outer dynein arm-docking complex in Chlamydomonas reinhardtii

    March 14, 2017
    Author(s): Jason M. Brown, Matthew Mosley, Daniela Montes-Berrueta, Yuqing Hou, Fan Yang, Chasity Scarbrough, George B. Witman, Maureen Wirschell
    Source: PloS one
    We have used an insertional mutagenesis approach to generate new C. reinhardtii motility mutants. Of 56 mutants isolated, one is a new allele at the ODA3 locus, called oda3-6. Similar to the previously characterized oda3 alleles, oda3-6 has a slow-jerky swimming phenotype and reduced swimming speed. The oda3-6 mutant fails to assemble the outer dynein arm motor and outer dynein arm-docking complex (ODA-DC) in the ciliary axo...
  • Development of a high resolution MRI intracranial atherosclerosis imaging phantom

    March 09, 2017
    Author(s): Juyu Chueh, Kajo van der Marel, Matthew J. Gounis, Robert M. King, Shaokuan Zheng, Olivia W. Brooks, Jeff W. Rappleye
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Currently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor a gold standard phantom to compare MR sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD. MATERIALS AND METHODS: A patient specific injection mold was 3D printed to construct a ...
  • Towards standardization of x-ray beam filters in digital mammography and digital breast tomosynthesis: Monte Carlo simulations and analytical modelling

    March 07, 2017
    Author(s): Suman Shrestha, Srinivasan Vedantham, Andrew Karellas
    Source: Physics in medicine and biology
    In digital breast tomosynthesis and digital mammography, the x-ray beam filter material and thickness vary between systems. Replacing K-edge filters with Al was investigated with the intent to reduce exposure duration and to simplify system design. Tungsten target x-ray spectra were simulated with K-edge filters (50 microm Rh; 50 microm Ag) and Al filters of varying thickness. Monte Carlo simulations were conducted to quanti...
  • Tourniquet parent artery occlusion after flow diversion

    March 06, 2017
    Author(s): Visish M. Srinivasan, Maxim Mokin, Edward A. Duckworth M, Stephen Chen, Ajit S. Puri, Peter Kan
    Source: Journal of neurointerventional surgery
    BACKGROUND: The Pipeline Embolization Device (PED) is increasingly used for both on- and off-label purposes for treatment of intracranial aneurysms. The device gradually slows flow of blood into the aneurysm, but the high metal coverage of PED promotes endothelialization of the device. Occasionally, this leads to in-stent stenosis that is clinically well tolerated. We present a multi-institutional Pipeline series that includ...
  • Surpass Flow Diverter for Treatment of Posterior Circulation Aneurysms

    March 01, 2017
    Author(s): C. A. Taschner, Srinivasan Vedantham, J. de Vries, A. Biondi, J. Boogaarts, N. Sakai, P. Lylyk, I. Szikora, S. Meckel, H. Urbach, P. Kan, R. Siekmann, J. Bernardy, Matthew J. Gounis, Ajay K. Wakhloo
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Flow diverters for the treatment of posterior circulation aneurysms remain controversial. We aimed to identify factors contributing to outcome measures in patients treated with the Surpass flow diverter for aneurysms in this location. MATERIALS AND METHODS: We conducted an observational study of 53 patients who underwent flow-diverter treatment for posterior circulation aneurysms at 15 centers. Key ou...
  • Emergency Radiology Practice Patterns: Shifts, Schedules, and Job Satisfaction

    March 01, 2017
    Author(s): Tarek N. Hanna, Haris Shekhani, Christine Lamoureux, Hanna Mar, Refky Nicola, Clint Sliker, Jamlik-Omari Johnson
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: To assess the practice environment of emergency radiologists with a focus on schedule, job satisfaction, and self-perception of health, wellness, and diagnostic accuracy. METHODS: A survey drawing from prior radiology and health care shift-work literature was distributed via e-mail to national societies, teleradiology groups, and private practices. The survey remained open for 4 weeks in 2016, with one reminder. Dat...
  • Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry

    March 01, 2017
    Author(s): Larissa I. Estrada, Amy A. Robinson, Ana C. Amaral, Eustathia Lela Giannaris, Nadine C. Heyworth, Farzad Mortazavi, Laura B. Ngwenya, Debra E. Roberts, Howard J. Cabral, Ronald J. Killiany, Douglas L. Rosene
    Source: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society research, authorship, and/or publication of this article.
    Storage of tissue sections for long periods allows multiple samples, acquired over months or years, to be processed together, in the same reagents, for quantitative histochemical studies. Protocols for freezer storage of free-floating frozen sections using sucrose with different additives have been reported and assert that storage has no effect on histochemistry, but no quantitative support has been provided. The present stu...
  • The Relevance of Ultrasound Imaging of Suspicious Axillary Lymph Nodes and Fine-needle Aspiration Biopsy in the Post-ACOSOG Z11 Era in Early Breast Cancer

    March 01, 2017
    Author(s): Gopal Vijayaraghavan, Srinivasan Vedantham, Milliam Kataoka, Carolynn M. Debenedectis, Robert M. Quinlan
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: Evaluation of nodal involvement in early-stage breast cancers (T1 or T2) changed following the Z11 trial; however, not all patients meet the Z11 inclusion criteria. Hence, the relevance of ultrasound imaging of the axilla and fine-needle aspiration biopsy (FNA) in early-stage breast cancers was investigated. MATERIALS AND METHODS: In this single-center, retrospective study, 758 subjects had patholog...
  • Prioritizing the Protocol: Improving the Process of Scheduling Imaging Examinations in a Radiology Department With Partially Integrated IT Systems

    March 01, 2017
    Author(s): Cole DiRoberto, Scott Henderson, Crystal Lehto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    The final product of a diagnostic imaging study is the completed image set on the radiologists’ PACS and radiology information system worklist. Before the case is completed, multiple prior steps are required. The clinical provider must order the imaging study, the radiologist must complete the protocol, the administration must obtain insurance preauthorization, and the schedulers must book the imaging examination. Improving ...
  • Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform

    March 01, 2017
    Author(s): Kajo van der Marel, Srinivasan Vedantham, I. M. J. van der Bom, Mary Howk, T. Narain, Kimberly Ty, Andrew Karellas, Matthew J. Gounis, Ajit S. Puri, Ajay K. Wakhloo
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Advancements in medical device and imaging technology as well as accruing clinical evidence have accelerated the growth of the endovascular treatment of cerebrovascular diseases. However, the augmented role of these procedures raises concerns about the radiation dose to patients and operators. We evaluated patient doses from an x-ray imaging platform with radiation dose-reduction technology, which com...
  • Facial Drooping, Aphasia, and an Incidental Lung Mass in a Nonsmoker

    March 01, 2017
    Author(s): Justin K. Lui, Lacey J. McIntosh, Jorge Escobar Valle, Thomas J. Stockl, Stephen Summers
    Source: Journal of intensive care medicine
    BACKGROUND: Atrial fibrillation and atrial flutter are atrial tachycardias associated with embolic strokes. To date, there have only been a few reports highlighting the incidence of these atrial tachycardias due to mechanical compression of myocardial structures and the pulmonary vasculature in certain mediastinal masses and cysts. CASE: We present a case of a 75-year-old gentleman who is a nonsmoker with a history of hypert...
  • Magnetic Resonance Imaging-Directed Ultrasound Imaging of Non-Mass Enhancement in the Breast: Outcomes and Frequency of Malignancy

    March 01, 2017
    Author(s): Adrienne Newburg, Chloe M. Chhor, Leng Leng Young Lin, Samantha L. Heller, Jennifer Gillman, Hildegard K. Toth, Linda Moy
    Source: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
    OBJECTIVES: This study was performed to determine the frequency, predictors, and outcomes of ultrasound (US) correlates for non-mass enhancement. METHODS: From January 2005 to December 2011, a retrospective review of 5837 consecutive breast magnetic resonance imaging examinations at our institution identified 918 non-mass enhancing lesions for which follow-up or biopsy was recommended. Retrospective review of the images iden...
  • Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments

    February 21, 2017
    Author(s): Robert W. Kensler, Roger Craig, Richard L. Moss
    Source: Proceedings of the National Academy of Sciences of the United States of America
    Cardiac myosin binding protein C (cMyBP-C) has a key regulatory role in cardiac contraction, but the mechanism by which changes in phosphorylation of cMyBP-C accelerate cross-bridge kinetics remains unknown. In this study, we isolated thick filaments from the hearts of mice in which the three serine residues (Ser273, Ser282, and Ser302) that are phosphorylated by protein kinase A in the m-domain of cMyBP-C were replaced by e...
  • Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study

    February 08, 2017
    Author(s): Rene Aquarius, Debby Smits, Matthew J. Gounis, William P. Leenders, Joost de Vries
    Source: Journal of neurointerventional surgery
    BACKGROUND: More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model. METHODS: An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted. RESU...
  • Correction of hysteretic respiratory motion in SPECT myocardial perfusion imaging: Simulation and patient studies

    February 01, 2017
    Author(s): Paul K. R. Dasari, Arda Konik, P. Hendrik Pretorius, Karen L. Johnson, William P. Segars, Mohammed S. Shazeeb, Michael A. King
    Source: Medical physics
    PURPOSE: Amplitude-based respiratory gating is known to capture the extent of respiratory motion (RM) accurately but results in residual motion in the presence of respiratory hysteresis. In our previous study, we proposed and developed a novel approach to account for respiratory hysteresis by applying the Bouc-Wen (BW) model of hysteresis to external surrogate signals of anterior/posterior motion of the abdomen and chest wit...
  • Review of paratesticular pathology: findings on ultrasound and MRI

    February 01, 2017
    Author(s): Refky Nicola, Christine O. Menias, Nirvikar Dahiya, Kathryn Robinson, Amy K. Hara, Cary Lynn Siegel
    Source: Abdominal radiology (New York)
    The paratesticular scrotal contents consist of the spermatic cord, epididymis, and fascia, which originate from the embryologic descent of the testis through the abdominal wall. Historically, the primary diagnostic modality has been high-resolution ultrasound. Magnetic resonance imaging (MRI) is an alternative imaging option. Both contrast MRI and diffusion weighted imaging can assist in differentiating between benign and ma...
  • An in vitro evaluation of distal emboli following Lazarus Cover-assisted stent retriever thrombectomy

    February 01, 2017
    Author(s): Juyu Chueh, Ajit S. Puri, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: Formation of clot fragments during mechanical thrombectomy for acute ischemic stroke can occlude the distal vasculature, which may reduce the rate of good clinical outcome. OBJECTIVE: To examine the hypothesis that distal embolization can be reduced using stent retriever thrombectomy in combination with Lazarus Cover technology. METHODS: Hard, fragment-prone clots were used to create middle cerebral artery occlus...
  • Treatment of complex anterior cerebral artery aneurysms with Pipeline flow diversion: mid-term results

    February 01, 2017
    Author(s): Guilherme Dabus, Jonathan A. Grossberg, C. Michael Cawley, Jacques E. Dion, Ajit S. Puri, Ajay K. Wakhloo, Douglas Gonsales, Pedro Aguilar-Salinas, Eric Sauvageau, Italo Linfante, Ricardo A. Hanel
    Source: Journal of neurointerventional surgery
    BACKGROUND: The off-label use of flow diverters in the treatment of distal aneurysms continues to be debated. OBJECTIVE: To report our multicenter experience in the treatment of complex anterior cerebral artery aneurysms with the Pipeline embolization device (PED). METHODS: The neurointerventional databases of the four participating institutions were retrospectively reviewed for aneurysms treated with PED between October 201...
  • Proceedings of the third international molecular pathological epidemiology (MPE) meeting

    February 01, 2017
    Author(s): P. T. Campbell, Alexei A. Bogdanov, Shuji Ogino
    Source: Cancer causes and control : CCC
    Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatme...
  • SPECT/CT: an update on technological developments and clinical applications

    January 16, 2017
    Author(s): Michael Ljungberg, P. Hendrik Pretorius
    Source: The British journal of radiology
    Functional nuclear medicine imaging with single-photon emission CT (SPECT) in combination with anatomical CT has been commercially available since the beginning of this century. The combination of the two modalities has improved both the sensitivity and specificity of many clinical applications and CT in conjunction with SPECT that allows for spatial overlay of the SPECT data on good anatomy images. Introduction of diagnosti...
  • Apocrine Metaplasia Found at MR Biopsy: Is There Something to be Learned

    January 12, 2017
    Author(s): Yiming Gao, Vandana Dialani, Carolynn M. Debenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
    Source: The breast journal
    The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast l...
  • Emergent Endovascular Management of Long-Segment and Flow-Limiting Carotid Artery Dissections in Acute Ischemic Stroke Intervention with Multiple Tandem Stents

    January 11, 2017
    Author(s): S. A. Ansari, Anna L. Kuhn, A. R. Honarmand, M. Khan, M. C. Hurley, M. B. Potts, B. S. Jahromi, A. Shaibani, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Although most cervical dissections are managed medically, emergent endovascular treatment may become necessary in the presence of intracranial large-vessel occlusions, flow-limiting and long-segment dissections with impending occlusion, and/or hypoperfusion-related ischemia at risk of infarction. We investigated the role of emergent endovascular stenting of long-segment carotid dissections in the acut...
  • T-Cell Non-Hodgkin Lymphomas: Spectrum of Disease and the Role of Imaging in the Management of Common Subtypes

    January 05, 2017
    Author(s): Hye Sun Park, Lacey J. McIntosh, Marta Braschi-Amirfarzan, Atul B. Shinagare, Katherine M. Krajewski
    Source: Korean journal of radiology
    T-cell non-Hodgkin lymphomas (NHLs) are biologically diverse, uncommon malignancies characterized by a spectrum of imaging findings according to subtype. The purpose of this review is to describe the common subtypes of T-cell NHL, highlight important differences between cutaneous, various peripheral and precursor subtypes, and summarize imaging features and the role of imaging in the management of this diverse set of disease...
  • Molecular Imaging of Stems Cells: In Vivo Tracking and Clinical Translation

    January 02, 2017
    Author(s): Stefania Rizzo, Francesco Petrella, Letterio S. Politi, Ping Wang
    Source: Stem cells international
    After further evaluation of different possibilities of tracking stem cells, we do expect that many clinical questions, raised from applications of stem cells-based therapies, will find an answer in molecular imaging. Therefore, we do believe that stem cell-based therapies and molecular imaging will live together happily ever after.
  • Coming Out of the Dark: A Curriculum for Teaching and Evaluating Radiology Residents' Communication Skills Through Simulation

    January 01, 2017
    Author(s): Carolynn M. Debenedectis, Jean-Marc Gauguet, Joseph Makris, Stephen D. Brown, Max P. Rosen
    Source: Journal of the American College of Radiology : JACR
    Case report: The purpose of this pilot is to develop and implement a curriculum to teach radiology residents communication skills through simulation.
  • Radiologic-Pathologic Discordance and Outcome After MRI-Guided Vacuum-Assisted Biopsy

    January 01, 2017
    Author(s): Alana A. Lewin, Samantha L. Heller, Sonam Jaglan, Kristin Elias, Adrienne Newburg, Amy Melsaether, Linda Moy
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to determine the rate, characteristics, and outcomes of discordant MRI-guided vacuum-assisted biopsy (VAB) in women with suspected breast cancer. MATERIALS AND METHODS: This retrospective study reviewed 1314 MRI-guided VABs performed in 1211 women between 2007 and 2013 and yielded 25 discordant results in 24 women. MRI characteristics; BI-RADS assessments; whether the lesion was misse...
  • Open-cell stent and use of cone-beam CT enables a safe and effective coil embolization of true ophthalmic artery and anterior choroidal artery aneurysms with preservation of parent vessel: Clinical and angiographic results

    January 01, 2017
    Author(s): Samuel Y. Hou, Anna L. Kuhn, Ajit S. Puri, Ajay K. Wakhloo
    Source: Interventional neuroradiology: journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background:Treatment of true ophthalmic artery (OA) or anterior choroidal artery (AChA) aneurysms with preservation of the parent vessel may be challenging. Flow diverters have limitations when dealing with branch vessels arising from the aneurysm sac. Visual loss or AChA territory infarcts have been reported both for surgical and endovascular treatment. Methods: We evaluated the safety and efficacy of an open-cell design, l...
  • What to Expect When They are Expecting: Magnetic Resonance Imaging of the Acute Abdomen and Pelvis in Pregnancy

    December 15, 2016
    Author(s): Hemang M. Kotecha, Lacey J. McIntosh, Hao S. Lo, Byron Y. Chen, Carolyn S. Dupuis
    Source: Current problems in diagnostic radiology
    In this article, we discuss the challenges in the diagnosis of acute abdominopelvic pain in pregnant patients, role of imaging, and advantages of MRI over other modalities. Methods consist of pictorial review. We review the differential diagnoses and illustrate the MRI findings in pregnant patients with acute abdominopelvic pain, including gastrointestinal, gynecologic, urologic, and vascular etiologies.
  • Advantages of day-before lymphoscintigraphy and undiluted methylene blue dye injections for sentinel lymph node biopsies for melanoma

    December 01, 2016
    Author(s): Kate Dinh, Ariana Harris, Jennifer LaFemina, Giles F. Whalen, Mary F. Sullivan, Robert Licho, Thomas Hill, Laura A. Lambert
    Source: Journal of surgical oncology
    BACKGROUND AND OBJECTIVES: Lymphatic mapping (LM) and blue dye injections are essential to identification of sentinel lymph nodes (SLN) for melanoma. LM is performed the day before (DB) or the same day (SD) of surgery, but the optimal timing is unknown. Similarly, methylene blue (MB), used during SLN biopsy (SLNB), is administered diluted (dMB) or undiluted (uMB), but the relative efficacies are unknown. METHODS: Patients wh...
  • CAD-RADS: Coronary Artery Disease - Reporting and Data System: An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Radiology (ACR) and the North American Society for Cardiovascular Imaging (NASCI). Endorsed by the American College of Cardiology

    December 01, 2016
    Author(s): Ricardo C. Cury, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    The intent of CAD-RADS - Coronary Artery Disease Reporting and Data System is to create a standardized method to communicate findings of coronary CT angiography (coronary CTA) in order to facilitate decision-making regarding further patient management. The suggested CAD-RADS classification is applied on a per-patient basis and represents the highest-grade coronary artery lesion documented by coronary CTA. It ranges from CAD-...
  • Thoracic Spine Fracture in a Survivor of Out-of-Hospital Cardiac Arrest with Mechanical CPR

    December 01, 2016
    Author(s): Robert Trevor. Marshall, Hemang M. Kotecha, Takuyo Chiba, Joseph Tennyson
    Source: Prehospital and disaster medicine
    This is a report of a thoracic vertebral fracture in a 79-year-old male survivor of out-of-hospital cardiac arrest with chest compressions provided by a LUCAS 2 (Physio-Control Inc.; Lund Sweden) device. This is the first such report in the literature of a vertebral fracture being noted in a survivor of cardiac arrest where an automated compression device was used.
  • Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome

    November 01, 2016
    Author(s): Steven Schaub, Hartley M. Sirkis, Jonathan Kay
    Source: Rheumatic diseases clinics of North America
    Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region clas...
  • ACR Appropriateness Criteria Imaging After Shoulder Arthroplasty

    November 01, 2016
    Author(s): Soterios Gyftopoulos, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    There has been a rapid increase in the number of shoulder arthroplasties, including partial or complete humeral head resurfacing, hemiarthroplasty, total shoulder arthroplasty, and reverse total shoulder arthroplasty, performed in the United States over the past two decades. Imaging can play an important role in diagnosing the complications that can occur in the setting of these shoulder arthroplasties. This review is divide...
  • Signal attenuation of PFG restricted anomalous diffusions in plate, sphere, and cylinder

    November 01, 2016
    Author(s): Guoxing Lin, Shaokuan Zheng, Xinli Liao
    Source: Journal of magnetic resonance (San Diego, Calif. : 1997)
    Pulsed field gradient (PFG) NMR is a noninvasive tool to study anomalous diffusion, which exists widely in many systems such as in polymer or biological systems, in porous material, in single file structures and in fractal geometries. In a real system, the diffusion could be a restricted or a tortuous anomalous diffusion, rather than a free diffusion as the domains for fast and slow transport could coexist. Though there are ...
  • Case 33-2016. A 30-Year-Old Woman with Severe Lower Abdominal Pain and Chills

    October 27, 2016
    Author(s): Leigh H. Simmons, Alan J. Goldstein, David M. Boruta 2nd, Jennifer N. Stall
    Source: The New England journal of medicine
  • Cholecystostomy Treatment in an ICU Population: Complications and Risks

    October 01, 2016
    Author(s): Ann-Kristin U. Friedrich, Kevin P. Baratta, Joanne Lewis, Adib R. Karam, Margaret Hudlin, Demetrius E. M. Litwin, Mitchell A. Cahan
    Source: Surgical laparoscopy, endoscopy and percutaneous techniques
    BACKGROUND: Percutaneous cholecystostomy tube placement has widely been used as an alternative treatment to cholecystectomy, especially in advanced disease or critically ill patients. Reported postprocedural complication rates have varied significantly over the last decade. The goal of this study is to evaluate the safety of percutaneous cholecystostomy tube treatment in critically ill patients. STUDY DESIGN: We performed a ...
  • White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome

    October 01, 2016
    Author(s): Jatinder Patti, Johanna Helenius, Ajit S. Puri, Nils Henninger
    Source: Stroke
    BACKGROUND AND PURPOSE: There is increasing interest in defining stroke lesion volume thresholds to predict poststroke outcome. However, there is a paucity of data on factors that impact the association between critical infarct thresholds volume and outcome. We sought to determine whether lesion thresholds best predicting outcome depend on the degree of preexisting white matter hyperintensity (WMH) lesion burden. METHODS: Ma...
  • Endovascular reconstruction of unruptured intradural vertebral artery dissecting aneurysms with the Pipeline embolization device

    October 01, 2016
    Author(s): Anna L. Kuhn, Peter Kan, Francesca Massi, Juan Diego Lozano, Samuel Y. Hou, Mary Howk, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Dissecting aneurysms of the vertebral artery (VA) are difficult to treat using current surgical and endovascular techniques. OBJECTIVE: To analyze retrospectively the efficacy and safety of flow diverters in the treatment of dissecting aneurysms of the vertebral artery. METHODS: We identified six patients with six unruptured VA dissecting aneurysms either arising from the V4 or V3-V4 junction that were treated wi...
  • How to Effectively Implement a Peer Review Process for Interventional Radiology Procedures

    September 01, 2016
    Author(s): Michael Caruso, Cole DiRoberto, John Howe Jr., Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    The purpose of this communication is to share our experience in creating an interventional radiology (IR)-specific peer review process, provide our initial results, and discuss future modifications and refinements to the system so that our institution— and others—can improve on the process of implementing peer review moving forward
  • Metastatic Renal Cell Carcinoma in a Hepatic Hemangioma: A Case Report and Review of the Literature

    September 01, 2016
    Author(s): Joshua Cohen, Rashna Meunier, Sarah Jamshed, Adib R. Karam, Jennifer Yates, Xiaofei Wang, Jennifer LaFemina
    Source: International journal of surgical pathology
    We report the case of 55-year-old female with biopsy-proven clear cell renal cell carcinoma with a suspicious lesion found in the liver who presented for right radical nephrectomy and partial hepatectomy. Histologic evaluation of the hepatic specimen demonstrated metastatic renal cell carcinoma within a hepatic hemangioma. Herein we provide a review of the literature for this uncommon scenario.
  • Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography

    September 01, 2016
    Author(s): Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Brian W. Pogue, Keith D. Paulsen, Steven P. Poplack
    Source: Journal of biomedical optics
    Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT).
  • Academic-industry Collaborations in Translational Stroke Research

    August 01, 2016
    Author(s): Johannes Boltze, Daniel-Christoph Wagner, Henryk Barthel, Matthew J. Gounis
    Source: Translational stroke research
    Academic-industry collaborations are an emerging format of translational stroke research. Next to classic contract research models, a multitude of collaboration models has been developed, some of which even allowing for multinational or intercontinental research programs. This development has recently been paralleled by first successful attempts to overcome the translational stroke research road block, such as the unpreceden...
  • Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT

    August 01, 2016
    Author(s): Kajo van der Marel, Matthew J. Gounis, John P. Weaver, Antonius M. de Korte, Robert M. King, Jennifer M. Arends, Olivia W. Brooks, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating long-term surveillance imaging. To facilitate quantitative evaluation of deployed devices, a novel algorithm is presented that generates intuitive two-dimensional representations of wall apposition from either high-resolution contrast-enhanced cone-beam CT (Vaso...
  • Library based x-ray scatter correction for dedicated cone beam breast CT

    August 01, 2016
    Author(s): Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Lei Zhu
    Source: Medical physics
    PURPOSE: The image quality of dedicated cone beam breast CT (CBBCT) is limited by substantial scatter contamination, resulting in cupping artifacts and contrast-loss in reconstructed images. Such effects obscure the visibility of soft-tissue lesions and calcifications, which hinders breast cancer detection and diagnosis. In this work, we propose a library-based software approach to suppress scatter on CBBCT images with high ...
  • Detection of Klebsiella. Pneumoniae Infection with an Antisense Oligomer Against its Ribosomal RNA

    August 01, 2016
    Author(s): Ling Chen, Dengfeng Cheng, Guozheng Liu, Shuping Dou, Yuzhen Wang, Xinrong Liu, Yuxia Liu, Mary Rusckowski
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: Previously, we demonstrated specific accumulation into bacteria of a 12-mer phosphorodiamidate morpholino (MORF) oligomer complementary to a ribosomal RNA (rRNA) segment found in all bacteria using the universal probe called Eub338 (Eub). Here, two MORF oligomers Eco and Kpn with sequences specific to the rRNA of Escherichia coli (Eco) and Klebsiella pneumoniae (Kpn) were investigated along with Eub and control (non...
  • Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT

    August 01, 2016
    Author(s): Kajo van der Marel, Matthew J. Gounis, John P. Weaver, Antonius M. de Korte, Robert M. King, Jennifer M. Arends, Olivia W. Brooks, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating long-term surveillance imaging. To facilitate quantitative evaluation of deployed devices, a novel algorithm is presented that generates intuitive two-dimensional representations of wall apposition from either high-resolution contrast-enhanced cone-beam CT (Vaso...
  • The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation

    July 29, 2016
    Author(s): Michael I. Carr
    Source: GSBS Dissertations and Theses
    The p53 tumor suppressor protein is upregulated in response to DNA damage and other stress signals. The upregulation of p53 involves freeing it from negative regulation imposed by Mdm2 and MdmX (Mdm4). Accumulating evidence indicates that phosphorylation of Mdm proteins by different stress-activated kinases such as ATM or c-Abl significantly impacts p53 functions. We have previously shown that ATM phosphorylation of Mdm2 Ser...
  • Hydrophobic-core PEGylated graft copolymer-stabilized nanoparticles composed of insoluble non-nucleoside reverse transcriptase inhibitors exhibit strong anti-HIV activity

    July 25, 2016
    Author(s): Anita M. Leporati, Mikhail S. Novikov, Vladimir T. Valuev-Elliston, Sergey P. Korolev, Anastasia L. Khandazhinskaya, Sergey N. Kochetkov, Suresh Gupta, Julian Goding, Elijah M. Bolotin, Marina B. Gottikh, Alexei A. Bogdanov Jr.
    Source: Nanomedicine : nanotechnology, biology, and medicine
    Benzophenone-uracil (BPU) scaffold-derived candidate compounds are efficient non-nucleoside reverse transcriptase inhibitors (NNRTI) with extremely low solubility in water. We proposed to use hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer (HC-PGC) technology for stabilizing nanoparticle-based formulations of BPU NNRTI in water. Co-lyophilization of NNRTI/HC-PGC mixtures resulted in dry powders that ...
  • MCQs in Neuroradiology: Brain and Physics

    July 19, 2016
    Author(s): Deepak Takhtani
    Source: Radiology Publications and Presentations
    Version 1.4 of this book contains 500 multiple choice questions (MCQs) in Neuroradiology dealing with subjects of brain and physics, to assist in preparing for certification exams. The MCQs are organized into easy, intermediate and difficult categories. The answer page covers not only the topic of the MCQ but also the related material. The MCQs have been prepared mostly from the review articles especially RadioGraphics.
  • Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery

    July 14, 2016
    Author(s): Takamitsu Tamura, David E. Rex, Miklos G. Marosfoi, Ajit S. Puri, Matthew J. Gounis, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    We describe an interesting case of trigeminocardiac reflex (TCR) caused by selective angiography of the middle meningeal artery (MMA). A 28-year-old woman presented with a symptomatic meningioma. Preoperative tumour embolisation was performed. In the procedure, when selective MMA angiography was done with Omnipaque 300 mg I/mL for 3 mL by manual injection, the patient complained of flashing lights in her eye followed by vomi...
  • Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm

    July 07, 2016
    Author(s): Eduardo Scortegagna, Adib R. Karam, Shirin Sioshansi, Adel Bozorgzadeh, Curtis T. Barry, Sarwat Hussain
    Source: Clinical Imaging
    Purpose: Evaluate the recurrence pattern of hepatocellular carcinoma (HCC) following liver transplantation. Materials and Methods: A total of 54 patients underwent liver transplantation for HCC; 9 patients developed biopsy proven recurrent HCC (16.6%). The site of HCC recurrence along with other factors were analyzed. Results: Seven patients were diagnosed with HCC prior to liver transplantation and 2 patients had incidental...
  • Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery

    July 05, 2016
    Author(s): Takamitsu Tamura, David E. Rex, Miklos G. Marosfoi, Ajit S. Puri, Matthew J. Gounis, Ajay K. Wakhloo
    Source: BMJ case reports
    We describe an interesting case of trigeminocardiac reflex (TCR) caused by selective angiography of the middle meningeal artery (MMA). A 28-year-old woman presented with a symptomatic meningioma. Preoperative tumour embolisation was performed. In the procedure, when selective MMA angiography was done with Omnipaque 300 mg I/mL for 3 mL by manual injection, the patient complained of flashing lights in her eye followed by vomi...
  • Ultrasonography of the scrotum in adults

    July 01, 2016
    Author(s): Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim
    Source: Ultrasonography (Seoul, Korea)
    Ultrasonography is the ideal noninvasive imaging modality for evaluation of scrotal abnormalities. It is capable of differentiating the most important etiologies of acute scrotal pain and swelling, including epididymitis and testicular torsion, and is the imaging modality of choice in acute scrotal trauma. In patients presenting with palpable abnormality or scrotal swelling, ultrasonography can detect, locate, and characteri...
  • ACR Appropriateness Criteria Clinically Suspected Pulmonary Arteriovenous Malformation

    July 01, 2016
    Author(s): Michael Hanley, Osmanuddin Ahmed, Ankur Chandra, Kenneth L. Gage, Marie D. Gerhard-Herman, Michael Ginsburg, Heather L. Gornik, Pamela T. Johnson, Isabel B. Oliva, Thomas Ptak, Michael L. Steigner, Richard Strax, Frank J. Rybicki, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Pulmonary arteriovenous malformations are often included in the differential diagnosis of common clinical presentations, including hypoxemia, hemoptysis, brain abscesses, and paradoxical stroke, as well as affecting 30% to 50% of patients with hereditary hemorrhagic telangiectasia (HHT). Various imaging studies are used in the diagnostic and screening settings, which have been reviewed by the ACR Appropriateness Criteria Vas...
  • Reducing Radiation Exposure Without Compromising Image Quality for Lumbar Spine CT

    July 01, 2016
    Author(s): Byron Y. Chen, Cole DiRoberto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    In light of the heightened awareness of radiation’s cancer-causing potential and the dramatic increase in the number of CT studies, minimizing radiation exposure is a paramount objective in radiology. An issue that complicates this goal is that image quality is a function of the dose of radiation. In other words, larger doses result in higher quality images. The goal then is to strike a balance to maximize patient safety: re...
  • CAD-RADS(TM) Coronary Artery Disease - Reporting and Data System. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Radiology (ACR) and the North American Society for Cardiovascular Imaging (NASCI). Endorsed by the American College of Cardiology

    July 01, 2016
    Author(s): Ricardo C. Cury, Karin E. Dill
    Source: Journal of cardiovascular computed tomography
    The intent of CAD-RADS - Coronary Artery Disease Reporting and Data System is to create a standardized method to communicate findings of coronary CT angiography (coronary CTA) in order to facilitate decision-making regarding further patient management. The suggested CAD-RADS classification is applied on a per-patient basis and represents the highest-grade coronary artery lesion documented by coronary CTA. It ranges from CAD-...
  • Redefining Budd-Chiari syndrome: A systematic review

    June 08, 2016
    Author(s): Naomi Shin, Young H. Kim, Hao Xu, Hai-Bin Shi, Qing-Qiao Zhang, Jean Paul Colon Pons, Ducksoo Kim, Yi Xu, Fei-Yun Wu, Samuel Han, Byung-Boong Lee, Lin-Sun Li
    Source: World journal of hepatology
    AIM: To re-examine whether hepatic vein thrombosis (HVT) (classical Budd-Chiari syndrome) and hepatic vena cava-Budd Chiari syndrome (HVC-BCS) are the same disorder. METHODS: A systematic review of observational studies conducted in adult subjects with primary BCS, hepatic vein outflow tract obstruction, membranous obstruction of the inferior vena cava (IVC), obliterative hepatocavopathy, or HVT during the period of January ...
  • Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation

    June 02, 2016
    Author(s): Jennifer J. VanOudenhove
    Source: GSBS Dissertations and Theses
    Key regulatory events take place at very early stages of human embryonic stem cell (hESC) differentiation to accommodate their ability to differentiate into different lineages; this work examines two separate regulatory events. To investigate precise mechanisms that link alterations in the cell cycle and early differentiation, we examined the initial stages of mesendodermal lineage commitment and observed a cell cycle pause ...
  • ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience

    June 01, 2016
    Author(s): Francesco Massari, Nils Henninger, Juan Diego Lozano, Anand Patel, Anna L. Kuhn, Mary Howk, Mary Perras, Christopher Brooks, Matthew J. Gounis, Peter Kan, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    BACKGROUND: A new generation of highly navigable large-bore aspiration catheters and retriever devices for intracranial mechanical thrombectomy has markedly improved recanalization rates, time and clinical outcomes. We report collected clinical data utilizing a new technique based on combined large lumen aspiration catheter and partially resheathed stent retriever (ARTS: Aspiration (catheter)-(stent) Retriever Technique for ...
  • Successful treatment of a giant pediatric fusiform basilar trunk aneurysm with surpass flow diverter

    June 01, 2016
    Author(s): Peter Kan, Maxim Mokin, Ajit S. Puri, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    Fusiform aneurysms present a unique challenge to traditional microsurgical and endovascular treatment because of the lack of a discernible neck and the involvement of parent vessel. Flow diversion has increasingly become the treatment of choice for fusiform aneurysms in the anterior circulation, but its results in the posterior circulation are variable. We report successful treatment of a giant fusiform upper basilar trunk a...
  • Stent-assisted coil embolization of aneurysms with small parent vessels: safety and efficacy analysis

    June 01, 2016
    Author(s): Anna L. Kuhn, Samuel Y. Hou, Ajit S. Puri, Christine F. Silva, Matthew J. Gounis, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND: Stent-assisted coil embolization (SACE) is a viable therapeutic approach for wide-neck intracranial aneurysms. However, it can be technically challenging in small cerebral vessels ( OBJECTIVE: To present our experience with stents approved for SACE in aneurysms with small parent arteries. METHODS: All patients who underwent stent-assisted aneurysm treatment with either a Neuroform or an Enterprise stent device a...
  • T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell-Derived Experimental Glioblastomas

    June 01, 2016
    Author(s): Letterio S. Politi, G. Brugnara, A. Castellano, M. Cadioli, L. Altabella, M. Peviani, S. Mazzoleni, A. Falini, R. Galli
    Source: AJNR. American journal of neuroradiology
    We read with great interest the article by Arevalo-Perez et al, describing the potential value of T1-weighted dynamic contrast-enhanced MR imaging (DCE-MR imaging) as a biomarker for epidermal growth factor receptor variant III (EGFRvIII) mutation in patients with glioblastoma (GBM).
  • Evaluation of Rigid-Body Motion Compensation in Cardiac Perfusion SPECT Employing Polar-Map Quantification

    June 01, 2016
    Author(s): P. Hendrik Pretorius, Karen L. Johnson, Michael A. King
    Source: IEEE transactions on nuclear science
    We have recently been successful in the development and testing of rigid-body motion tracking, estimation and compensation for cardiac perfusion SPECT based on a visual tracking system (VTS). The goal of this study was to evaluate in patients the effectiveness of our rigid-body motion compensation strategy. Sixty-four patient volunteers were asked to remain motionless or execute some predefined body motion during an addition...
  • MRI Findings of Injury to the Longus Colli Muscle in Patients With Neck Trauma

