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2019 News

September 12, 2019, New publication from the Korostelev lab.  Extensive ribosome and RF2 rearrangements during translation termination.  Egor Svidritskiy, Gabriel Demo, Anna B Loveland, Chen Xu, Andrei A Korostelev. eLife 2019;8:e46850 DOI: 10.7554/eLife.46850

September 10, 2019, Congratulations to Dr. Anna Loveland, a postdoctoral fellow in Dr. Korostelev’s lab - she is the RNA Society member highlighted in the September 2019 Member Spotlight. Written by Spotlight team member Nandini Kundu, this month’s piece describes how early childhood experiences fueled Anna's scientific curiosity and what inspired her to study ribosome dynamics with cryo-electron microscopy.

August 22, 2019, New publication from the Sontheimer lab.  Tissue-restricted Genome Editing in vivo Specified by MicroRNA-repressible Anti-CRISPR Proteins.  Lee J, Mou H, Ibraheim R, Liang SQ, Liu P, Xue W, Sontheimer EJ. RNA. 2019 Aug 22. pii: rna.071704.119. doi: 10.1261/rna.071704.119. [Epub ahead of print] PMID: 31439808 [PubMed - as supplied by publisher]

August 19, 2019, Congratulations to Zack Kennedy.  "For ALS medical scientist, finding a cure is personal". Farragher, Thomas (2019) Boston Globe, 19 August 2019.

August 19, 2019, New publication from the Grunwald lab. Live-Cell Imaging of mRNP-NPC Interactions in Budding Yeast. Lari A, Farzam F, Bensidoun P, Oeffinger M, Zenklusen D, Grunwald D, Montpetit B. Methods Mol Biol. 2019;2038:131-150. doi: 10.1007/978-1-4939-9674-2_9. PMID: 31407282 [PubMed - in process]

August 2, 2019, New publication from the Khvorova lab. A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system. Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. Nat Biotechnol. 2019 Aug;37(8):884-894. doi: 10.1038/s41587-019-0205-0. Epub 2019 Aug 2. PMID: 31375812 

July 25, 2019, Congratulations to Dr. Athma Pai for the Pai lab’s first grant awarded at UMass Medical School, an R35 Maximizing Investigators' Research Award (MIRA) from NIGMS, entitled “Tracking transcriptome diversity in real-time”!

July 3, 2019, New publication from the Zamore lab. High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2.  Becker WR, Ober-Reynolds B, Jouravleva J, Jolly SM, Zamore PD, Greenleaf WJ. Mol Cell. 2019 Jul 3. pii: S1097-2765(19)30445-9. doi: 10.1016/j.molcel.2019.06.012. [Epub ahead of print]PMID: 31324449

June 21, 2019, New publication from the Sontheimer lab. X-Tracking a New CRISPR-Cas Genome-Editing Platform from Metagenomic Data Sets.  Sontheimer EJ.CRISPR J. 2019 Jun;2:148-150. doi: 10.1089/crispr.2019.29061.ejs. No abstract available. PMID:31225753 

June 12, 2019, New publication from the Xue lab.  The depletion of TRRAP induces p53‐independent senescence in liver cancer by downregulating mitotic genes.  Suet‐Yan Kwan,  Ankur Sheel, Chun‐Qing Song,  Xiao‐Ou Zhang,  Tingting Jiang,  Hien Dang,  Yueying Cao, Deniz M. Ozata,  Haiwei Mou,  Hao Yin,  Zhiping Weng,  Xin Wei Wang,  Wen Xue.  AASLD 2019 June 12 doi: 10.1002/hep.30807 

May 11, 2019, New publication from the Zamore lab. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Ge DT, Wang W, Tipping C, Gainetdinov I, Weng Z, Zamore PD. Mol Cell. 2019 Apr 26. pii: S1097-2765(19)30276-X. doi: 10.1016/j.molcel.2019.04.006. [Epub ahead of print] PMID: 31076285 

May 8, 2019, New pre-print publication from the Sontheimer and Xue labs. 
Tissue-specific Genome Editing in vivo by MicroRNA-repressible Anti-CRISPR Proteins. Lee J, Mou H, Ibraheim R, Liang SQ, Xue W, Sontheimer EJ. BioRxiv. May 8, 2019. doi: https://doi.org/10.1101/631689 

April 29, 2019, New publication from Khvorova, Watts & Brown labs. Nucleic Acid Therapeutics for Neurological Diseases. Watts JK, Brown RH, Khvorova A. Neurotherapeutics. 2019 Apr 29. doi: 10.1007/s13311-019-00736-1.

April 16, 2019, New publication from the Xue lab. 
CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling. Mou† H, Ozata† DM, Smith† JL, Sheel A, Kwan SY, Hough S, Kucukural A, Zachary Kennedy Z, Cao Y and Xue W. Genome Medicine 2019 11:21

Press coverage:

March 7, 2019 Congratulations, Alireza Edraki (Sontheimer lab) for receiving an F31 Fellowship!!

March 1, 2019 Congratulations, Jordan Smith (Xue lab) for receiving an NCI F30 fellowship!!

February 25, 2019, New publication from the Xue lab. Adenine base editing in an adult mouse model of tyrosinemia. Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G Anderson, David R. Liu, Hao Yin & Wen Xue. Nature BME. 25 February 2019

February 12, 2019, New publication from the Watts lab. Next-Generation Peptide Nucleic Acid Chimeras Exhibit High Affinity and Potent Gene Silencing. Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts JK. Biochemistry. 2019 Feb 12;58(6):582-589. doi: 10.1021/acs.biochem.8b00827. Epub 2018 Dec 18. PMID: 30520300

February 12, 2019, New book chapter from the Khvorova lab. Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics–Pharmacodynamics Relationships of Medicinal Oligonucleotides. Godinho BMDC, Coles AH, and Khvorova K. Chapter 10. Advances in Nucleic Acid Therapeutics. 2019 Feb 11. http://dx.doi.org/10.1039/9781788015714

Jon Watts

February 6, 2019, Rett Syndrome Research Trust provides $2.7 million in new funding for research to Jonathan Watts and colleagues working to develop a therapy to fix faulty gene in Rett syndrome

CRISPRJanuary 21, 2019, New publication from the Xue labCRISPR–Cas: a tool for cancer research and therapeutics. Yin H, Xue W, Anderson DG. Nat Rev Clin Oncol. 2019 Jan 21. doi: 10.1038/s41571-019-0166-8. [Epub ahead of print] Review. PMID: 30664678

January 17, 2019, New publication from the Zamore and Grunwald labs. An automated Bayesian pipeline for rapid analysis of single-molecule binding data. Smith CS, Jouravleva K, Huisman M, Jolly SM, Zamore PD, Grunwald D. Nat Commun. 2019 Jan 17;10(1):272. doi: 10.1038/s41467-018-08045-5. PMID: 30655518

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