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2021 NEWS

 

Sept 6, 2021 - New publication from the Khvorova Lab - AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma Keitaro Fukuda, Ken Okamura , Rebecca L Riding , Xueli Fan , Khashayar Afshari , Nazgol-Sadat Haddadi , Sean M McCauley , Mehmet H Guney , Jeremy Luban, Takeru Funakoshi , Tomonori Yaguchi , Yutaka Kawakami , Anastasia Khvorova, Katherine A Fitzgerald , John E Harris J Exp Med. 2021 Sep 6;218(9):e20200962. doi: 10.1084/jem.20200962. Epub 2021 Jul 29. PMID: 34325468

July 30, 2021 - New publication from the Korostelev Lab - Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation.  Demo, G., Gamper, H.B., Loveland, A.B. et al. Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun12, 4644 (2021). https://doi.org/10.1038/s41467-021-24911-1

May 21, 2021 - New publication from the Grunwald Lab - REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology. Sarkans U, Chiu W, Collinson L, Darrow MC, Ellenberg J, Grunwald D, Hériché JK, Iudin A, Martins GG, Meehan T, Narayan K, Patwardhan A, Russell MRG, Saibil HR, Strambio-De-Castillia C, Swedlow JR, Tischer C, Uhlmann V, Verkade P, Barlow M, Bayraktar O, Birney E, Catavitello C, Cawthorne C, Wagner-Conrad S, Duke E, Paul-Gilloteaux P, Gustin E, Harkiolaki M, Kankaanpää P, Lemberger T, McEntyre J, Moore J, Nicholls AW, Onami S, Parkinson H, Parsons M, Romanchikova M, Sofroniew N, Swoger J, Utz N, Voortman LM, Wong F, Zhang P, Kleywegt GJ, Brazma A. Nat Methods. 2021 May 21. doi: 10.1038/s41592-021-01166-8. Online ahead of print. PMID: 34021280 

May 18, 2021 - New publication from the Mello Lab - PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans. Kim H, Ding YH, Lu S, Zuo MQ, Tan W, Conte D Jr, Dong MQ, Mello CC. Elife. 2021 May 18;10:e63300. doi: 10.7554/eLife.63300. PMID: 34003111

May 18, 2021 - New publication from the Mello Lab - HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans. Kim H, Ding YH, Zhang G, Yan YH, Conte D Jr, Dong MQ, Mello CC. Elife. 2021 May 18;10:e63299. doi: 10.7554/eLife.63299. PMID: 34003109

May 1, 2021 - Craig Mello, PhD was featured on the Nature Magazine First Rounders podcast.  You can find it here: https://play.acast.com/s/naturebiotechnologypodcast/craigmello.

April 21, 2021, Congratulations to the RTI's Nikolaus Grigorieff for his election into The National Academy of Sciences! When Niko is not using his gadget of choice, a 300,000 volt electron microscope, he is taking gorgeous images of the night sky.  Well deserved, Niko!

April 21, 2021 - New publication from the Grigorieff Lab. Locating Macromolecular Assemblies in Cells by 2D Template Matching with cisTEM.  Bronwyn A. Lucas, Benjamin A. Himes, Liang Xue, Timothy Grant, Julia Mahamid, Nikolaus Grigorieff  bioRxiv 2021.04.20.440648; doi: https://doi.org/10.1101/2021.04.20.440648

April 9, 2021 - New publication from the Xue Lab - Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.  Liu, P., Liang, SQ., Zheng, C. et al. Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Nat Commun 122121 (2021). https://doi.org/10.1038/s41467-021-22295-w

April 9, 2021 - New publication from the Sontheimer Lab - The NIH Somatic Cell Genome Editing program. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB Jr, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J; SCGE Consortium. Nature. 2021 Apr;592(7853):195-204. doi: 10.1038/s41586-021-03191-1. Epub 2021 Apr 7. PMID: 33828315 Review.

April 7, 2021 - Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium.

April 6, 2021 - New publication from the Khvorova Lab. Kinetics of HTT lowering in brain of YAC 128 mice following single and repetitive intranasal dosing of siRNA packaged in chitosan-based nanoparticle. Sava V, Fihurka O, Khvorova A, Sanchez-Ramos J. J Drug Deliv Sci Technol. 2021 Jun;63:102517. doi: 10.1016/j.jddst.2021.102517. Epub 2021 Apr 

March 24, 2021 New publication from the Watts Lab. Hybrid Aptamer-Molecularly Imprinted Polymer (aptaMIP) Nanoparticles from Protein Recognition-A Trypsin Model. Sullivan MV, Clay O, Moazami MP, Watts JK, Turner NW. Macromol Biosci. 2021 Mar 24:e2100002. doi: 10.1002/mabi.202100002. Online ahead of print. PMID: 33760365

March 10, 2021 Congratulations, Khvorova lab! The Khvorova lab’s 2019 publication: ‘A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system’ was selected as one of Nature Biotech’s 25 landmark papers of the last 25 years!

March 3, 2021 New publication from the Mello lab. Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility.  Spichal M, Heestand B, Billmyre KK, Frenk S, Mello CC, Ahmed S. Nat Commun. 2021 Mar 3;12(1):1420. doi: 10.1038/s41467-021-21635-0. PMID: 33658512

February 19, 2021 Dr. Craig Mello was featured on WBZ Channel 4 Boston Next  - 
Local Nobel Prize Winner Hopes COVID Vaccine RNA Technology Can Fight Other Diseases

January 30, 2021 Please join us in congratulating former RTI faculty member Melissa J. Moore for being selected as the recipient of the 2021 Lifetime Achievement in Science Award from the RNA Society.  Melissa J. Moore is well known for her mechanistic and structural analyses of spliceosomes and mRNPs, co-discovery of the exon junction complex (EJC), and studies of intracellular RNA transport and quality control pathways. She was also instrumental in developing multiple enabling technologies for the field, including methods for introducing site-specific modifications into long RNA molecules and single molecule methods for observing the dynamics of RNP complex assembly and disassembly. Following a nineteen-year run as an HHMI Investigator (1997-2016), Melissa resigned from HHMI to become the Chief Scientific Officer of Platform Research at Moderna Therapeutics, where she leads the translation of RNA biology to drug development. By designing new strategies to increase the functional output and longevity of therapeutic mRNAs, Melissa´s insights were key for the success of the Covid-19 vaccine. One overarching piece of advice Melissa offers women looking to advance their career: No fear. “Fear holds you back and prevents you from taking the types of risks that can pay off with huge rewards”, she said. ​ 

January 22, 2021 New publication from the Zamore Lab. Defining the functions of PIWI-interacting RNAsWu PH, Zamore PD. Nat Rev Mol Cell Biol. 2021 Jan 22. doi: 10.1038/s41580-021-00336-y. Online ahead of print. PMID: 33483697 No abstract available.

January 21, 2021 New publication from the Zamore Lab. To Degrade a MicroRNA, Destroy Its Argonaute Protein. Pei-Hsuan We, Phillip D. Zamore, Molecular Cell, Col 81 Iss 2, 21 Jan 2021, Pages 223-225. https://doi.org/10.1016/j.molcel.2020.12.043

January 4, 2021 New publication from the Zamore Lab. Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes. Tianxiong Yu, Kaili Fan, Deniz M. Özata Gen Zhang,YuFu, William E. Theurkauf, Phillip D. Zamore & Zhiping Weng NATURE COMMUNICATIONS | (2021)12:73 | https://doi.org/10.1038/s41467-020-20345-3