    May 25, 2016
    Author(s): Deepak Takhtani, Eduardo Scortegagna, Oguz Cataltepe, Sathish Kumar Dundamadappa
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The longus colli muscle (LCM) forms the bulk of the deep flexor muscles of the neck. To our knowledge, very little information on the effects of trauma on this muscle group has been published. We describe MRI findings related to injury of the LCM in patients with a history of neck trauma. MATERIAL AND METHODS: A radiology department database was searched to identify patient medical records from 2008 to 2013 that i...
  • Improving the Transcription of Patient Information From Image Requisitions to the Radiology Information System

    May 25, 2016
    Author(s): Cole DiRoberto, Crystal Lehto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: The purpose of this study was to improve the transcription of patient information from imaging study requisitions to the radiology information database at a single institution. METHODS: Five hundred radiology reports from adult outpatient radiographic examinations were chosen randomly from the radiology information system (RIS) and categorized according to their degree of concordance with their corresponding clinica...
  • Three-dimensional reconstruction of Haversian systems in human cortical bone using synchrotron radiation-based micro-CT: morphology and quantification of branching and transverse connections across age

    May 01, 2016
    Author(s): Isabel S. Maggiano, Corey M. Maggiano, John G. Clement, C. David L. Thomas, Yasmin Carter, David M.L. Cooper
    Source: Journal of anatomy
    This study uses synchrotron radiation-based micro-computed tomography (CT) scans to reconstruct three-dimensional networks of Haversian systems in human cortical bone in order to observe and analyse interconnectivity of Haversian systems and the development of total Haversian networks across different ages. A better knowledge of how Haversian systems interact with each other is essential to improve understanding of remodelin...
  • Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia

    May 01, 2016
    Author(s): Ronn P. Walvick, John P. Roche, Austin L. Reno, Matthew J. Gounis, Mitchell S. Albert
    Source: Magnetic resonance in medicine
    PURPOSE: In this study, a new model of pulmonary embolism in rats was developed and tested, to examine if hyperpolarized (HP) (3) He MR images can measure impairment of the exchange of oxygen from the airspaces to the blood during pulmonary embolism. METHODS: HP (3) He MRI was used to image six treatment-group rats in which a branch of the pulmonary artery was embolized, and six control-group rats. HP (3) He MR images were u...
  • Improved frame-based estimation of head motion in PET brain imaging

    May 01, 2016
    Author(s): Joyeeta Mitra Mukherjee, Cliff Lindsay, A. Mukherjee, P. Olivier, L. Shao, Michael A. King, Robert Licho
    Source: Medical physics
    PURPOSE: Head motion during PET brain imaging can cause significant degradation of image quality. Several authors have proposed ways to compensate for PET brain motion to restore image quality and improve quantitation. Head restraints can reduce movement but are unreliable; thus the need for alternative strategies such as data-driven motion estimation or external motion tracking. Herein, the authors present a data-driven mot...
  • Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications

    May 01, 2016
    Author(s): Srinivasan Vedantham, Suman Shrestha, Andrew Karellas, Linxi Shi, Matthew J. Gounis, Ronaldo Bellazzini, Gloria Spandre, Alessandro Brez, Massimo Minuti
    Source: Medical physics
    PURPOSE: High-resolution, photon-counting, energy-resolved detector with fast-framing capability can facilitate simultaneous acquisition of precontrast and postcontrast images for subtraction angiography without pixel registration artifacts and can facilitate high-resolution real-time imaging during image-guided interventions. Hence, this study was conducted to determine the spatial resolution characteristics of a hexagonal ...
  • Onyx embolization in distal dissecting posterior inferior cerebellar artery aneurysms

    May 01, 2016
    Author(s): Ajit S. Puri, Francesca Massi, Samuel Y. Hou, Juan Diego Lozano, Mary Howk, Mary Perras, Christopher Brooks, Matthew J. Gounis, Peter Kan, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND: Dissecting aneurysms located along the distal segments of the posterior inferior cerebellar artery (PICA) are extremely rare, accounting for only 0.5-0.7% of all intracranial aneurysms. Treatment of these aneurysms is challenging, both surgically and endovascularly. We present our preliminary experience and clinical data utilizing Onyx as an embolization agent in the treatment of these lesions with proximal paren...
  • The Decision Analysis Matrix: A Systematic Method to Improve Collaborative Decision Making

    April 12, 2016
    Author(s): Cole DiRoberto, Crystal Lehto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
  • Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection

    April 01, 2016
    Author(s): Ajit S. Puri, Matthew J. Gounis, Francesco Massari, Mary Howk, John P. Weaver, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    Isolated middle cerebral artery dissection is a rare clinical entity, with descriptions limited to a few case reports and case series. Symptomatic dissection in the anterior circulation can present as an ischemic stroke in a young population; however, it is rarely associated with subarachnoid hemorrhage. We describe a young patient who presented with acute headache from a subarachnoid hemorrhage that was ultimately determine...
  • Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging

    February 17, 2016
    Author(s): Alexei A. Bogdanov Jr., Adam J. Dixon, Suresh Gupta, Lejie Zhang, Shaokuan Zheng, Mohammed S. Shazeeb, Surong Zhang, Alexander L. Klibanov
    Source: Bioconjugate chemistry
    Magnetic resonance (MR) and photoacoustic (PA) imaging are currently being investigated as complementing strategies for applications requiring sensitive detection of cells in vivo. While combined MR/PAI detection of cells requires biocompatible cell labeling probes, water-based synthesis of dual-modality MR/PAI probes presents significant technical challenges. Here we describe facile synthesis and characterization of hybrid ...
  • Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death

    February 17, 2016
    Author(s): Kasey J. Clear, Kara M. Harmatys, Douglas R. Rice, William R. Wolter, Mark A. Suckow, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
    Source: Bioconjugate chemistry
    Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich mem...
  • Substrate-Based Near-Infrared Imaging Sensors Enable Fluorescence Lifetime Contrast via Built-in Dynamic Fluorescence Quenching Elements

    February 09, 2016
    Author(s): Anand T. N. Kumar, William L. Rice, Jessica C. López, Suresh Gupta, Craig J. Goergen, Alexei A. Bogdanov Jr.
    Source: ACS Sensors
    Enzymatic activity sensing in fluorescence lifetime (FLT) mode with “self-quenched” macromolecular near-infrared (NIR) sensors is a highly promising strategy for in vivo imaging of proteolysis. However, the mechanisms of FLT changes in such substrate-based NIR sensors have not yet been studied. We synthesized two types of sensors by linking the near-infrared fluorophore IRDye 800CW to macromolecular graft copolymers of metho...
  • Quantitative assessment of device-clot interaction for stent retriever thrombectomy

    February 01, 2016
    Author(s): Kajo van der Marel, Ju-Yu Chueh, Olivia W. Brooks, Robert M. King, Miklos G. Marosfoi, Erin T. Langan, Sarena L. Carniato, Matthew J. Gounis, Raul G. Nogueira, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    PURPOSE: Rapid revascularization in emergent large vessel occlusion with endovascular embolectomy has proven clinical benefit. We sought to measure device-clot interaction as a potential mechanism for efficient embolectomy. METHODS: Two different radiopaque clot models were injected to create a middle cerebral artery occlusion in a patient-specific vascular phantom. A radiopaque stent retriever was deployed within the clot b...
  • Risk of distal embolization with stent retriever thrombectomy and ADAPT

    February 01, 2016
    Author(s): Ju-Yu Chueh, Ajit S. Puri, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: There is a discrepancy in clinical outcomes and the achieved recanalization rates with stent retrievers in the endovascular treatment of ischemic stroke. It is our hypothesis that procedural release of embolic particulate may be one contributor to poor outcomes and is a modifiable risk. The goal of this study is to assess various treatment strategies that reduce the risk of distal emboli. METHODS: Mechanical thro...
  • Detection of Klebsiella. Pneumoniae Infection with an Antisense Oligomer Against its Ribosomal RNA

    February 01, 2016
    Author(s): Ling Chen, Dengfeng Cheng, Guozheng Liu, Shuping Dou, Yuzhen Wang, Xinrong Liu, Yuxia Liu, Mary Rusckowski
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: Previously, we demonstrated specific accumulation into bacteria of a 12-mer phosphorodiamidate morpholino (MORF) oligomer complementary to a ribosomal RNA (rRNA) segment found in all bacteria using the universal probe called Eub338 (Eub). Here, two MORF oligomers Eco and Kpn with sequences specific to the rRNA of Escherichia coli (Eco) and Klebsiella pneumoniae (Kpn) were investigated along with Eub and control (non...
  • Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death

    February 01, 2016
    Author(s): Kasey J. Clear, Kara M. Harmatys, Douglas R. Rice, William R. Wolter, Mark A. Suckow, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
    Source: Bioconjugate chemistry
    Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich mem...
  • NeuN(+) neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure

    February 01, 2016
    Author(s): Tobias B. Halene, Alexey Kozlenkov, Yan Jiang, Amanda C. Mitchell, Behnam Javidfar, Aslihan Dincer, Royce Park, Jennifer Wiseman, Paula L. Croxson, Eustathia Lela Giannaris, Patrick R. Hof, Panos Roussos, Stella Dracheva, Scott E. Hemby, Schahram Akbarian
    Source: Schizophrenia research
    Increased neuronal densities in subcortical white matter have been reported for some cases with schizophrenia. The underlying cellular and molecular mechanisms remain unresolved. We exposed 26 young adult macaque monkeys for 6months to either clozapine, haloperidol or placebo and measured by structural MRI frontal gray and white matter volumes before and after treatment, followed by observer-independent, flow-cytometry-based...
  • LROC Investigation of Three Strategies for Reducing the Impact of Respiratory Motion on the Detection of Solitary Pulmonary Nodules in SPECT

    February 01, 2016
    Author(s): Mark S. Smyczynski, Howard C. Gifford, Joyoni Dey, Andre Lehovich, Joseph E. McNamara, W. Paul Segars, Michael A. King
    Source: IEEE transactions on nuclear science
    The objective of this investigation was to determine the effectiveness of three motion reducing strategies in diminishing the degrading impact of respiratory motion on the detection of small solitary pulmonary nodules (SPN) in single photon emission computed tomographic (SPECT) imaging in comparison to a standard clinical acquisition and the ideal case of imaging in the absence of respiratory motion. To do this non-uniform r...
  • Modeling the respiratory motion of solitary pulmonary nodules and determining the impact of respiratory motion on their detection in SPECT imaging

    February 01, 2016
    Author(s): Mark S. Smyczynski, Howard C. Gifford, Andre Lehovich, Joseph E. McNamara, W. Paul Segars, Eric A. Hoffman, Benjamin M. W. Tsui, Michael A. King
    Source: IEEE transactions on nuclear science
    The objectives of this investigation were to model the respiratory motion of solitary pulmonary nodules (SPN) and then use this model to determine the impact of respiratory motion on the localization and detection of small SPN in SPECT imaging for four reconstruction strategies. The respiratory motion of SPN was based on that of normal anatomic structures in the lungs determined from breath-held CT images of a volunteer acqu...
  • Design of a Multi-Pinhole Collimator for I-123 DaTscan Imaging on Dual-Headed SPECT Systems in Combination with a Fan-Beam Collimator

    February 01, 2016
    Author(s): Michael A. King, Joyeeta Mitra Mukherjee, Arda Konik, I. George Zubal, Joyoni Dey, Robert Licho
    Source: IEEE transactions on nuclear science
    For the 2011 FDA approved Parkinson's Disease (PD) SPECT imaging agent I-123 labeled DaTscan, the volume of interest (VOI) is the interior portion of the brain. However imaging of the occipital lobe is also required with PD for calculation of the striatal binding ratio (SBR), a parameter of significance in early diagnosis, differentiation of PD from other disorders with similar clinical presentations, and monitoring progress...
  • Reducing Radiation Exposure Without Compromising Image Quality for Lumbar Spine CT

    January 20, 2016
    Author(s): Byron Chen, Cole DiRoberto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Case study in clinical practice management on reducing radiation exposure without compromising image quality for lumbar spine CT.
  • Targeted scVEGF/(177)Lu radiopharmaceutical inhibits growth of metastases and can be effectively combined with chemotherapy

    January 16, 2016
    Author(s): Mary Rusckowski, Yuzhen Wang, Francis G. Blankenberg, Zoia Levashova, Marina V. Backer, Joseph M. Backer
    Source: EJNMMI research
    BACKGROUND: scVEGF/(177)Lu is a novel radiopharmaceutical targeted by recombinant single-chain (sc) derivative of vascular endothelial growth factor (VEGF) that binds to and is internalized by vascular endothelial growth factor receptors (VEGFR). scVEGF/(177)Lu potential as adjuvant and neoadjuvant anti-angiogenic therapy was assessed in metastatic and orthotopic mouse models of triple-negative breast cancer. METHODS: Metast...
  • Opportunities for Patient-centered Outcomes Research in Radiology

    January 01, 2016
    Author(s): Matthew E. Zygmont, Diana L. Lam, Kristina M. Nowitzki, Kirsteen R. Burton, Leon Lenchik, Tatum A. McArthur, Aarti K. Sekhar, Jason N. Itri
    Source: Academic radiology
    Recently created in 2010, the Patient-Centered Outcomes Research Institute (PCORI) supports patient-centered comparative effectiveness research with a focus on prioritizing high-impact studies and improving trial design methodology. The Association of University Radiologists Radiology Research Alliance Task Force on patient-centered outcomes research in Radiology aims to review recently funded imaging-centric projects that a...
  • Limited-angle effect compensation for respiratory binned cardiac SPECT

    January 01, 2016
    Author(s): Wenyuan Qi, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Michael A. King
    Source: Medical physics
    PURPOSE: In cardiac single photon emission computed tomography (SPECT), respiratory-binned study is used to combat the motion blur associated with respiratory motion. However, owing to the variability in respiratory patterns during data acquisition, the acquired data counts can vary significantly both among respiratory bins and among projection angles within individual bins. If not properly accounted for, such variation coul...
  • Prototypes of self-powered radiation detectors employing intrinsic high-energy current

    January 01, 2016
    Author(s): Piotr Zygmanski, Suman Shrestha, Davide Briovio, Andrew Karellas, Erno Sajo
    Source: Medical physics
    PURPOSE: The authors experimentally investigate the effect of direct energy conversion of x-rays via selfpowered Auger- and photocurrent, potentially suitable to practical radiation detection and dosimetry in medical applications. Experimental results are compared to computational predictions. The detector the authors consider is a thin-film multilayer device, composed of alternating disparate electrically conductive and ins...
  • Case of the Week: A 51-year-old Man with Headaches and Visual Disturbances

    December 31, 2015
    Author(s): Anna L. Kuhn, Aly Abayazeed, Deepak Takhtani
    Source: American Journal of Neuroradiology
    "Case of the Week" for the American Journal of Neuroradiology, with the following description: Sagittal T1WI pre- (A) and postcontrast (B) show a large, lobulated, heterogeneously-enhancing pituitary mass that expands the sella and demonstrates a suprasellar extension. Axial (C) and sagittal (D) T2WI demonstrate diffuse thickening of the calvarium with heterogeneous marrow signal. Axial (E) and coronal (F) noncontrast CT thr...
  • Quantitative microstructural deficits in chronic phase of stroke with small volume infarcts: A Diffusion Tensor 3-D Tractographic Analysis

    December 29, 2015
    Author(s): Prachi Dubey, Vasileios-Arsenios Lioutas, Rafeeque Bhadelia, Brad Manor, Peter Novak, Magdy Selim, Vera Novak
    Source: Magnetic resonance imaging
    BACKGROUND: Non-infarct zone white matter wallerian degeneration is well-documented in large volume territorial infarctions. However to what extent these abnormalities exist in small volume infarction is not known, particularly since routine T2/FLAIR MR images show minimal changes in such cases. We therefore utilized DTI based quantitative 3D tractography for quantitative assessment of white matter integrity in chronic phase...
  • Safety, efficacy, and short-term follow-up of the use of Pipeline Embolization Device in small (

    December 23, 2015
    Author(s): Ajit S. Puri, Francesco Massari, Takumi Asai, Miklos G. Marosfoi, Peter Kan, Samuel Y. Hou, Mary Howk, Mary Perras, Christopher Brooks, Frederic Clarencon, Matthew J. Gounis, Ajay K. Wakhloo
    Source: Neuroradiology
    INTRODUCTION: Flow diversion is being increasingly used to treat cerebral aneurysms. We present our experience using these stents to treat aneurysms distal to the circle of Willis with parent arteries smaller than 2.5 mm. METHODS: Aneurysms treated with a Pipeline Embolization Device in vessels less than 2.5 mm between June 2012 and August 2014 were included. We evaluated risk factors, family history of aneurysms, aneurysm c...
  • Association Between Confidence Level of Acute Pulmonary Embolism Diagnosis on CTPA images and Clinical Outcomes

    December 01, 2015
    Author(s): Arash Bedayat, Rani Sewatkar, Tianrun Cai, Elizabeth George, Amir Imanzadeh, Zoha Hussain, Ruth M. Dunne, Andetta R. Hunsaker, Frank J. Rybicki, Kanako K. Kumamaru
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: The purpose was to evaluate clinical characteristics associated with low confidence in diagnosis of acute pulmonary embolism (PE) as expressed in computed tomography pulmonary angiography (CTPA) reports and to evaluate the effect of confidence level in PE diagnosis on patient clinical outcomes. MATERIALS AND METHODS: This study included radiology reports from 1664 consecutive CTPA considered positiv...
  • Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators

    December 01, 2015
    Author(s): Peng Fan, Brian F. Hutton, Maria Holstensson, Michael Ljungberg, P. Hendrik Pretorius, Rameshwar Prasad, Tianyu Ma, Yaqiang Liu, Shi Wang, Stephanie L. Thorn, Mitchel R. Stacy, Albert J. Sinusas, Chi Liu
    Source: Medical physics
    PURPOSE: The energy spectrum for a cadmium zinc telluride (CZT) detector has a low energy tail due to incomplete charge collection and intercrystal scattering. Due to these solid-state detector effects, scatter would be overestimated if the conventional triple-energy window (TEW) method is used for scatter and crosstalk corrections in CZT-based imaging systems. The objective of this work is to develop a scatter and crosstalk...
  • Digital Breast Tomosynthesis: State of the Art

    December 01, 2015
    Author(s): Srinivasan Vedantham, Andrew Karellas, Gopal Vijayaraghavan, Daniel B. Kopans
    Source: Radiology
    This topical review on digital breast tomosynthesis (DBT) is provided with the intent of describing the state of the art in terms of technology, results from recent clinical studies, advanced applications, and ongoing efforts to develop multimodality imaging systems that include DBT. Particular emphasis is placed on clinical studies. The observations of increase in cancer detection rates, particularly for invasive cancers, a...
  • Multifocal Langerhans Cell Histiocytosis in an Adult

    December 01, 2015
    Author(s): Natalie Nielsen, Ali Akalin, Hartley M. Sirkis, Mathew J. Most
    Source: American journal of orthopedics (Belle Mead, N.J.)
    Eosinophilic granuloma (EG) is the most common and benign form of the spectrum of disorders referred to as Langerhans cell histiocytosis (LCH). Langerhans cell histiocytosis is primarily regarded as a pediatric disease, with few adult cases of multifocal EG of bone reported. We report a case of multifocal EG in a 48-year-old woman, who presented with right knee pain. Radiographs showed a small lytic lesion in the medial femo...
  • Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion

    December 01, 2015
    Author(s): Miklos G. Marosfoi, Matthew J. Gounis, Srinivasan Vedantham, Erin T. Langan, Olivia W. Brooks, Ajit S. Puri, Juyu Chueh, Ajay K. Wakhloo
    Source: Stroke
    BACKGROUND AND PURPOSE: The goal of this study is to combine temporary endovascular bypass (TEB) with a novel shear-activated nanotherapeutic (SA-NT) that releases recombinant tissue-type plasminogen activator (r-tPA) when exposed to high levels of hemodynamic stress and to determine if this approach can be used to concentrate r-tPA at occlusion sites based on high shear stresses created by stent placement. METHODS: A rabbit...
  • A Finite Element Method to Predict Adverse Events in Intracranial Stenting Using Microstents: In Vitro Verification and Patient Specific Case Study

    November 30, 2015
    Author(s): Francesco Iannaccone, Matthieu De Beule, Sander De Bock, Imramsjah M.J. Van der Bom, Matthew J. Gounis, Ajay K. Wakhloo, Matthieu Boone, Benedict Verhegghe, Patrick Segers
    Source: Annals of biomedical engineering
    Clinical studies have demonstrated the efficacy of stent supported coiling for intra-cranial aneurysm treatment. Despite encouraging outcomes, some matters are yet to be addressed. In particular closed stent designs are influenced by the delivery technique and may suffer from under-expansion, with the typical effect of "hugging" the inner curvature of the vessel which seems related to adverse events. In this study we propose...
  • Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography

    November 19, 2015
    Author(s): Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Steven P. Poplack, Andrew Karellas, Brian W. Pogue, Keith D. Paulsen
    Source: Biomedical optics express
    Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclu...
  • Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles

    November 16, 2015
    Author(s): Zu T. Shen, Shaokuan Zheng, Matthew J. Gounis, Alexander B. Sigalov
    Source: PloS one
    Cardiovascular disease is the leading cause of death in Western cultures. The vast majority of cardiovascular events, including stroke and myocardial infarction, result from the rupture of vulnerable atherosclerotic plaques, which are characterized by high and active macrophage content. Current imaging modalities including magnetic resonance imaging (MRI) aim to characterize anatomic and structural features of plaques rather...
  • Ultrasonography of adnexal causes of acute pelvic pain in pre-menopausal non-pregnant women

    October 01, 2015
    Author(s): Carolyn S. Dupuis, Young H. Kim
    Source: Ultrasonography (Seoul, Korea)
    Acute-onset pelvic pain is an extremely common symptom in premenopausal women presenting to the emergency department. After excluding pregnancy in reproductive-age women, ultrasonography plays a major role in the prompt and accurate diagnosis of adnexal causes of acute pelvic pain, such as hemorrhagic ovarian cysts, endometriosis, ovarian torsion, and tubo-ovarian abscess. Its availability, relatively low cost, and lack of i...
  • Conventional Medical Education and the History of Simulation in Radiology

    October 01, 2015
    Author(s): Alison L. Chetlen, Mishal Mendiratta-Lala, Linda Probyn, William F. Auffermann, Carolynn M. DeBenedectis, Jamie Marko, Bradley B. Pua, Takashi Shawn Sato, Brent P. Little, Carol M. Dell, David Sarkany, Lori Mankowski Gettle
    Source: Academic radiology
    Simulation is a promising method for improving clinician performance, enhancing team training, increasing patient safety, and preventing errors. Training scenarios to enrich medical student and resident education, and apply toward competency assessment, recertification, and credentialing are important applications of simulation in radiology. This review will describe simulation training for procedural skills, interpretive an...
  • Imaging Inflammation in Cerebrovascular Disease

    October 01, 2015
    Author(s): Matthew J. Gounis, Kajo van der Marel, Miklos G. Marosfoi, Mary L. Mazzanti, Frederic Clarencon, Ju-Yu Chueh, Ajit S. Puri, Alexei A. Bogdanov
    Source: Stroke; a journal of cerebral circulation
    Imaging inflammation in large intracranial artery pathology may play an important role in the diagnosis of and risk stratification for a variety of cerebrovascular diseases. Looking beyond the lumen has already generated widespread excitement in the stroke community, and the potential to unveil molecular processes in the vessel wall is a natural evolution to develop a more comprehensive understanding of the pathogenesis of d...
  • Pitfalls in imaging of female infertility

    October 01, 2015
    Author(s): Carolynn M. DeBenedectis, Erica Ghosh, Elizabeth Lazarus
    Source: Seminars in roentgenology
    Imaging plays a crucial role in determining which factors may be involved in female infertility.
  • Treatment failure of fetal posterior communicating artery aneurysms with the pipeline embolization device

    September 11, 2015
    Author(s): Peter Kan, Edward Duckworth, Ajit S. Puri, Greg Velat, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    Aneurysms that involve the internal carotid artery and posterior communicating artery junction and incorporate a fetal posterior cerebral artery are known as fetal posterior communicating artery aneurysms. We report the outcomes of four patients with fetal posterior communicating artery aneurysms who underwent treatment with the pipeline embolization device with or without adjunctive coil embolization. In our study, all four...
  • Bilateral Intracranial Vertebral Artery Stenosis Presenting as Recurrent Prolonged Presyncopal Episodes

    August 24, 2015
    Author(s): Banu Sundar, Majaz Moonis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Case Reports in Neurological Medicine
    Amongst various mechanisms of presyncopal events, posterior circulation disease needs to be considered. This particular mechanism has been underrecognized. We describe a case of a 76-year-old patient with recurrent posterior circulation TIAs, presenting as recurrent prolonged presyncopal events.
  • Comparison of the scanning linear estimator (SLE) and ROI methods for quantitative SPECT imaging

    August 21, 2015
    Author(s): Arda Konik, Meredith Kupinski, P. Hendrik Pretorius, Michael A. King, Harrison H. Barrett
    Source: Physics in medicine and biology
    In quantitative emission tomography, tumor activity is typically estimated from calculations on a region of interest (ROI) identified in the reconstructed slices. In these calculations, unpredictable bias arising from the null functions of the imaging system affects ROI estimates. The magnitude of this bias depends upon the tumor size and location. In prior work it has been shown that the scanning linear estimator (SLE), whi...
  • Monte Carlo simulation of a prototypical patient dosimetry system for fluoroscopic procedures

    August 07, 2015
    Author(s): Lukas Goertz, Panagiotis Tsiamas, Andrew Karellas, Erno Sajo, Piotr Zygmanski
    Source: Physics in medicine and biology
    The purpose of this study is to investigate feasibility of a novel real-time dosimetry method for fluoroscopically guided interventions utilizing thin-film detector arrays in several potential locations with respect to the patient and x-ray equipment. We employed Monte Carlo (MC) simulation to establish the fluoroscopic beam model to determine dosimetric quantities directly from measured doses in thin-film detector arrays at...
  • Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody

    August 03, 2015
    Author(s): Shuping Dou, John Virostko, Dale L. Greiner, Alvin C. Powers, Guozheng Liu
    Source: Molecular pharmaceutics
    Quantitative prediction of in vivo behavior using an in vitro assay would dramatically accelerate pharmaceutical development. However, studies quantitatively correlating in vivo properties with in vitro assay results are rare because of the difficulty in quantitatively understanding the in vivo behavior of an agent. We now demonstrate such a correlation as a case study based on our quantitative understanding of the in vivo c...
  • Effect of Non-Alignment/Alignment of Attenuation Map Without/With Emission Motion Correction in Cardiac SPECT/CT

    August 01, 2015
    Author(s): Joyoni Dey, W. Paul Segars, P. Hendrik Pretorius, Michael A. King
    Source: IEEE transactions on nuclear science
    PURPOSE: We investigate the differences without/with respiratory motion correction in apparent imaging agent localization induced in reconstructed emission images when the attenuation maps used for attenuation correction (from CT) are misaligned with the patient anatomy during emission imaging due to differences in respiratory state. METHODS: We investigated use of attenuation maps acquired at different states of a 2 cm ampl...
  • Novel DNA Polymer for Amplification Pretargeting

    July 27, 2015
    Author(s): Xiaoshan Liang, Qingqing Huang, Jie Xiao, Guozheng Liu, Shuping Dou, Mary Rusckowski, Hongcheng Shi, Yuxia Liu, Dengfeng Cheng
    Source: ACS medicinal chemistry letters
    In this Letter, different from conventional pretargeting, an additional novel DNA polymer with multiple copies of a target was first designed to be administrated between the antitumor antibody, and the labeled effector served as an amplification pretargeting strategy. Two phosphorothioate DNA strands, a bridging and a target strand, were hybridized to form a polymer. Polymer size, as a function of molar ratios, was then moni...
  • Ultrasonography of intrauterine devices

    July 01, 2015
    Author(s): Kristina M. Nowitzki, Matthew L. Hoimes, Byron Chen, Larry Zheng, Young H. Kim
    Source: Ultrasonography (Seoul, Korea)
    The intrauterine device (IUD) is gaining popularity as a reversible form of contraception. Ultrasonography serves as first-line imaging for the evaluation of IUD position in patients with pelvic pain, abnormal bleeding, or absent retrieval strings. This review highlights the imaging of both properly positioned and malpositioned IUDs. The problems associated with malpositioned IUDs include expulsion, displacement, embedment, ...
  • Technical Note: Nanometric organic photovoltaic thin film detectors for dose monitoring in diagnostic x-ray imaging

    July 01, 2015
    Author(s): Bassem Elshahat, Hardeep Singh Gill, Ilya Filipyev, Suman Shrestha, Jurgen Hesser, Jayant Kumar, Andrew Karellas, Piotr Zygmanski, Erno Sajo
    Source: Medical physics
    PURPOSE: To fabricate organic photovoltaic (OPV) cells with nanometric active layers sensitive to ionizing radiation and measure their dosimetric characteristics in clinical x-ray beams in the diagnostic tube potential range of 60-150 kVp. METHODS: Experiments were designed to optimize the detector's x-ray response and find the best parameter combination by changing the active layer thickness and the area of the electrode. T...
  • Breast: Sezary Syndrome: A Unique Presentation

    July 01, 2015
    Author(s): Arash Bedayat, Marjan Mirzabeigi, Hongbo Yu, Rebecca Hultman, Sue MacMaster
    Source: The breast journal
    Sezary syndrome is a subtype of cutaneous T cell lymphoma which usually presents as generalized skin disease with erytheroderma. Distal organ involvement is rare and is usually a late finding in the course of the disease. Breast involvement is extremely rare. Herein, we present a case report of a patient whose initial presentation involved an intramammary lymph node prior to the onset of more characteristic skin disease. Sez...
  • ACR Appropriateness Criteria(R) Right Lower Quadrant Pain-Suspected Appendicitis

    June 01, 2015
    Author(s): Martin P. Smith, Douglas S. Katz, Tasneem Lalani, Laura R. Carucci, Brooks D. Cash, David H. Kim, Robert J. Piorkowski, William C. Small, Stephanie E. Spottswood, Mark Tulchinsky, Vahid Yaghmai, Judy Yee, Max P. Rosen
    Source: Ultrasound quarterly
    The most common cause of acute right lower quadrant (RLQ) pain requiring surgery is acute appendicitis (AA). This narrative's focus is on imaging procedures in the diagnosis of AA, with consideration of other diseases causing RLQ pain. In general, Computed Tomography (CT) is the most accurate imaging study for evaluating suspected AA and alternative etiologies of RLQ pain. Data favor intravenous contrast use for CT, but the ...
  • A resting state functional magnetic resonance imaging study of concussion in collegiate athletes

    June 01, 2015
    Author(s): Suzanne M. Czerniak, Elif M. Sikoglu, Ana A. Liso Navarro, Joseph McCafferty, Jordan Eisenstock, J. Herbert Stevenson, Jean A. King, Constance M. Moore
    Source: Brain imaging and behavior
    Sports-related concussions are currently diagnosed through multi-domain assessment by a medical professional and may utilize neurocognitive testing as an aid. However, these tests have only been able to detect differences in the days to week post-concussion. Here, we investigate a measure of brain function, namely resting state functional connectivity, which may detect residual brain differences in the weeks to months after ...
  • Dawning of a new era for acute stroke therapy

    June 01, 2015
    Author(s): Marc Fisher, Ajay K. Wakhloo
    Source: Stroke; a journal of cerebral circulation
  • Techniques in distal access of wide-necked giant intracranial aneurysms during treatment with flow diversion

    May 28, 2015
    Author(s): Peter Kan, Ajay K. Wakhloo, Maxim Mokin, Ajit Puri
    Source: Surgical neurology international
    BACKGROUND: Accessing the normal distal vessel in treatment of wide-necked giant intracranial aneurysms with flow diversion can be difficult. CASE DESCRIPTION: Through illustrative cases, the authors present several useful techniques in distal access of wide-necked giant aneurysms during flow diversion treatment. Obtaining an optimal projection that separates the outflow limb from the aneurysm is most critical. Each of the t...
  • Introduction: Advances and trends in image formation in X-ray computed tomography

    May 01, 2015
    Author(s): Frederic Noo, Andrew Karellas
    Source: Medical physics
    Introduction to articles in a special focus series on CT imaging.
  • A feasible approach to evaluate the relative reactivity of NHS-ester activated group with primary amine-derivatized DNA analogue and non-derivatized impurity

    April 15, 2015
    Author(s): Shuping Dou, John Virostko, Dale L. Greiner, Alvin C. Powers, Guozheng Liu
    Source: Nucleosides, nucleotides and nucleic acids
    Synthetic DNA analogues with improved stability are widely used in life science. The 3'and/or 5' equivalent terminuses are often derivatized by attaching an active group for further modification, but a certain amount of non-derivatized impurity often remains. It is important to know to what extent the impurity would influence further modification. The reaction of an NHS ester with primary amine is one of the most widely used...
  • Dosimetric properties of high energy current (HEC) detector in keV x-ray beams

    April 07, 2015
    Author(s): Piotr Zygmanski, Suman Shrestha, Bassem Elshahat, Andrew Karellas, Erno Sajo
    Source: Physics in medicine and biology
    We introduce a new x-ray radiation detector. The detector employs high-energy current (HEC) formed by secondary electrons consisting predominantly of photoelectrons and Auger electrons, to directly convert x-ray energy to detector signal without externally applied power and without amplification. The HEC detector is a multilayer structure composed of thin conducting layers separated by dielectric layers with an overall thick...
  • A Tale of Two Projects: Basis for Centrosome Amplification after DNA Damage and Practical Assessment of Photodamage in Live-Cell Imaging: A Dissertation

    April 02, 2015
    Author(s): Stephen Douthwright
    Source: GSBS Dissertations and Theses
    This thesis comprises two separate studies that focus on the consequences of cellular damage. The first investigates the effects of DNA damage on centriole behavior and the second characterizes phototoxicity during live-cell imaging. Cancer treatments such as ionizing radiation and/or chemotherapeutic DNA damaging agents are intended to kill tumor cells, but they also damage normal proliferating cells. Although centrosome am...
  • Improving radiographic quality at a busy outpatient imaging center

    April 01, 2015
    Author(s): Steven J. Baccei, Christopher Cerniglia
    Source: Journal of the American College of Radiology : JACR
    A multidisciplinary task force, including musculoskeletal radiologists and technologist leads, was established to assess and correct the large number of quality defects observed on adult musculoskeletal radiology plain radiographs (x-rays).
  • Evaluation of [(1)(1)(1)In]-labeled zinc-dipicolylamine tracers for SPECT imaging of bacterial infection

    April 01, 2015
    Author(s): Douglas R. Rice, Adam J. Plaunt, Serhan Turkyilmaz, Miles Smith, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: This study prepared three structurally related zinc-dipicolylamine (ZnDPA) tracers with [(111)In] labels and conducted biodistribution and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging studies of a mouse leg infection model. PROCEDURES: Two monovalent tracers, ZnDPA-[(111)In]DTPA and ZnDPA-[(111)In]DOTA, each with a single zinc-dipicolylamine targeting unit, and a divalent tracer,...
  • Effect of a balloon-expandable intracranial stent vs medical therapy on risk of stroke in patients with symptomatic intracranial stenosis: the VISSIT randomized clinical trial

    March 24, 2015
    Author(s): Osama O. Zaidat, Ajay K. Wakhloo, VISSIT Trial Investigators
    Source: JAMA
    IMPORTANCE: Intracranial stenosis is one of the most common etiologies of stroke. To our knowledge, no randomized clinical trials have compared balloon-expandable stent treatment with medical therapy in symptomatic intracranial arterial stenosis. OBJECTIVE: To evaluate the efficacy and safety of the balloon-expandable stent plus medical therapy vs medical therapy alone in patients with symptomatic intracranial stenosis (/=70...
  • Endovascular treatment of tandem vascular occlusions in acute ischemic stroke

    March 01, 2015
    Author(s): Ajit S. Puri, Anna L. Kuhn, Hyon-Jo Kwon, Muhib Khan, Samuel Y. Hou, Eugene Lin, Juyu Chueh, Imramsjah M. J. van der Bom, Guilherme Dabus, Italo Linfante, Matthew J. Gounis, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Tandem vascular occlusions are an important cause of acute ischemic stroke (AIS) and present unique treatment challenges. We report our experience of managing a subset of AIS patients with extracranial vascular stenting/angioplasty and intracranial revascularization. METHODS: Consecutive patients who presented at three centers with AIS from tandem vascular occlusions confirmed by brain and neck CT ima...
  • Techniques for Endovascular Treatment of Acute Ischemic Stroke: From Intra-Arterial Fibrinolytics to Stent-Retrievers

