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2020 News

September 24, 2020 - New publication from the Watts Lab. Detecting chromatin interactions between and along sister chromatids with SisterC. Oomen ME, Hedger AK, Watts JK, Dekker J. Detecting chromatin interactions between and along sister chromatids with SisterC. Nat Methods. 2020 Sep 23. doi: 10.1038/s41592-020-0930-9. Epub ahead of print. PMID: 32968250.

September 24, 2020 - New publication from the Mello Lab.  Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans. Ghanta KS, Mello CC. Genetics. 2020 Sep 22:genetics.303564.2020. doi: 10.1534/genetics.120.303564. Online ahead of print.  PMID: 32963112

September 19, 2020 - New publication from the Mello Lab.  PIE-1 promotes SUMOylation and activation of HDAC1 during the C. elegans oogenesis.  Heesun Kim, Yue-He Ding, Shan Lu, Mei-Qing Zuo, Darryl Conte Jr., Meng-Qiu Dong, Craig C. Mello bioRxiv 2020.08.17.253955; doi: https://doi.org/10.1101/2020.08.17.253955

September 19, 2020 - New publication from the Mello Lab.  HDAC1 SUMOylation promotes Argonaute directed transcriptional silencing in C. elegans.  Heesun Kim, Yue-He Ding, Gangming Zhang, Yong-Hong Yan, Darryl Conte Jr., Meng-Qiu Dong, Craig C. Mello bioRxiv 2020.08.17.254466; doi: https://doi.org/10.1101/2020.08.17.254466

September 15, 2020 - New publication from the Aronin Lab.  Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next.  Howland D, Ellederova Z, Aronin N, Fernau D, Gallagher J, Taylor A, Hennebold J, Weiss A, Gray-Edwards H, McBride J. J Huntingtons Dis. 2020 Sep 10. doi: 10.3233/JHD-200425. Online ahead of print.PMID: 32925082 Review.

September 8, 2020 - New publication from the Zamore Lab. Terminal Modification, Sequence, and Length Determine Small RNA Stability in Animals Ildar Gainetdinov, Cansu Colpan, Katharine Cecchini, Paul Albosta, Karina Jouravleva, Joel Vega-Badillo, Yongjin Lee, Deniz M. Özata,  Phillip D. Zamore. bioRxiv,

September 7, 2020 - Post Magazine interviewed Erik Sontheimer, PhD for the article What is CRISPR? The gene-editing technology carries much promise - and peril - amid pandemic. Mike Hodgkinson

September 4, 2020 - New publication from the Aronin Lab. Huntington's Disease: Les Jeux Sont Faits? Pfister EL, Aronin N. Trends Mol Med. 2020 Sep 4:S1471-4914(20)30206-9. doi: 10.1016/j.molmed.2020.08.004. Online ahead of print. PMID: 32893090

September 1, 2020 - Congratulations to Chantal M. Ferguson in the Khvorova lab for receiving the Dr. Alan M. Gewirtz Memorial Scholarship Award for Graduate Students from the Oligonucleotide Therapeutics Society (OTS).

September 1, 2020 - Congratulations to Annabelle Biscans, PhD, formerly of the Khvorova Lab for receiving the Dr. Alan M. Gewirtz Memorial Scholarship Award for Postdoctoral Fellows and Junior Industrial Professionals from the Oligonucleotide Therapeutics Society (OTS).

August 31, 2020 - New publication from the Korostelev Lab. Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. bioRxiv,

August 25, 2020 - New publication from the Zamore Lab.  Thermus thermophilus Argonaute Functions in the Completion of DNA Replication.  Jolly Samson, Gainestdinov Ildar, Jouravleva Karina, Zhang Han, Strittmatter Lara, Bailey Shannon, Hendricks Gregory, Dhabaria Avantika, Ueberheide Beatric, Zamore Phillip. Cell 2020, August 25 https://doi.org/10.1016/j.cell.2020.07.036 

August 22, 2020 - New publication from the Korostelev Lab. Termi-Luc: a versatile assay to monitor full-protein release from ribosomes. Susorov D, Egri S, Korostelev AA. RNA. 2020 Aug 14:rna.076588.120. doi: 10.1261/rna.076588.120. Online ahead of print. PMID: 32817446

