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Developing Breakthrough RNA Therapeutics

By interweaving nucleic acid scientists with clinicians dedicated to finding new cures, our goal is to create a new paradigm for organizing molecular research that enables the rapid application of new biological discoveries to solutions for unmet challenges in human health.

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RTI Spotlight

UMass Chan has licensed a siRNA technology for dermatological diseases developed by Julia Alterman, PhD, assistant professor, RTI, to Aldena Therapeutics for clinical development. The siRNA-based therapeutics have the potential to help alleviate a host of skin diseases, including alopecia areata, atopic dermatitis and vitiligo through local treatment such as intradermal injection or topical, transepidermal applications. Read more»

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2023 RNA Therapeutics: From Concept to Clinic

Save the dates for June 21-23, 2023 for the 5th annual RNA Therapeutics Symposium. Inclusivity and family support awards are available!

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ScienceLIVE Educational Outreach Program

ScienceLIVE is an educational science outreach program for Worcester area middle schools. We provide opportunities for students to engage with our diverse postdoctoral and graduate student trainees through interactive, exciting virtual and hands-on STEM activities.


Support Our Next Breakthrough

For decades, scientists at UMass Chan have been pioneers in RNA biology and leading innovators in the development of information-based therapeutics: cutting-edge therapeutic tools that leverage our understanding of the human genome in ways that are revolutionizing how we treat disease. With your support, we are poised to unleash their power, and change the world for the better.


Research Spotlight


Athma Pai receives the first NSF CAREER grant at UMass Chan Medical School. The NSF awarded Dr. Athma Pai a CAREER award for her work entitled, Uncovering the regulation of low fidelity mRNA splicing. The Faculty Early Career Development (CAREER) Program is a Foundation-wide activity that offers the National Science Foundation's most prestigious awards in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization.  

Award Link      More RTI Publications



Journey of a Nobel Discovery

Presented by ICBA, BBC StoryWorks

Meet Craig Mello, part of the RTI at UMass Chan, who was awarded the 2006 Nobel Prize in Physiology or Medicine, with Andrew Z. Fire, for the discovery of RNA interference. The discovery of RNAi has given scientists unprecedented opportunities to develop new life-saving therapies and advance our basic understanding of biology. 

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