    March 01, 2015
    Author(s): Laurent Pierot, Sebastien Soize, Azzedine Benaissa, Ajay K. Wakhloo
    Source: Stroke; a journal of cerebral circulation
  • Skull fractures in pediatric patients on computerized tomogram: comparison between routing bone window images and 3D volume-rendered images

    February 20, 2015
    Author(s): Sathish Kumar Dundamadappa, Senthur Thangasamy, Nancy Resteghini, Srinivasan Vedantham, Andrew Chen, Deepak Takhtani
    Source: Emergency radiology
    Skull fracture is a common finding following head trauma. It has a prognostic significance and its presence points to severe trauma. Additionally, there is a greater possibility of detecting associated small underlying extra-axial hematomas and subtle injuries to the brain parenchyma. In pediatric patients, the presence of multiple open sutures often makes fracture evaluation challenging. In our experience, 3D volume (3DV)-r...
  • Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia

    February 01, 2015
    Author(s): Thomas F. Flood, Imramsjah M. J. van der Bom, Lara Strittmatter, Ajit S. Puri, Gregory M. Hendricks, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: Intracranial in-stent hyperplasia is a stroke-associated complication that requires routine surveillance. OBJECTIVE: To compare the results of in vivo experiments to determine the accuracy and precision of in-stent hyperplasia measurements obtained with modified C-arm contrast-enhanced, cone-beam CT (CE-CBCT) imaging with those obtained by 'gold standard' histomorphometry. Additionally, to carry out clinical anal...
  • Early detachment of the Solitaire stent during thrombectomy retrieval: an in vitro investigation

    February 01, 2015
    Author(s): Hyon-Jo Kwon, Juyu Chueh, Ajit S. Puri, Hyeon-Song Koh
    Source: Journal of neurointerventional surgery
    OBJECTIVE: To elucidate the early detachment of the Solitaire stent during mechanical thrombectomy, we tested the stent in vitro under various conditions and evaluated with microscopy. METHODS: A total of five stents were tested. Using a dynamic mechanical analysis machine, we calculated the tensile force needed for separation of the four stents from the pusher wire. Stent Nos 1 and 2 were tested without any prior manipulati...
  • Ultra-small diameter coils for treatment of intracranial aneurysms

    February 01, 2015
    Author(s): Gaurav Jindal, Timothy Miller, Narlin Beaty, Ajit S. Puri, Dheeraj Gandhi
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    This study reports our initial clinical experience treating very small intracranial aneurysms using only Target(R) Nano coils. Retrospective angiographic and clinical analysis was performed on a non-randomized single arm registry of all intracranial aneurysms treated with only Target(R) Nano coils (1 mm and 1.5 mm diameter only) during a 12 month period at two academic hospitals. Fourteen patients with 14 intracranial aneury...
  • Gold nanoparticles stabilized with MPEG-grafted poly(l-lysine): in vitro and in vivo evaluation of a potential theranostic agent

    January 21, 2015
    Author(s): Alexei A. Bogdanov Jr., Suresh Gupta, Nadezhda Koshkina, Stuart J. Corr, Surong Zhang, Steven A. Curley, Gang Han
    Source: Bioconjugate chemistry
    As the number of diagnostic and therapeutic applications utilizing gold nanoparticles (AuNPs) increases, so does the need for AuNPs that are stable in vivo, biocompatible, and suitable for bioconjugation. We investigated a strategy for AuNP stabilization that uses methoxypolyethylene glycol-graft-poly(l-lysine) copolymer (MPEG-gPLL) bearing free amino groups as a stabilizing molecule. MPEG-gPLL injected into water solutions ...
  • Gold nanoparticles stabilized with MPEG-grafted poly(l-lysine): in vitro and in vivo evaluation of a potential theranostic agent

    January 21, 2015
    Author(s): Alexei A. Bogdanov, Suresh Gupta, Nadezhda Koshkina, Stuart J. Corr, Surong Zhang, Steven A. Curley, Gang Han
    Source: Bioconjugate chemistry
    As the number of diagnostic and therapeutic applications utilizing gold nanoparticles (AuNPs) increases, so does the need for AuNPs that are stable in vivo, biocompatible, and suitable for bioconjugation. We investigated a strategy for AuNP stabilization that uses methoxypolyethylene glycol-graft-poly(l-lysine) copolymer (MPEG-gPLL) bearing free amino groups as a stabilizing molecule. MPEG-gPLL injected into water solutions ...
  • Nonmass enhancement on breast MRI: review of patterns with radiologic-pathologic correlation and discussion of management

    January 15, 2015
    Author(s): Tamuna Chadashvili, Erica Ghosh, Valerie Fein-Zachary, Tejas S. Mehta, Shambhavi Venkataraman, Vandana Dialani, Priscilla J. Slanetz
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this article is to review the varied appearances and associated diagnoses of nonmass enhancement on breast MRI with radiologic-pathologic correlation. CONCLUSION: Knowledge of the distribution and internal characteristics of these findings is helpful to determine when core needle biopsy is indicated. Correlating imaging with pathologic findings is critical in making appropriate recommendations regar...
  • MR Imaging of Myeloperoxidase Activity in a Model of the Inflamed Aneurysm Wall

    January 01, 2015
    Author(s): Matthew J. Gounis, Imramsjah M. J. van der Bom, Ajay K. Wakhloo, Shaokuan Zheng, Juyu Chueh, Anna L. Kuhn, Alexei A. Bogdanov Jr.
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Although myeloperoxidase activity in vivo can be visualized by using noninvasive imaging, successful clinical translation requires further optimization of the imaging approach. We report a motion-sensitized driven-equilibrium MR imaging approach for the detection of a myeloperoxidase activity-specific gadolinium-containing imaging agent in experimental aneurysm models, which compensates for irregular ...
  • Reducing radiology report addenda using provisionally signed status

    January 01, 2015
    Author(s): Steven J. Baccei, Matthew L. Hoimes, Heeseop Shin, Adib R. Karam
    Source: Journal of the American College of Radiology : JACR
  • Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics

    January 01, 2015
    Author(s): Netanel Korin, Matthew J. Gounis, Ajay K. Wakhloo, Donald E. Ingber
    Source: JAMA neurology
    Obstruction of normal blood flow, which occurs in a variety of diseases, including thromboembolism in stroke and atherosclerosis, is a leading cause of death and long-term adult disability in the Western world. This review focuses on a novel nanotherapeutic drug-delivery platform that is mechanically activated within blood vessels by high-fluid shear stresses to selectively target drugs to sites of vascular obstruction. In v...
  • Surpass flow diverter in the treatment of intracranial aneurysms: a prospective multicenter study

    January 01, 2015
    Author(s): Ajay K. Wakhloo, Matthew J. Gounis, Surpass Study Group
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Incomplete occlusion and recanalization of large and wide-neck brain aneurysms treated by endovascular therapy remains a challenge. We present preliminary clinical and angiographic results of an experimentally optimized Surpass flow diverter for treatment of intracranial aneurysms in a prospective, multicenter, nonrandomized, single-arm study. MATERIALS AND METHODS: At 24 centers, 165 patients with 19...
  • Risk of distal embolization with stent retriever thrombectomy and ADAPT

    December 24, 2014
    Author(s): Juyu Chueh, Ajit S. Puri, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: There is a discrepancy in clinical outcomes and the achieved recanalization rates with stent retrievers in the endovascular treatment of ischemic stroke. It is our hypothesis that procedural release of embolic particulate may be one contributor to poor outcomes and is a modifiable risk. The goal of this study is to assess various treatment strategies that reduce the risk of distal emboli. METHODS: Mechanical thro...
  • Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report

    December 11, 2014
    Author(s): Yunis M. Mayasi, Deepak Takhtani, Neeta Garg
    Source: Neurology(R) neuroimmunology and neuroinflammation
    OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated encephalitis. METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. RESULTS: The diagnosis of LGI1 antibody-associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric sympto...
  • Flow artifact in the anterior communicating artery resembling aneurysm on the time of flight MR angiogram

    December 01, 2014
    Author(s): Deepak Takhtani, Sathish Kumar Dundamadappa, Ajit S. Puri, Ajay K. Wakhloo
    Source: Acta radiologica (Stockholm, Sweden : 1987)
    BACKGROUND: Magnetic resonance angiogram (MRA) of the brain is a widely employed non-invasive test to diagnose aneurysms. However, its overall accuracy is less than digital subtraction angiography and is prone to give false-positive or false-negative results. False-negative results can be seen with hemorrhage, lipoma, dermoid, posterior lobe of the pituitary gland, and the flow artifacts. PURPOSE: To describe the findings as...
  • Diffuse bone marrow sarcoid-like reaction associated with renal cell carcinoma

    December 01, 2014
    Author(s): Timothy F. Madden, Steven J. Baccei
    Source: Skeletal radiology
    Sarcoid-like reaction has been documented in association with several types of malignancy, including renal cell carcinoma. We report the case of a 41-year-old man with nonmetastatic renal cell carcinoma and concomitant non-caseating granulomas distributed diffusely throughout the bone marrow. The granulomas resolved after nephrectomy. As far as we know, this is the first reported case of a sarcoid-like reaction primarily inv...
  • ACR Appropriateness Criteria(R) acute pancreatitis

    December 01, 2014
    Author(s): Mark E. Baker, Rendon C. Nelson, Max P. Rosen, Michael A. Blake, Brooks D. Cash, Nicole M. Hindman, Ihab R. Kamel, Harmeet Kaur, Robert J. Piorkowski, Aliya Qayyum, Gail M. Yarmish
    Source: Ultrasound quarterly
    The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every two years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness ...
  • Assessment of repeatability of hyperpolarized gas MR ventilation functional imaging in cystic fibrosis

    December 01, 2014
    Author(s): Brian O'Sullivan, Marcus Couch, John P. Roche, Ronn P. Walvick, Shaokuan Zheng, Dawn Baker, Mac Johnson, Martyn Botfield, Mitchell S. Albert
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: Hyperpolarized (HP) gas magnetic resonance imaging (MRI) is an advanced imaging technique that provides high-resolution regional information on lung function without using ionizing radiation. Before this modality can be considered for assessing clinical or investigational interventions, baseline repeatability needs to be established. We assessed repeatability of lung function measurement using HP he...
  • Dedicated Breast CT: Feasibility for Monitoring Neoadjuvant Chemotherapy Treatment

    November 29, 2014
    Author(s): Srinivasan Vedantham, Avice M. O'Connell, Linxi Shi, Andrew Karellas, Alissa J. Huston, Kristin A. Skinner
    Source: Journal of clinical imaging science
    OBJECTIVES: In this prospective pilot study, the feasibility of non-contrast dedicated breast computed tomography (bCT) to determine primary tumor volume and monitor its changes during neoadjuvant chemotherapy (NAC) treatment was investigated. MATERIALS AND METHODS: Eleven women who underwent NAC were imaged with a clinical prototype dedicated bCT system at three time points - pre-, mid-, and post-treatment. The study radiol...
  • Diaphragm injury after liver stereotactic body radiation therapy

    November 20, 2014
    Author(s): Shirin Sioshansi, Paul Rava, Adib R. Karam, Marie Lithgow, Linda Ding, Wei Xing, Thomas J. Fitzgerald
    Source: Practical radiation oncology
  • Large-angle x-ray scatter in Talbot-Lau interferometry for breast imaging

    November 07, 2014
    Author(s): Srinivasan Vedantham, Linxi Shi, Andrew Karellas
    Source: Physics in medicine and biology
    Monte Carlo simulations were used to investigate large-angle x-ray scatter at design energy of 25 keV during small field of view (9.6 cm x 5 cm) differential phase contrast imaging of the breast using Talbot-Lau interferometry. Homogenous, adipose and fibroglandular breasts of uniform thickness ranging from 2 to 8 cm encompassing the field of view were modeled. Theoretically determined transmission efficiencies of the gratin...
  • Effect of needle gauge and lobe laterality on parenchymal liver biopsy outcome: a retrospective analysis

    November 04, 2014
    Author(s): Gopal Vijayaraghavan, Srinivasan Vedantham, Vikram Rangan, Adib R. Karam, Larry Zheng, Abhijit Roychowdhury, Sarwat Hussain
    Source: Abdominal imaging
    PURPOSE: To analyze the effect of lobe selection, needle gauge, and number of passes on procedure outcomes in terms of specimen length and post-procedure complications. METHODS: In this HIPAA-compliant, IRB-approved retrospective study, the data from 771 ultrasound-guided adult parenchymal liver biopsies were analyzed. Post-procedure complications were assigned a 3-point rating scale. Associations between specimen length and...
  • The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples

    November 01, 2014
    Author(s): Avice M. O'Connell, Andrew Karellas, Srinivasan Vedantham
    Source: The breast journal
    Mammography is the gold standard in routine screening for the detection of breast cancer in the general population. However, limitations in sensitivity, particularly in dense breasts, has motivated the development of alternative imaging techniques such as digital breast tomosynthesis, whole breast ultrasound, breast-specific gamma imaging, and more recently dedicated breast computed tomography or "breast CT". Virtually all d...
  • Adaptation of the modified Bouc-Wen model to compensate for hysteresis in respiratory motion for the list-mode binning of cardiac SPECT and PET acquisitions: testing using MRI

    November 01, 2014
    Author(s): Paul K. R. Dasari, Mohammed S. Shazeeb, Arda Konik, Cliff Lindsay, Joyeeta Mitra Mukherjee, Karen Johnson, Michael A. King
    Source: Medical physics
    PURPOSE: Binning list-mode acquisitions as a function of a surrogate signal related to respiration has been employed to reduce the impact of respiratory motion on image quality in cardiac emission tomography (SPECT and PET). Inherent in amplitude binning is the assumption that there is a monotonic relationship between the amplitude of the surrogate signal and respiratory motion of the heart. This assumption is not valid in t...
  • Leukoaraiosis predicts a poor 90-day outcome after endovascular stroke therapy

    November 01, 2014
    Author(s): Jingyan Zhang, Ajit S. Puri, Muhammad A. Khan, Richard P. Goddeau Jr, Nils Henninger
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Leukoaraiosis is a common finding among patients with ischemic stroke and has been associated with poor stroke outcomes. Our aim was to ascertain whether the severity of pre-existing leukoaraiosis is associated with outcome in patients with acute ischemic stroke who are treated with endovascular stroke therapy. MATERIALS AND METHODS: We retrospectively analyzed data from 129 consecutive, prospectively...
  • Human adipose-derived mesenchymal stem cells attenuate liver ischemia-reperfusion injury and promote liver regeneration

    November 01, 2014
    Author(s): Reza F. Saidi, Barur R. Rajeshkumar, Ahmad Shariftabrizi, Alexei A. Bogdanov, Shaokuan Zheng, Karen A. Dresser, Otto Walter
    Source: Surgery
    BACKGROUND: Ischemia-reperfusion injury (IRI) of the liver is a well-known cause of morbidity and mortality after liver transplantation. Effective treatment strategies aimed at decreasing hepatic IRI injury and accelerating liver regeneration could offer major benefits in liver transplantation, especially in the case of partial allografts. Human adipose-derived mesenchymal stem cells (HADMSCs) are an attractive source for re...
  • Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial

    October 24, 2014
    Author(s): Susanne Muehlschlegel, Raphael A. Carandang, Wiley R. Hall, Nisha Kini, Saef Izzy, Bridget Garland, Cynthia Ouillette, Imramsjah M. J. van der Bom, Thomas F. Flood, Matthew J. Gounis, John P. Weaver, Bruce A. Barton, Ajay K. Wakhloo
    Source: Journal of neurology, neurosurgery, and psychiatry
    BACKGROUND: Dantrolene is neuroprotective in animal models and may attenuate cerebral vasospasm (cVSP) in human aneurysmal subarachnoid haemorrhage (aSAH). We evaluated safety, feasibility and tolerability of intravenous dantrolene (IV-D) in patients with aSAH. METHODS: In this single-centre, randomised, double blind, placebo-controlled trial, 31 patients with aSAH were randomised to IV-D 1.25 mg every 6 h for 7 days (n=16) ...
  • Graphic representation of clinical symptoms: a tool for improving detection of subtle fractures on foot radiographs

    October 01, 2014
    Author(s): Ammar Sarwar, Jim S. Wu, Justin Kung, Alexander Brook, Karen S. Lee, Jean-Marc Gauguet, Max P. Rosen
    Source: AJR. American journal of roentgenology
    OBJECTIVE. The purpose of this study was to assess changes in accuracy, degree of confidence, and evaluation time in radiography of subtle foot fractures when the text history is supplemented by a graphic indicating the site of pain. MATERIALS AND METHODS. Radiographs from 226 foot examinations (three views), including 126 examinations showing one subtle fracture ( RESULTS. Use of a graphic increased overall sensitivity for...
  • Feasibility of Small Animal Anatomical and Functional Imaging with Neutrons: A Monte Carlo Simulation Study

    October 01, 2014
    Author(s): D. C. Medich, B. H. Currier, Andrew Karellas
    Source: IEEE Transactions on Nuclear Science
    A novel technique is presented for obtaining a single in-vivo image containing both functional and anatomical information in a small animal model such as a mouse. This technique, which incorporates appropriate image neutron-scatter rejection and uses a neutron opaque contrast agent, is based on neutron radiographic technology and was demonstrated through a series of Monte Carlo simulations. With respect to functional imaging...
  • Endovascular coiling of a ruptured basilar apex aneurysm with associated pseudoaneurysm

    September 01, 2014
    Author(s): Vijay Yanamadala, Ning Lin, Hekmat Zarzour, Kai U. Frerichs, Brian P. Walcott, Ajith J. Thomas, Ajit S. Puri
    Source: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
    Acute intracranial pseudoaneurysms secondary to aneurysmal rupture are a rare entity with no clear evidence-based guidelines for treatment to our knowledge. There are numerous examples of successful treatment of pseudoaneurysms both surgically and endovascularly, the latter mainly within the anterior circulation. Risk of pseudoaneurysm rupture in the acute state during endovascular procedures with subsequent difficulty in co...
  • Iterative reconstruction using a Monte Carlo based system transfer matrix for dedicated breast positron emission tomography

    August 28, 2014
    Author(s): Krishnendu Saha, Kenneth J. Straus, Yu Chen, Stephen J. Glick
    Source: Journal of applied physics
    To maximize sensitivity, it is desirable that ring Positron Emission Tomography (PET) systems dedicated for imaging the breast have a small bore. Unfortunately, due to parallax error this causes substantial degradation in spatial resolution for objects near the periphery of the breast. In this work, a framework for computing and incorporating an accurate system matrix into iterative reconstruction is presented in an effort t...
  • Evaluation of [In]-Labeled Zinc-Dipicolylamine Tracers for SPECT Imaging of Bacterial Infection

    August 13, 2014
    Author(s): Douglas R. Rice, Adam J. Plaunt, Serhan Turkyilmaz, Miles Smith, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: This study prepared three structurally related zinc-dipicolylamine (ZnDPA) tracers with [111In] labels and conducted biodistribution and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging studies of a mouse leg infection model. PROCEDURES: Two monovalent tracers, ZnDPA-[111In]DTPA and ZnDPA-[111In]DOTA, each with a single zinc-dipicolylamine targeting unit, and a divalent tracer, Bis(Z...
  • Revolution in aneurysm treatment: flow diversion to cure aneurysms: a paradigm shift

    August 01, 2014
    Author(s): Ajay K. Wakhloo, Matthew J. Gounis
    Source: Neurosurgery
  • Dynamic contrast-enhanced MRI findings of acute pancreatitis in ectopic pancreatic tissue: case report and review of the literature

    July 28, 2014
    Author(s): Senthur Thangasamy, Larry Zheng, Lacey J. Mcintosh, Paul Lee, Abhijit Roychowdhury
    Source: JOP : Journal of the pancreas
    CONTEXT: Acute pancreatitis in ectopic pancreatic tissue is an uncommon cause of acute abdominal pain and can be difficult to diagnose on imaging. Our aim is to raise awareness and aid in the diagnosis of this entity by highlighting helpful dynamic contrast-enhanced MRI imaging findings. CASE REPORT: We report a 51-year-old man with acute onset epigastric pain presented to ER. With the presence of elevated serum lipase, the ...
  • Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice

    July 24, 2014
    Author(s): Shuping Dou, John Virostko, Mary Rusckowski, Dale L. Greiner, Alvin C. Powers, Guozheng Liu
    Source: Frontiers in pharmacology
    Although an increasing number of antibody conjugates are being used in the clinic, there remain many unmet needs in antibody targeting. Normal tissue background is one of the key issues that limits the therapeutic efficacy and the detection sensitivity. Background reduction coupled with dose increase may provide the required target accumulation of the label or toxin at an acceptable normal tissue background. However, the kno...
  • Digital anthropomorphic phantoms of non-rigid human respiratory and voluntary body motion for investigating motion correction in emission imaging

    July 21, 2014
    Author(s): Arda Konik, Caitlin M. Connolly, Karen Johnson, Paul K. R. Dasari, Paul W. Segars, P. Hendrik Pretorius, Clifford Lindsay, Joyoni Dey, Michael A. King
    Source: Physics in medicine and biology
    The development of methods for correcting patient motion in emission tomography has been receiving increased attention. Often the performance of these methods is evaluated through simulations using digital anthropomorphic phantoms, such as the commonly used extended cardiac torso (XCAT) phantom, which models both respiratory and cardiac motion based on human studies. However, non-rigid body motion, which is frequently seen i...
  • Flow diverter stents for unruptured saccular anterior circulation perforating artery aneurysms: safety, efficacy, and short-term follow-up

    July 21, 2014
    Author(s): Anna L. Kuhn, Samuel Y. Hou, Mary Perras, Christopher Brooks, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Anterior circulation perforating artery aneurysms including anterior choroidal artery and lenticulostriate artery aneurysms are rare. Injury to these vessels can lead to severe debilitating symptoms. OBJECTIVE: To present a new approach to treatment using flow diversion technology. METHODS: Patients treated with a Pipeline embolization device (PED) for perforator artery aneurysms at our institution between June 2...
  • Aneurysm permeability following coil embolization: packing density and coil distribution

    July 16, 2014
    Author(s): Juyu Chueh, Srinivasan Vedantham, Ajay K. Wakhloo, Sarena L. Carniato, Ajit S. Puri, Conrad Bzura, Spencer Coffin, Alexei A. Bogdanov, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: Rates of durable aneurysm occlusion following coil embolization vary widely, and a better understanding of coil mass mechanics is desired. The goal of this study is to evaluate the impact of packing density and coil uniformity on aneurysm permeability. METHODS: Aneurysm models were coiled using either Guglielmi detachable coils or Target coils. The permeability was assessed by taking the ratio of microspheres pas...
  • Use of intermediate guide catheters as an adjunct in extracranial embolization to avoid onyx reflux into the anastomotic vasculature. A technical note

    July 01, 2014
    Author(s): Ajit S. Puri, Anna L. Kuhn, Samuel Y. Hou, Ajay K. Wakhloo
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Onyx is a non-adhesive polymer used for embolization of arteriovenous malformations and dural arteriovenous fistulas (DAVFs). The limiting factor for Onyx embolization is usually the amount of microcatheter reflux, which can be safely tolerated. The dual microcatheter technique, compliant balloon use proximally and the use of the dual lumen Scepter balloon have been described to prevent and limit proximal Onyx reflux. We des...
  • ACR Appropriateness Criteria colorectal cancer screening

    June 01, 2014
    Author(s): Judy Yee, David H. Kim, Max P. Rosen, Tasneem Lalani, Laura R. Carucci, Brooks D. Cash, Barry W. Feig, Kathryn J. Fowler, Douglas S. Katz, Martin P. Smith, Vahid Yaghmai
    Source: Journal of the American College of Radiology : JACR
    Colorectal cancer is the third leading cause of cancer deaths in the United States. Most colorectal cancers can be prevented by detecting and removing the precursor adenomatous polyp. Individual risk factors for the development of colorectal cancer will influence the particular choice of screening tool. CT colonography (CTC) is the primary imaging test for colorectal cancer screening in average-risk individuals, whereas the ...
  • Correlation of apparent diffusion coefficient with Ki-67 proliferation index in grading meningioma

    June 01, 2014
    Author(s): Yi Tang, Sathish Kumar Dundamadappa, Senthur Thangasamy, Thomas Flood, Richard P. Moser, Thomas W. Smith, Keith A. Cauley, Deepak Takhtani
    Source: AJR. American journal of roentgenology
    OBJECTIVE: A noninvasive method to predict aggressiveness of high-grade meningiomas would be desirable because it would help anticipate tumor recurrence and improve tumor management and the treatment outcomes. The Ki-67 protein is a marker of tumor proliferation, and apparent diffusion coefficient (ADC) is related to tumor cellularity. Therefore, we sought to determine whether there is a statistically significant correlation...
  • The development and expression of physical nicotine dependence corresponds to structural and functional alterations in the anterior cingulate-precuneus pathway

    May 01, 2014
    Author(s): Wei Huang, Jean A. King, W. W. Sanouri A. Ursprung, Shaokuan Zheng, Nanyin Zhang, David N. Kennedy, Douglas M. Ziedonis, Joseph R. DiFranza
    Source: Brain and behavior
    INTRODUCTION: Perturbations in neural function provoked by a drug are thought to induce neural adaptations, which, in the absence of the drug, give rise to withdrawal symptoms. Previously published structural data from this study indicated that the progressive development of physical dependence is associated with increasing density of white matter tracts between the anterior cingulum bundle and the precuneus. METHODS: Using ...
  • Assessment of liver fat in an obese patient population using noncontrast CT fat percent index

    May 01, 2014
    Author(s): Ali F. Jon, Ahmad R. Cheema, Atif N. Khan, Vassilios Raptopoulos, Thomas Hauser, Imad Nasser, Francine K. Welty, Andrew Karellas, Melvin E. Clouse
    Source: Clinical imaging
    OBJECTIVE: To develop a simplified method to quantify liver fat using computed tomography (CT) fat % index (CTFPI) compared to liver spleen method (CTL/S, CTL-S). METHODS: Noncontrast CT of the liver was performed in 89 patients (overweight, obese, severely obese) to quantify fat, using the following: CTFPI = [(65-patient HU)/65]x100, normal live r = 65 HU. RESULTS: There was a strong linear correlation between CTFPI and the...
  • Liposome-encapsulated superoxide dismutase mimetic: theranostic potential of an MR detectable and neuroprotective agent

    May 01, 2014
    Author(s): Mohammed Salman Shazeeb, Giancarlo Feula, Alexei A. Bogdanov Jr.
    Source: Contrast media and molecular imaging
    Endogenous manganese based superoxide dismutase (Mn-SOD) provides the primary defense against excess production of potentially toxic superoxide anion (O2 (-) ). M40401 is a synthetic enzyme mimetic that has a catalytic activity rate exceeding that of the native SOD enzymes. The presence of a paramagnetic Mn(II) cation in M40401 suggests that the delivery and spatial distribution of this enzyme mimetic in vivo may be directly...
  • Myeloperoxidase in human intracranial aneurysms: preliminary evidence

    May 01, 2014
    Author(s): Matthew J. Gounis, Srinivasan Vedantham, John P. Weaver, Ajit S. Puri, Christopher S. Brooks, Ajay K. Wakhloo, Alexei A. Bogdanov Jr.
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: Noninvasive imaging identifying a predictive biomarker of the bleeding risk of unruptured intracranial aneurysms (UIAs) is needed. We investigated a potential biomarker of UIA instability, myeloperoxidase, in human aneurysm tissue. METHODS: Human brain aneurysms were harvested after clipping and were histologically and biochemically evaluated for the presence of myeloperoxidase. Of the tissue collecte...
  • Bioactive versus bare platinum coils in the treatment of intracranial aneurysms: the MAPS (Matrix and Platinum Science) trial

    May 01, 2014
    Author(s): C. G. McDougall, S. Claiborne Johnston, A. Gholkar, S. L. Barnwell, J. C. Vazquez Suarez, J. Masso Romero, J. C. Chaloupka, A. Bonafe, Ajay K. Wakhloo, D. Tampieri, C. F. Dowd, A. J. Fox, S. J. Imm, K. Carroll, A. S. Turk
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: The ability of polymer-modified coils to promote stable aneurysm occlusion after endovascular treatment is not well-documented. Angiographic aneurysm recurrence is widely used as a surrogate for treatment failure, but studies documenting the correlation of angiographic recurrence with clinical failure are limited. This trial compares the effectiveness of Matrix(2) polyglycolic/polylactic acid biopolym...
  • Computerized 3-dimensional localization of a video capsule in the abdominal cavity: validation by digital radiography

    April 01, 2014
    Author(s): Neil Marya, Andrew Karellas, Anne Foley, Abhijit Roychowdhury, David R. Cave
    Source: Gastrointestinal endoscopy
    BACKGROUND: Wireless video capsule endoscopy allows the noninvasive visualization of the small intestine. Currently, capsules do not provide localization information while traversing the GI tract. OBJECTIVE: To report on the radiological validation of 3-dimensional localization software incorporated in a newly developed capsule. By using radiofrequency transmission, the software measures the strength of the capsule's signal ...
  • Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: implications for translaboratory collaborations

    April 01, 2014
    Author(s): Marilena Marinescu, James P. Bouley, Juyu Chueh, Marc Fisher, Nils Henninger
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    Current recommendations encourage the use of embolic stroke (ES) models and replication of results across laboratories in preclinical research. Since such endeavors employ different surgeons, we sought to ascertain the impact of injection technique on outcome and response to thrombolysis in an ES model. Embolic stroke was induced in Male Wistar Kyoto rats (n=166) by a fast or a slow clot injection (CI) technique. Saline or r...
  • Perforation of the descending colon in severe acute pancreatitis: a case report and literature review

    April 01, 2014
    Author(s): Bilal Gondal, Adedotun Ogunsua, Lacey J. Mcintosh, Yousaf Shaikh, David R. Cave
    Source: Pancreas
  • ACR appropriateness criteria right upper quadrant pain

    March 01, 2014
    Author(s): Gail M. Yarmish, Martin P. Smith, Max P. Rosen, Mark E. Baker, Michael A. Blake, Brooks D. Cash, Nicole M. Hindman, Ihab R. Kamel, Harmeet Kaur, Rendon C. Nelson, Robert J. Piorkowski, Aliya Qayyum, Mark Tulchinsky
    Source: Journal of the American College of Radiology : JACR
    Acute right upper quadrant pain is a common presenting symptom in patients with acute cholecystitis. When acute cholecystitis is suspected in patients with right upper quadrant pain, in most clinical scenarios, the initial imaging modality of choice is ultrasound. Although cholescintigraphy has been shown to have slightly higher sensitivity and specificity for diagnosis, ultrasound is preferred as the initial study for a var...
  • Impaired cerebral autoregulation is associated with vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage

    March 01, 2014
    Author(s): Fadar Otite, Susanne Mink, Can Ozan Tan, Ajit S. Puri, Amir A. Zamani, Aujan Mehregan, Sherry Chou, Susannah Orzell, Sushmita Purkayastha, Rose Du, Farzaneh A. Sorond
    Source: Stroke
    BACKGROUND AND PURPOSE: Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH. METHODS: Sixty-eight patients (54+/-13 years) with a diagnosis of nontraumatic SAH were studied. Dynamic cerebral ...
  • Radiation oncologists' response to pundendal entrapment neuropathy

    March 01, 2014
    Author(s): Richard S. Pieters, Hartley Sirkis, Jesse N. Aronowitz
    Source: Pain physician
    Comment on: Pudendal entrapment neuropathy: a rare complication of pelvic radiation therapy. [Pain Physician. 2013]
  • MRI Investigation of the Linkage Between Respiratory Motion of the Heart and Markers on Patient's Abdomen and Chest: Implications for Respiratory Amplitude Binning List-Mode PET and SPECT Studies

    February 06, 2014
    Author(s): Paul K. R. Dasari, Karen Johnson, Joyoni Dey, Cliff Lindsay, Mohammed S. Shazeeb, Joyeeta Mitra Mukherjee, Shaokuan Zheng, Michael A. King
    Source: IEEE transactions on nuclear science
    Respiratory motion of the heart impacts the diagnostic accuracy of myocardial-perfusion emission-imaging studies. Amplitude binning has come to be the method of choice for binning list-mode based acquisitions for correction of respiratory motion in PET and SPECT. In some subjects respiratory motion exhibits hysteretic behavior similar to damped non-linear cyclic systems. The detection and correction of hysteresis between the...
  • Effects of Piecewise Spatial Smoothing in 4-D SPECT Reconstruction

    February 01, 2014
    Author(s): Wenyuan Qi, Yongyi Yang, Michael A. King
    Source: IEEE Transactions on Nuclear Science
    In nuclear medicine, cardiac gated SPECT images are known to suffer from significantly increased noise owing to limited data counts. Consequently, spatial (and temporal) smoothing has been indispensable for suppressing the noise artifacts in SPECT reconstruction. However, recently we demonstrated that the benefit of spatial processing in motion-compensated reconstruction of gated SPECT (aka 4-D) could be outweighed by its ad...
  • Advances in stroke: Advances in interventional radiology 2013

    February 01, 2014
    Author(s): Ajay K. Wakhloo, Matthew J. Gounis, Juyu Chueh, Laurent Pierot
    Source: Stroke
    The simultaneous publication of 3 randomized control trials comparing intravenous thrombolysis therapy to the endovascular treatment (EVT) of acute ischemic stroke might have lead to the erroneous conclusion that EVT has no place in the management of acute ischemic stroke.However, careful analysis of these studies shows that these reports have shortcomings because of changes in imaging and device technology and to study desi...
  • Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach

    January 01, 2014
    Author(s): Shuping Dou, Yuzhen Wang, Bruce A. Barton, Ling Chen, Mary Rusckowski, Leonard D. Shultz, Dale L. Greiner, Guozheng Liu
    Source: Nuclear medicine and biology
    INTRODUCTION: The differences between two agents often need to be accurately defined in vivo. Usually they are injected respectively into two groups of subjects. However, if the two agents do not interact with each other in vivo, a coinjection would serve the same purpose. We believe some individual differences in biodistribution may be circumvented through this approach by calculating organ level ratios. METHODS: A model sy...
  • Mismatch in breast and detector size during screening and diagnostic mammography results in increased patient radiation dose

    January 01, 2014
    Author(s): Catherine L. Wells, P. J. Slanetz, Max P. Rosen
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: When using mammographic detectors of different sizes, it can be difficult to match patient breast size to optimal detector size. We studied whether a mismatch between breast size and optimal detector size resulted in increased radiation exposure. MATERIALS AND METHODS: All screening and diagnostic (Dx) mammography patients during a 6-week period in November-December 2009 (864 patients) were evaluate...
  • Delayed splenic rupture presenting 70 days following blunt abdominal trauma

    January 01, 2014
    Author(s): Nancy Resteghini, Jonpaul Nielsen, Matthew L. Hoimes, Adib R. Karam
    Source: Clinical imaging
    Delayed splenic rupture following conservative management of splenic injury is an extremely rare complication. We report a case of an adult patient who presented with delayed splenic rupture necessitating splenectomy, 2 months following blunt abdominal trauma. Imaging at the initial presentation demonstrated only minimal splenic contusion and the patient was discharge following 24 hours of observation.
  • Gadoxetate disodium-enhanced liver MRI: gallbladder opacification patterns during hepatobiliary phase

    January 01, 2014
    Author(s): Adib R. Karam, Young H. Kim, Michael T. Corwin
    Source: Clinical imaging
    OBJECTIVE(S): To describe the different patterns of gallbladder lumen opacification on gadoxetate disodium-enhanced liver magnetic resonance imaging (MRI). METHODS: One hundred eighty-seven MRI examinations were reviewed by two abdominal imaging radiologists who described the different patterns of gallbladder opacification, based on comparing the post-contrast to the pre-contrast images. RESULTS: Four patterns of gallbladder...
  • Role of noncontrast head CT in the assessment of vascular abnormalities in the emergency room

    December 01, 2013
    Author(s): Deepak Takhtani, Sathish Kumar Dundamadappa, Jeevak Almast
    Source: Emergency radiology
    Noncontrast CT of the head is a widely used noninvasive investigation for a variety of acute and chronic neurological conditions. Since CT head without contrast is usually the first and often the only investigation in the emergency room for many neurological symptoms, it is imperative to detect subtle vascular changes, which in many patients can be life-saving. The vascular abnormalities may present with increased density an...
  • A method to synchronize signals from multiple patient monitoring devices through a single input channel for inclusion in list-mode acquisitions

