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2021 NEWS

March 24, 2021 New publication from the Watts Lab. Hybrid Aptamer-Molecularly Imprinted Polymer (aptaMIP) Nanoparticles from Protein Recognition-A Trypsin Model. Sullivan MV, Clay O, Moazami MP, Watts JK, Turner NW. Macromol Biosci. 2021 Mar 24:e2100002. doi: 10.1002/mabi.202100002. Online ahead of print. PMID: 33760365

March 10, 2021 Congratulations, Khvorova lab! The Khvorova lab’s 2019 publication: ‘A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system’ was selected as one of Nature Biotech’s 25 landmark papers of the last 25 years!

March 3, 2021 New publication from the Mello lab. Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility.  Spichal M, Heestand B, Billmyre KK, Frenk S, Mello CC, Ahmed S. Nat Commun. 2021 Mar 3;12(1):1420. doi: 10.1038/s41467-021-21635-0. PMID: 33658512

February 19, 2021 Dr. Craig Mello was featured on WBZ Channel 4 Boston Next  - 
Local Nobel Prize Winner Hopes COVID Vaccine RNA Technology Can Fight Other Diseases

January 30, 2021 Please join us in congratulating former RTI faculty member Melissa J. Moore for being selected as the recipient of the 2021 Lifetime Achievement in Science Award from the RNA Society.  Melissa J. Moore is well known for her mechanistic and structural analyses of spliceosomes and mRNPs, co-discovery of the exon junction complex (EJC), and studies of intracellular RNA transport and quality control pathways. She was also instrumental in developing multiple enabling technologies for the field, including methods for introducing site-specific modifications into long RNA molecules and single molecule methods for observing the dynamics of RNP complex assembly and disassembly. Following a nineteen-year run as an HHMI Investigator (1997-2016), Melissa resigned from HHMI to become the Chief Scientific Officer of Platform Research at Moderna Therapeutics, where she leads the translation of RNA biology to drug development. By designing new strategies to increase the functional output and longevity of therapeutic mRNAs, Melissa´s insights were key for the success of the Covid-19 vaccine. One overarching piece of advice Melissa offers women looking to advance their career: No fear. “Fear holds you back and prevents you from taking the types of risks that can pay off with huge rewards”, she said. ​ 

January 22, 2021 New publication from the Zamore Lab. Defining the functions of PIWI-interacting RNAsWu PH, Zamore PD. Nat Rev Mol Cell Biol. 2021 Jan 22. doi: 10.1038/s41580-021-00336-y. Online ahead of print. PMID: 33483697 No abstract available.

January 21, 2021 New publication from the Zamore Lab. To Degrade a MicroRNA, Destroy Its Argonaute Protein. Pei-Hsuan We, Phillip D. Zamore, Molecular Cell, Col 81 Iss 2, 21 Jan 2021, Pages 223-225. https://doi.org/10.1016/j.molcel.2020.12.043

January 4, 2021 New publication from the Zamore Lab. Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes. Tianxiong Yu, Kaili Fan, Deniz M. Özata Gen Zhang,YuFu, William E. Theurkauf, Phillip D. Zamore & Zhiping Weng NATURE COMMUNICATIONS | (2021)12:73 | https://doi.org/10.1038/s41467-020-20345-3