August 6, 2020 - New publication from Zamore lab. One small step for worms, one giant leap for small RNAs.  Phillip D. Zamore. Nat Rev Mol Cell Biol (2020). https://doi.org/10.1038/s41580-020-00281-2

July 25, 2020 - New publication from the Khvorova lab. Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy. Socheata Ly, Dimas Echeverria, Jacquelyn Sousa, Anastasia Khvorova. Molecular Therapy Nucleic Acids DOI 2020 Jul 25;21:991-1005 :https://doi.org/10.1016/j.omtn.2020.07.029

July 20, 2020 - Congratulations to Dr. Anastasia Khvorova, Professor, on her appointment to the The Remondi Family Chair in Biomedical Research. Anastasia becomes the fifth RTI faculty member to be recognized with an endowed chair position, and the fourth among our current faculty.

July 20, 2020 - Congratulations to Dr. Erik Sontheimer, Professor and Vice Chair, on his appointment to the Pillar Chair in Biomedical Research. Erik becomes the fourth RTI faculty member to be recognized with an endowed chair position, and the third endowed chair among our current faculty.

July 16, 2020 - New publication from the Khvorova lab. The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy. Biscans A, Caiazzi J, Davis S, McHugh N, Sousa J, Khvorova A. Nucleic Acids Res. 2020 Jul 16:gkaa595. doi: 10.1093/nar/gkaa595

July 6, 2020 - Congratulations, Dr. Phillip D. Zamore, NIH MIRA awardee for
Understanding the Evolution, Biology, and Molecular Mechanism of Argonaute Proteins!

July 3, 2020 - New perspective from the Sontheimer Lab.
Shutting down RNA-targeting CRISPR. Barrangou R & Sontheimer EJ. July 2020 Science

July 1, 2020 - New publication from the Korostelev Lab. 
Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Loveland AB, Demo G, & Korostelev AA. 1 July, 2020. Nature doi.org/10.1038/s41586-020-2447-x

June 29, 2020 - New publication from the Zamore Lab. The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility. Wu PH, Fu Y, Cecchini K, Özata DM, Arif A, Yu T, Colpan C, Gainetdinov I, Weng Z, & Zamore PD. Nat Genet (2020). https://doi.org/10.1038/s41588-020-0657-7

June 12, 2020 - New publication from the Khvorova Lab. Cell type impacts accessibility of mRNA to silencing by RNA interference. Ferguson CM, Echeverria D, Matthew Hassler M, Socheata Ly S, and Khvorova A.12 June 2020 Mol Therapy Nucleic Acids.

June 17, 2020 - RNA Collaborative Seminar Series, RTI Hosted 
Athma Pai, Ph.D. How efficiently do cells create mRNA? Balancing speed and accuracy in gene regulation
Jonathan Watts, Ph.D. Fighting an RNA virus with an RNA drug
Moderator: Phil Zamore
Watch On Demand

June 12, 2020 - Katherine Fitzgerald and Anastasia Khvorova named Harrington Scholars 
The Harrington Discovery Institute at University Hospitals in Cleveland, Ohio, in collaboration with Morgan Stanley GIFT Cures, has chosen two UMass Medical School faculty members to receive Harrington Scholar Awards for Coronavirus.

June 9, 2020 - New publication from the Korostelev Lab. Ribosome Engineering Reveals the Importance of 5S rRNA Autonomy for Ribosome Assembly  Huang S, Aleksashin NA, Loveland AB, Klepacki D, Reier K, Kefi A, Szal T, Remme J, Jaeger L, Vázquez-Laslop N, Korostelev AA, Mankin AS. Nat Commun, 2020 Jun 9;11(1):2900. doi: 10.1038/s41467-020-16694-8.

June 4, 2020 -  MD/PhD-student-led research finds potential new gene target for pediatric liver cancer -  MD/PhD student Jordan Smith, Xue Lab, shares details about new research into a promising therapeutic target for a rare, primarily pediatric liver cancer. UMassMedNow.

May 27, 2020 - Congratulations to Dr. Erik Sontheimer on his proposal, together with colleagues around the world, Editing the Failing Heart, has been awarded a grant under the Leducq Foundation Network's 2020 Transatlantic Networks of Excellence Program.