    December 01, 2013
    Author(s): J Michael O'Connor, P. Hendrik Pretorius, Karen Johnson, Michael A. King
    Source: Medical physics
    PURPOSE: This technical note documents a method that the authors developed for combining a signal to synchronize a patient-monitoring device with a second physiological signal for inclusion into list-mode acquisition. Our specific application requires synchronizing an external patient motion-tracking system with a medical imaging system by multiplexing the tracking input with the ECG input. The authors believe that their met...
  • Comparison of methods of acquiring attenuation maps for cardiac SPECT in the presence of respiratory motion

    December 01, 2013
    Author(s): Arda Konik, Janusz Kikut, Richard Lew, Karen Johnson, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: We investigated the effect of the respiratory motion on attenuation-corrected (AC) SPECT images for three different SPECT systems, each using a different approach in obtaining attenuation maps: scanning-line sources (SLS) acquired simultaneous with emission; slow cone-beam CT (CBCT) acquired sequentially to emission; and fast helical CT (HCT) acquired sequentially to emission. METHODS: A torso phantom filled with...
  • MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model

    December 01, 2013
    Author(s): Mohammed Salman Shazeeb, Suresh Gupta, Alexei A. Bogdanov Jr.
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: To investigate the potential of targeted MR signal amplification strategy for imaging of EGF receptor variant III (EGFRvIII) overexpression associated with the infiltrating margin of aggressive orthotopic brain tumors. PROCEDURES: F(ab')2 fragments of humanized anti-EGFRvIII monoclonal antibody (EMD72000) were linked to deglycosylated horseradish peroxidase (HRP) and glucose oxidase (GOX). Detection of the F(ab')2 c...
  • Personalized estimates of radiation dose from dedicated breast CT in a diagnostic population and comparison with diagnostic mammography

    November 21, 2013
    Author(s): Srinivasan Vedantham, Linxi Shi, Andrew Karellas, Avice M. O'Connell, David L. Conover
    Source: Physics in medicine and biology
    This study retrospectively analyzed the mean glandular dose (MGD) to 133 breasts from 132 subjects, all women, who participated in a clinical trial evaluating dedicated breast CT in a diagnostic population. The clinical trial was conducted in adherence to a protocol approved by institutional review boards and the study participants provided written informed consent. Individual estimates of MGD to each breast from dedicated b...
  • An evaluation of data-driven motion estimation in comparison to the usage of external-surrogates in cardiac SPECT imaging

    November 07, 2013
    Author(s): Joyeeta Mitra Mukherjee, Brian F. Hutton, Karen Johnson, P. Hendrik Pretorius, Michael A. King
    Source: Physics in medicine and biology
    Motion estimation methods in single photon emission computed tomography (SPECT) can be classified into methods which depend on just the emission data (data-driven), or those that use some other source of information such as an external surrogate. The surrogate-based methods estimate the motion exhibited externally which may not correlate exactly with the movement of organs inside the body. The accuracy of data-driven strateg...
  • Use of MRI to assess the prediction of heart motion with gross body motion in myocardial perfusion imaging by stereotracking of markers on the body surface

    November 01, 2013
    Author(s): Michael A. King, Joyoni Dey, Karen Johnson, Paul K. R. Dasari, Joyeeta Mitra Mukherjee, Joseph E, McNamara, Arda Konik, Cliff Lindsay, Shaokuan Zheng, Dennis Coughlin
    Source: Medical physics
    PURPOSE: The aim of this study is to determine using MRI in volunteers whether the rigid-body-motion (RBM) model can be approximately used to estimate the gross body-motion of the heart from that of external markers on patient's chest. Our target clinical application is to use a visual-tracking-system (VTS) which employs stereoimaging to estimate heart motion during SPECT/CT and PETCT myocardial perfusion imaging. METHODS: T...
  • Modality-specific occult intrarenal pseudoaneurysm in a renal allograft and the legacy of catheter angiography

    November 01, 2013
    Author(s): Neeraj Rastogi, Gethin Williams, Herlen Alencar
    Source: Annals of vascular surgery
    A 69-year-old man with history of end-stage-renal disease (ESRD) underwent successful kidney transplantation from a cadaveric donor in November 2011. However, posttransplant recovery was complicated by delayed graft function and recurrent gross hematuria. Serial Doppler ultrasound (US) of the renal allograft demonstrated a pseudoaneurysm with interval increase in size. However, it could not be visualized with other modalitie...
  • (99m)Tc-MORF oligomers specific for bacterial ribosomal RNA as potential specific infection imaging agents

    November 01, 2013
    Author(s): Ling Chen, Yi Wang, Dengfeng Cheng, Xinrong Liu, Shuping Dou, Guozheng Liu, Donald J. Hnatowich, Mary Rusckowski
    Source: Bioorganic and medicinal chemistry
    PURPOSE: Radiolabeled oligomers complementary to the 16S rRNA in bacteria were investigated as bacterial infection imaging agents. METHODS AND RESULTS: Identical sequences with backbones phosphorodiamidate morpholino (MORF), peptide nucleic acid (PNA), and phosphorothioate DNA (PS-DNA) were (99m)Tc-labeled and evaluated for binding to bacterial RNA. MORF binding to RNA from Escherichia coli strains SM101 and K12 was 4- and 1...
  • Reduction of coil mass artifacts in high-resolution flat detector conebeam CT of cerebral stent-assisted coiling

    November 01, 2013
    Author(s): Imramsjah M. J. van der Bom, Samuel Y. Hou, Ajit S. Puri, Gabriela Spilberg, D. Ruijters, P. van de Haar, B. Carelsen, Srinivasan Vedantham, Matthew J. Gounis, Ajay K. Wakhloo
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Developments in flat panel angiographic C-arm systems have enabled visualization of both the neurovascular stents and host arteries in great detail, providing complementary spatial information in addition to conventional DSA. However, the visibility of these structures may be impeded by artifacts generated by adjacent radio-attenuating objects. We report on the use of a metal artifact reduction algori...
  • Investigating the effect of characteristic x-rays in cadmium zinc telluride detectors under breast computerized tomography operating conditions

    October 14, 2013
    Author(s): Stephen J. Glick, Clay Didier
    Source: Journal of applied physics
    A number of research groups have been investigating the use of dedicated breast computerized tomography (CT). Preliminary results have been encouraging, suggesting an improved visualization of masses on breast CT as compared to conventional mammography. Nonetheless, there are many challenges to overcome before breast CT can become a routine clinical reality. One potential improvement over current breast CT prototypes would b...
  • The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores

    October 01, 2013
    Author(s): Valeriy G. Metelev, Surong Zhang, David Tabatadze, Anand T. N. Kumar, Alexei A. Bogdanov Jr.
    Source: Molecular bioSystems
    We report a general phenomenon of the formation of either a fluorescent or an entirely quenched oligodeoxynucleotide (ODN) duplex system by hybridizing pairs of complementary ODNs with identical chemical composition. The ODNs carried internucleoside tether-linked cyanines, where the cyanines were chosen to form a Forster's resonance energy transfer (FRET) donor-acceptor pair. The fluorescent and quenched ODN duplex systems d...
  • Design of the Vitesse Intracranial Stent Study for Ischemic Therapy (VISSIT) trial in symptomatic intracranial stenosis

    October 01, 2013
    Author(s): Osama O. Zaidat, Alicia C. Castonguay, Brian-Fred Fitzsimmons, Britton Keith Woodward, Zhigang Wang, Monika Killer-Oberpfalzer, Ajay K. Wakhloo, Rishi Gupta, Howard Kirshner, Misha Eliasziw, J. Thomas Megerian, Sujith Shetty, Meg Yoklavich Guilhermier, Stanley Barnwell, Wade S. Smith, Daryl R. Gress
    Source: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    BACKGROUND: Patients with high-grade symptomatic intracranial stenosis ( /= 70%) have an increased risk of recurrent stroke despite medical treatment with antiplatelet or anticoagulant therapy. Intracranial stenting has been proposed as a viable treatment option for this high-risk patient population; however, evaluation of this therapy in randomized multicenter trials is needed. In this article, we present the design and me...
  • Cement directed kyphoplasty reduces cement leakage as compared with vertebroplasty: results of a controlled, randomized trial

    September 15, 2013
    Author(s): Thomas J. Vogl, Robert Pflugmacher, Johannes Hierholzer, Gerd Stender, Matthew J. Gounis, Ajay K. Wakhloo, Christian Fiebig, Renate Hammerstingl
    Source: Spine
    STUDY DESIGN: A novel randomized, controlled, unblinded clinical trial comparing 2 procedural interventions for painful osteoporotic vertebral compression fractures. OBJECTIVE: The primary study objective was to evaluate cement leakage for a cement directed kyphoplasty system (CDKS) with anteriorly biased cement flow and vertebroplasty. The secondary study objective was to compare adjacent level fracture rates and vertebral ...
  • Target delineation for radiosurgery of a small brain arteriovenous malformation using high-resolution contrast-enhanced cone beam CT

    August 14, 2013
    Author(s): Imramsjah M. J. van der Bom, Matthew J. Gounis, Linda Ding, Anna L. Kuhn, David Goff, Ajit S. Puri, Ajay K. Wakhloo
    Source: BMJ Case Reports
    Three years following endovascular embolization of a 3 mm ruptured arteriovenous malformation (AVM) of the left superior colliculus in a 42-year-old man, digital subtraction angiography showed continuous regrowth of the lesion. Thin-slice MRI acquired for treatment planning did not show the AVM nidus. The patient was brought back to the angiography suite for high-resolution contrast-enhanced cone beam CT (VasoCT) acquired us...
  • Investigation of statistical iterative reconstruction for dedicated breast CT

    August 10, 2013
    Author(s): Andrey Makeev, Stephen J. Glick
    Source: Medical physics
    PURPOSE: Dedicated breast CT has great potential for improving the detection and diagnosis of breast cancer. Statistical iterative reconstruction (SIR) in dedicated breast CT is a promising alternative to traditional filtered backprojection (FBP). One of the difficulties in using SIR is the presence of free parameters in the algorithm that control the appearance of the resulting image. These parameters require tuning in orde...
  • Rules of thumb for maximum percent tumor accumulation

    August 01, 2013
    Author(s): Guozheng Liu
    Source: Nuclear medicine and biology
  • Diffusion-tensor imaging of small nerve bundles: cranial nerves, peripheral nerves, distal spinal cord, and lumbar nerve roots--clinical applications

    August 01, 2013
    Author(s): Keith A. Cauley, Christopher G. Filippi
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this article is to review recent advances in diffusion-tensor imaging (DTI) and tractography of the cranial and peripheral nerves. CONCLUSION: Advances in MR data acquisition and postprocessing methods are permitting high-resolution DTI of the cranial and peripheral nerves in the clinical setting. DTI offers information beyond routine clinical MRI, and DTI findings have implications for the diagnosi...
  • Investigation of energy weighting using an energy discriminating photon counting detector for breast CT

    August 01, 2013
    Author(s): Kesava S. Kalluri, Mufeed Mahd, Stephen J. Glick
    Source: Medical physics
    PURPOSE: Breast CT is an emerging imaging technique that can portray the breast in 3D and improve visualization of important diagnostic features. Early clinical studies have suggested that breast CT has sufficient spatial and contrast resolution for accurate detection of masses and microcalcifications in the breast, reducing structural overlap that is often a limiting factor in reading mammographic images. For a number of re...
  • Acute stroke imaging: recent updates

    July 18, 2013
    Author(s): Prachi Dubey, Sachin Pandey, Gul Moonis
    Source: Stroke research and treatment
    Acute ischemic stroke imaging is one of the leading causes of death and disability worldwide. Neuroimaging plays a crucial role in early diagnosis and yields essential information regarding tissue integrity, a factor that remains a key therapeutic determinant. Given the widespread public health implications of stroke and central role of neuroimaging in overall management, acute stroke imaging remains a heavily debated, exten...
  • Coexisting intrarenal arteriovenous and caliceovenous fistulae after percutaneous nephrolithotomy: Case report and literature review

    July 04, 2013
    Author(s): Neeraj Rastogi, Walter Zawacki, Herlen Alencar
    Source: Interventional medicine and applied science
    A 58-year-old man was re-admitted to the Urology service with delayed gross hematuria and unstable he-modynamics, following a percutaneous nephrolithotomy (PCNL) procedure performed for an obstructive solitary left lower calyceal stone. A selective left renal angiogram demonstrated an interpolar arteriovenous fistula (AVF), which was treated with successful coil embolization of a sub-segmental feeding branch. Sub-sequent nep...
  • Vertebral artery ostial stenosis: prevalence by digital subtraction angiography, MR angiography, and CT angiography

    July 01, 2013
    Author(s): Sathish Kumar Dundamadappa, Keith A. Cauley
    Source: Journal of neuroimaging : official journal of the American Society of Neuroimaging
    BACKGROUND AND PURPOSE: (1) To determine the prevalence of vertebral arterial ostial stenosis (VOS) as determined by the "gold standard" of digital subtraction angiography (DSA). (2) To learn the correlation between vertebral ostial stenosis and study indication. (3) To determine the ability of contrast-enhanced magnetic resonance angiography (CE MRA) and computed tomographic angiography (CTA) to reflect the true prevalence ...
  • Development and testing of a single frequency terahertz imaging system for breast cancer detection

    July 01, 2013
    Author(s): Benjamin St Peter, Sigfrid Yngvesson, Paul Siqueira, Patrick Kelly, Ashraf Khan, Stephen J. Glick, Andrew Karellas
    Source: IEEE journal of biomedical and health informatics
    The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of ...
  • Wingspan experience in the treatment of symptomatic intracranial atherosclerotic disease after antithrombotic failure

    July 01, 2013
    Author(s): Edgar A. Samaniego, Francesca Tari-Capone, Italo Linfante, Christine F. Silva, Gabriela Spilberg, Matthew J. Gounis, Ajay K. Wakhloo, Guilherme Dabus
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Intracranial stenting with the Wingspan system has been used as a revascularization strategy in symptomatic patients with intracranial atherosclerotic disease (ICAD). The latest results of the Stenting versus Aggressive Medical Therapy for Intracranial Artery Stenosis (SAMMPRIS) trial challenge this approach. Our experience in the treatment of symptomatic ICAD with the Wingspan system is reported. MAT...
  • Endovascular treatment of intracranial aneurysms: current status

    July 01, 2013
    Author(s): Laurent Pierot, Ajay K. Wakhloo
    Source: Stroke
    Although treatment of a ruptured aneurysm is accepted as an emergency, indication for treatment of unruptured intracranial aneurysms (IAs) is still being discussed.
  • Dedicated breast CT: geometric design considerations to maximize posterior breast coverage

    June 21, 2013
    Author(s): Srinivasan Vedantham, Andrew Karellas, Margaret M. Emmons, Lawrence J. Moss, Sarwat Hussain, Stephen P. Baker
    Source: Physics in medicine and biology
    An Institutional Review Board-approved protocol was used to quantify breast tissue inclusion in 52 women, under conditions simulating both craniocaudal (CC) and mediolateral oblique (MLO) views in mammography, dedicated breast CT in the upright subject position, and dedicated breast CT in the prone subject position. Using skin as a surrogate for the underlying breast tissue, the posterior aspect of the breast that is aligned...
  • Preclinical investigations for thrombectomy devices--does it translate to humans

    June 05, 2013
    Author(s): Matthew J. Gounis, Ajay K. Wakhloo, Juyu Chueh
    Source: Stroke; a journal of cerebral circulation
    Currently, most preclinical models to validate thrombectomy technologies have not directly translated to the clinical arena. Herein, we review our strategy that combines in vitro and in vivo modeling to assess thrombectomy device safety and efficacy quantitatively.
  • New generation of flow diverter (surpass) for unruptured intracranial aneurysms: a prospective single-center study in 37 patients

    June 01, 2013
    Author(s): Joost De Vries, Jeroen Boogaarts, Anouk Van Norden, Ajay K. Wakhloo
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: In patients harboring intracranial aneurysms, the major goal in treatment is to prevent bleeding. A new generation of an endoluminal device (Surpass Flow Diverter [Surpass]) was developed to reconstruct parent artery and occlude the aneurysm. We present our clinical and angiographic single-center experience. METHODS: Patients with a wide range of complex unruptured aneurysms were treated with the Surp...
  • Improved image quality and detection of small cerebral infarctions with diffusion-tensor trace imaging

    June 01, 2013
    Author(s): Keith A. Cauley, Senthur Thangasamy, Sathish Kumar Dundamadappa
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to test a hypothesis that routinely performed diffusion-tensor trace imaging is of sufficient image quality and sensitivity for infarct detection to safely and routinely replace standard diffusion-weighted imaging (DWI) in the clinical setting. MATERIALS AND METHODS: Both routine DWI and 15-direction diffusion-tensor imaging (DTI) with parallel acquisition technique were obtained on a...
  • ACR appropriateness criteria jaundice

    June 01, 2013
    Author(s): Tasneem Lalani, Max P. Rosen
    Source: Journal of the American College of Radiology : JACR
    A fundamental consideration in the workup of a jaundiced patient is the pretest probability of mechanical obstruction. Ultrasound is the first-line modality to exclude biliary tract obstruction. When mechanical obstruction is present, additional imaging with CT or MRI can clarify etiology, define level of obstruction, stage disease, and guide intervention. When mechanical obstruction is absent, additional imaging can evaluat...
  • Intraperitoneal Injection is Not Always a Suitable Alternative to Intravenous Injection for Radiotherapy

    May 13, 2013
    Author(s): Shuping Dou, Miles Smith, Yuzhen Wang, Mary Rusckowski, Guozheng Liu
    Source: Cancer biotherapy and radiopharmaceuticals
    Abstract Intraperitoneal (IP) injection is frequently reported to be as effective as intravenous (IV) injection. Because it allows administering a larger volume with more radioactivity, we have investigated this route and the possibility of using it to circumvent the volume constraint we earlier experienced with pretargeting radiotherapy. Using 99mTc as the label, the pharmacokinetics (PK) of the cMORF effector (a DNA analog...
  • Chemical exchange saturation transfer effect in blood

    May 09, 2013
    Author(s): Shaokuan Zheng, Imramsjah M. J. van der Bom, Zhongliang Zu, Guoxing Lin, Yansong Zhao, Matthew J. Gounis
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    PURPOSE: In this report, the feasibility of using blood as an agent for Chemical Exchange Saturation Transfer (CEST) effect is investigated. METHODS: The CEST effect of porcine blood samples was investigated on a 3.0 T MRI scanner using various power levels and on a 14.1 T NMR spectrometer. As a proof-of-concept that CEST can be used to image blood in vivo, the technique was applied in two locations of healthy human voluntee...
  • Double embolic protection during carotid artery stenting with persistent hypoglossal artery

    May 02, 2013
    Author(s): Christine F. Silva, Samuel Y. Hou, Anna L. Kuhn, Richard H. Whitten, Ajay K. Wakhloo
    Source: BMJ case reports
    A woman presented with 75% stenosis of the right internal carotid artery (ICA) with extension to the origin of a persistent hypoglossal artery (PHA). The PHA is a rare fetal variant of carotid-basilar anastomosis that elevates the risk of ischemia and embolic infarction within the posterior cerebral circulation in patients with carotid disease proximal to the anastomosis. Our case is highly unique because of the extremely ra...
  • A thromboembolic model for the efficacy and safety evaluation of combined mechanical and pharmacologic revascularization strategies

    May 01, 2013
    Author(s): Matthew J. Gounis, Raul G. Nogueira, Manik Mehra, Juyu Chueh, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Recanalization strategies mediated by intra-arterial fibrinolytic therapy in combination with mechanical clot disruption may be a more effective treatment approach than either therapy used alone. There are few preclinical animal models to evaluate these strategies. Here we report on a model to simultaneously evaluate both of these treatment approaches. METHODS: Allogeneic clot was injected through the...
  • Malignancy and acute pulmonary embolism: risk stratification including the right to left ventricle diameter ratio in 1596 subjects

    May 01, 2013
    Author(s): Bryan Cai, Arash Bedayat, Elizabeth George, Andetta R. Hunsaker, Karin E. Dill, Frank J. Rybicki, Kanako K. Kumamaru
    Source: Journal of thoracic imaging
    PURPOSE: To test the hypothesis that subjects with a known malignancy at the time of acute pulmonary embolism (PE) have different clinical characteristics and predictors of 30-day all-cause mortality when compared with subjects with no known malignancy. MATERIALS AND METHODS: A retrospective (August 2003 to March 2010) cohort of 1596 consecutive positive (for acute PE) computed tomography pulmonary angiograms (CTPAs) perform...
  • Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study

    May 01, 2013
    Author(s): Juyu Chueh, Anna L. Kuhn, Ajit S. Puri, Scott D. Wilson, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Stroke
    BACKGROUND AND PURPOSE: To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS: Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide catheter, were used to ascertain the impact of proximal flow control on the size and number of distal emboli gen...
  • Generation of voxelized breast phantoms from surgical mastectomy specimens

    April 01, 2013
    Author(s): J. Michael O'Connor, Mini Das, Clay S. Dider, Mufeed Mahd, Stephen J. Glick
    Source: Medical physics
    PURPOSE: In the research and development of dedicated tomographic breast imaging systems, digital breast object models, also known as digital phantoms, are useful tools. While various digital breast phantoms do exist, the purpose of this study was to develop a realistic high-resolution model suitable for simulating three-dimensional (3D) breast imaging modalities. The primary goal was to design a model capable of producing s...
  • X-ray phase contrast imaging of the breast: analysis of tissue simulating materials

    April 01, 2013
    Author(s): Srinivasan Vedantham, Andrew Karellas
    Source: Medical physics
    PURPOSE: Phase contrast imaging, particularly of the breast, is being actively investigated. The purpose of this work is to investigate the x-ray phase contrast properties of breast tissues and commonly used breast tissue substitutes or phantom materials with an aim of determining the phantom materials best representative of breast tissues. METHODS: Elemental compositions of breast tissues including adipose, fibroglandular, ...
  • Renal biopsy: comparative yield of cranial versus caudal needle trajectory. An ex vivo analysis

    April 01, 2013
    Author(s): Adib R. Karam, Gopal Vijayaraghavan, Ashraf Khan, Berrin Ustun, Sarwat Hussain
    Source: Nephrology (Carlton, Vic.)
    AIM: To compare the diagnostic quality of tissue cores obtained using cranial and caudal angulation of the renal biopsy needle. Comparison was made in terms of the number of glomeruli and proportion of renal cortex with medulla on pathological analysis. METHODS: A total of 40 desktop, renal biopsies were performed on 10 ex vivo porcine kidneys using two different targeting angles. Biopsies were obtained from the 'lower pole'...
  • Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO2 challenges in mouse brain

    April 01, 2013
    Author(s): Shuning Huang, Christian T Farrar, Guangping Dai, Seon Joo Kwon, Alexei A. Bogdanov Jr., Bruce R. Rosen, Young R. Kim
    Source: NMR in biomedicine
    The integrity of the blood-brain barrier (BBB) is critical to normal brain function. Traditional techniques for the assessment of BBB disruption rely heavily on the spatiotemporal analysis of extravasating contrast agents. However, such methods based on the leakage of relatively large molecules are not suitable for the detection of subtle BBB impairment or for the performance of repeated measurements in a short time frame. Q...
  • Porcine brachial artery tortuosity for in vivo evaluation of neuroendovascular devices

    April 01, 2013
    Author(s): S. Carniato, M. Mehra, R. M. King, Ajay K. Wakhloo, Matthew J. Gounis
    Source: AJNR. American journal of neuroradiology
    We report a novel model of arterial tortuosity in the porcine brachial artery for testing of endovascular devices in the flexed forelimb position. This provides an ideal vascular territory for an in vivo assessment of guidewires, microcatheters, and endovascular implants because it closely mimics the challenging curvature at the carotid siphon.
  • Focal absence of diffusion tensor tracts from primary motor cortex in primary lateral sclerosis

    April 01, 2013
    Author(s): Johnny S. Salameh, N. Patel, Shaokuan Zheng, Keith A. Cauley
    Source: European journal of neurology
  • Estimating the effective radiation dose imparted to patients by intraoperative cone-beam computed tomography in thoracolumbar spinal surgery

    March 01, 2013
    Author(s): Jeffrey Lange, Andrew Karellas, John Street, Jason C. Eck, Anthony Lapinsky, Patrick J. Connolly, Christian P. DiPaola
    Source: Spine
    STUDY DESIGN: Observational. OBJECTIVE: To estimate the radiation dose imparted to patients during typical thoracolumbar spinal surgical scenarios. SUMMARY OF BACKGROUND DATA: Minimally invasive techniques continue to become more common in spine surgery. Computer-assisted navigation systems coupled with intraoperative cone-beam computed tomography (CT) represent one such method used to aid in instrumented spinal procedures. ...
  • Technical note: Skin thickness measurements using high-resolution flat-panel cone-beam dedicated breast CT

    March 01, 2013
    Author(s): Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Avice M. O'Connell
    Source: Medical physics
    PURPOSE: To determine the mean and range of location-averaged breast skin thickness using high-resolution dedicated breast CT for use in Monte Carlo-based estimation of normalized glandular dose coefficients. METHODS: This study retrospectively analyzed image data from a clinical study investigating dedicated breast CT. An algorithm similar to that described by Huang et al. ["The effect of skin thickness determined using bre...
  • AIRP best cases in radiologic-pathologic correlation: lactating adenoma

    March 01, 2013
    Author(s): Allyson N. Parnes, Ali Akalin, Robert M. Quinlan, Gopal R. Vijayaraghavan
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    RadioGraphics continues to publish radiologic-pathologic case material selected from the American Institute for Radiologic Pathology (AIRP) “best case” presentations. The AIRP conducts a 4-week Radiologic Pathology Correlation Course, which is offered five times per year. On the penultimate day of the course, the best case presentation is held at the American Film Institute Silver Theater and Cultural Center in Silver Spring...
  • Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles

    March 01, 2013
    Author(s): Sandra Reichstetter, Gerardo M. Castillo, Israel Rubinstein, Akiko Nishimoto-Ashfield, Manshun Lai, Cynthia C. Jones, Aryamitra A. Banerjee, Alex Lyubimov, Duane C. Bloedow, Alexei A. Bogdanov Jr., Elijah M. Bolotin
    Source: Pharmaceutical research
    PURPOSE: To determine and compare pharmacokinetics and toxicity of two nanoformulations of Vasoactive Intestinal Peptide (VIP). METHODS: VIP was formulated using a micellar (Sterically Stabilized Micelles, SSM) and a polymer-based (Protected Graft Copolymer, PGC) nanocarrier at various loading percentages. VIP binding to the nanocarriers, pharmacokinetics, blood pressure, blood chemistry, and acute maximum tolerated dose (MT...
  • Yield of radiographic skeletal surveys for detection of hand, foot, and spine fractures in suspected child abuse

    March 01, 2013
    Author(s): Paul K. Kleinman, Nicole B. Morris, Joseph Makris, Rebecca L. Moles, Patricia L. Kleinman
    Source: AJR. American journal of roentgenology
    OBJECTIVE: Previous studies have found that fractures involving the spine, hands, and feet are rare on skeletal surveys in cases of suspected child abuse, leading some authors to suggest eliminating these regions from the initial skeletal survey protocol. We assessed this recommendation by performing a historical review of these injuries in a pediatric population undergoing film screen-based radiographic skeletal surveys for...
  • Focus series introduction. X-ray computed tomography: 2012 advances in image formation

    February 28, 2013
    Author(s): Andrew Karellas, Frederic Noo
    Source: Medical physics
  • Gallstone ileus

    February 01, 2013
    Author(s): Amanda Collins, Dennis Coughlin, Marie T. Mullen
    Source: The Journal of emergency medicine
    Patients presenting to the Emergency Department with the complaint of abdominal pain can pose a diagnostic challenge. History and physical examination in conjunction with age, comorbidities, and laboratory values may not yield the expected diagnosis. The authors present a case of an uncommon disease with high morbidity and mortality presenting outside the expected patient population.
  • 4D reconstruction for low-dose cardiac gated SPECT

    February 01, 2013
    Author(s): Mingwu Jin, Xiaofeng Niu, Wenyuan Qi, Yongyi Yang, Joyoni Dey, Michael A. King, Seth T. Dahlberg, Miles N. Wernick
    Source: Medical physics
    PURPOSE: Due to the combination of high-frequency use and relatively high diagnostic radiation dose (9 mSv for one scan), there is a need to lower the radiation dose used in myocardial perfusion imaging (MPI) studies in cardiac gated single photon emission computed tomography (GSPECT) in order to reduce its population based cancer risk. The aim of this study is to assess quantitatively the potential utility of advanced 4D re...
  • ACR-AAPM-SIIM practice guideline for determinants of image quality in digital mammography

    February 01, 2013
    Author(s): Kalpana M. Kanal, Elizabeth Krupinski, Eric A. Berns, William R. Geiser, Andrew Karellas, Martha B. Mainiero, Melissa C. Martin, Samir B. Patel, Daniel L. Rubin, Jon D. Shepard, Eliot L. Siegel, Judith A. Wolfman, Tariq A. Mian, Mary C. Mahoney
    Source: Journal of digital imaging
  • Detection of Aspergillus fumigatus pulmonary fungal infections in mice with (99m)Tc-labeled MORF oligomers targeting ribosomal RNA

    January 09, 2013
    Author(s): Yuzhen Wang, Ling Chen, Xinrong Liu, Dengfeng Cheng, Guozheng Liu, Yuxia Liu, Shuping Dou, Donald J. Hnatowich, Mary Rusckowski
    Source: Nuclear medicine and biology
    PURPOSE: Invasive aspergillosis is a major cause of infectious morbidity and mortality in immunocompromised patients. The fungus Aspergillus fumigatus (A. fumigatus) is the primary causative agent of invasive aspergillosis. However, A. fumigatus infections remain difficult to diagnose particularly in the early stages due to the lack of a rapid, sensitive and specific diagnostic approach. In this study, we investigated (99m)T...
  • Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain

    January 01, 2013
    Author(s): Imramsjah M. J. van der Bom, Richard P. Moser, Guangping Gao, Miguel Sena-Esteves, Neil Aronin, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    INTRODUCTION: Convection-enhanced delivery (CED) has been shown to be an effective method of administering macromolecular compounds into the brain that are unable to cross the blood-brain barrier. Because the administration is highly localized, accurate cannula placement by minimally invasive surgery is an important requisite. This paper reports on the use of an angiographic c-arm system which enables truly frameless multimo...
  • Scaling-law for the energy dependence of anatomic power spectrum in dedicated breast CT

    January 01, 2013
    Author(s): Srinivasan Vedantham, Linxi Shi, Stephen J. Glick, Andrew Karellas
    Source: Medical physics
    PURPOSE: To determine the x-ray photon energy dependence of the anatomic power spectrum of the breast when imaged with dedicated breast computed tomography (CT). METHODS: A theoretical framework for scaling the empirically determined anatomic power spectrum at one x-ray photon energy to that at any given x-ray photon energy when imaged with dedicated breast CT was developed. Theory predicted that when the anatomic power spec...
  • Leukoaraiosis and sex predict the hyperacute ischemic core volume

    January 01, 2013
    Author(s): Nils Henninger, Eugene Lin, Diogo C. Haussen, Laura L. Lehman, Deepak Takhtani, Magdy Selim, Majaz Moonis
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: Leukoaraiosis (LA) and male sex have been associated with decreased cerebrovascular reactivity, which potentially adversely affects tissue viability in acute stroke. Therefore, we aimed to elucidate the contribution of LA-severity and sex to the extent of the hyperacute ischemic core volume after intracranial large artery occlusion. METHODS: We analyzed data from 87 patients with acute intracranial la...
  • Stereoscopic digital mammography: improved specificity and reduced rate of recall in a prospective clinical trial

    January 01, 2013
    Author(s): Carl J. D'Orsi, David J. Getty, Ronald M. Pickett, Ioannis Sechopoulos, Mary S. Newell, Kathleen R. Gundry, Sandra R. Bates, Robert M. Nishikawa, Edward A. Sickles, Andrew Karellas, Ellen M. D'Orsi
    Source: Radiology
    PURPOSE: To compare stereoscopic digital mammography (DM) with standard DM for the rate of patient recall and the detection of cancer in a screening population at elevated risk for breast cancer. MATERIALS AND METHODS: Starting in September 2004 and ending in December 2007, this prospective HIPAA-compliant, institutional review board-approved screening trial, with written informed consent, recruited female patients at elevat...
  • Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging

    January 01, 2013
    Author(s): Alexei A. Bogdanov Jr., Mary L. Mazzanti
    Source: Progress in molecular biology and translational science
    Macromolecular imaging probes (or sensors) of enzymatic activity have a unique place in the armamentarium of modern optical imaging techniques. Such probes were initially developed by attaching optically "silent" fluorophores via enzyme-sensitive linkers to large copolymers of biocompatible poly(ethylene glycol) and poly(amino acids). In diseased tissue, where the concentration of enzymes is high, the fluorophores are freed ...
  • A next-generation, flow-diverting implant used to treat brain aneurysms: in vitro evaluation of magnetic field interactions, heating and artifacts at 3-T

    January 01, 2013
    Author(s): Alexandra M. Karacozoff, Frank G. Shellock, Ajay K. Wakhloo
    Source: Magnetic resonance imaging
    BACKGROUND AND PURPOSE: Fine-mesh braided, stent-like structures (flow diverters) have been proposed for treatment of brain aneurysms. To date, the safety of performing magnetic resonance imaging (MRI) in patients with these implants is unknown. Therefore, the purpose of this study was to evaluate MRI issues at 3-T for a new flow-diverting implant used to treat brain aneurysms. METHODS: The Surpass NeuroEndoGraft (Surpass Me...
  • Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery

    January 01, 2013
    Author(s): I. M. J. van der Bom, Richard P. Moser, Guangping Gao, Erica Mondo, Denice O'Connell, Matthew J. Gounis, Sarah McGowan, J. Chaurette, N. Bishop, Miguel Sena-Esteves, Christian Mueller, Neil Aronin
    Source: Journal of Huntington's disease
    Our goal is delivery of a long-term treatment for Huntington's disease. We administer intracerebrally in sheep adeno-associated virus (AAV) to establish optimal safety, spread and neuronal uptake of AAV based therapeutics. Sheep have large gyrencephalic brains and offer the opportunity to study a transgenic Huntington's disease model. However, lack of a relevant brain stereotactic atlas and the difficulty of skull fixation m...
  • Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams

    December 07, 2012
    Author(s): Bernard L. Jones, Nivedh Manohar, Francisco Reynoso, Andrew Karellas, Sang Hyun Cho
    Source: Physics in medicine and biology
    This report presents the first experimental demonstration, to our knowledge, of benchtop polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) for a simultaneous determination of the spatial distribution and amount of gold nanoparticles (GNPs) within small-animal-sized objects. The current benchtop experimental setup successfully produced XFCT images accurately showing the regions containing small amount of G...
  • Dedicated breast CT: fibroglandular volume measurements in a diagnostic population

    December 01, 2012
    Author(s): Srinivasan Vedantham, Linxi Shi, Andrew Karellas, Avice M. O'Connell
    Source: Medical physics
    PURPOSE: To determine the mean and range of volumetric glandular fraction (VGF) of the breast in a diagnostic population using a high-resolution flat-panel cone-beam dedicated breast CT system. This information is important for Monte Carlo-based estimation of normalized glandular dose coefficients and for investigating the dependence of VGF on breast dimensions, race, and pathology. METHODS: Image data from a clinical trial ...
  • Incidental genitourinary findings on obstetrics/gynecology ultrasound

    December 01, 2012
    Author(s): Carolynn M. Debenedectis, Deborah Levine
    Source: Ultrasound quarterly
    Ultrasound is the standard-of-care imaging modality for initial imaging in obstetrics and gynecology. Given the close proximity of the genitourinary system to the uterus and adnexa, it is not surprising that these studies can result in the discovery of incidental genitourinary findings such as ureterocele, ectopic ureter, bladder mass, ureteral stones, cystitis, bladder diverticulum, and pelvic kidney. Recognition of the eti...
  • A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology

    November 07, 2012
    Author(s): Kjell Erlandsson, Irene Buvat, P. Hendrik Pretorius, Benjamin A. Thomas, Brian F. Hutton
    Source: Physics in medicine and biology
    Accurate quantification in PET and SPECT requires correction for a number of physical factors, such as photon attenuation, Compton scattering and random coincidences (in PET). Another factor affecting quantification is the limited spatial resolution. While considerable effort has gone into development of routine correction techniques for the former factors, less attention has been paid to the latter. Spatial resolution-relat...
  • Pneumothorax following ultrasound-guided jugular vein puncture for central venous access in interventional radiology: 4 years of experience

