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Craig Mello, PhD

Professor, RNA Therapeutics Institute, Investigator, Howard Hughes Medical Institute, and Blais Chair of Molecular Medicine

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Research Focus - Mechanisms of Small-RNA-directed Search Pathways

  • Investigation of the mechanism of RNA interference
  • Investigation of how embryonic cells differentiate and communicate during development

Representative Publications

  • 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, Lawson ND, Rivera-Pérez JA, Sontheimer EJ, Watts JK, Mello CC.Elife. 2021 Oct 19;10:e72216. doi: 10.7554/eLife.72216.PMID: 34665130 Read Publication
More Publications

In the News

  • Atalanta Therapeutics founded by UMass Medical School and three faculty members
    Jan 12, 2021

    Atalanta Therapeutics founded by UMass Medical School and three faculty members

    Atalanta Therapeutics, a biotech founded by UMass Medical School and three faculty research scientists to pioneer treatment options for neurodegenerative diseases, has launched with financing by venture capital fund F-Prime Capital and strategic collaborations with Biogen and Genentech.

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  • Biomedical sciences student works toward a future in genetic engineering
    Jan 31, 2022

    Biomedical sciences student works toward a future in genetic engineering

    PhD student Katya Makeyeva investigates how small RNA pathways regulate gene expression of reproductive cells in the lab of Nobel Laureate Craig Mello, PhD.

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  • NIH funds Kirschstein Award recipient Johan Girgenrath’s fertility research
    Aug 21, 2023

    NIH funds Kirschstein Award recipient Johan Girgenrath’s fertility research

    PhD candidate John Girgenrath has received a competitive award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development to conduct fertility research.

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  • Inside the new mRNA vaccines for COVID-19
    Dec 18, 2020

    Inside the new mRNA vaccines for COVID-19

    The new vaccines by Pfizer/BioNTech and Moderna use messenger RNA to stimulate the immune system to protect against COVID-19. These vaccines are the first of their kind and researchers at UMass Medical School are among the leading RNA biologists in the world.

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  • Biomedical sciences student studying fertility in Mello lab
    Jun 14, 2022

    Biomedical sciences student studying fertility in Mello lab

    Movies piqued PhD candidate Humberto Ochoa’s interest in science. He’s conducting RNA research in the lab of Nobel Laureate Craig C. Mello, PhD, to understand the national decline in fertility.

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