May 27, 2020 - Dr. Wen Xue presented "CRISPR-Based In Vivo Genome Editing and Base Editing" webinar - View Now

May 26, 2020 - New publication from the Xue and Sontheimer Labs. YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte‚Äźlike cells. Smith JL, Rodríguez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Zhiping Weng Z, Sontheimer EJ, Xue W. 2020 26 May, AASLD, doi:10.1002/hep.31389

May 19, 2020 - New publication from the Grigorieff and Korostelev Labs. mRNA Stem-Loops Can Pause the Ribosome by Hindering A-site tRNA Binding.  Bao C, Loerch S, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN. ELife 2020 May 19;9:e55799. doi: 10.7554/eLife.55799

May 18, 2020 - New publication from the Sontheimer Lab. A Cas9 with PAM recognition for adenine dinucleotides. Chatterjee P, Lee J, Lisa Nip, Koseki SRT, Tysinger T, Sontheimer EJ, Jacobson JM, & Jakimo N, 18 May 2020, Nature CommunicationsDOI: 10.1038/s41467-020-16117-8

May 18, 2020 - Congratulations to Dr. Anastasia Khvorova for receiving the Women in Science & Health Achievement Faculty Award! 

May 15, 2020 - New publication from the Khvorova lab. 2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA. Davis SM, Sousa J, Vangjeli L, Hassler MR, Echeverria D, Knox E, Turanov AA, Alterman JF, Khvorova A. Mol Ther Nucleic Acids. 2020 May 15;21:266-277. doi: 10.1016/j.omtn.2020.05.010

May 11, 2020 - Anastasia Khvorova elected director of the American Society of Gene and Cell Therapy  UMass Medical School RNA therapeutics expert Anastasia Khvorova, PhD, has been elected by the membership of the American Society of Gene and Cell Therapy to a three-year term as director-at-large/scientific & research council chair, which will begin at the 2020 ASGCT virtual annual meeting.

May 11, 2020 - New publication from the Sontheimer Lab. An engineered ScCas9 with broad PAM range and high specificity and activity. Chatterjee P, Jakimo N, Lee J, Amrani N, Rodríguez T, Koseki SRT, Emma Tysinger, Qing R, Hao S, Sontheimer EJ, & Jacobson J. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0517-0

May 5, 2020 - New publication from the Watts Lab. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Chembiochem. 2020 May 5. doi: 10.1002/cbic.202000136. [Epub ahead of print] PMID: 32372560

April 27, 2020 - New publication from the Watts Lab. RNA therapeutics on the rise. Wang F, Zuroske T, Watts JK.  Nat Rev Drug Discov. 2020 Apr 27. doi: 10.1038/d41573-020-00078-0. No abstract available.

April 24, 2020 - New publicaton from the Xue Lab. Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope  Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, Liu DR, & Xue W. Nat Commun 11, 1979 (2020). https://doi.org/10.1038/s41467-020-15892-8

March 19, 2020 - New publication from the Sontheimer Lab. Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems. Davidson AR, Lu WT, Stanley SY, Wang J, Mejdani M, Trost CN, Hicks BT, Lee J, Sontheimer EJ. Annu Rev Biochem. 2020 Mar 18. doi: 10.1146/annurev-biochem-011420-111224. PMID: 32186918

March 6, 2020 - New publication from the Khvorova Lab. Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo. Meirav Segal, Annabelle Biscans, Maud-Emmanuelle Gilles, Eleni Anastasiadou, Roberto De  Luca, Jihoon Lim, Anastasia Khvorova, Frank J.Slack. Molecular Therapy Nucleic Acids, Volume 19, 6 March 2020, Pages 267-277 https://doi.org/10.1016/j.omtn.2019.11.008

February 4, 2020 - New publication from the Zamore & Gao LabsEffective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold. Xie J, Tai PWL, Brown A, Gong S, Zhu S, Wang Y, Li C, Colpan C, Su Q, He R, Ma H, Li J, Ye H, Ko J, Zamore PD, Gao G. Mol Ther. 2020 Feb 5;28(2):422-430. doi: 10.1016/j.ymthe.2019.11.018. Epub 2019 Nov 27.

January 13, 2020 - New review from the Watts Lab. RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease.  Watts JK, Ockene IS. Nucleic Acid Ther. 2020 Jan 13. doi: 10.1089/nat.2019.0835. PMID: 31928497