    November 01, 2012
    Author(s): Banu Oner, Adib R. Karam, Padmaja Surapaneni, David A. Phillips
    Source: Journal of intensive care medicine
    PURPOSE: The purpose of our study was to review the rate of pneumothorax following central venous access, using real-time ultrasound guidance. MATERIALS AND METHODS: Data related to ultrasound-guided venous puncture, for central venous access, performed between July 1, 2004 and June 30, 2008 was retrospectively and prospectively collected. Access route, needle gauge, catheter type, and diagnosis of pneumothorax on the intrap...
  • Effectiveness of mechanical endovascular thrombectomy in a model system of cerebrovascular occlusion

    November 01, 2012
    Author(s): Juyu Chueh, Ajay K. Wakhloo, Matthew J. Gounis
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: A number of thrombectomy devices are currently undergoing clinical evaluation; meanwhile, various novel devices are under investigation. The aims of this study were to quantify flow restoration and the particle size distribution of the effluent pursuant to MET in an in vitro occlusion model. MATERIALS AND METHODS: The model system was composed of 3 elements: an ICA/MCA replica, a clot model with mecha...
  • Reviewing imaging examination results with a radiologist immediately after study completion: patient preferences and assessment of feasibility in an academic department

    October 01, 2012
    Author(s): Jay Pahade, Corey Couto, Roger B. Davis, Payal Patel, Bettina Siewert, Max P. Rosen
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to assess patient preferences about receiving radiology results and reviewing the images and findings directly with a radiologist after completion of an examination. SUBJECTS AND METHODS: A prospective survey of English-speaking outpatients undergoing either nononcologic CT of the chest, abdomen, and pelvis or nonobstetric ultrasound examinations was completed between December 2010 an...
  • The effect of intracranial stent implantation on the curvature of the cerebrovasculature

    October 01, 2012
    Author(s): R. M. King, Juyu Chueh, I. M. J. van der Bom, C. F. Silva, S. L. Carniato, Gabriela Spilberg, Ajay K. Wakhloo, Matthew J. Gounis
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Recently, the use of stents to assist in the coiling and repair of wide-neck aneurysms has been shown to be highly effective; however, the effect of these stents on the RC of the parent vessel has not been quantified. The purpose of this study was to quantify the effect of intracranial stenting on the RC of the implanted artery using 3D datasets. MATERIALS AND METHODS: Twenty-four patients receiving F...
  • Closed-cell stent for coil embolization of intracranial aneurysms: clinical and angiographic results

    October 01, 2012
    Author(s): Ajay K. Wakhloo, I. Linfante, C. F. Silva, E. A. Samaniego, G. Dabus, V. Etezadi, Gabriela Spilberg, Matthew J. Gounis
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Recanalization is observed in 20-40% of endovascularly treated intracranial aneurysms. To further reduce the recanalization and expand endovascular treatment, we evaluated the safety and efficacy of closed-cell SACE. MATERIALS AND METHODS: Between 2007 and 2010, 147 consecutive patients (110 women; mean age, 54 years) presenting at 2 centers with 161 wide-neck ruptured and unruptured aneurysms were tr...
  • A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo

    September 08, 2012
    Author(s): Mohammed S. Shazeeb, Suresh Gupta, Alexei A. Bogdanov Jr., Yang Xie
    Source: Molecular imaging
    Bis-phenylamides and bis-hydroxyindolamides of diethylenetriaminepentaacetic acid-gadolinium (DTPA(Gd)) are paramagnetic reducing substrates of peroxidases that enable molecular imaging of peroxidase activity in vivo. Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activit...
  • Comparison study of temporal regularization methods for fully 5D reconstruction of cardiac gated dynamic SPECT

    September 07, 2012
    Author(s): Xiaofeng Niu, Yongyi Yang, Michael A. King
    Source: Physics in medicine and biology
    Temporal regularization plays a critical role in cardiac gated dynamic SPECT reconstruction, of which the goal is to obtain an image sequence from a single acquisition which simultaneously shows both cardiac motion and tracer distribution change over the course of imaging (termed 5D). In our recent work, we explored two different approaches for temporal regularization of the dynamic activities in gated dynamic reconstruction...
  • Fatty acid binding protein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma

    August 01, 2012
    Author(s): Oguz Cataltepe, Meltem Cevik Arikan, E Ghelfi, C Karaaslan, Y Ozsurekci, Y Li, T. W. Smith, Karen A. Dresser, Sule Cataltepe
    Source: Neuropathology and applied neurobiology
    AIMS: Glioblastoma (GBM) is the most common and aggressive primary brain tumour in adults. Angiogenesis and vasculogenesis play key roles in progression of GBMs. Fatty acid binding protein 4 (FABP4) is an intracellular chaperone for free fatty acids. FABP4 is detected in microvascular endothelial cells (ECs) in several normal tissues and promotes proliferation of ECs. The goal of this study was to characterize the tissue dis...
  • A quantitative study of motion estimation methods on 4D cardiac gated SPECT reconstruction

    August 01, 2012
    Author(s): Wenyuan Qi, Yongyi Yang, Xiaofeng Niu, Michael A. King
    Source: Medical physics
    PURPOSE: Motion-compensated temporal processing can have a major impact on improving the image quality in gated cardiac single photon emission computed tomography (SPECT). In this work, we investigate the effect of different optical flow estimation methods for motion-compensated temporal processing in gated SPECT. In particular, we explore whether better motion estimation can substantially improve reconstructed image quality...
  • Photon-counting digital mammography: evaluation of performance under clinically relevant conditions

    August 01, 2012
    Author(s): Andrew Karellas
    Source: Academic radiology
    Comment on: Comparison of radiologist performance with photon-counting full-field digital mammography to conventional full-field digital mammography. [Acad Radiol. 2012]
  • Orthotopic expression of noggin protein in cancer cells inhibits human lung carcinoma growth in vivo

    August 01, 2012
    Author(s): Hye won Kang, Suresh Gupta, Alexei A. Bogdanov Jr.
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: We explored the effect of Noggin protein expression on tumor growth in vivo by using fluorescence imaging. PROCEDURES: Human lung carcinoma MV522 cells were transduced by using bicistronic (EGFP/Nog) or a control (EGFP) lentivirus at 95% efficacy. The transduced cells were implanted in athymic mice either individually or after mixing with DsRed2-expressing MV522 cells. RESULTS: The expression of Noggin protein was ...
  • Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes

    August 01, 2012
    Author(s): Alexei A. Bogdanov Jr., Valeriy G. Metelev, Surong Zhang, Anand T. N. Kumar
    Source: Molecular bioSystems
    We designed and synthesized sensors for imaging transcription factor-DNA interactions using a complementary pair of 21-base pair long oligonucleotides (ODNs) carrying two internucleoside phosphate-linked cyanine fluorophores that can either engage in Forster's resonance energy transfer (FRET) with fluorescence emission or assemble into a ground state quenched dimer with short fluorescence lifetimes (FL). Cyanine fluorophores...
  • MR imaging of acute cervical spinal ligamentous and soft tissue trauma

    August 01, 2012
    Author(s): Sathish Kumar Dundamadappa, Keith A. Cauley
    Source: Emergency radiology
    The increasing availability of magnetic resonance imaging (MRI) and the high sensitivity of MRI for soft tissue injury are resulting in the increased use of MRI for the evaluation of acute trauma. As cervical spine injury can have a devastating consequence, MRI is being more commonly used to evaluate cervical spine injury in the acute setting, necessitating emergent interpretation by the on-call radiologist. Unless one is fo...
  • Establishing a computed tomography screening clinic

    July 01, 2012
    Author(s): Max P. Rosen, Jane Corey, Bettina Siewert
    Source: Journal of thoracic imaging
    Since the publication of the National Lung Screening Trial results, there has been increasing interest among radiologists to establish computed tomography (CT) screening centers. During the past 10 years, we have operated a CT screening center in suburban Boston, MA. The purpose of this paper is to describe our process for performing self-referred CT lung screening exams, including our organizational structure, marketing, pa...
  • Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody

    July 01, 2012
    Author(s): Guozheng Liu, Shuping Dou, Ali Akalin, Mary Rusckowski, Philip R. Streeter, Leonard D. Shultz, Dale L. Greiner
    Source: Nuclear medicine and biology
    INTRODUCTION: We previously demonstrated MORF/cMORF pretargeting of human islets and betalox 5 cells (a human beta cell line) transplanted subcutaneously in mice with the anti-human islet antibody, HPi1. We now compare pretargeting with direct targeting in the beta cell transplant model to evaluate the degree to which target/non-target (T/NT) ratios may be improved by pretargeting. METHODS: Specific binding of an anti-human ...
  • Radiolabeled Zn-DPA as a potential infection imaging agent

    July 01, 2012
    Author(s): Xinrong Liu, Dengfeng Cheng, Brian D. Gray, Yuzhen Wang, Ali Akalin, Mary Rusckowski, Koon Y. Pak, Donald J. Hnatowich
    Source: Nuclear medicine and biology
    INTRODUCTION: A zinc-dipicolylamine analog (Zn-DPA) conjugated with a fluorophore (PSVue(R)794) has been shown to image bacterial infections in mice. However, radiolabeled Zn-DPA has not previously been considered for nuclear imaging of infection. METHODS: Both 111In-labeled DOTA-biotin and Zn-DPA-biotin were combined using streptavidin (SA) as a noncovalent linker. Mice injected intramuscularly with Streptococcus pyogenes (...
  • Her2/neu small interfering RNA delivered in culture by a streptavidin nanoparticle

    July 01, 2012
    Author(s): Xinrong Liu, Kayoko Nakamura, Dengfeng Cheng, Cong Peng, Nan Xiao, Yuxia Liu, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Current drug delivery
    A three-component nanoparticle consisting of biotinylated Trastuzumab antiHer2 antibody, tat transferring peptide and radiolabeled antisense oligomer, linked together through streptavidin, have shown promise in the delivery to Her2+ tumor in mice following intravenous administration and with evidence of radiotherapeutic efficacy. These results have encouraged us to consider the nanoparticle as a delivery vehicle for RNA inte...
  • Preclinical acute ischemic stroke modeling

    July 01, 2012
    Author(s): Manik Mehra, Nils Henninger, Joshua A. Hirsch, Juyu Chueh, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Journal of Neurointerventional Surgery
    Preclinical ischemic stroke is at the crossroads in search of reliable and robust simulation models as past experiences with their translation from the laboratory to the standard of clinical care have often been disappointing. The efficacy of neuroprotective agents is still elusive, and the use of thrombolytics alone is limited to the narrow time window of presentation from the onset of the deficit. Hence, the focus has shif...
  • The Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease

    July 01, 2012
    Author(s): Raul G. Nogueira, Elad I. Levy, Matthew J. Gounis, Adnan H. Siddiqui
    Source: Journal of neurointerventional surgery
    BACKGROUND: The currently available mechanical devices fail to achieve recanalization in as many as 20-40% of proximal arterial occlusion strokes. OBJECTIVE: The preclinical evaluation of the safety and efficacy of a novel thrombectomy device designed to achieve immediate flow restoration by quickly removing clot is reported. METHODS: Four confirmatory animal studies were performed with the Trevo device (Concentric Medical I...
  • Protected Graft Copolymer (PGC) in Imaging and Therapy: A Platform for the Delivery of Covalently and Non-Covalently Bound Drugs

    June 04, 2012
    Author(s): Alexei A. Bogdanov Jr., Mary L. Mazzanti, Gerardo Castillo, Elijah Bolotin
    Source: Theranostics
    Initially developed in 1992 as an MR imaging agent, the family of protected graft copolymers (PGC) is based on a conjugate of polylysine backbone to which methoxypoly(ethylene glycol) (MPEG) chains are covalently linked in a random fasion via N-epsilon-amino groups. While PGC is relatively simple in terms of its chemcial composition and structure, it has proved to be a versatile platform for in vivo drug delivery. The advant...
  • Focused peer review: the end game of peer review

    June 01, 2012
    Author(s): Sarwat Hussain, Jawad S. Hussain, Adib R. Karam, Gopal Vijayaraghavan
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: The aim of this report is to describe the authors' experience with expanding the routine peer-review process to include misdiagnoses from all sources and the use of focused peer review (FPR) in faculty accountability and management. METHODS: A department-wide routine peer review was conducted. Each radiologist was assigned 12 cases per month. In addition, clinically reported errors, missed diagnoses discovered outsi...
  • Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation

    May 25, 2012
    Author(s): Christopher R. Dowdy
    Source: GSBS Dissertations and Theses
    Runx1 is a master regulator of hematopoiesis, required for the initiation of definitive hematopoiesis in the embryo and essential for appropriate differentiation of many hematopoietic lineages in the adult. The roles of Runx1 in normal hematopoiesis are juxtaposed with the high frequency of Runx1 mutations and translocations in leukemia. Leukemia associated Runx1 mutations that retain DNA-binding ability have truncations or ...
  • In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium

    May 23, 2012
    Author(s): Craig J. Goergen, Howard H. Chen, Alexei A. Bogdanov Jr., David E. Sosnovik, Anand T. N. Kumar
    Source: Journal of biomedical optics
    Activatable fluorescent molecular probes are predominantly nonfluorescent in their inactivated state due to intramolecular quenching, but increase fluorescence yield significantly after enzyme-mediated hydrolysis of peptides. Continuous wave in vivo detection of these protease-activatable fluorophores in the heart, however, is limited by the inability to differentiate between activated and nonactivated fractions of the probe...
  • Clinical evaluation of a new kyphoplasty technique with directed cement flow

    May 01, 2012
    Author(s): Baron Zarate, Jorge Gutierrez, Ajay K. Wakhloo, Matthew J. Gounis, Alejandro Reyes-Sanchez
    Source: Journal of spinal disorders and techniques
    STUDY DESIGN: Prospective, single-center 2-year study. OBJECTIVE: The long-term clinical performance of a new cement-directing kyphoplasty system was evaluated for treatment of painful osteoporotic compression fractures. SUMMARY OF BACKGROUND DATA: Cement leakage is a common clinical complication of vertebroplasty and kyphoplasty procedures. Balloon kyphoplasty restricts cement flow and reduces leakage by injection of high-v...
  • Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion

    April 25, 2012
    Author(s): Nils Henninger, Eugene Lin, Stephen P. Baker, Ajay K. Wakhloo, Deepak Takhtani, Majaz Moonis
    Source: Cerebrovascular diseases (Basel, Switzerland)
    BACKGROUND: To date limited information regarding outcome-modifying factors in patients with acute intracranial large artery occlusion (ILAO) in the anterior circulation is available. Leukoaraiosis (LA) is a common finding among patients with ischemic stroke and has been associated with poor post-stroke outcomes but its association with ILAO remains poorly characterized. This study sought to clarify the contribution of basel...
  • Protected graft copolymer (PGC) basal formulation of insulin as potentially safer alternative to Lantus(R) (insulin-glargine): a streptozotocin-induced, diabetic Sprague Dawley rats study

    April 01, 2012
    Author(s): Sandra Reichstetter, Gerardo M. Castillo, ManShun Lai, Akiko Nishimoto-Ashfield, Aryamitra Banerjee, Alexei A. Bogdanov Jr., Alexander V. Lyubimov, Elijah M. Bolotin
    Source: Pharmaceutical research
    PURPOSE: To develop a long-acting formulation of native human insulin with a similar pharmacodynamics (PD) profile as the insulin analogue insulin glargine (Lantus(R), Sanofi-Aventis) with the expectation of retaining native human insulin's superior safety profile as insulin glargine is able to activate the insulin-like growth factor 1 (IGF-1) receptor and is linked to a number of malignancies at a higher rate than regular h...
  • Protected graft copolymer (PGC) basal formulation of insulin as potentially safer alternative to Lantus(R) (insulin-glargine): a streptozotocin-induced, diabetic Sprague Dawley rats study

    April 01, 2012
    Author(s): Sandra Reichstetter, Gerardo M. Castillo, ManShun Lai, Akiko Nishimoto-Ashfield, Aryamitra Banerjee, Alexei A. Bogdanov, Alexander V. Lyubimov, Elijah M. Bolotin
    Source: Pharmaceutical research
    PURPOSE: To develop a long-acting formulation of native human insulin with a similar pharmacodynamics (PD) profile as the insulin analogue insulin glargine (Lantus(R), Sanofi-Aventis) with the expectation of retaining native human insulin's superior safety profile as insulin glargine is able to activate the insulin-like growth factor 1 (IGF-1) receptor and is linked to a number of malignancies at a higher rate than regular h...
  • Temporal evolution of susceptibility artifacts from coiled aneurysms on MR angiography: an in vivo canine study

    April 01, 2012
    Author(s): Gabriela Spilberg, Sarena L. Carniato, R. M. King, Imramsjah M. J. van der Bom, Manik Mehra, Ronn P. Walvick, Ajay K. Wakhloo, Matthew J. Gounis
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Intracranial aneurysms treated by coiling have a risk for recurrence, requiring surveillance imaging. MRA has emerged as an attractive technique for postcoiling aneurysm imaging. Previous research has evaluated MR imaging artifacts of the coil mass in vitro. Our aim in this study was to evaluate MR imaging artifacts of coiled aneurysms in vivo with time. MATERIALS AND METHODS: Four sidewall aneurysms ...
  • Dedicated breast CT: radiation dose for circle-plus-line trajectory

    March 03, 2012
    Author(s): Srinivasan Vedantham, Linxi Shi, Andrew Karellas, Frederic Noo
    Source: Medical physics
    PURPOSE: Dedicated breast CT prototypes used in clinical investigations utilize single circular source trajectory and cone-beam geometry with flat-panel detectors that do not satisfy data-sufficiency conditions and could lead to cone beam artifacts. Hence, this work investigated the glandular dose characteristics of a circle-plus-line trajectory that fulfills data-sufficiency conditions for image reconstruction in dedicated ...
  • Determination of cystic duct patency using hepatobiliary MRI with gadoxetate disodium: Is T1 precontrast imaging necessary

    March 01, 2012
    Author(s): Michael T. Corwin, Adib R. Karam, Stephen P. Baker, Young H. Kim
    Source: Journal of magnetic resonance imaging : JMRI
    PURPOSE: To determine the need for precontrast T1-weighted imaging in determining cystic duct patency using hepatobiliary phase imaging with gadoxetate disodium-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: MRI exams using gadoxetate disodium from October 4, 2008 to April 14, 2010 were reviewed in a retrospective fashion. Two reviewers independently reviewed only the 20-minute T1-weighted delayed postcont...
  • Quality initiatives: lean approach to improving performance and efficiency in a radiology department

    March 01, 2012
    Author(s): Jonathan B. Kruskal, Allen Reedy, Laurie Pascal, Max P. Rosen, Phillip M. Boiselle
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    Many hospital radiology departments are adopting "lean" methods developed in automobile manufacturing to improve operational efficiency, eliminate waste, and optimize the value of their services. The lean approach, which emphasizes process analysis, has particular relevance to radiology departments, which depend on a smooth flow of patients and uninterrupted equipment function for efficient operation. However, the applicatio...
  • Determination of cystic duct patency using hepatobiliary MRI with gadoxetate disodium: is T1 precontrast imaging necessary

    March 01, 2012
    Author(s): Michael T. Corwin, Adib R. Karam, Stephen P. Baker, Young H. Kim
    Source: Journal of magnetic resonance imaging : JMRI
    PURPOSE: To determine the need for precontrast T1-weighted imaging in determining cystic duct patency using hepatobiliary phase imaging with gadoxetate disodium-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: MRI exams using gadoxetate disodium from October 4, 2008 to April 14, 2010 were reviewed in a retrospective fashion. Two reviewers independently reviewed only the 20-minute T1-weighted delayed postcont...
  • Anisotropic properties of bovine nasal cartilage

    March 01, 2012
    Author(s): Yang Xia, Shaokuan Zheng, Matthew Szarko, Jihyun Lee
    Source: Microscopy research and technique
    To investigate the structural anisotropy in bovine septal cartilage, quantitative procedures in microscopic magnetic resonance imaging (muMRI), polarized light microscopy (PLM), and mechanical indentation were used to measure the tissue in three orthogonal planes: vertical, medial, and caudocephalic. The quantitative T2 imaging experiments in muMRI found strong anisotropy in the images of both vertical and caudocephalic plan...
  • Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination

    February 09, 2012
    Author(s): Sigfrid K. Yngvesson, Benjamin St Peter, Paul Siqueira, Patrick Kelly, Stephen J. Glick, Andrew Karellas, Ashraf Khan
    Source: Proceedings of SPIE--the International Society for Optical Engineering
    In breast conservation surgery, surgeons attempt to remove malignant tissue along with a surrounding margin of healthy tissue. Subsequent pathological analysis determines if those margins are clear of malignant tissue, a process that typically requires at least one day. Only then can it be determined whether a follow-up surgery is necessary. This possibility of re-excision is undesirable in terms of reducing patient morbidit...
  • Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

    February 05, 2012
    Author(s): Hikaru Sugimoto, Valerie S LeBleu, Dattatreyamurty Bosukonda, Peter Keck, Gangadhar Taduri, Wibke Bechtel, Hirokazu Okada, William Carlson Jr., Philippe Bey, Mary Rusckowski, Bjorn Tampe, Desiree Tampe, Keizo Kanasaki, Michael Zeisberg, Raghu Kalluri
    Source: Nature medicine
    Molecules associated with the transforming growth factor beta (TGF-beta) superfamily, such as bone morphogenic proteins (BMPs) and TGF-beta, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that the BMP receptor activin-like kinase 3 (Alk3) is elevated early in diseased kidneys after injury. We also found that its deletion in the tubular epithelium leads to enhanced TGF-beta1-Smad family m...
  • Advances in stroke: advances in interventional neuroradiology

    February 01, 2012
    Author(s): Laurent Pierot, Imramsjah M. J. van der Bom, Ajay K. Wakhloo
    Source: Stroke
  • Quantitative evaluation of C-arm CT cerebral blood volume in a canine model of ischemic stroke

    February 01, 2012
    Author(s): Imramsjah M. J. van der Bom, Manik Mehra, Ronn P. Walvick, Juyu Chueh, Matthew J. Gounis
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Previous studies have shown the feasibility of assessing qualitative CBV measurements in the angiography suite by using FPD-CBCT systems. We have investigated the correlation of FPD-CBCT CBV lesion volumes to the infarct volume. MATERIALS AND METHODS: Unilateral strokes were created in 7 adult dogs. MR imaging and FPD-CBCT data were obtained after MCA occlusion. FPD-CBCT CBV and ADC maps were generate...
  • Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation

    January 01, 2012
    Author(s): Yuxia Liu, Dengfeng Cheng, Xinrong Liu, Guozheng Liu, Shuping Dou, Nan Xiao, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Nuclear medicine and biology
    INTRODUCTION: Auger radiotherapy requires adequate tumor delivery and high nuclear accumulation and retention. We hypothesize that the noncovalent nature of a streptavidin/biotin three-component nanoparticle possessing these qualities may be required for dissociation of the radiolabeled oligomer and its accumulation into the cell nucleus. METHODS: As a test of our hypothesis, the intracellular fate of an antisense oligomer w...
  • Simple measurement of aneurysm residual after treatment: the SMART scale for evaluation of intracranial aneurysms treated with flow diverters

    January 01, 2012
    Author(s): Iris Quasar Grunwald, M. Kamran, R. A. Corkill, Anna L. Kuhn, I. S. Choi, S. Turnbull, D. Dobson, K. Fassbender, D Watson, Matthew J. Gounis
    Source: Acta neurochirurgica
    BACKGROUND: Primary endovascular reconstruction with flow diversion represents a fundamental paradigm shift in the technique of endovascular aneurysm treatment. Unlike coil embolization, often there remains residual post-procedural filling within the aneurysm with flow diverters, the curative reconstruction presumably occurring over a period of weeks. Thus, conventional grading scales for post-procedural aneurysm occlusion a...
  • 90Y labeled phosphorodiamidate morpholino oligomer for pretargeting radiotherapy

    December 21, 2011
    Author(s): Guozheng Liu, Shuping Dou, Yuxia Liu, Yuzhen Wang, Mary Rusckowski, Donald J. Hnatowich
    Source: Bioconjugate chemistry
    While (188)Re has been used successfully in mice for tumor radiotherapy by MORF/cMORF pretargeting, previous radiolabeling of the amine-derivatized cMORF with (90)Y, a longer physical half-life nuclide, was not very successful. After developing a method involving a prepurification heating step during conjugation that increases labeling efficiency and label stability, the biodistribution of (90)Y-DOTA-Bn-SCN-cMORF ((90)Y-DOTA...
  • Effects of motion, attenuation, and scatter corrections on gated cardiac SPECT reconstruction

    December 01, 2011
    Author(s): Xiaofeng Niu, Yongyi Yang, Mingwu Jin, Miles N. Wernick, Michael A. King
    Source: Medical physics
    PURPOSE: In gated cardiac single photon emission computed tomography (SPECT), image reconstruction is often hampered by various degrading factors including depth-dependent spatial blurring, attenuation, scatter, motion blurring, and low data counts. Consequently, there has been significant development in image reconstruction methods for improving the quality of reconstructed images. The goal of this work is to investigate ho...
  • Imaging the pancreatic vasculature in diabetes models

    November 10, 2011
    Author(s): Zdravka Medarova, Dale L. Greiner, Marytheresa Ifediba, Guangping Dai, Elijah Bolotin, Gerardo Castillo, Alexei A. Bogdanov Jr., Mohanraja Kumar, Anna Moore
    Source: Diabetes/metabolism research and reviews
    BACKGROUND: Vascular parameters, such as vascular volume, flow, and permeability, are important disease biomarkers for both type 1 and type 2 diabetes. Therefore, it is essential to develop approaches to monitor the changes in pancreatic microvasculature non-invasively. METHODS: Here, we describe the application of the long-circulating, paramagnetic T1 contrast agent, protected Graft Copolymer bearing covalently linked gadol...
  • Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients

    November 01, 2011
    Author(s): Yanping Sun, Brian P. O'Sullivan, John P. Roche, Ronn P. Walvick, Austin Reno, Dawn Baker, Joey Mansour, Mitchell Albert
    Source: Journal of magnetic resonance imaging : JMRI
    PURPOSE: To use hyperpolarized (HP) (3)He MR imaging to assess functional lung ventilation in subjects with cystic fibrosis (CF) before and after treatment. MATERIALS AND METHODS: We performed HP (3)He static ventilation MRI scans on three subjects, using a Philips 3.0 Tesla (T) Achieva MRI scanner, before and after 11 days of in-patient treatment with combined intravenous and inhaled therapies for pulmonary exacerbations of...
  • ACR Appropriateness Criteria(R) right lower quadrant pain--suspected appendicitis

    November 01, 2011
    Author(s): Max P. Rosen, Alexander Ding, Michael A. Blake, Mark E. Baker, Brooks D. Cash, Jeff L. Fidler, Thomas H. Grant, Frederick L. Greene, Bronwyn Jones, Douglas S. Katz, Tasneem Lalani, Frank H. Miller, William C. Small, Stephanie Spottswood, Gary S. Sudakoff, Mark Tulchinsky, David M. Warshauer, Judy Yee, Brian D. Coley
    Source: Journal of the American College of Radiology : JACR
    The diagnostic imaging of patients presenting with right lower quadrant pain and suspected appendicitis may be organized according to age and gender and to the presence or absence of "classic" signs and symptoms of acute appendicitis. Among adult patients presenting with clinical signs of acute appendicitis, the sensitivity and specificity of CT are greater than those of ultrasound, with improved performance when CT is perfo...
  • Comparing two TAG-72 binding peptides previously identified by phage display as potential imaging agents

    October 01, 2011
    Author(s): Ling Chen, Yi Wang, Dengfeng Cheng, Shuping Dou, Xinrong Liu, Guozheng Liu, Donald J. Hnatowich, Mary Rusckowski
    Source: Nuclear medicine communications
    AIM: To evaluate the targeting property in vitro and in vivo of two tumor-associated glycoprotein 72 (TAG-72) binding peptides, previously identified in this laboratory by phage selection using different elution conditions. MATERIALS AND METHODS: The peptides GGVSCMQTSPVCENNL (A2-6) and NPGTCKDKWEICLLNGG (A3-10) were radiolabeled with technetium-99m ((99m)Tc) using N-hydroxysuccinimidyl-S-acetyl-mercaptoacetyltriglycine (NHS...
  • Semi-automated segmentation and classification of digital breast tomosynthesis reconstructed images

    September 01, 2011
    Author(s): Srinivasan Vedantham, Linxi Shi, Andrew Karellas, Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Brian W. Pogue, Keith D. Paulsen
    Source: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
    Digital breast tomosynthesis (DBT) is a limited-angle tomographic x-ray imaging technique that reduces the effect of tissue superposition observed in planar mammography. An integrated imaging platform that combines DBT with near infrared spectroscopy (NIRS) to provide co-registered anatomical and functional imaging is under development. Incorporation of anatomic priors can benefit NIRS reconstruction. In this work, we provid...
  • Improving the quantitation accuracy in noninvasive small animal single photon emission computed tomography imaging

    August 01, 2011
    Author(s): Dengfeng Cheng, Mary Rusckowski, P. Hendrik Pretorius, Ling Chen, Nan Xiao, Yuxia Liu, Guozheng Liu, Min Min Liang, Xinrong Liu, Shuping Dou, Donald J. Hnatowich
    Source: Nuclear medicine and biology
    INTRODUCTION: Noninvasive imaging of small animals to measure biodistributions and pharmacokinetics of radiolabeled agents is increasingly seen as an effective alternative to external counting of tissues obtained by sacrifice and dissection. However, we have observed important disagreements in measuring the accumulation of (111)In-labeled antibodies in organs such as liver and kidneys when comparing imaging to ex vivo counti...
  • Regulation of Runx Proteins in Human Cancers: A Dissertation

    July 20, 2011
    Author(s): Sandhya Pande
    Source: GSBS Dissertations and Theses
    Runt related transcription factors (Runx) play an important role in mammalian development by regulating the expression of key genes involved in cell proliferation, differentiation and growth. The work described in this thesis details the mechanisms by which the activity of two members of this family are regulated in human cells. Chapter One provides a brief introduction of Runx transcription factors. Chapter Two describes th...
  • Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model

    June 06, 2011
    Author(s): Guozheng Liu, Shuping Dou, Dengfeng Cheng, Jean H. Leif, Mary Rusckowski, Philip R. Streeter, Leonard D. Shultz, Donald J. Hnatowich, Dale L. Greiner
    Source: Molecular pharmaceutics
    Noninvasive measurement of human islet cell mass in pancreas or following islet transplantation by nuclear imaging has yet to be achieved. It has been shown using mouse tumor models that pretargeting imaging strategies are sensitive and can greatly increase target to nontarget signal ratios. The objective now is to demonstrate the specific pretargeting of human islet cells in mice. Our pretargeting strategy uses an anti-huma...
  • The effect of imaging capacity on the imaging workup of patients with stroke: a preliminary case for a cross-country comparison

    June 01, 2011
    Author(s): Max P. Rosen, Natalie Oake, Alan J. Forster, Ari Goelman, Frank Levy
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: Medical imaging is a large and growing component of health care expenditures. To better understand some of the determinants of imaging ordering behavior, the authors analyzed the effect of differential capacity on the imaging workup of patients with acute nonhemorrhagic stroke. METHODS: All patients at a US teaching hospital and a two-campus Canadian teaching hospital between 2001 and 2005 discharged with diagnoses ...
  • The Importance of the Centrosomal Localization Sequence of Cyclin E for Promoting Centrosome Duplication: A Dissertation

    May 24, 2011
    Author(s): Joshua J. Nordberg
    Source: GSBS Dissertations and Theses
    This thesis comprises three separate studies that investigate the consequences of supernumary centrosomes, the effect of centrosome loss, and a control mechanism for regulating CDK2/cyclin E activity in centrosome duplication. The centrosome is the major microtubule-organizing center of the cell. When the cell enters mitosis, it is of critical importance that the cell has exactly two centrosomes in order to properly segregat...
  • Creation of 3D Digital Anthropomorphic Phantoms which Model Actual Patient Non-rigid Body Motion as Determined from MRI and Position Tracking Studies of Volunteers

    May 02, 2011
    Author(s): Caitlin M. Connolly, Arda Konik, Paul K. R. Dasari, P. Segars, Shaokuan Zheng, K. L. Johnson, Joyoni Dey, Michael A. King
    Source: Senior Scholars Program
    Background: Patient motion during emission imaging can create artifacts in the reconstructed emission distributions, which may mislead the diagnosis. For example, in myocardial-perfusion imaging, these artifacts can be mistaken for defects. Various software and hardware approaches have been developed to detect and compensate for motion. There are various ways of testing the effectiveness of motion correction methods applied ...
  • Assessment of Olfactory Processing in Parkinson’s Disease Patients

    May 02, 2011
    Author(s): Mary Linton Peters, Jacob Kleinman, Wei Huang, Keith A. Cauley, Paula D. Ravin, Peter Novak, Ali Bourisly, Jean A. King, Julie G. Pilitsis
    Source: Senior Scholars Program
    Background: Hyposmia is an early symptom of Parkinson’s Disease (PD) that often predates motor symptoms by years. Hyposmia has been shown to have a more consistent link to idiopathic PD than to other movement disorders. Olfaction has the potential to be used as a biomarker for PD, either through clinical evaluation or imaging. Objectives: This study uses functional magnetic resonance imaging (fMRI) to assess differences in o...
  • Assessing antibody pharmacokinetics in mice with in vivo imaging

    May 01, 2011
    Author(s): Jack Hoppin, Kelly Davis Orcutt, Jacob Y. Hesterman, Matthew D. Silva, Dengfeng Cheng, Christian Lackas, Mary Rusckowski
    Source: The Journal of pharmacology and experimental therapeutics
    Recent advances in small-animal molecular imaging instrumentation combined with well characterized antibody-labeling chemistry have enabled detailed in vivo measurements of antibody distribution in mouse models. This article reviews the strengths and limitations of in vivo antibody imaging methods with a focus on positron emission tomography and single-photon emission computed tomography and a brief discussion of the role of...
  • Barriers and opportunities for early detection of breast cancer in Gaza women

    April 11, 2011
    Author(s): R. Shaheen, P. J. Slanetz, S. Raza, Max P. Rosen
    Source: Breast (Edinburgh, Scotland)
    A survey of 100 women living inside Gaza (WIG) and 55 Gaza women residing outside Gaza (WOG) was conducted to investigate barriers and opportunities for breast cancer screening, and to better understand possible differences based on residency. The survey found that over 90% of both groups were willing to undergo a diagnostic mammogram for a breast complaint and 86% of WIG and 85% of WOG believed survival was increased with e...
  • Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy

    April 01, 2011
    Author(s): Ronn P. Walvick, Bernt T. Bratane, Nils Henninger, Kenneth M. Sicard, James P. Bouley, Zhanyang Yu, Eng H. Lo, Xiaoying Wang, Marc Fisher
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: The purpose of this study was to develop a novel MRI method for imaging clot lysis in a rat embolic stroke model and to compare tissue plasminogen activator (tPA)-based clot lysis with and without recombinant Annexin-2 (rA2). METHODS: In experiment 1 we used in vitro optimization of clot visualization using multiple MRI contrast agents in concentrations ranging from 5 to 50 muL in 250 muL blood. In ex...
  • Hairpin-like fluorescent probe for imaging of NF-kappaB transcription factor activity

    April 01, 2011
    Author(s): Valeriy G. Metelev, Surong Zhang, David Tabatadze, Alexei A. Bogdanov Jr.
    Source: Bioconjugate chemistry
    Three oligodeoxyribonucleotides (ODN) covalently labeled with near-infrared (NIR) fluorochromes were synthesized and characterized with a goal of comparing in vitro a hairpin-based and a duplex-based FRET probe designed for the detection of human recombinant NF-kappaB p50/p65 heterodimer binding to DNA. Using deoxyguanosine phosphoramidite with a phosphorus-linked aminoethylene (diethylene glycol) hydrophilic linker, we synt...
  • Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma

    March 15, 2011
    Author(s): Mohammed S. Shazeeb, Christopher H. Sotak, Michael J. DeLeo III, Alexei A. Bogdanov Jr.
    Source: Cancer research
    Epidermal growth factor receptor (EGFR) imaging in brain tumors is essential to visualize overexpression of EGFRvIII variants as a signature of highly aggressive gliomas and to identify patients that would benefit from anti-EGFR therapy. Seeking imaging improvements, we tested a novel pretargeting approach that relies on initial administration of enzyme-linked anti-EGFR monoclonal antibodies (mAb; EMD72000) followed by admin...
  • Reducing the background fluorescence in mice receiving fluorophore/inhibitor DNA duplexes

