Focus:Pathogenesis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.
Focus:High-resolution electron cryo-microscopy of macromolecular machines to understand their molecular mechanisms and the cellular processes they are involved in.
Focus:The interface between microscopy development and (nuclear) cell biology, with a strong focus on the travels of mRNA and nucleocytoplasmic transport.
Focus:Development of novel oligonucleotide-based therapeutics, drug development. Mechanism of small RNA trafficing, RNA medicinal chemistry and delivery.
Focus:Structure and function of ribosome.
Focus:Investigation of the mechanism of RNA interference; investigation of how embryonic cells differentiate and communicate during development.
Focus:Post-transcriptional gene regulation in eukaryotes via mechanisms involving RNA.
Focus:Kinetics of RNA processing; genetic and genomic investigations of the dynamics of alternative mRNA splicing.
Focus:Biology and mechanism of RNA-based gene regulation; CRISPR interference; RNA-directed genome editing and gene control.
Focus:Chemistry and chemical biology of oligonucleotides; Nucleic acid drug development.
Focus:Mouse models of cancer. Use CRISPR genome editing to functionally dissect cancer mutations in liver and lung cancer.
Focus:Dissecting the RNAi and miRNA pathways.