Search Close Search
Search Close Search

Developing Breakthrough RNA Therapeutics

By interweaving nucleic acid scientists with clinicians dedicated to finding new cures, our goal is to create a new paradigm for organizing molecular research that enables the rapid application of new biological discoveries to solutions for unmet challenges in human health.


RTI Spotlight

Athma A. Pai, PhD, assistant professor of RNA therapeutics, was awarded a nearly $1 million CAREER grant from the National Science Foundation (NSF) to use new high-throughput genomics approaches to study the regulation of mRNA splicing. Read more»

 1920x1000 background image.jpg

2023 RNA Therapeutics: From Concept to Clinic

Our 5th annual RNA Therapeutics Symposium is right around the corner on June 21-23, 2023! We are currently sold out of in-person registrations; virtual registrations available until June 20th at 12:00pm EST.

 ScienceLIVE scopes.jpg

ScienceLIVE Educational Outreach Program

ScienceLIVE is an educational science outreach program for Worcester area middle schools. We provide opportunities for students to engage with our diverse postdoctoral and graduate student trainees through interactive, exciting virtual and hands-on STEM activities.


Support Our Next Breakthrough

For decades, scientists at UMass Chan have been pioneers in RNA biology and leading innovators in the development of information-based therapeutics: cutting-edge therapeutic tools that leverage our understanding of the human genome in ways that are revolutionizing how we treat disease. With your support, we are poised to unleash their power, and change the world for the better.
 Screenshot 2023-04-04 at 2.27.15 PM.png

Research Spotlight


Dr. Wen Xue at the RNA Therapeutics Institute at University of Massachusetts Chan Medical School and Dr. Daniel Anderson at MIT have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA (mRNA) encoding useful proteins. mRNA holds great potential as a therapeutic for treating a variety of diseases caused by faulty genes. One obstacle to its deployment thus far has been difficulty in delivering it to the right part of the body, without off-target effects. Read more about Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing at Nature Biotechnology.

Award Link      More RTI Publications



Journey of a Nobel Discovery

Presented by ICBA, BBC StoryWorks

Meet Craig Mello, part of the RTI at UMass Chan, who was awarded the 2006 Nobel Prize in Physiology or Medicine, with Andrew Z. Fire, for the discovery of RNA interference. The discovery of RNAi has given scientists unprecedented opportunities to develop new life-saving therapies and advance our basic understanding of biology. 

Page Menu