    February 07, 2011
    Author(s): Min Min Liang, Xinrong Liu, Guozheng Liu, Shuping Dou, Dengfeng Cheng, Yuxia Liu, Mary Rusckowski, Donald J. Hnatowich
    Source: Molecular pharmaceutics
    In principle, a DNA duplex consisting of an antisense fluorophore-conjugated major strand hybridized to a shorter complementary inhibitor-conjugated minor strand should provide fluorescence only in the tumor after intravenous administration if designed to remain intact except in the presence in tumor of its mRNA target. While we have obtained impressive tumor images in mice using this approach, there remains some background ...
  • MRI of stroke using hyperpolarized 129Xe

    February 01, 2011
    Author(s): Xin Zhou, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, Marc Fisher, Mitchell Albert
    Source: NMR in biomedicine
    Because there is no background signal from xenon in biological tissue, and because inhaled xenon is delivered to the brain by blood flow, we would expect a perfusion deficit, such as is seen in stroke, to reduce the xenon concentration in the region of the deficit. Thermal polarization yields negligible xenon signal relative to hyperpolarized xenon; therefore, hyperpolarized xenon can be used as a tracer of cerebral blood fl...
  • Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal

    February 01, 2011
    Author(s): Guozheng Liu, Shuping Dou, Yuxia Liu, Min Min Liang, Ling Chen, Dengfeng Cheng, Dale L. Greiner, Mary Rusckowski, Donald J. Hnatowich
    Source: Nuclear medicine and biology
    In connection with pretargeting, an amine-derivatized morpholino phosphorodiamidate oligomer (NH(2)-cMORF) was conjugated conventionally with p-isothiocyanate benzyl-DTPA (p-SCN-Bn-DTPA). However, after (111)In radiolabeling, unexpected label instability was observed. To understand this instability, the NH(2)-cMORF and, as control, the native cMORF without the amine were conjugated in the conventional manner. Surprisingly, t...
  • Molecular magnetic resonance contrast agents for the detection of cancer: past and present

    February 01, 2011
    Author(s): Alexei A. Bogdanov Jr., Mary L. Mazzanti
    Source: Seminars in oncology
    Magnetic resonance imaging (MRI) is a powerful diagnostic tool with unsurpassed spatial resolution that is capable of providing detailed information about the structure and composition of tumors. The use of exogenously administered contrast agents allows compartment-specific enhancement of tumors, enabling imaging of functional blood and interstitial volumes. Current efforts are directed at enhancing the capabilities of MRI ...
  • Glowing in the dark: time of day as a determinant of radiographic imaging in the evaluation of abdominal pain in children

    January 18, 2011
    Author(s): Andrew T. Burr, Elizabeth Renaud, Mariann M. Manno, Joseph Makris, Erin K. Cooley, Anthony DeRoss, Michael P. Hirsh
    Source: Journal of pediatric surgery
    BACKGROUND/PURPOSE: Although ultrasound is often the preferred pediatric imaging study, many institutions lack ultrasound access at night; and computerized tomography (CT) becomes the only radiological method available for evaluation of appendicitis in children. The purpose of this study was to characterize patterns of daytime and nighttime use of ultrasound or CT for evaluation of pediatric appendicitis and to measure conse...
  • A brief evaluation of tumor imaging in mice with 99mTc-glucarate including a comparison with 18F-FDG

    January 01, 2011
    Author(s): Dengfeng Cheng, Mary Rusckowski, Yuzhen Wang, Yuxia Liu, Guozheng Liu, Xinrong Liu, Donald J. Hnatowich
    Source: Current radiopharmaceuticals
    OBJECTIVE: Recently 99mTc-glucarate, a radiolabeled glucose analogue, has been considered as a SPECT alternative to 18F-FDG and PET for non-invasive detection of certain tumors. Thus far there have been few studies on (99m) Tcglucarate for tumor imaging and fewer, if any, studies comparing (99m)Tc-glucarate with 18F-FDG. As a preliminary indication of the properties of (99m)Tc-glucarate as a possible substitute for 18F-FDG i...
  • Identification of a high affinity TAG-72 binding peptide by phage display selection

    January 01, 2011
    Author(s): Nan Xiao, Dengfeng Cheng, Yi Wang, Ling Chen, Xinrong Liu, Shuping Dou, Guozheng Liu, Min Min Liang, Donald J. Hnatowich, Mary Rusckowski
    Source: Cancer biology and therapy
    PURPOSE: Phage display was used to select novel peptides that specifically bind the TAG-72 antigen and with properties suitable for imaging TAG-72 positive cancers. RESULTS: After three rounds of selection against TAG-72 and using two different elution conditions including a long elution, the consensus sequences FRERCDKHPQKCTKFL and DPRHCQKRVLPCPAWL were expressed on phages G3-15 and T3-15 respectively. ELISA, fluorescence-a...
  • Estimation and correction of cardiac respiratory motion in SPECT in the presence of limited-angle effects due to irregular respiration

    December 01, 2010
    Author(s): Joyoni Dey, William P. Segars, P. Hendrik Pretorius, Ronn P. Walvick, Philippe P. Bruyant, Seth T. Dahlberg, Michael A. King
    Source: Medical physics
    PURPOSE: One issue with amplitude binning list-mode studies in SPECT for respiratory motion correction is that variation in the patient's respiratory pattern will result in binned motion states with little or no counts at various projection angles. The reduced counts result in limited-angle reconstruction artifacts which can impact the accuracy of the necessary motion estimation needed to correct the images. In this work, th...
  • Adding a clearing agent to pretargeting does not lower the tumor accumulation of the effector as predicted

    December 01, 2010
    Author(s): Guozheng Liu, Shuping Dou, Xiangji Chen, Ling Chen, Xinrong Liu, Mary Rusckowski, Donald J. Hnatowich
    Source: Cancer biotherapy and radiopharmaceuticals
    Clearing agents are often used in pretargeting despite the potential for decreased tumor accumulation of the effector. However, according to the authors' semiempirical model, a clearing agent should not necessarily decrease tumor accumulation. In this study, the authors have added a clearing step to their model-morpholino phosphorodiamidate oligomer (MORF)/complement MORF (cMORF) pretargeting system-to confirm this predictio...
  • MRI Contrast Agent Studies of Compartmental Differentiation, Dose-Dependence, and Tumor Characterization in the Brain: A Dissertation

    November 23, 2010
    Author(s): Mohammed S. Shazeeb
    Source: GSBS Dissertations and Theses
    Magnetic resonance imaging (MRI) has increasingly become the preferred imaging modality in modern day research to study disease. MRI presents an imaging technique that is practically non-invasive and without any ionizing radiation. This dissertation presents the use of contrast agents in MRI studies to differentiate compartments, to study dose dependence of relaxation times, and to characterize tumors using signal amplifying...
  • Evaluation of an improved algorithm for producing realistic 3D breast software phantoms: application for mammography

    November 01, 2010
    Author(s): K. Bliznakova, Sankararaman Suryanarayanan, Andrew Karellas, N. Pallikarakis
    Source: Medical physics
    PURPOSE: This work presents an improved algorithm for the generation of 3D breast software phantoms and its evaluation for mammography. METHODS: The improved methodology has evolved from a previously presented 3D noncompressed breast modeling method used for the creation of breast models of different size, shape, and composition. The breast phantom is composed of breast surface, duct system and terminal ductal lobular units,...
  • Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model

    October 17, 2010
    Author(s): Jian-ming Li, Peter E. Newburger, Matthew J. Gounis, Phong Dargon, Xueqing Zhang, Louis M. Messina
    Source: Gene therapy
    Both atherosclerosis and arterial interventions induce oxidative stress mediated in part by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases that have a pivotal role in the development of neointimal hyperplasia and restenosis. For small interfering RNA (siRNA) targeting of the NOX2 (Cybb) component of the NADPH oxidase to prevent restenosis, gene transfer with viral vectors is effective, but raises safety issues ...
  • A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49

    October 15, 2010
    Author(s): Guozheng Liu, Shuping Dou, Stephen P. Baker, Ali Akalin, Dengfeng Cheng, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Cancer biology and therapy
    The utility of MORF/cMORF pretargeting for the radiotherapy of cancer requires further validation in tumored mice before clinical trials. We now report on a therapeutic study in mice pretargeted with MORF-CC49 (an anti-TAG-72 antibody CC49 conjugated with MORF, a phosphorodiamidate morpholino oligomer) and then targeted by 188Re-cMORF (a 188Re labeled complementary MORF). Before the dose-escalating therapeutic study, a preta...
  • Magnetic Resonance Imaging of Neural and Pulmonary Vascular Function: A Dissertation

    September 01, 2010
    Author(s): Ronn P. Walvick
    Source: GSBS Dissertations and Theses
    Magnetic resonance imaging (MRI) has emerged as the imaging modality of choice in a wide variety experimental and clinical applications. In this dissertation, I will describe novel MRI techniques for the characterization of neural and pulmonary vascular function in preclinical models of disease. In the first part of this dissertation, experimental results will be presented comparing the identification of ischemic lesions in ...
  • Detectability of perfusion defect in five-dimensional gated-dynamic cardiac SPECT images

    September 01, 2010
    Author(s): Xiaofeng Niu, Yongyi Yang, Michael A. King, Miles N. Wernick
    Source: Medical physics
    PURPOSE: In previous work, the authors developed and demonstrated the concept of an image reconstruction procedure aimed to unify gated and dynamic nuclear cardiac imaging, which the authors have termed five-dimensional (5D) SPECT. Gated imaging permits the clinician to evaluate wall motion and, through the use of stress and rest scans, allows perfusion defects to be observed. Dynamic imaging depicts kinetics in the myocardi...
  • Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation

    September 01, 2010
    Author(s): Guozheng Liu, Shuping Dou, Mary Rusckowski, Dale L. Greiner, Donald J. Hnatowich
    Source: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
    An ability to quantitate the beta cell mass by noninvasive nuclear imaging will be very useful in the prevention, diagnosis, and treatment of diabetes. However, to be successful, radioactivity from the pancreas must not be obscured by the background radioactivity in the abdomen. Pretargeting offers the promise of achieving high target organ to normal tissue ratios. In preparation for pancreas imaging studies by pretargeting ...
  • Comparison of 18F PET and 99mTc SPECT imaging in phantoms and in tumored mice

    August 18, 2010
    Author(s): Dengfeng Cheng, Yi Wang, Xinrong Liu, P. Hendrik Pretorius, Min Min Liang, Mary Rusckowski, Donald J. Hnatowich
    Source: Bioconjugate chemistry
    Our objective was to compare the performance of a micro-single photon emission computed tomography (micro-SPECT) with that of a micro-positron emission tomography (microPET) in a Her2+ tumored mice using an anti-Her2 nanoparticle radiolabeled with (99m)Tc and (18)F. Camera performance was first compared using phantoms; then a tumored mouse administered the (99m)Tc-nanoparticle was imaged on a Bioscan NanoSPECT/CT, while anot...
  • Affinity enhancement pretargeting: synthesis and testing of a 99mTc-labeled bivalent MORF

    August 02, 2010
    Author(s): Jiang He, Yi Wang, Shuping Dou, Xinrong Liu, Surong Zhang, Guozheng Liu, Donald J. Hnatowich
    Source: Molecular pharmaceutics
    Pretargeting with bivalent effectors capable of bridging antitumor antibodies (affinity enhancement pretargeting) has been reported to provide superior results by affinity enhancement. Phosphorodiamidate morpholinos (MORFs) and other DNA analogues used for pretargeting are ideally suited as bivalent effectors since they are easily synthesized and the distance between binding regions, a determinant of binding, may be adjusted...
  • Multimodality nuclear and fluorescence tumor imaging in mice using a streptavidin nanoparticle

    July 21, 2010
    Author(s): Min Min Liang, Xinrong Liu, Dengfeng Cheng, Guozheng Liu, Shuping Dou, Yi Wang, Mary Rusckowski, Donald J. Hnatowich
    Source: Bioconjugate chemistry
    Combining two or more different imaging modalities in the same agent can be of considerable value in molecular imaging. We describe the use of streptavidin nanoparticle-based complexes as multimodality imaging agents to achieve tumor detection in a mouse model by both fluorescence and nuclear imaging. Up to four biotinylated functionalities can be readily attached to these streptavidin nanoparticles without apparent influenc...
  • ACR Appropriateness Criteria on Crohn's disease

    July 01, 2010
    Author(s): James E. Huprich, Max P. Rosen, Jeff L. Fidler, Spencer B. Gay, Thomas H. Grant, Frederick L. Greene, Tasneem Lalani, Frank H. Miller, Don C. Rockey, Gary S. Sudakoff, Richard Gunderman, Brian D. Coley
    Source: Journal of the American College of Radiology : JACR
    In the past decade, new therapeutic agents have been developed that permit gastroenterologists to treat virtually all forms of Crohn's disease. The success of these treatments depends on an accurate diagnosis of the nature and extent of disease. Fortunately, radiologists now possess a powerful arsenal of imaging techniques to guide the choice of therapy. This article discusses the usefulness of both traditional and newer ima...
  • Intra-arterial abciximab for the treatment of thrombus formation during coil embolization of intracranial aneurysms

    June 01, 2010
    Author(s): Italo Linfante, Vahid Etezadi, Vincenzo Andreone, Michael J. DeLeo III, Sara Alehashemi, Kate Shaw, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Thrombus formation during endovascular embolization of intracranial aneurysms occurs in 2.9%-6% of patients. Use of IIb/IIIA inhibitors such as abciximab or eptifibatide intravenously has been reported in management of this complication. Because the intra-arterial infusion of IIb/IIIA inhibitors may require lower doses to achieve thrombolysis, it may reduce the risk of haemorrhage. Therefore, we retro...
  • Quantitative Study of Rigid-Body and Respiratory Motion of Patients Undergoing Stress and Rest Cardiac SPECT Imaging

    June 01, 2010
    Author(s): Joyeeta Mitra Mukherjee, Karen Johnson, Joseph E. McNamara, Michael A. King
    Source: IEEE transactions on nuclear science
    We report patient motion in 110 Tl-201 cardiac perfusion SPECT studies in 66 patients. The imaging consisted of emission followed by sequential transmission imaging during which motion tracking with a visual tracking system (VTS) was performed. We investigated the extent, time, and frequency of respiratory and rigid-body motion in these patients. We also determined whether the motion occurred gradually or in sudden jumps, wh...
  • Regularized Fully 5D Reconstruction of Cardiac Gated Dynamic SPECT Images

    June 01, 2010
    Author(s): Xiaofeng Niu, Yongyi Yang, Mingwu Jin, Miles N. Wernick, Michael A. King
    Source: IEEE transactions on nuclear science
    In our recent work, we proposed an image reconstruction procedure aimed to unify gated imaging and dynamic imaging in nuclear cardiac imaging. With this procedure the goal is to obtain an image sequence from a single acquisition which shows simultaneously both cardiac motion and tracer distribution change over the course of imaging. In this work, we further develop and demonstrate this procedure for fully 5D (3D space plus t...
  • Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector

    June 01, 2010
    Author(s): Guozheng Liu, Shuping Dou, P. Hendrik Pretorius, Xinrong Liu, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging
    AIM: Using the antiCEA antibody MN14, a LS174T mouse tumor model has been successfully targeted with (⁹⁹m)Tc for imaging and ¹⁸⁸Re for radiotherapy by phosphorodiamidate morpholino oligomers (MORF)/complementary MORF (cMORF) pretargeting strategy. This investigation evaluated the antiTAG-72 antibody CC49 as an alternative to MN14 for this application. METHODS: Both CC49 and MN14 were labeled with ¹¹¹In via SCN-benzyl-DTPA a...
  • Auger-mediated cytotoxicity of cancer cells in culture by an 125I-antisense oligomer delivered as a three-component streptavidin nanoparticle

    April 01, 2010
    Author(s): Xinrong Liu, Kayoko Nakamura, Yi Wang, Dengfeng Cheng, Min Min Liang, Nan Xiao, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Journal of biomedical nanotechnology
    We reported recently that a three-component nanoparticle, consisting of a targeting antibody, a transfecting peptide and an 111In-antiRIalpha MORF antisense oligomer, provided Auger electron-mediated, antisense-mediated, cytotoxicity of cells in culture. We have now measured the cytotoxicity of the nanoparticle in culture with the 111In replaced by 125I, another attractive Auger electron emitter. The nanoparticle consisted o...
  • Modeling the performance characteristics of computed radiography (CR) systems

    March 01, 2010
    Author(s): Srinivasan Vedantham, Andrew Karellas
    Source: IEEE transactions on medical imaging
    Computed radiography (CR) using storage phosphors is widely used in digital radiography and mammography. A cascaded linear systems approach wherein several parameter values were estimated using Monte Carlo methods was used to model the image formation process of a single-side read flying spot CR system using a granular phosphor. Objective image quality metrics such as modulation transfer function and detective quantum effici...
  • Advances in interventional neuroradiology

    February 01, 2010
    Author(s): Matthew J. Gounis, Michael J. DeLeo III, Ajay K. Wakhloo
    Source: Stroke; a journal of cerebral circulation
  • Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector

    December 19, 2009
    Author(s): Guozheng Liu, Shuping Dou, P. Hendrik Pretorius, Xinrong Liu, L. Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
    AIM: Using the antiCEA antibody MN14, a LS174T mouse tumor model has been successfully targeted with 99mTc for imaging and 188Re for radiotherapy by phosphorodiamidate morpholino oligomers (MORF)/complementary MORF (cMORF) pretargeting strategy. This investigation evaluated the antiTAG-72 antibody CC49 as an alternative to MN14 for this application. METHODS: Both CC49 and MN14 were labeled with 111In via SCN-benzyl-DTPA and ...
  • Estimation of Cardiac Respiratory-Motion by Semi-Automatic Segmentation and Registration of Non-Contrast-Enhanced 4D-CT Cardiac Datasets

    December 08, 2009
    Author(s): Joyoni Dey, Tinsu Pan, David J. Choi, Dionyssios A. Robotis, Mark S. Smyczynski, M.D., P. Hendrik Pretorius, Michael A. King
    Source: IEEE transactions on nuclear science
    The goal of this work is to investigate, for a large set of patients, the motion of the heart with respiration during free-breathing supine medical imaging. For this purpose we analyzed the motion of the heart in 32 non-contrast enhanced respiratory-gated 4D-CT datasets acquired during quiet unconstrained breathing. The respiratory-gated CT images covered the cardiac region and were acquired at each of 10 stages of the respi...
  • In vitro and In vivo imaging of antivasculogenesis induced by Noggin protein expression in human venous endothelial cells

    December 01, 2009
    Author(s): Hye-Won Kang, Ronn P. Walvick, Alexei A. Bogdanov Jr.
    Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    Noggin protein is a potent bone morphogenetic protein (BMP) antagonist capable of inhibiting vasculogenesis even in the presence of provasculogenic VEGF and FGF-2. We found that human umbilical vein endothelial cells (HUVECs) do not express Noggin in culture and used these cells for modeling of antivasculogenesis. We hypothesized that high-efficiency transduction of HUVECs with bicistronic lentiviral vector encoding Noggin a...
  • Tumor delivery of antisense oligomer using trastuzumab within a streptavidin nanoparticle

    December 01, 2009
    Author(s): Yi Wang, Xinrong Liu, Ling Chen, Dengfeng Cheng, Mary Rusckowski, Donald J. Hnatowich
    Source: European journal of nuclear medicine and molecular imaging
    PURPOSE: Trastuzumab (Herceptin) is often internalized following binding to Her2+ tumor cells. The objective of this study was to investigate whether trastuzumab can be used as a specific carrier to deliver antisense oligomers into Her2+ tumor cells both in vitro and in vivo. METHODS: A biotinylated MORF oligomer antisense to RhoC mRNA and its biotinylated sense control were labeled with either lissamine for fluorescence det...
  • Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms

    December 01, 2009
    Author(s): Bo Hong, Neil V. Patel, Matthew J. Gounis, Michael J. DeLeo 3rd, Italo Linfante, Joan C. Wojak, Ajay K. Wakhloo
    Source: Neurosurgery
    OBJECTIVE: Stent-assisted coiling of intracranial aneurysms is performed by placing a microcatheter through a stent's interstices or jailing the microcatheter between the stent and the artery. Both approaches impede manipulation of the microcatheter during coiling. We describe a modified jailing technique that improves catheter maneuverability and report the safety and efficacy of the method for the treatment of complex, wid...
  • The ratio of maximum percent tumour accumulations of the pretargeting agent and the radiolabelled effector is independent of tumour size

    November 01, 2009
    Author(s): Guozheng Liu, Shuping Dou, Min Min Liang, Xiangji Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: European journal of cancer (Oxford, England : 1990)
    Our previous studies have indicated that the optimal dosage ratio of pretargeting antibody to effector is proportional to their maximum percent tumour accumulations (MPTAs). This study quantitatively describes how both MPTAs and their ratio change with tumour size, to simplify pretargeting optimisation when tumour size varies. The CC49 antibody dosages below saturation of the tumour antigen level were first examined for the ...
  • A convenient thiazole orange fluorescence assay for the evaluation of DNA duplex hybridization stability

    November 01, 2009
    Author(s): Min Min Liang, Xinrong Liu, Kayoko Nakamura, Xiangji Chen, Dengfeng Cheng, Guozheng Liu, Shuping Dou, Yi Wang, Mary Rusckowski, Donald J. Hnatowich
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    OBJECTIVE: A simple and rapid method for measuring the hybridization stability of duplexes of DNAs and other oligomers in different environments is described. When added to an oligomer duplex, the thiazole orange (TO) dye intercalates and in this state is fluorescent. Therefore, when duplex dissociation occurs, the release of TO results in a detectable change in fluorescence intensity. This assay was developed primarily to s...
  • Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL

    October 15, 2009
    Author(s): Bernt T. Bratane, Ronn P. Walvick, Claire Corot, Eric Lancelot, Marc Fisher
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for infarction. In this study we compared the volumetric quantification of the perfusion deficit in two rat middle-cerebral-artery occlusion (MCAO) models using two gadolinium-based contrast agents (P1152 (Guerbet) and Magnevist (Bayer-Schering, Pittsburgh, PA, USA)) as compared with our well established continuous arterial spin labeling...
  • Theoretical and Numerical Study of MLEM and OSEM Reconstruction Algorithms for Motion Correction in Emission Tomography

    October 01, 2009
    Author(s): Joyoni Dey, Michael A. King
    Source: IEEE transactions on nuclear science
    Patient body-motion and respiratory-motion impacts the image quality of cardiac SPECT and PET perfusion images. Several algorithms exist in the literature to correct for motion within the iterative maximum-likelihood reconstruction framework. In this work, three algorithms are derived starting with Poisson statistics to correct for patient motion. The first one is a motion compensated MLEM algorithm (MC-MLEM). The next two a...
  • Improved Dynamic Cardiac Phantom Based on 4D NURBS and Tagged MRI

    October 01, 2009
    Author(s): P. Segars, David S. Lalush, Eric C. Frey, Dinesh Manocha, Michael A. King, Benjamin M. W. Tsui
    Source: IEEE transactions on nuclear science
    We previously developed a realistic phantom for the cardiac motion for use in medical imaging research. The phantom was based upon a gated magnetic resonance imaging (MRI) cardiac study and using 4D non-uniform rational b-splines (NURBS). Using the gated MRI study as the basis for the cardiac model had its limitations. From the MRI images, the change in the size and geometry of the heart structures could be obtained, but wit...
  • In vivo delivery of antisense MORF oligomer by MORF/carrier streptavidin nanoparticles

    October 01, 2009
    Author(s): Yi Wang, Xinrong Liu, Kayoko Nakamura, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Cancer biotherapy and radiopharmaceuticals
    Tumor targeting by oligomers is largely limited by the pharmacokinetics and cell-membrane transport obstacles. In this article, we describe the use of a delivery nanoparticle, in which streptavidin served as a convenient bridge between a biotinylated oligomer and a biotinylated cell-membrane-penetrating peptide, to improve the delivery of an antisense phosphorodiamidate morpholino (MORF) oligomer in vivo. A biotinylated (99m...
  • A quantitative evaluation study of four-dimensional gated cardiac SPECT reconstruction

    September 21, 2009
    Author(s): Mingwu Jin, Yongyi Yang, Xiaofeng Niu, Thibault Marin, Jovan G. Brankov, Bing Feng, Petrus Hendrik Pretorius, Michael A. King, Miles N. Wernick
    Source: Physics in medicine and biology
    In practice, gated cardiac SPECT images suffer from a number of degrading factors, including distance-dependent blur, attenuation, scatter and increased noise due to gating. Recently, we proposed a motion-compensated approach for four-dimensional (4D) reconstruction for gated cardiac SPECT and demonstrated that use of motion-compensated temporal smoothing could be effective for suppressing the increased noise due to lowered ...
  • Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study

    September 01, 2009
    Author(s): Michael J. DeLeo 3rd, Matthew J. Gounis, Bo Hong, John C. Ford, Ajay K. Wakhloo, Alexei A. Bogdanov Jr.
    Source: Radiology
    PURPOSE: To demonstrate the feasibility of using a myeloperoxidase (MPO)-specific paramagnetic magnetic resonance (MR) contrast agent to identify active inflammation in an animal model of common carotid artery (CCA) aneurysm. MATERIALS AND METHODS: All animal experiments were approved by the institutional animal care and use committee. Elastase-induced saccular aneurysms were created at the root of the right CCA in 16 New Z...
  • Impact on reader performance for lesion-detection/ localization tasks of anatomical priors in SPECT reconstruction

    September 01, 2009
    Author(s): Andre Lehovich, Philippe P. Bruyant, Howard C. Gifford, Peter B. Schneider, Shayne Squires, Robert Licho, Gene Gindi, Michael A. King
    Source: IEEE transactions on medical imaging
    With increasing availability of multimodality imaging systems, high-resolution anatomical images can be used to guide the reconstruction of emission tomography studies. By measuring reader performance on a lesion detection task, this study investigates the improvement in image-quality due to use of prior anatomical knowledge, for example organ or lesion boundaries, during SPECT reconstruction. Simulated (67)Ga -citrate sourc...
  • Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation

    September 01, 2009
    Author(s): Guozheng Liu, Dengfeng Cheng, Shuping Dou, Xiangji Chen, Min Min Liang, P. Hendrik Pretorius, Mary Rusckowski, Donald J. Hnatowich
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: To reduce accumulation in the abdomen by MORF/cMORF pretargeting, 111In was compared to 99mTc as the radiolabel. PROCEDURES: After receiving either 99mTc (MAG3)-cMORF or 111In (DTPA)-cMORF, normal mice were imaged and sacrificed for pharmacokinetics. Thereafter, tumored mice were pretargeted withMORF-antibody, 48 h later were given an injection of 99mTc- or 111In-cMORF, and finally were imaged repeatedly. RESULTS: T...
  • Cerecyte versus platinum coils in the treatment of intracranial aneurysms: packing attenuation and clinical and angiographic midterm results

    August 22, 2009
    Author(s): Italo Linfante, Michael J. DeLeo, Matthew J. Gounis, Ajay K. Wakhloo
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: As modifications are made to coils, monitoring the safety profile, ability to achieve high packing attenuation, and durability of occlusion as compared to the standard bare platinum coils is of paramount importance. We compared packing attenuation, initial occlusion, and recanalization rates between Cerecyte and bare platinum coils in the treatment of ruptured and unruptured cerebral aneurysms. MATERI...
  • Plate capture assay of fluorescent oligonucleotide duplex reporter-transcription factor complexes

    August 19, 2009
    Author(s): Surong Zhang, Alexei A. Bogdanov Jr.
    Source: Bioconjugate chemistry
    We previously developed prototype oligodeoxyribonucleotide (ODN) duplex fluorescence energy transfer (FRET) reporters for optical sensing of NF-kappaB transcription factor. We report here a plate-binding assay designed for optimizing the above reporters. Nitrilotriacetate-bearing plates were prepared by using sequential (1) aminosilylation; (2) carboxylation; (3) coupling of Nalpha,Nalpha-bis(carboxymethyl)-L-lysine or, alte...
  • Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques

    August 18, 2009
    Author(s): John A. Ronald, John W. Chen, Yuanxin Chen, Amanda M. Hamilton, Elisenda Rodriguez, Fred Reynolds, Robert A. Hegele, Kem A. Rogers, Manel Querol, Alexei A. Bogdanov Jr., Ralph Weissleder, Brian K. Rutt
    Source: Circulation
    BACKGROUND: Inflammation undermines the stability of atherosclerotic plaques, rendering them susceptible to acute rupture, the cataclysmic event that underlies clinical expression of this disease. Myeloperoxidase is a central inflammatory enzyme secreted by activated macrophages and is involved in multiple stages of plaque destabilization and patient outcome. We report here that a unique functional in vivo magnetic resonance...
  • Optical antisense tumor targeting in vivo with an improved fluorescent DNA duplex probe

    June 17, 2009
    Author(s): Min Min Liang, Xinrong Liu, Dengfeng Cheng, Kayoko Nakamura, Yi Wang, Shuping Dou, Guozheng Liu, Mary Rusckowski, Donald J. Hnatowich
    Source: Bioconjugate chemistry
    Fluorescent conjugated DNA oligonucleotides for antisense targeting of mRNA has the potential of improving tumor/normal tissue ratios over that achievable by nuclear antisense imaging. By conjugating the Cy5.5 emitter to the 3' equivalent end of a 25 mer phosphorothioate (PS) antisense major DNA and hybridizing with a shorter 18 mer phosphodiester (PO) complementary minor DNA (cDNA) with the Black Hole inhibitor BHQ3 on its ...
  • Advances in interventional neuroradiology

    May 01, 2009
    Author(s): Ajay K. Wakhloo, Michael J. DeLeo III, Martin M. Brown
    Source: Stroke; a journal of cerebral circulation
    In 2008 we witnessed a rapid advancement in stent technology, which is reflected in the high number of case reports, publications of case series, and randomized trials. Stents not only served for a combined intrasaccular and extrasaccular treatment of challenging aneurysms but also assisted the revascularization in acute and chronic ischemic conditions of the neurovascular system. Although a self-expanding nitinol semiopen c...
  • A flexible multicamera visual-tracking system for detecting and correcting motion-induced artifacts in cardiac SPECT slices

    May 01, 2009
    Author(s): Joseph E. McNamara, P. Hendrik Pretorius, Karen Johnson, Joyeeta Mitra Mukherjee, Joyoni Dey, Michael A. Gennert, Michael A. King
    Source: Medical physics
    Patient motion is inevitable in SPECT and PET due to the lengthy period of time patients are imaged. The authors hypothesized that the use of external-tracking devices which provide additional information on patient motion independent of SPECT data could be employed to provide a more robust correction than obtainable from data-driven methods. Therefore, the authors investigated the Vicon MX visual-tracking system (VTS) which...
  • Characterization of scatter in cone-beam CT breast imaging: comparison of experimental measurements and Monte Carlo simulation

    April 22, 2009
    Author(s): Yu Chen, Bob Liu, J. Michael O'Connor, Clay S. Didier, Stephen J. Glick
    Source: Medical physics
    It is commonly understood that scattered radiation in x-ray computed tomography (CT) degrades the reconstructed image. As a precursor to developing scatter compensation methods, it is important to characterize this scatter using both empirical measurements and Monte Carlo simulations. Previous studies characterizing scatter using both experimental measurements and Monte Carlo simulations have been reported in diagnostic radi...
  • Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In

    April 01, 2009
    Author(s): Xinrong Liu, Yi Wang, Kayoko Nakamura, Sumi Kawauchi, Ali Akalin, Dengfeng Cheng, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    When antisense oligomers are intracellular, they migrate to and are retained in the nucleus of tumor cells and therefore may be used to carry Auger electron-emitting radionuclides such as (111)In for effective tumor radiotherapy. METHODS: Our nanoparticle consists of streptavidin that links 3 biotinylated components: the antiHer2 antibody trastuzumab (to improve pharmacokinetics), the tat peptide (to improve cell membrane tr...
  • Neurovascular modeling: small-batch manufacturing of silicone vascular replicas

    March 27, 2009
    Author(s): Juyu Chueh, Ajay K. Wakhloo, Matthew J. Gounis
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Realistic, population based cerebrovascular replicas are required for the development of neuroendovascular devices. The objective of this work was to develop an efficient methodology for manufacturing realistic cerebrovascular replicas. MATERIALS AND METHODS: Brain MR angiography data from 20 patients were acquired. The centerline of the vasculature was calculated, and geometric parameters were measur...
  • Role of Supervillin, a Membrane Raft Protein, in Cytoskeletal Organization and Invadopodia Function

    February 12, 2009
    Author(s): Jessica Lynn Crowley
    Source: GSBS Dissertations and Theses
    Crucial to a cell’s ability to migrate is the organization of its plasma membrane and associated proteins in a polarized manner to interact with and respond to its surrounding environment. Cells interact with the extracellular matrix (ECM) through specialized contact sites, including podosomes and invadopodia. Tumor cells use F-actin-rich invadopodia to degrade ECM and invade tissues; related structures, termed podosomes, ar...
  • Imaging nanoprobe for prediction of outcome of nanoparticle chemotherapy by using mammography

    February 04, 2009
    Author(s): Efstathios Karathanasis, Sankararaman Suryanarayanan, Sri R. Balusu, Kathleen McNeeley, Ioannis Sechopoulos, Andrew Karellas, Ananth V. Annapragada, Ravi V. Bellamkonda
    Source: Radiology
    PURPOSE: To prospectively predict the effectiveness of a clinically used nanochemotherapeutic agent by detecting and measuring the intratumoral uptake of an x-ray contrast agent nanoprobe by using digital mammography. MATERIALS AND METHODS: All animal procedures were approved by the institutional animal care and use committee. A long-circulating 100-nm-scale injectable liposomal probe encapsulating 155 mg/mL iodine was devel...
  • Estimation of Rigid-Body and Respiratory Motion of the Heart From Marker-Tracking Data for SPECT Motion Correction

    February 01, 2009
    Author(s): Joyeeta Mitra Mukherjee, Joseph E. McNamara, Karen Johnson, Joyoni Dey, Michael A. King
    Source: IEEE transactions on nuclear science
    Motion of patients undergoing cardiac SPECT perfusion imaging causes artifacts in the acquired images which may lead to difficulty in interpretation. Our work investigates a technique of obtaining patient motion estimates from retro-reflective markers on stretchy bands wrapped around the chest and abdomen of patients being imaged clinically. Motion signals obtained from the markers consist of at least two components, body mo...
  • Diminishing the impact of the partial volume effect in cardiac SPECT perfusion imaging

    January 01, 2009
    Author(s): P. Hendrik Pretorius, Michael A. King
    Source: Medical physics
    The partial volume effect (PVE) significantly restricts the absolute quantification of regional myocardial uptake and thereby limits the accuracy of absolute measurement of blood flow and coronary flow reserve by SPECT. The template-projection-reconstruction method has been previously developed for PVE compensation. This method assumes the availability of coregistered high-spatial resolution anatomical information as is now ...
  • An Assessment of a Low-Cost Visual Tracking System (VTS) to Detect and Compensate for Patient Motion during SPECT

    December 17, 2008
    Author(s): Joseph E. McNamara, Karen Johnson, Bing Feng, Songxiang Gu, Philippe P. Bruyant, Michael A. Gennert, Michael A. King
    Source: IEEE transactions on nuclear science
    Patient motion is inevitable in SPECT and PET due to the lengthy period of time patients are imaged and patient motion can degrade diagnostic accuracy. The goal of our studies is to perfect a methodology for tracking and correcting patient motion when it occurs. In this paper we report on enhancements to the calibration, camera stability, accuracy of motion tracking, and temporal synchronization of a low-cost visual tracking...
  • A new TAG-72 cancer marker peptide identified by phage display

    December 08, 2008
    Author(s): Ling Chen, Yi Wang, Xinrong Liu, Shuping Dou, Guozheng Liu, Donald J. Hnatowich, Mary Rusckowski
    Source: Cancer letters
    Radiolabeled peptides as markers of cancer targets have demonstrated their value in diagnostic imaging and radiotherapy. The 16 mer f88-4/Cys6 phage display library was applied to affinity purified TAG-72 and three consensus peptides were identified: VHHSCTKLTHCCQNWH (A2-13), GGVSCMQTSPVCENNL (A2-6) and TKRDCSAQNYGCQKAI (A2-11). The A2-13 and A2-6 phages showed the highest percent binding to LS-174T cells by flow cytometry a...
  • The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI

    November 22, 2008
    Author(s): Yang-Sheng Tzeng, Kenneth Lutchen, Mitchell Albert
    Source: Journal of applied physiology (Bethesda, Md. : 1985)
    In this pilot study, algorithms for quantitatively evaluating the distribution and heterogeneity of human ventilation imaged with hyperpolarized (HP) (3)He MRI were developed for the goal of examining structure-function relationships within the asthmatic lung. Ten asthmatic and six healthy human subjects were imaged with HP (3)He MRI before bronchial challenge (pre-MCh), after bronchial challenge (post-MCh), and after a seri...
  • An evaluation of iterative reconstruction strategies based on mediastinal lesion detection using hybrid Ga-67 SPECT images

    November 01, 2008
    Author(s): Nicholas F. Pereira, Howard C. Gifford, P. Hendrik Pretorius, Mark S. Smyczynski, Robert Licho, Peter B. Schneider, Troy H. Farncombe, Michael A. King
    Source: Medical physics
    Using psychophysical studies, the authors have evaluated the effectiveness of various strategies for compensating for physical degradations in SPECT imaging. The particular application was Ga-67-citrate imaging of mediastinal tumors, which was chosen because Ga-67 is a particularly challenging radionuclide for imaging. The test strategies included compensations for nonuniform attenuation, distance-dependent spatial resolutio...
  • Synthesis and in vitro characterization of a dendrimer-MORF conjugate for amplification pretargeting

    July 24, 2008
    Author(s): Xiangji Chen, Shuping Dou, Guozheng Liu, Xinrong Liu, Yi Wang, Ling Chen, Mary Rusckowski, Donald J. Hnatowich
    Source: Bioconjugate chemistry
    Amplification pretargeting can play an important role in molecular imaging by significantly increasing the accumulation of signal in target tissues. Multiple-step amplification pretargeting offers the potential to greatly improve target localization of effector molecules through the intermediate use of polymers conjugated with multiple copies of complementary oligomers. In this study, PAMAM dendrimer generation 3 (G3) was co...
  • Retrievable closed cell intracranial stent for foreign body and clot removal

    July 18, 2008
    Author(s): Ajay K. Wakhloo, Matthew J. Gounis
    Source: Neurosurgery
    OBJECTIVE: To assess the technical feasibility of using a retrievable, closed cell intracranial stent delivered through a microcatheter for safe removal of foreign bodies or clot. METHODS: In vitro and in vivo testing were performed to demonstrate the feasibility of using retrievable intracranial stents for foreign body or clot removal. In vitro testing was performed in an anatomically correct silicone vascular replica by pa...
  • Convolution-Based Forced Detection Monte Carlo Simulation Incorporating Septal Penetration Modeling

    June 01, 2008
    Author(s): Shaoying Liu, Michael A. King, Aaron B. Brill, Michael G. Stabin, Troy H. Farncombe
    Source: IEEE transactions on nuclear science
    In SPECT imaging, photon transport effects such as scatter, attenuation and septal penetration can negatively affect the quality of the reconstructed image and the accuracy of quantitation estimation. As such, it is useful to model these effects as carefully as possible during the image reconstruction process. Many of these effects can be included in Monte Carlo (MC) based image reconstruction using convolution-based forced ...
  • MDCT of 220 consecutive patients with suspected acute pulmonary embolism: incidence of pulmonary embolism and of other acute or non-acute thoracic findings

    May 22, 2008
    Author(s): Silvia Tresoldi, Young H. Kim, Stephen P. Baker, Krishna Kandarpa
    Source: La Radiologia medica
    PURPOSE: This study was undertaken to evaluate the incidence of pulmonary embolism (PE) and other clinically relevant thoracic findings discovered on contrast-enhanced multidetector computed tomography (MDCT) examination in patients with a suspicion of acute PE. MATERIALS AND METHODS: We retrospectively reviewed 220 reports of 40-row MDCT exams in consecutive patients (101 men, 119 women; mean age 55 years+/-18) suspected fo...
  • An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector

    May 17, 2008
    Author(s): Guozheng Liu, Shuping Dou, Mary Rusckowski, Donald J. Hnatowich
    Source: Molecular cancer therapeutics
    In treating tumors by pretargeting, the antitumor antibody and the cytotoxic effector (e.g., toxins and radioactivity) are separately administered. Therefore, pretargeting is more complicated with many variables. We are conducting studies to understand the influence of each variable using a novel recognition pair of mutually complementary phosphorodiamidate morpholino oligomers (MORF/cMORF). Earlier we developed a semi-empir...
  • Investigation of four (99m)Tc-labeled bacteriophages for infection-specific imaging

    May 17, 2008
    Author(s): Mary Rusckowski, Suresh Gupta, Guozheng Liu, Shuping Dou, Donald J. Hnatowich
    Source: Nuclear medicine and biology
    INTRODUCTION: This study investigated radiolabeled bacteriophages for specific detection of infection through gamma imaging. Previously, a (99m)Tc-labeled M13 phage demonstrated specific binding for its host Escherichia coli in vitro and in mice through imaging. METHODS: This study was extended to phages P22, E79, VD-13 and phage 60. Each was radiolabeled with (99m)Tc using the chelator MAG(3), and were evaluated for binding...
  • Fournier gangrene: role of imaging

    March 20, 2008
    Author(s): Robin B. Levenson, Ajay K. Singh, Robert A. Novelline
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    Fournier gangrene is a rapidly progressing necrotizing fasciitis involving the perineal, perianal, or genital regions and constitutes a true surgical emergency with a potentially high mortality rate. Although the diagnosis of Fournier gangrene is often made clinically, emergency computed tomography (CT) can lead to early diagnosis with accurate assessment of disease extent. CT not only helps evaluate the perineal structures ...
  • Fluorescence resonance energy transfer in near-infrared fluorescent oligonucleotide probes for detecting protein-DNA interactions

    March 14, 2008
    Author(s): Surong Zhang, Valeriy G. Metelev, David Tabatadze, Paul Zamecnik, Alexei A. Bogdanov
    Source: Proceedings of the National Academy of Sciences of the United States of America
    Optical imaging in the near-infrared (NIR) range enables detecting ligand-receptor interactions and enzymatic activity in vivo due to lower scattering and absorption of NIR photons in the tissue. We designed and tested prototype NIR fluorescent oligodeoxyribonucleotide (ODN) reporters that can sense transcription factor NF-kappaB p50 protein binding. The reporter duplexes included donor NIR Cy5.5 indodicarbocyanine fluorochr...
  • Control of Bleeding from the Portal/Superior Mesenteric Vein

    December 01, 2007
    Author(s): Joshua S. Hill, Sridhar Shankar, Douglas B. Evans, Jennifer F. Tseng
    Source: Management of Intraoperative Complications
    No abstract available.
  • Body Deformation Correction for SPECT Imaging

    November 01, 2007
    Author(s): Songxiang Gu, Joseph E. McNamara, Joyeeta Mitra, Howard C. Gifford, Karen Johnson, Michael A. Gennert, Michael A. King
    Source: IEEE transactions on nuclear science
    Patient motion degrades the quality of SPECT studies. Body bend and twist are types of patient deformation, which may occur during SPECT imaging, and which has been generally ignored in SPECT motion correction strategies. To correct for these types of motion, we propose a deformation model and its inclusion within an iterative reconstruction algorithm. Two experiments were conducted to investigate the applicability of our mo...
  • Adult intestinal intussusception: can abdominal MDCT distinguish an intussusception caused by a lead point

    October 10, 2007
    Author(s): Silvia Tresoldi, Young H. Kim, Michael A. Blake, Mukesh G. Harisinghani, Peter F. Hahn, Stephen P. Baker, Peter R. Mueller, Krishna Kandarpa
    Source: Abdominal imaging
    BACKGROUND : Aim of our study was to assess the ability of computed tomography to distinguish between an intussusception with a lead-point from one without it. METHODS : Approval was granted by the Institutional Review Board. Ninety-three consecutive patients diagnosed with an intussusception on abdominal CT were classified with or without lead-point by surgery, clinical or radiological follow-up. Two radiologists blinded to...
  • Pretargeting CWR22 prostate tumor in mice with MORF-B72.3 antibody and radiolabeled cMORF

    October 03, 2007
    Author(s): Guozheng Liu, Shuping Dou, P. Hendrik Pretorius, Xinrong Liu, Mary Rusckowski, Donald J. Hnatowich
    Source: European journal of nuclear medicine and molecular imaging
    PURPOSE: We have now applied our MORF/cMORF pretargeting technology to the targeting of CWR22 prostate tumor in nude mice. METHODS: The antiTAG-72 antibody B72.3 was conjugated with an 18 mer MORF while the cMORF was radiolabeled with (99m)Tc. The specific binding of the antibody to the CWR22 cells was first confirmed in an assay placing the radiolabeled B72.3 antibody in competition with increasing concentrations of native ...
  • Quantification of the Association Between the Apparent Diffusion Coefficient and Age in Normal Pediatric Hips

    June 01, 2007
    Author(s): Katharine Taylor
    Source: Senior Scholars Program
    Background:The growing skeleton complicates our understanding of how diffusion-weighted imaging (DWI) may add diagnostic value in musculoskeletal disorders. Conventional MRI demonstrates changes in skeletal composition during bone development [1] as the tissue composition at the ends of bone (epiphyses) undergoes a transformation from cellular, highly vascularized hematopoietic marrow to adult marrow containing mainly adipoc...
  • Labeling biomolecules with radiorhenium: a review of the bifunctional chelators

    May 17, 2007
    Author(s): Guozheng Liu, Donald J. Hnatowich
    Source: Anti-cancer agents in medicinal chemistry
    For radiotherapy, biomolecules such as intact antibodies, antibody fragments, peptides, DNAs and other oligomers have all been labeled with radiorhenium ((186)Re and (188)Re). Three different approaches have been employed that may be referred to as direct, indirect and integral labeling. Direct labeling applies to proteins and involves the initial reduction of endogenous disulfide bridges to provide chelation sites. Indirect...
  • Identification and Characterization of Components of the Intraflagellar transport (IFT) Machinery: a Dissertation

    May 11, 2007
    Author(s): Yuqing Hou
    Source: GSBS Dissertations and Theses
    Intraflagellar transport (IFT), the bi-directional movement of particles along the length of flagella, is required for flagellar assembly. The IFT particles are moved by kinesin II from the base to the tip of the flagellum, where flagellar assembly occurs. The IFT particles are then moved in the retrograde direction by cytoplasmic dynein 1b/2 to the base of the flagellum. The IFT particles of Chlamydomonas are composed of ~1...
  • A novel pretargeting method for measuring antibody internalization in tumor cells

    April 28, 2007
    Author(s): Guozheng Liu, Shuping Dou, Dongguang Yin, Shayne Squires, Xinrong Liu, Yi Wang, Mary Rusckowski, Donald J. Hnatowich
    Source: Cancer biotherapy and radiopharmaceuticals
    A novel pretargeting method has been developed to quantitate antibody cellular internalization. In this study, the antibody was conjugated with a phosphorodiamidate morpholino oligomer (MORF) specific for the complementary MORF (cMORF) as an effector. Half the tumor cells were incubated with the MORF-antibody (pretargeting group) and the other half with the same MORF-antibody at the same concentration but radiolabeled (direc...
  • Multispectral quantification of tissue types in a RIF-1 tumor model with histological validation. Part I

    February 28, 2007
    Author(s): Erica C. Henning, Chieko Azuma, Christopher H. Sotak, Karl G. Helmer
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    Accurate assessments of therapeutic efficacy are confounded by intra- and intertumor heterogeneity. To address this issue we employed multispectral (MS) analysis using the apparent diffusion coefficient (ADC), T(2), proton density (M(0)), and k-means (KM) clustering algorithm to identify multiple compartments within both viable and necrotic tissue in a radiation-induced fibrosarcoma (RIF-1) tumor model receiving single-dose ...
  • Multispectral tissue characterization in a RIF-1 tumor model: monitoring the ADC and T2 responses to single-dose radiotherapy. Part II

    February 28, 2007
    Author(s): Erica C. Henning, Chieko Azuma, Christopher H. Sotak, Karl G. Helmer
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    A multispectral (MS) approach that combines apparent diffusion coefficient (ADC) and T(2) parameter maps with k-means (KM) clustering was employed to distinguish multiple compartments within viable tumor tissue (V1 and V2) and necrosis (N1 and N2) following single-dose (1000 cGy) radiotherapy in a radiation-induced fibrosarcoma (RIF-1) tumor model. The contributions of cell kill and tumor growth kinetics to the radiotherapy-...
  • Brain aneurysms and arteriovenous malformations: advancements and emerging treatments in endovascular embolization

    February 27, 2007
    Author(s): Italo Linfante, Ajay K. Wakhloo
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: Brain aneurysms and vascular malformations can cause cerebral hemorrhages, with devastating consequences for the patients and their families. Since the development of microcatheters and materials used for endovascular embolization, we have witnessed a rapid advancement in the technology and in the number or patients treated with this approach. The aim of this review is to survey recent data relevant t...
  • Estimation of 6-Degree-of-Freedom (6-DOF) Rigid-Body Patient Motion From Projection Data by the Principal-Axes Method in Iterative Reconstruction

    November 01, 2006
    Author(s): Bing Feng, Michael A. King
    Source: IEEE transactions on nuclear science
    We developed a unique method for estimating and compensating rigid-body translations and rotations from scatter and-attenuation-compensated projection data in iterative reconstruction when multiple projection angles are acquired at the same time. During reconstruction, both the non-attenuated and attenuated line-integrals are calculated. Their ratios are then multiplied to the scatter-corrected projection data to estimate sc...
  • Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice

    October 06, 2006
    Author(s): Guozheng Liu, Shuping Dou, Jiang He, Xinrong Liu, Mary Rusckowski, Donald J. Hnatowich
    Source: European journal of nuclear medicine and molecular imaging
    PURPOSE: Pretargeting with phosphorodiamidate morpholino oligomers (MORFs) involves administration of a MORF-conjugated anti-tumor antibody such as MN14 as a pretargeting agent before that of the radiolabeled complementary MORF (cMORF) as the effector. The dosages of the pretargeting agent and effector, the pretargeting interval, and the detection time are the four pretargeting variables. The goal of this study was to develo...
  • Successful radiotherapy of tumor in pretargeted mice by 188Re-radiolabeled phosphorodiamidate morpholino oligomer, a synthetic DNA analogue

    August 18, 2006
    Author(s): Guozheng Liu, Shuping Dou, George Mardirossian, Jiang He, Surong Zhang, Xinrong Liu, Mary Rusckowski, Donald J. Hnatowich
    Source: Clinical cancer research : an official journal of the American Association for Cancer Research
    PURPOSE: Pretargeting has been attracting increasing attention as a drug delivery approach. We recently proposed Watson-Crick pairing of phosphorodiamidate morpholino oligomers (MORF) for the recognition system in tumor pretargeting. MORF pretargeting involves the initial i.v. injection of a MORF-conjugated antitumor antibody and the subsequent i.v. injection of the radiolabeled complement. Our laboratory has reported on MOR...
  • Radiolabeling of MAG3-morpholino oligomers with 188Re at high labeling efficiency and specific radioactivity for tumor pretargeting

    May 30, 2006
    Author(s): Guozheng Liu, Shuping Dou, Jiang He, Dongguang Yin, Suresh Gupta, Surong Zhang, Yi Wang, Mary Rusckowski, Donald J. Hnatowich
    Source: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
    We are investigating a novel pretargeting approach involving an initial IV injection of antitumor antibody conjugated with a phosphorodiamidate morpholino oligomer (MORF, a DNA analog) and the subsequent IV injection of the radiolabeled complement oligomer (cMORF). In this paper, the cMORF was labeled with (188)Re using MAG(3) as chelator for therapeutic applications. Since (c)MORFs are unstable in acidic condition, an optim...
  • Adult intestinal intussusception: CT appearances and identification of a causative lead point

    May 17, 2006
    Author(s): Young H. Kim, Michael A. Blake, Mukesh G. Harisinghani, Krystal Archer-Arroyo, Peter F. Hahn, Martha B. Pitman, Peter R. Mueller
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    The widespread application of computed tomography (CT) in different clinical situations has increased the detection of intussusception, particularly non-lead point intussusception, which tends to be transient. Consequently, determining the clinical significance of intussusception seen at CT poses a diagnostic challenge. Patients with intussusception may or may not be symptomatic, and symptoms can be acute, intermittent, or c...
  • Initial mechanistic studies of antisense targeting in cells

    February 04, 2006
    Author(s): Xinrong Liu, Kayoko Nakamura, Yi Wang, Yee Wang, Guozheng Liu, Jiang He, Hongliu Ding, Peiyuan Lu, Mary Rusckowski, Atsushi Kubo, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    The continued development of antisense targeting will require a better understanding of the mechanism. METHODS: We performed initial studies of the mechanism of intracellular antisense targeting through measurements of in situ transcription, immunofluorescence, reverse transcription polymerase chain reaction (RT-PCR), 32P-labeled uridine-5'-triphosphate (alpha-32P-UTP) incorporation, nuclear accumulations of 99mTc-labeled DN...
  • Acute epiploic appendagitis and its mimics

    November 15, 2005
    Author(s): Ajay K. Singh, Debra A. Gervais, Peter F. Hahn, Pallavi Sagar, Peter R. Mueller, Robert A. Novelline
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    Acute epiploic appendagitis most commonly manifests with acute lower quadrant pain. Its clinical features are similar to those of acute diverticulitis or, less commonly, acute appendicitis. The conditions that may mimic acute epiploic appendagitis at computed tomography (CT) include acute omental infarction, mesenteric panniculitis, fat-containing tumor, and primary and secondary acute inflammatory processes in the large bow...
  • Detection of early antiangiogenic effects in human colon adenocarcinoma xenografts: in vivo changes of tumor blood volume in response to experimental VEGFR tyrosine kinase inhibitor

    October 19, 2005
    Author(s): Young Ro Kim, Anna Yudina, Joseluis Figueiredo, Wilfried Reichardt, Dana D. Hu-Lowe, Alexander Petrovsky, Hye won Kang, Denise Torres, Umar Mahmood, Ralph Weissleder, Alexei A. Bogdanov Jr.
    Source: Cancer research
    Antiangiogenesis is emerging as efficient strategy for targeting and potentially eliminating neoplastic tumor vessels. The main goal of this study was to establish whether absolute tumor blood volume (V(b)) change could be used as an early predictor of antiangiogenesis in ectopic and orthotopic colon carcinomas. To assess therapy-induced changes of V(b), we did comparative analysis of signal intensities in tumors and muscle ...
  • Further investigations of morpholino pretargeting in mice--establishing quantitative relations in tumor

    September 01, 2005
    Author(s): Guozheng Liu, Jiang He, Shuping Dou, Suresh Gupta, Mary Rusckowski, Donald J. Hnatowich
    Source: European journal of nuclear medicine and molecular imaging
    PURPOSE: This laboratory has previously published on phosphorodiamidate morpholino (MORF) pretargeting of tumor in which an anti-tumor antibody conjugated with MORF (a DNA analogue) is first administered, followed at a later time by the radiolabeled complementary MORF (cMORF) as the effector. In the present study, the pharmacokinetics of the antibody and effector were measured under different conditions in mice to establish ...
  • Polyglycolide/polylactide-coated platinum coils for patients with ruptured and unruptured cerebral aneurysms: a single-center experience

    July 30, 2005
    Author(s): Italo Linfante, Nabil M. Akkawi, Alain Perlow, Vincenzo Andreone, Ajay K. Wakhloo
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: Recanalization of cerebral aneurysm is a limitation of bare platinum coils (BPCs). In a swine aneurysm model, polyglycolide/polylactide (a polymer)-coated platinum coils (Matrix) accelerated clot fibrosis and reduced recanalization rate and aneurysmal volume. We aimed to evaluate the safety of Matrix coils in patients with intracranial aneurysm. METHODS: This is a single-center, prospective study of p...
  • Imaging diagnosis of cystic pancreatic lesions: pseudocyst versus nonpseudocyst

    May 13, 2005
    Author(s): Young H. Kim, Sanjay Saini, Dushant Sahani, Peter F. Hahn, Peter R. Mueller, Yong H. Auh
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    Although the clinical, radiologic, and pathologic features of cystic pancreatic lesions are well known, preoperative diagnosis is difficult. Differentiation between a pancreatic pseudocyst and a cystic pancreatic neoplasm is crucial in determining the proper treatment. Careful evaluation of the patient's clinical history is important for accurate diagnosis of a pseudocyst. Clinical scenarios include a pseudocyst developing a...
  • Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution

    May 03, 2005
    Author(s): Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, Timothy Q. Duong, Marc Fisher
    Source: Brain research
    High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of normal, ischemic, and at-risk tissue. We compared the capability of low (400 x 400 microm(2)) and high (200 x 200 microm(2)) spatial resolution imaging in characterizing the spatiotemporal evolution of the ischemic lesion in a permanent middle artery occlusion (MCAO) model in rats. Serial measurem...
  • Transpulmonary CT-guided radiofrequency ablation of liver metastasis

    May 01, 2005
    Author(s): Sridhar Shankar, Pankaj Bhargava, Farajallah Habib, Manisha S. Desai, Girish Tyagi, Giles F. Whalen
    Source: Cardiovascular and interventional radiology
    The percutaneous approach for RF ablation of liver lesions high up in the dome is always difficult. The authors describe a transpulmonary approach that may be simpler and safer to use.
  • Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging

    March 31, 2005
    Author(s): Erica C. Henning, Xiangjun Meng, Marc Fisher, Christopher H. Sotak
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex relative to the contralateral control region was 60 +/- 30% following two KCl applications. MEMRI signal increase for a single (40%) versus double (80%) KCl application suggests an integration effect over successive CSD episodes...
  • Best cases from the AFIP: intrarenal teratoma

    March 31, 2005
    Author(s): David J. Choi, E. Christine Wallace, Armando E. Fraire, Daniel Baiyee
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
  • Regulation and Function of Runx2 During Chondrogenic and Osteogenic Differentiation: a Dissertation

    December 02, 2004
    Author(s): Christopher J. Lengner
    Source: GSBS Dissertations and Theses
    Members of the Runx family of transcription factors play essential roles in the differentiation and development of several organ systems. Here we address the contribution of the osteoblast-related Runx gene, Runx2, to the osteogenic and chondrogenic differentiation of mesenchymal stem cells. Using a transgenic mouse model, we observe Runx2 transcription through one of its two known promoters (designated P1 in pre-cartilagino...
  • Preparation and properties of 99mTc(CO)3+-labeled N,N-bis(2-pyridylmethyl)-4-aminobutyric acid

    November 18, 2004
    Author(s): Guozheng Liu, Shuping Dou, Jiang He, Jean-Luc Vanderheyden, Mary Rusckowski, Donald J. Hnatowich
    Source: Bioconjugate chemistry
    Labeling biomolecules with (99m)Tc(CO)(3)(+) ((99m)Tc tricarbonyl) is attracting increasing attention. Although histidine is often considered an ideal bifunctional chelator for (99m)Tc (or (188)Re) tricarbonyl, the family of dipicolylamine carboxylate chelators may be a useful alternative because of the expected ease of synthesis and because the structure provides a pendent carboxylate for potential conjugation to biomolecul...
  • Combined radiofrequency and alcohol injection for percutaneous hepatic tumor ablation

    October 27, 2004
    Author(s): Sridhar Shankar, Eric vanSonnenberg, Paul R. Morrison, Kemal Tuncali, Stuart G. Silverman
    Source: AJR. American journal of roentgenology
    OBJECTIVE: We sought to determine if alcohol potentiates radiofrequency energy by obtaining larger ablative volumes in 30 liver tumors in human patients. SUBJECTS AND METHODS: We compared two groups of patients: one group treated with radiofrequency ablation alone (radiofrequency-alone group), and a second group treated with radiofrequency ablation and immediate prior injection of alcohol (combined group). The radiofrequency...
  • Investigations of a (99m)Tc-labeled bacteriophage as a potential infection-specific imaging agent

    July 06, 2004
    Author(s): Mary Rusckowski, Suresh Gupta, Guozheng Liu, Shuping Dou, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Because bacteriophages (phages) have a natural specificity for bacteria, it may be possible to develop radiolabeled phages as infection-specific agents. METHODS: The M13 phage was radiolabeled with (99m)Tc via mercaptoacetyltriglycine and purified by polyethylene glycol precipitation. After radiolabeling, the phage was tested for binding at 1, 5, and 10 min to Escherichia coli strain 2537, E. coli strain 25922, and Staphyloc...
  • Amplification targeting: a modified pretargeting approach with potential for signal amplification-proof of a concept

    June 08, 2004
    Author(s): Jiang He, Guozheng Liu, Suresh Gupta, Yumin Zhang, Mary Rusckowski, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Conventional nuclear medicine imaging with large radiolabeled molecules such as antitumor antibodies suffers from slow localization and clearance. Pretargeting is under active investigation as an alternative using either (strept)avidin/biotin, bispecific antibodies, or oligomers. However, only the use of oligomers such as phosphorodiamidate morpholinos (MORFs) in pretargeting offers the potential of signal amplification at t...
  • Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats

    June 03, 2004
    Author(s): Mark Kazemi, Matthew D. Silva, Fuhai Li, Marc Fisher, Christopher H. Sotak
    Source: Magnetic resonance imaging
    Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative surrogate end-point for investigating the efficacy of drug treatment or studying the temporal evolution of cerebral ischemia. Methodology is described for estimating ischemic lesion volumes in a rat model of permanent middle cerebral artery occlusion (MCAO) based on absolute and percent-reduction thre...
  • Microsphere-induced embolic stroke: an MRI study

    June 02, 2004
    Author(s): Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Marc Fisher, Yoram Cohen, Christopher H. Sotak
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for stroke is still lacking, emphasizing the need for further development and characterization of experimental stroke models. In the present study, the rather unexplored multifocal microsphere-induced stroke model in rats was characterized by multiparametric MRI. We induced microembolic infarction in a group of Sprague-Dawley rat...
  • Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging

    March 01, 2004
    Author(s): Qiang Shen, Marc Fisher, Christopher H. Sotak, Timothy Q. Duong
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain injury in rats were evaluated on a pixel-by-pixel basis using quantitative cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) measurements every 30 minutes for 3 hours and compared to post-mortem histology at 24 hours. Four biologically relevant clusters were classified based on ADC (0.53 +/- 0.02 x 10mm/s...
  • Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia

    February 03, 2004
    Author(s): Xiangjun Meng, Marc Fisher, Qiang Shen, Christopher H. Sotak, Timothy Q. Duong
    Source: Annals of neurology
    Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke patients. The PWI volume is typically substantially larger than the DWI volume shortly after onset, that is, a diffusion/ perfusion mismatch. The aims of this study were to follow the evolution of the diffusion/ perfusion mismatch in permanent and 60- minute temporary focal experimental ischemia models in...
  • Chlamydomonas Reinhardtii ODA5 Encodes an Axonemal Protein Required for Assembly of the Outer Dynein Arm and an Associated Flagellar Adenylate Kinase: A Dissertation

    January 22, 2004
    Author(s): Maureen Wirschell
    Source: GSBS Dissertations and Theses
    The first type of dynein identified, axonemel dynein (Gibbons and Rowe, 1965), slides adjacent microtubules within the axoneme, generating the force necessary for ciliary and flagellar beating. The outer dynein arm is an important component of the flagellar axoneme, providing up to 60% of the force for flagellar motility. In the absence of the outer arm, cells swim with a slow-jerky motion at about 1/3rd the speed of wild-ty...
  • Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging

    December 01, 2003
    Author(s): Qiang Shen, Xiangjun Meng, Marc Fisher, Christopher H. Sotak, Timothy Q. Duong
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion and diffusion magnetic resonance imaging every 30 minutes for 3 hours. The normal left-hemisphere apparent diffusion coefficient (ADC) was 0.76 +/- 0.03 x 10(-3) mm(2)/s and CBF was 0.7 +/- 0.3 mL x g(-1) x min(-1) (mean +/- SD, n=5). The ADC and CBF viability thresholds yielding the lesion ...
  • Human-observer receiver-operating-characteristic evaluation of attenuation, scatter, and resolution compensation strategies for (99m)Tc myocardial perfusion imaging

    November 07, 2003
    Author(s): Manoj V. Narayanan, Michael A. King, P. Hendrik Pretorius, Seth T. Dahlberg, Frederick A. Spencer, Ellen Simon, Eric Ewald, Edward C. Healy, Kirk MacNaught, Jeffrey A. Leppo
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Nonuniform attenuation, scatter, and distance-dependent resolution are confounding factors inherent in SPECT imaging. Iterative reconstruction algorithms permit modeling and compensation of these degradations. We investigated through human-observer receiver-operating-characteristic (ROC) studies which (if any) combination of such compensation strategies best improves the accuracy of detection of coronary artery disease (CAD)...
  • F-actin and myosin II binding domains in supervillin

    August 15, 2003
    Author(s): Yu Chen, Norio Takizawa, Jessica Lynn Crowley, Sang W. Oh, Cheryl Lynn Gatto, Taketoshi Kambara, Osamu Sato, Xiang-Dong Li, Mitsuo Ikebe, Elizabeth J. Luna
    Source: The Journal of biological chemistry
    Detergent-resistant membranes contain signaling and integral membrane proteins that organize cholesterol-rich domains called lipid rafts. A subset of these detergent-resistant membranes (DRM-H) exhibits a higher buoyant density ( approximately 1.16 g/ml) because of association with membrane skeleton proteins, including actin, myosin II, myosin 1G, fodrin, and an actin- and membrane-binding protein called supervillin (Nebl, T...
  • Involvement of CDP/Cux in the Regulation of Histone H4 Gene Expression, Proliferation and Differentiation: a Dissertation

    May 07, 2003
    Author(s): Mai X. Luong
    Source: GSBS Dissertations and Theses
    Proliferation and differentiation are essential processes for the growth and development of higher eukaryotic organisms. Regulation of gene expression is essential for control of cell division and differentiation. Normal eukaryotic cells have a limited proliferative capacity, and ultimately undergo cellular senescence and apoptosis. Terminal differentiation of cells is associated with loss of proliferative capacity and acqui...
  • Intranuclear Trafficking of RUNX/AML/CBFA/PEBP2 Transcription Factors in Living Cells: A Dissertation

    March 28, 2003
    Author(s): Kimberly Stacy Harrington
    Source: GSBS Dissertations and Theses
    The family of runt related transcription factors (RUNX/Cbfa/AML/PEBP2) are essential for cellular differentiation and fetal development. RUNX factors are distributed throughout the nucleus in punctate foci that are associated with the nuclear matrix/scaffold and generally correspond with sites of active transcription. Truncations of RUNX proteins that eliminate the C-terminus including a 31-amino acid segment designated the ...
  • The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats

    February 08, 2003
    Author(s): Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, Christopher H. Sotak, Marc Fisher
    Source: Journal of neuroscience methods
    BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for the simulation of focal cerebral ischemia in rats. This technique causes hypothalamic injury resulting in hyperthermia, which can worsen outcome and obscure neuroprotective effects. Herein, we introduce a new MCAO model that avoids these disadvantages. METHODS: Permanent MCAO was performed by intraarterial embolization using s...
  • Flat-panel digital mammography system: contrast-detail comparison between screen-film radiographs and hard-copy images

    December 04, 2002
    Author(s): Sankararaman Suryanarayanan, Andrew Karellas, Srinivasan Vedantham, Hetal Ved, Stephen P. Baker, Carl J. D'Orsi
    Source: Radiology
    PURPOSE: To compare the contrast-detail (CD) characteristics of screen-film (SF) and postprocessed digital images by using a phantom-based method. MATERIALS AND METHODS: Images of a CD phantom with polymerized methyl methacrylate were acquired with SF and full-field digital mammography systems at matched exposure conditions. A four-alternative forced-choice experiment was conducted with seven observers participating in the s...
  • Mechanisms Contributing to Transcriptional Regulation and Chromatin Remodeling of the Bone Specific Osteocalcin Gene

    November 20, 2002
    Author(s): Soraya Elisa Gutierrez Gallegos
    Source: GSBS Dissertations and Theses
    Activation of tissue-specific genes is a tightly controlled process that normally involves the combined action of several transcription factors and transcriptional co-regulators. The bone-specific osteoca1cin gene (OC) has been used as a prototype to study both tissue-specific and hormonal responsiveness. In this study we have examined the role of Runx2, VDR and C/EBP factors in the regulation of OC gene transcription. Contr...
  • Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain

    November 01, 2002
    Author(s): Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, Marc Fisher, Christopher H. Sotak
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured in normal and ischemic rat brain. Selective T(1)-relaxation enhancement of the EC water, using intracerebroventricular (ICV) infusion of an NMR contrast reagent (CR), was used to separate the IC and EC signal contributions. In the CR-infused, normal brain (n = 4), T(1) = 235 +/- 10 ms and T(2) = 46 +/- 2 ...
  • Physiologic subperiosteal new bone formation: prevalence, distribution, and thickness in neonates and infants

    September 20, 2002
    Author(s): David S. Kwon, Melissa R. Spevak, Kenneth E. Fletcher, Paul K. Kleinman
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The objective of our study was to determine the prevalence, distribution, and thickness of physiologic subperiosteal new bone formation in neonates and infants. MATERIALS AND METHODS: High-detail postmortem skeletal radiologic surveys of 101 neonates and infants who had died from sudden infant death syndrome were reviewed. The average age at the time of death was 2.6 months (range, 2 weeks-8 months 2 weeks). The l...
  • Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog

    March 09, 2002
    Author(s): Guozheng Liu, Kennedy O. Mang'era, Ning Liu, Suresh Gupta, Mary Rusckowski, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Over the past several years, investigators in this laboratory and elsewhere have been studying tumor localization by pretargeting with streptavidin and biotin or with avidin and biotin. Despite encouraging results, difficulties related to endogenous biotin and the immunogenicities of streptavidin and avidin have made a search for alternative strategies sensible. Recently, we have considered the use of DNAs and peptide nuclei...
  • A comparison in monkeys of (99m)Tc labeled to a peptide by 4 methods

    December 26, 2001
    Author(s): Mary Rusckowski, Tong Qu, Suresh Gupta, Arthur C. Ley, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Although a number of different strategies for labeling peptides with (99m)Tc have been developed, only a few studies have compared the in vivo properties of (99m)Tc when attached to different chelators. Furthermore, these comparisons are usually in mice, whereas results obtained in nonhuman primates may be expected to be more relevant to the clinical situation. METHODS: We evaluated the influence of 4 common chelators on the...
  • In vitro investigations of tumor targeting with (99m)Tc-labeled antisense DNA

    November 07, 2001
    Author(s): Yu-Min Zhang, Yi Wang, Ning Liu, Zhi-Hong Zhu, Mary Rusckowski, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    One objective of this investigation was to determine whether chemical modifications of oligonucleotides to permit radiolabeling with gamma- or positron emitters interferes with hybridization and target cell accumulation. A second objective was to establish to a reasonable extent whether cellular accumulation of radiolabeled oligonucleotides can be explained by an antisense mechanism. METHODS: An 18mer uniform phosphorothioat...
  • Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia

    August 01, 2001
    Author(s): Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, Marc Fisher, Joseph D. Fenstermacher
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue after cerebral artery occlusion. This acute drop is thought to be caused by the loss of extracellular fluid and the gain of intracellular fluid. To test the latter possibility, changes in ADC and the size of several cellular compartments were assessed in 3 regions of rat brain at the end of 90 minutes of focal cerebral ...
  • Evaluation of geometric sensitivity for hybrid PET

    July 05, 2001
    Author(s): Robert Z. Stodilka, Stephen J. Glick
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Hybrid PET systems have spatially varying sensitivity profiles. These profiles are dependent on imaging parameters, namely, number of heads, head configuration, spacing between gantry stops, radius of rotation (RoR), and coincident head acceptance angle. METHODS: Sensitivity profiles were calculated across a 500-mm field of view (FoV) for a representative set of existing and theoretic 2-, 3-, and 4-head hybrid PET systems. T...
  • Effect of various doses of recombinant human thyrotropin on the thyroid radioactive iodine uptake and serum levels of thyroid hormones and thyroglobulin in normal subjects

    April 12, 2001
    Author(s): Mira Sofia Torres, Luis Ramirez, Peter H. Simkin, Lewis E. Braverman, Charles H. Emerson
    Source: The Journal of clinical endocrinology and metabolism
    Recombinant human TSH (rhTSH), usually given as 0.9-mg doses im on 2 successive days, increases serum thyroglobulin (Tg) and radioactive iodine uptake (RAIU) in residual thyroid tissue in patients with thyroid cancer. We previously reported that a single, relatively low dose of rhTSH (0.1 mg im) is a potent stimulator of T(4), T(3), and Tg secretion in normal subjects. The present study describes the effects of higher doses ...
  • Evaluation of linear and nonlinear tomosynthetic reconstruction methods in digital mammography

    March 16, 2001
    Author(s): Sankararaman Suryanarayanan, Andrew Karellas, Srinivasan Vedantham, Stephen P. Baker, Stephen J. Glick, Carl J. D'Orsi, Richard L. Webber
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: The purpose of this study was to comparatively evaluate digital planar mammography and both linear and nonlinear tomosynthetic reconstruction methods. MATERIALS AND METHODS: A "disk" (ie, target) identification study was conducted to compare planar and reconstruction methods. Projective data using a composite phantom with circular disks were acquired in both planar and tomographic modes by using a f...
  • Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology

    February 07, 2001
    Author(s): Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Marc Fisher, Chung Y. Hsu, Weili Lin
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible. The purposes of this study were to determine whether resolution of initial DWI lesions is transient or permanent after different brief periods of focal brain ischemia and to evaluate histological outcomes. METHODS: Sixteen rats were subjected to 10 minutes (n=7) or 30 minutes (n=7) of temporary midd...
  • Superior vena cava syndrome secondary to an angiotropic large cell lymphoma

    January 03, 2001
    Author(s): Diane M. F. Savarese, Michael Zavarin, Mark S. Smyczynski, Michael J. Rohrer, Michael J. Hutzler
    Source: Cancer
    BACKGROUND: Angiotropic large cell lymphoma (ALCL) is characterized by the intravascular proliferation of malignant lymphoid cells in small and medium-sized blood vessels. In the current study, the authors report an unusual case in which the initial presentation of the ALCL was that of superior vena cava (SVC) syndrome. METHODS: The case is presented, followed by a general review of the literature regarding ALCL. RESULTS: Su...
  • Comparison of tomosynthesis methods used with digital mammography

    December 29, 2000
    Author(s): Sankararaman Suryanarayanan, Andrew Karellas, Srinivasan Vedantham, Stephen J. Glick, Carl J. D'Orsi, Stephen P. Baker, Richard L. Webber
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: The authors performed this study to investigate the potential applicability of tomosynthesis to digital mammography. Four methods of tomosynthesis-tuned aperture computed tomography (TACT)-backprojection, TACT-iterative restoration, iterative reconstruction with expectation maximization, and Bayesian smoothing-were compared to planar mammography and analyzed in terms of their contrast-detail charact...
  • Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat

    September 15, 2000
    Author(s): Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, Uwe Pschorn, Marc Fisher
    Source: Journal of the neurological sciences
    Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution of focal ischemic injury. We studied the effects of a novel, broad-spectrum inhibitor of several cation channels, LOE 908 MS, on acute ischemic lesion development with diffusion-weighted magnetic resonance imaging (DWI) and on cerebral perfusion with perfusion imaging (PI) in vivo and on cerebral infarct size using 2,3...
  • Comparing filtered backprojection and ordered-subsets expectation maximization for small-lesion detection and localization in 67Ga SPECT

    August 17, 2000
    Author(s): R. Glenn Wells, Michael A. King, Peter H. Simkin, Philip F. Judy, A. Bertrand Brill, Howard C. Gifford, Robert Licho, P. Hendrik Pretorius, Peter B. Schneider, David W. Seldin
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Iterative reconstruction of SPECT images has recently become clinically available as an alternative to filtered backprojection (FBP). However, there is conflicting evidence on whether iterative reconstruction, such as with the ordered-subsets expectation maximization (OSEM) algorithm, improves diagnostic performance over FBP. The study objective was to determine if the detection and localization of small lesions in simulated...
  • Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats

    August 12, 2000
    Author(s): Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, Christopher H. Sotak, Marc Fisher
    Source: Annals of neurology
    This study was designed to characterize the initial and secondary changes of the apparent diffusion coefficient (ADC) of water with high temporal resolution measurements of ADC values and to correlate ADC changes with functional outcomes. Fourteen rats underwent 30 minutes of temporary middle cerebral artery occlusion (MCAO). Diffusion-, perfusion-, and T2-weighted imaging was performed during MCAO and every 30 minutes for a...
  • Experience with endoluminal colonic wall stents for the management of large bowel obstruction for benign and malignant disease

    April 18, 2000
    Author(s): Wael Z. Tamim, Ali Ghallai, Timothy C. Counihan, Richard S. Swanson, Jay M. Colby, W. Brian Sweeney
    Source: Archives of surgery (Chicago, Ill. : 1960)
    HYPOTHESIS: To assess the applicability and efficacy of endoluminal colonic wall stents (ECWSs) in the management of large bowel obstruction (LBO). DESIGN: Inception cohort study. SETTING: University-based tertiary medical center. PATIENTS: Eleven consecutive patients with LBO in the absence of peritonitis. INTERVENTION: Placement of ECWS under endoscopic and fluoroscopic guidance. MAIN OUTCOME MEASURES: The success rate in ...
  • Channelized hotelling and human observer correlation for lesion detection in hepatic SPECT imaging

    March 15, 2000
    Author(s): Howard C. Gifford, Michael A. King, Daniel J. de Vries, Edward J. Soares
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Mathematic "model" observers that predict human performance are of interest in medical imaging as substitutes in psychophysical studies. We have examined the correlations between human observers and several forms of the channelized Hotelling observer (CHO) for a tumor detection task with simulated SPECT liver images that were used to study the effects of scatter and scatter correction on detection. METHODS: A receiver operat...
  • Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys

    February 25, 2000
    Author(s): Mary Rusckowski, Tong Qu, James M. Pullman, Robin Marcel, Arthur C. Ley, Robert C. Ladner, Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    A radiolabeled human neutrophil elastase inhibitor (EPI-HNE-2) may represent an improved nuclear medicine imaging agent for inflammation and infection. This peptide displays rapid pharmacokinetics due to its low molecular weight and localizes specifically on neutrophil elastase released in inflammatory sites by activated neutrophils. METHODS: In this investigation, the peptide was radiolabeled with 99mTc using N-hydroxysucci...
  • Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI

    February 08, 2000
    Author(s): Fuhai Li, Matthew D. Silva, Christopher H. Sotak, Marc Fisher
    Source: Neurology
    OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within minutes after the onset of ischemia. This study was designed to determine whether acute reversibility of DWI abnormalities is transient following brief temporary focal brain ischemia and to characterize the temporal evolution of in vivo ischemic lesions. METHODS: Eight rats were subjected to 30 minutes of te...
  • Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats

    September 11, 1999
    Author(s): Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, Christopher H. Sotak, Marc Fisher
    Source: Annals of neurology
    Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral artery occlusion (n = 5 per group) or sham occlusion (n = 2) in the magnetic resonance imaging unit. Diffusion-, perfusion-, and T2-weighted imaging were acquired before and during occlusion, and after reperfusion. A coregistration method was used to correlate the acute changes of the average apparent diffusion coefficient (ADCav) with th...
  • Effects of scatter substraction on detection and quantitation in hepatic SPECT

    August 19, 1999
    Author(s): Daniel J. de Vries, Michael A. King, Edward J. Soares, Benjamin M. W. Tsui, Charles E. Metz
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    The purpose of this investigation was to examine the effects of subtractive scatter compensation methods on lesion detection and quantitation. METHODS: Receiver operating characteristic (ROC) methodology was used to measure human observer detection accuracy for tumors in the liver using synthetic images. Furthermore, ROC results were compared with mathematical models for detection and activity quantitation to examine (a) the...
  • Imaging brain activity in conscious animals using functional MRI

    May 01, 1999
    Author(s): Katariina M. Lahti, Craig F. Ferris, Fuhai Li, Christopher H. Sotak, Jean A. King
    Source: Journal of neuroscience methods
    Functional magnetic resonance imaging (fMRI) in humans has helped improve our understanding of the neuroanatomical organization of behavior. Unfortunately, fMRI in animal studies has not kept pace with the human work. Experiments are limited because animals must be anesthetized to prevent motion artifacts, precluding most studies involving neuroimaging of brain activity during behavior. The present study tested a newly devel...
  • Antisense and nuclear medicine

    April 21, 1999
    Author(s): Donald J. Hnatowich
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Despite many uncertainties concerning mechanism, synthetic single-strand antisense deoxyribonucleic acids (DNAs) are now in clinical trials for the chemotherapy of viral infections such as human immunodeficiency virus (HIV) and human papilloma virus; several cancers, including follicular lymphoma and acute myelogenous leukemia; inflammatory processes such as Crohn's disease and rheumatoid arthritis and in allergic disorders....
  • Bone SPECT of the spine: a comparison of attenuation correction techniques

    April 21, 1999
    Author(s): James A. Case, Robert Licho, Michael A. King, John P. Weaver
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Image artifacts from variable self-attenuation are recognized as major sources of diagnostic uncertainty in SPECT. For myocardial perfusion studies, an attenuation map is often obtained from a separate transmission study. However, for many applications such as bone SPECT, it has been believed to be unnecessary to obtain a transmission study to correct for the effects of attenuation. We have had significant success in clinica...
  • Pretargeting of bacterial endocarditis in rats with streptavidin and 111In-labeled biotin

    March 23, 1999
    Author(s): Miklos C. Fogarasi, James M. Pullman, Paul T. Winnard, Donald J. Hnatowich, Mary Rusckowski
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    A radioimaging approach for the detection of endocarditis has been investigated using two-step pretargeting with streptavidin and radiolabeled biotin. METHODS: Hemodynamic alterations within the rat heart were induced by placing an in-dwelling catheter into the left ventricle through the aortic valves. The animals were subsequently infected with Staphylococcus aureus through a tail vein. After an incubation period, rats were...
  • Attenuation compensation in 99mTc SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans

    March 23, 1999
    Author(s): Robert Licho, Stephen J. Glick, Weishi Xia, Tin-Su Pan, Bill C. Penney, Michael A. King
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Brain SPECT imaging using 99mTc lipophilic tracers such as hexamethyl propyleneamine oxime (HMPAO) attempts to estimate cerebral, cerebellar and subcortical perfusion by assessing the relative amount of tracer uptake among these regions. Most commonly, comparison is made with cerebellar activity. Because the assessment of relative tracer uptake may be rendered inaccurate by photon attenuation by the nonuniform attenuation pr...
  • Comparison of evoked cortical activity in conscious and propofol-anesthetized rats using functional MRI

    March 18, 1999
    Author(s): Katariina M. Lahti, Craig F. Ferris, Fuhai Li, Christopher H. Sotak, Jean A. King
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    Changes in cortical activity during foot shock were assessed under conscious and propofol-anesthetized conditions using functional magnetic resonance imaging (fMRI). Increases in signal intensity were observed in the contralateral somatosensory cortex in response to electrical shock of the hindpaw under both conditions. These increases in cortical signal ranged from 6% to 26% while awake and from 1% to 6% under propofol anes...
  • Determination of focal ischemic lesion volume in the rat brain using multispectral analysis

    December 16, 1998
    Author(s): Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, Marc Fisher, Christopher H. Sotak
    Source: Journal of magnetic resonance imaging : JMRI
    Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain after permanent middle cerebral arterial occlusion. MS analysis used a four-dimensional MS model consisting of an estimate of the average apparent diffusion coefficient of water (ADC(av)), T2, proton density, and perfusion. Four classification methods were investigated: (a) multivariate gaussian (MVG); (b) k-nearest neighbor (k-NN);...
  • The postpneumonectomy state

    October 29, 1998
    Author(s): Scott E. Kopec, Richard S. Irwin, Cynthia B. Umali, Jerry P. Balikian, A. Alan Conlan
    Source: Chest
  • Transcriptional Regulation of a Human H4 Histone Gene is Mediated by Multiple Elements Interacting with Similar Transcription Factors: A Dissertation

    May 01, 1998
    Author(s): Thomas J. Last
    Source: GSBS Dissertations and Theses
    Synthesis of histone proteins occurs largely during the S phase of the cell cycle and coincides with DNA replication to provide adequate amounts of histones necessary to properly package newly replicated DNA. Controlling transcription from cell cycle dependent and proliferation specific genes, including histone H4, is an important level of regulation in the overall governance of the cell growth process. Coordination of histo...
  • Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging

    April 01, 1998
    Author(s): Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, H. D. Kleinert, Marc Fisher
    Source: Neurology
    OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and i.v. delivery in a rat embolic stroke model, using diffusion (DWI) and perfusion (PI) magnetic resonance imaging to assess in vivo effects on ischemic lesion evolution and reperfusion. BACKGROUND: Thrombolytic therapy with recombinant tissue-type plasminogen activator (rt-PA) for acute ischemic stroke is usef...
  • Tracheal bronchus: a cause of prolonged atelectasis in intubated children

    February 14, 1998
    Author(s): Brian P. O'Sullivan, Joseph J. Frassica, Shawn M. Rayder
    Source: Chest
    Tracheal bronchus is a common anomaly that occurs in approximately 2% of people. Two children with multiple medical problems which led to endotracheal intubation are described. The hospital course for each child was complicated by persistent right upper lobe atelectasis. The presence of a tracheal bronchus was not recognized in either case initially; identification of this anatomic variant allowed appropriate changes in airw...
  • A regional approach to the classic metaphyseal lesion in abused infants: the distal femur

    January 10, 1998
    Author(s): Paul K. Kleinman, Sandy C. Marks, Jr.
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to analyze the spectrum of morphologic alterations of the classic metaphyseal lesion involving the distal femur of abused infants and to identify features that aid in radiologic diagnosis and assessment of healing. MATERIALS AND METHODS: Thirty-one infants who died with evidence of inflicted skeletal injury were studied with high-detail skeletal surveys, resected specimen radiography,...
  • Pretargeting with Amplification Using Polymeric Peptide Nucleic Acid

    December 24, 1997
    Author(s): Mary Rusckowski, Timothy Qu, F. Chang, Donald J. Hnatowich
    Source: Cancer
    One goal of this investigation was to develop a polymer conjugated with multiple copies of peptide nucleic acid (PNA) and with pharmacokinetic properties suitable for applications in vivo. The second goal was to establish whether the multiple copies of PNA on the polymer could be targeted by hybridization in vitro and in vivo with 99mTc-labeled complementary PNA (cPNA). If successful, this approach could then be considered i...
  • Early results in the irrational design of new bifunctional chelators

    December 24, 1997
    Author(s): F. Chang, Mary Rusckowski, Timothy Qu, Donald J. Hnatowich
    Source: Cancer
    BACKGROUND: The development of a simple route for the synthesis of the N-hydroxysuccinimide (NHS) ester of S-acetyl-protected mercaptoacetyltriglycine (MAG3) has opened the possibility of preparing novel bifunctional N3S chelators for technetium-99m (99mTc) and other radionuclides. In particular, the synthesis may be applied to a vast number of tripeptides in place of triglycine, to provide a "library" of bifunctional N3S ch...
  • Evaluation of right and left ventricular volume and ejection fraction using a mathematical cardiac torso phantom

    October 23, 1997
    Author(s): P. Hendrik Pretorius, Weishi Xia, Michael A. King, Benjamin M. W. Tsui, Tin-Su Pan, Bernard J. Villegas
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    The availability of gated SPECT has increased the interest in the determination of volume and ejection fraction of the left ventricle (LV) for clinical diagnosis. However, the same indices for the right ventricle (RV) have been neglected. The objective of this investigation was to use a mathematical model of the anatomical distribution of activity in gated blood-pool imaging to evaluate the accuracy of two ventricular volume...
  • Bilateral anaerobic empyemas complicating infectious mononucleosis

    October 07, 1997
    Author(s): Scott E. Kopec, Richard S. Irwin, Curtis J. Mello, Cynthia B. Umali
    Source: Chest
  • Critical uses of intraoperative gynecologic sonography

    August 01, 1997
    Author(s): Karen L. Reuter
    Source: AJR. American journal of roentgenology
  • Fractures of the hands and feet in child abuse: imaging and pathologic features

    April 01, 1997
    Author(s): Katherine Nimkin, Melissa R. Spevak, Paul K. Kleinman
    Source: Radiology
    PURPOSE: To determine the imaging and histopathologic appearance of fractures of the hands and feet in abused infants. MATERIALS AND METHODS: The imaging findings in 11 abused infants with fractures of the hands and feet were examined retrospectively. All 11 infants underwent skeletal surveys; five infants also underwent nuclear bone scanning. Postmortem radiographs of the specimen and histopathologic data were available in ...
  • A regional approach to the classic metaphyseal lesion in abused infants: the proximal humerus

    December 01, 1996
    Author(s): Paul K. Kleinman, Sandy C. Marks, Jr.
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to systematically analyze the spectrum of morphologic alterations of the classic metaphyseal lesion (CML) involving the proximal humerus of abused infants and to identify radiologic features that aid in the diagnosis and assessment of healing. MATERIALS AND METHODS: Thirty-one infants who died with evidence of inflicted skeletal injury were studied with high-detail skeletal surveys, r...
  • Follow-up skeletal surveys in suspected child abuse

    October 01, 1996
    Author(s): Paul K. Kleinman, Katherine Nimkin, Melissa R. Spevak, Shawn M. Rayder, Deborah L. Madansky, Yvonne A. Shelton, Miki M. Patterson
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to assess the additional yield of a repeat skeletal survey in identifying and dating skeletal injury for cases in which child abuse was strongly suspected. MATERIALS AND METHODS: Twenty-three infants and toddlers strongly suspected of being physically abused on the basis of findings on the initial skeletal survey, other imaging studies, history, or physical examination underwent a fol...
  • Thickened endometrial stripe and/or endometrial fluid as a marker of pathology: fact or fancy

    October 01, 1996
    Author(s): Sandra E. Brooks, M. Yeatts-Peterson, Stephen P. Baker, Karen L. Reuter
    Source: Gynecologic oncology
    OBJECTIVE: To evaluate the implication of a thickened endometrial stripe (ES) and endometrial fluid (EF) in postmenopausal women. METHODS: Between 1991 and 1995, 897 consecutive postmenopausal patients underwent pelvic ultrasound at our institution. Clinical and ultrasound data were reviewed for the 624 patients in whom a comprehensive evaluation of the uterus and adnexae was performed. Of this study group, 495 had normal ES...
  • Imaging osteomyelitis with streptavidin and indium-111-labeled biotin

    October 01, 1996
    Author(s): Mary Rusckowski, Giovanni Paganelli, Donald J. Hnatowich, Patrizia Magnani, F. Virzi, Miklos C. Fogarasi, C. DiLeo, Francesco Sudati, Ferruccio Fazio
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Animal studies of infection imaging by a two-step protocol have shown that important improvements in target to nontarget ratios are possible. In this protocol, unlabeled streptavidin is administered and allowed sufficient time to accumulate in the lesion, probably by nonspecific processes, and to clear elsewhere. Thereafter, 111Inbiotin is administered. A fraction of the labeled biotin may be retained in the lesion because o...
  • Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water

    September 01, 1996
    Author(s): Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, Christopher H. Sotak, Marc Fisher
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary severe hypoglycemia on the apparent diffusion coefficient (ADC) acquired by diffusion-weighted MRI of brain water with the use of serial multislice ADC mapping in rats. Severe hypoglycemia reduces the extracellular space volume, as does ischemia. Demonstrating a reduction of ADC with hypoglycemia should increase our understanding of the m...
  • Rib fractures in 31 abused infants: postmortem radiologic-histopathologic study

    September 01, 1996
    Author(s): Paul K. Kleinman, Sandy C. Marks, Katherine Nimkin, Shawn M. Rayder, Stanton C. Kessler
    Source: Radiology
    PURPOSE: To examine the morphologic alterations of fractures of the lateral and anterior rib arcs and costochondral junction (CCJ) to better understand the factors that influence radiographic visualization and to gain insight into the mechanism of injury in rib fractures of abused infants. MATERIALS AND METHODS: Thirty-one infants (average age, 3 months) who died with inflicted skeletal injuries were studied with high-detail...
  • Sonographic appearance of the endometrium and ovaries during cycles stimulated with human menopausal gonadotropin

    July 01, 1996
    Author(s): Karen L. Reuter, Stephen Cohen, Linda Furey, Stephen P. Baker
    Source: The Journal of reproductive medicine
    OBJECTIVE: To determine the measurable factors that correlated with a higher conception ratio in one of our subpopulations of infertility patients. STUDY DESIGN: We analyzed 58 menstrual cycles in 24 consecutive infertility patients treated only with human menopausal gonadotropin (hMG) and intrauterine insemination between January 1992 and February 1993 to compare those cycles leading to conception with those that did not wi...
  • Gadopentetate dimeglumine-enhanced MR imaging of subdural hematoma in an abused infant

    June 01, 1996
    Author(s): Paul K. Kleinman, Ronald L. Ragland
    Source: AJR. American journal of roentgenology
  • Thymic uptake of iodine-131 in the anterior mediastinum

    June 01, 1996
    Author(s): Irini E. Veronikis, Peter H. Simkin, Lewis E. Braverman
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Two thyroidectomized patients with a history of differentiated thyroid carcinoma are presented who had nonmetastatic mediastinal 131I uptake following therapeutic doses of 131I. Chest CT scans in both patients demonstrated an anterior mediastinal mass. Surgical excision in one patient and a percutaneous CT-guided fine needle aspiration biopsy in the other disclosed normal thymus tissue. Iodine-131 uptake in the anterior medi...
  • A regional approach to classic metaphyseal lesions in abused infants: the distal tibia

    May 01, 1996
    Author(s): Paul K. Kleinman, Sandy C. Marks, Jr.
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to analyze systematically the spectrum of morphologic alterations of classic metaphyseal lesions (CML) involving the distal tibia of abused infants and to identify features that assist in the radiologic diagnosis and assessment of healing. MATERIALS AND METHODS: Thirty-one infants who died with evidence of inflicted injury were studied with high-detailed skeletal surveys, resected-spe...
  • The American College of Radiology mammography lexicon: an initial attempt to standardize terminology

    April 01, 1996
    Author(s): Carl J. D'Orsi
    Source: AJR. American journal of roentgenology
  • The role of spreading depression in focal ischemia evaluated by diffusion mapping

    March 01, 1996
    Author(s): Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, Christopher H. Sotak, Marc Fisher
    Source: Annals of neurology
    This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution of focal ischemia in vivo. We induced focal ischemia in 12 rats using the middle cerebral artery suture occlusion (MCAO) method. Chemical stimulation of nonischemic ipsilateral cortex by potassium chloride application (KCl group; n = 7) and saline (NaCl group; n = 5) was performed at 15, 30, 45, and 60 minutes following MCA...
  • A regional approach to the classic metaphyseal lesion in abused infants: the proximal tibia

    February 01, 1996
    Author(s): Paul K. Kleinman, Sandy C. Marks, Jr.
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to systematically analyze the spectrum of morphologic alterations of the classic metaphyseal lesion (CML) involving the proximal tibia of abused infants and to identify features that aid in the radiologic diagnosis and assessment of healing. MATERIALS AND METHODS: Thirty-one infants who died with evidence of inflicted skeletal injury were studied with high-detail skeletal surveys, res...
  • Chromatin Structure of the Rat Osteocalcin Gene Promoter in Bone-Derived Cells

    November 15, 1995
    Author(s): Martin A. Montecino
    Source: GSBS Dissertations and Theses
    Transcription of the osteocalcin gene, which encodes a bone-specific 10 kDa protein, is controlled by the coordinated utilization of modularly organized basal and hormone-responsive enhancer elements. Activation of these sequences involves the interaction of specific transcription factors to these promoter elements. It is becoming increasingly accepted that nuclear architecture provides a basis for support of tightly regulat...
  • Inflicted skeletal injury: a postmortem radiologic-histopathologic study in 31 infants

    September 01, 1995
    Author(s): Paul K. Kleinman, Sandy C. Marks, Jr., Joann M. Richmond, Brian D. Blackbourne
    Source: AJR. American journal of roentgenology
    OBJECTIVE. The objective of this postmortem study was to use high-detail skeletal surveys, specimen radiography, and histopathologic analysis to determine the number, distribution, and age of inflicted skeletal injuries in infants studied at the University of Massachusetts Medical Center from 1984 to 1994. MATERIALS AND METHODS. Thirty-one infants (average age, 3 months) who died with inflicted skeletal injuries were studied...
  • Comparison of iodine-125-BMIPP and thallium-201 in myocardial hypoperfusion

    September 01, 1995
    Author(s): Christopher P. Reinhardt, Howard Weinstein, Robin Marcel, Jeffrey A. Leppo
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Radiolabeled fatty acids such as 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) have unique metabolic properties of potential use as myocardial perfusion tracers. Accordingly, we compared the in vivo pattern of uptake of BMIPP and 201Tl in hypoperfused rabbit myocardium. METHODS: Animals were intubated, ventilated and their arterial pressures monitored. A left thoracotomy was performed. After ligation of a major br...
  • Cortical blindness after correction of symptomatic hyponatremia: dynamic cerebral dysfunction visualized using serial SPECT scanning

    July 01, 1995
    Author(s): Catherine Hagerty, Robert Licho, Lawrence D. Recht
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    A 70-yr-old woman developed cortical blindness after correction of hyponatremia. Regional hyperperfusion was noted on SPECT scans obtained in the acute phase. One month later when symptoms had largely resolved, a repeat examination was normal. This regional hyperperfusion, which was not associated with any apparent structural damage, may have represented either luxury perfusion or a transient increased metabolic requirement ...
  • Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain

    March 01, 1995
    Author(s): Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, Christopher H. Sotak, Marc Fisher
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion coefficient (ADC) of water in eight contiguous coronal slices, encompassing the entire rat brain, before and after local cortical stimulation. We applied chemical (potassium chloride application; n = 6) and mechanical (needle stab; n = 4) stimulations to the right posterior parietal rat cortex. In ...
  • Management of the breast specimen

    February 01, 1995
    Author(s): Carl J. D'Orsi
    Source: Radiology
  • Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model

    January 01, 1995
    Author(s): W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, Christopher H. Sotak, Marc Fisher
    Source: Neurology
    Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset of ischemia. The use of a DWI echo-planar multislice technique in this study and the mapping of the apparent diffusion coefficient (ADC) of water, a reliable indicator of ischemic regions, allow for the detection of the three-dimensional (3-D) evolution of ischemia in a rat stroke model. We eval...
  • MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia

    August 01, 1994
    Author(s): Yasuhiro Hasegawa, Marc Fisher, Lawrence L. Latour, Bernard J. Dardzinski, Christopher H. Sotak
    Source: Neurology
    The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic insult is thought to reflect intracellular water accumulation (cytotoxic edema) related to high-energy metabolism failure and loss of ion homeostasis. We attempted to clarify whether varying ranges of ADC measurements in ischemic brain tissue can be used to differentiate between reversible and irreversible ischemic lesions befor...
  • Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain

    August 01, 1994
    Author(s): Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, Marc Fisher, Christopher H. Sotak
    Source: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
    A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading depression (SD) was elicited in rats by topical application of potassium chloride to the exposed cortex. The apparent diffusion coefficient (Dapp) of water in a region of the cortex, measured using a PFG-NMR spin echo sequence with an observation time of 40 ms, declines 35% within 30 s and recovers to the normal value...
  • Tailored low-dose fluoroscopic voiding cystourethrography for the reevaluation of vesicoureteral reflux in girls

    May 01, 1994
    Author(s): Paul K. Kleinman, David A. Diamond, Andrew Karellas, Melissa R. Spevak, Katherine Nimkin, Patricia L. Belanger
    Source: AJR. American journal of roentgenology
    OBJECTIVE. Radionuclide voiding cystography is generally advocated for the reevaluation of proved vesicoureteral reflux. The purpose of this study was to assess the efficacy of tailored low-dose fluoroscopic voiding cystourethrography for this purpose. SUBJECTS AND METHODS. Forty-five girls (2 years 9 months to 19 years 7 months old; mean, 7.4 years) who had proved reflux were examined with tailored low-dose voiding cystoure...
  • Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats

    May 01, 1994
    Author(s): Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, Bernard J. Dardzinski, Marc Fisher
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in brain tissue, the ADC values of normal rat brain were measured over a range of body temperatures with monitoring of head temperature using a small water reference implanted under the temporalis muscle. An initial experiment using thermocouples implanted into the cortex, caudate-putamen, temporalis muscle, and rectum demonstra...
  • Dipyridamole myocardial perfusion imaging

    April 01, 1994
    Author(s): Jeffrey A. Leppo
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Dipyridamole is a pharmacologic stressor used in place of exercise for myocardial perfusion imaging in patients who cannot exercise due to various physical limitations. Perfusion studies with dipyridamole can identify coronary artery disease (CAD) as accurately as maximal exercise stress testing. In addition, dipyridamole myocardial perfusion studies are useful to stratify patients according to risk of subsequent cardiac eve...
  • Surface coil MR imaging: utility of image intensity correction filter

    March 01, 1994
    Author(s): Nicholas D. Gelber, Ronald L. Ragland, John R. Knorr
    Source: AJR. American journal of roentgenology
  • Adrenal hemorrhage in abused children: imaging and postmortem findings

    March 01, 1994
    Author(s): Katherine Nimkin, Susan Teeger, Michael T. Wallach, John C. DuVally, Melissa R. Spevak, Paul K. Kleinman
    Source: AJR. American journal of roentgenology
    OBJECTIVE. Adrenal hemorrhage associated with child abuse has received little attention in published reports. We review imaging studies or pathologic findings of adrenal hemorrhage in five cases of proved child abuse. SUBJECTS AND METHODS. The imaging findings in three children with adrenal hemorrhage were analyzed retrospectively. All three had abdominal CT scans and skeletal radiographs. One also had abdominal sonograms an...
  • Investigations of ascorbate for direct labeling of antibodies with technetium-99m

    January 01, 1994
    Author(s): Donald J. Hnatowich, F. Virzi, Paul T. Winnard, M. Fogarasi, Mary Rusckowski
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Recently, a method for the direct labeling of antibodies with 99mTc was described in which sulfhydryls were reportedly generated by reduction of antibody disulfides with ascorbic acid. Thereafter, these proteins may be labeled at high efficiency with 99mTc following reduction of pertechnetate with dithionite. This investigation was initially conducted to evaluate the mechanism of the increased stability towards cysteine chal...
  • Effect of triphenyl tetrazolium chloride staining on the distribution of radiolabeled pharmaceuticals

    October 01, 1993
    Author(s): Christopher P. Reinhardt, Howard Weinstein, John Wironen, Jeffrey A. Leppo
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Myocardial tissue is routinely exposed to the vital stain triphenyl tetrazolium chloride (TTC) to delineate infarction in conjunction with myocardial isotope research. However, it is unknown whether TTC has a direct effect on tracer deposition. We evaluated this possibility in rabbit hearts injected with either teboroxime, sestamibi or 201Tl. The hearts were excised and treated as follows: (1) TTC or normal saline was perfus...
  • Myocardial extraction of technetium-99m-[2-(1-methoxybutyl) isonitrile] in the isolated rabbit heart: a myocardial perfusion agent with high extraction and stable retention

    June 01, 1993
    Author(s): Seth T. Dahlberg, Denis J. Meerdink, Madeleine P. Gilmore, Jeffrey A. Leppo
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Technetium-99m-[2-(1-methoxybutyl) isonitrile] (MBI) is a potential new compound for the scintigraphic imaging of coronary flow. Evaluation in the blood-perfused isolated rabbit heart model showed this compound to have a myocardial uptake comparable to 201Tl and higher than sestamibi. Although the mean +/- s.d. maximum extraction (Emax) and capillary permeability-surface area product (PScap) of 99mTc-MBI (Emax = 0.45 +/- 0.1...
  • A complication involving a braided hook-wire localization device

    May 01, 1993
    Author(s): Carl J. D'Orsi, Richard S. Swanson, Lawrence J. Moss, Frank R. Reale, Michael D. Wertheimer
    Source: Radiology
    At the authors' institution, needle localization of breast lesions with a braided hook wire involves the wire being cut 1-2 cm from the point of entry before dissection, to avoid contamination of the sterile field with the nonsterile portion of wire. During dissection, the wire is brought through the skin into the area of dissection. In one patient, fragments of wire filaments were left within the breast. Braided hook wires ...
  • Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI

    February 01, 1993
    Author(s): Kazuo Minematsu, Marc Fisher, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, Christopher H. Sotak
    Source: Neurology
    We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first 3 hours after permanent occlusion of the middle cerebral artery in rats. Using DWI as early as 30 minutes after the onset of ischemia, it was possible to identify the areas of brain destined to progress to infarction over the next 24 hours in untreated animals, as demonstrated by postmortem evaluation. DWI studies revealed t...
  • Directly and indirectly technetium-99m-labeled antibodies--a comparison of in vitro and animal in vivo properties

    January 01, 1993
    Author(s): Donald J. Hnatowich, George Mardirossian, Mary Rusckowski, M. Fogarasi, F. Virzi, Paul T. Winnard
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    To investigate the in vivo and in vitro properties of 99mTc when labeled to antibodies via one direct and one indirect method, the B72.3 and C110 IgG antibodies were radiolabeled directly via stannous ion reduction and indirectly via the hydrazino nicotinamide chelator and compared in vitro and in vivo. Antibody avidity (but not immunoreactive fraction) appeared to be independent of labeling methods for both antibodies. Foll...
  • Planar myocardial perfusion imaging with technetium-99m-teboroxime: comparison by vascular territory with thallium-201 and coronary angiography

    October 01, 1992
    Author(s): Seth T. Dahlberg, Howard Weinstein, Robert C. Hendel, Brenda A. McSherry, Jeffrey A. Leppo
    Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    Myocardial perfusion agents labeled with 99mTc offer improved physical imaging properties compared to 201TI. Teboroxime is a new 99mTc-labeled compound for myocardial perfusion imaging that shows a high myocardial extraction and rapid clearance. Sixty-seven patients underwent planar teboroxime imaging with a rapid acquisition protocol. Agreement of teboroxime and 201TI for the presence or absence of disease occurred in 56/65...
  • Fractures of the rib head in abused infants

    October 01, 1992
    Author(s): Paul K. Kleinman, Sandy C. Marks, Melissa R. Spevak, Joann M. Richmond
    Source: Radiology
    Fractures of the posterior ribs are well-recognized sequelae of infant abuse. Previous reports have indicated a predilection for fracture near the costotransverse process. This study expands the spectrum to include fractures involving the rib head. The radiologic and histologic features are described, and the mechanism of injury of this lesion is examined. In situ and specimen radiography, followed by histopathologic examina...
  • Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats

    September 01, 1992
    Author(s): Kazuo Minematsu, Limin Li, Christopher H. Sotak, Michael A. Davis, Marc Fisher
    Source: Stroke; a journal of cerebral circulation
    BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within minutes after the onset of ischemia. We performed the present study to determine the effects of 1 and 2 hours of temporary ischemia on DWI. METHODS: We examined DWI and T2-weighted magnetic resonance images (T2WI) during and after 1 and 2 hours of temporary middle cerebral artery occlusion i...
  • Reading and decision aids for improved accuracy and standardization of mammographic diagnosis

    September 01, 1992
    Author(s): Carl J. D'Orsi, David J. Getty, John A. Swets, Ronald M. Pickett, Steven E. Seltzer, Barbara J. McNeil
    Source: Radiology
    Image-reading and decision aids were designed to improve the accuracy of mammogram interpretation. The reading aid was a list of diagnostic radiographic features and scales for quantification of each feature. The decision aid, a computer program, converted the reader's scaled values, weighted for predictive power, into an advisory estimate of the probability of malignancy. The features were identified and their importance wa...
  • New magnetic resonance techniques for evaluating cerebrovascular disease

    August 01, 1992
    Author(s): Marc Fisher, Christopher H. Sotak, Kazuo Minematsu, Limin Li
    Source: Annals of neurology
    Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel MR technologies, now in preclinical and clinical development, will contribute to stroke diagnosis and perhaps help to guide therapy. MR angiography is the most clinically advanced new MR technology and offers the clinician a method to image noninvasively the extra- and intracranial vasculature. Diffusion-weighted MR i...
  • Mediastinal pseudocyst caused by pharyngeal perforation during child abuse

    May 01, 1992
    Author(s): Paul K. Kleinman, Melissa R. Spevak, Maynard C. Hansen
    Source: AJR. American journal of roentgenology
  • Intracranial metastatic adenoid cystic carcinoma: presumed hematogenous spread from a primary tumor in the parotid gland

    May 01, 1992
    Author(s): Nicholas D. Gelber, Ronald L. Ragland, John R. Knorr, Thomas W. Smith, Bernard B. Stone
    Source: AJR. American journal of roentgenology