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2020 News

July 6, 2020 - Congratulations, Dr. Phillip D. Zamore, NIH MIRA awardee for Understanding the Evolution, Biology, and Molecular Mechanism of Argonaute Proteins!

July 3, 2020 - New perspective from the Sontheimer Lab.
Shutting down RNA-targeting CRISPR. Barrangou R & Sontheimer EJ. July 2020 Science

July 1, 2020 - New publication from the Korostelev Lab. 
Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Loveland AB, Demo G, & Korostelev AA. 1 July, 2020. Nature doi.org/10.1038/s41586-020-2447-x

June 29, 2020 - New publication from the Zamore Lab. The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility. Wu PH, Fu Y, Cecchini K, Özata DM, Arif A, Yu T, Colpan C, Gainetdinov I, Weng Z, & Zamore PD. Nat Genet (2020). https://doi.org/10.1038/s41588-020-0657-7

June 17, 2020 - RNA Collaborative Seminar Series, RTI Hosted 
Athma Pai, Ph.D. How efficiently do cells create mRNA? Balancing speed and accuracy in gene regulation
Jonathan Watts, Ph.D. Fighting an RNA virus with an RNA drug
Moderator: Phil Zamore
Watch On Demand

June 12, 2020 - Katherine Fitzgerald and Anastasia Khvorova named Harrington Scholars 
The Harrington Discovery Institute at University Hospitals in Cleveland, Ohio, in collaboration with Morgan Stanley GIFT Cures, has chosen two UMass Medical School faculty members to receive Harrington Scholar Awards for Coronavirus.

June 9, 2020 - New publication from the Korostelev Lab. Ribosome Engineering Reveals the Importance of 5S rRNA Autonomy for Ribosome Assembly  Huang S, Aleksashin NA, Loveland AB, Klepacki D, Reier K, Kefi A, Szal T, Remme J, Jaeger L, Vázquez-Laslop N, Korostelev AA, Mankin AS. Nat Commun, 2020 Jun 9;11(1):2900. doi: 10.1038/s41467-020-16694-8.

June 4, 2020 -  MD/PhD-student-led research finds potential new gene target for pediatric liver cancer -  MD/PhD student Jordan Smith, Xue Lab, shares details about new research into a promising therapeutic target for a rare, primarily pediatric liver cancer. UMassMedNow.

May 27, 2020 - Congratulations to Dr. Erik Sontheimer on his proposal, together with colleagues around the world, Editing the Failing Heart, has been awarded a grant under the Leducq Foundation Network's 2020 Transatlantic Networks of Excellence Program.

May 27, 2020 - Dr. Wen Xue presented "CRISPR-Based In Vivo Genome Editing and Base Editing" webinar - View Now

May 26, 2020 - New publication from the Xue and Sontheimer Labs. YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte‚Äźlike cells. Smith JL, Rodríguez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Zhiping Weng Z, Sontheimer EJ, Xue W. 2020 26 May, AASLD, doi:10.1002/hep.31389

May 19, 2020 - New publication from the Grigorieff and Korostelev Labs. mRNA Stem-Loops Can Pause the Ribosome by Hindering A-site tRNA Binding.  Bao C, Loerch S, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN. ELife 2020 May 19;9:e55799. doi: 10.7554/eLife.55799

May 18, 2020 - New publication from the Sontheimer Lab. A Cas9 with PAM recognition for adenine dinucleotides. Chatterjee P, Lee J, Lisa Nip, Koseki SRT, Tysinger T, Sontheimer EJ, Jacobson JM, & Jakimo N, 18 May 2020, Nature CommunicationsDOI: 10.1038/s41467-020-16117-8

Press coverage:

May 18, 2020 - Congratulations to Dr. Anastasia Khvorova for receiving the Women in Science & Health Achievement Faculty Award! 

May 11, 2020 - Anastasia Khvorova elected director of the American Society of Gene and Cell Therapy  UMass Medical School RNA therapeutics expert Anastasia Khvorova, PhD, has been elected by the membership of the American Society of Gene and Cell Therapy to a three-year term as director-at-large/scientific & research council chair, which will begin at the 2020 ASGCT virtual annual meeting.

May 11, 2020 - New publication from the Sontheimer Lab. An engineered ScCas9 with broad PAM range and high specificity and activity. Chatterjee P, Jakimo N, Lee J, Amrani N, Rodríguez T, Koseki SRT, Emma Tysinger, Qing R, Hao S, Sontheimer EJ, & Jacobson J. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0517-0

May 5, 2020 - New publication from the Watts Lab. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Chembiochem. 2020 May 5. doi: 10.1002/cbic.202000136. [Epub ahead of print] PMID: 32372560

April 27, 2020 - New publication from the Watts Lab. RNA therapeutics on the rise. Wang F, Zuroske T, Watts JK.  Nat Rev Drug Discov. 2020 Apr 27. doi: 10.1038/d41573-020-00078-0. No abstract available.

April 24, 2020 - New publicaton from the Xue Lab. Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope  Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, Liu DR, & Xue W. Nat Commun 11, 1979 (2020). https://doi.org/10.1038/s41467-020-15892-8

April 23, 2020 - Congratulations to Dr. Erik Sontheimer, Professor and Vice Chair, on his appointment to the Pillar Chair in Biomedical Research. Erik becomes the fourth RTI faculty member to be recognized with an endowed chair position, and the third endowed chair among our current faculty. 

March 19, 2020 - New publication from the Sontheimer Lab. Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems. Davidson AR, Lu WT, Stanley SY, Wang J, Mejdani M, Trost CN, Hicks BT, Lee J, Sontheimer EJ. Annu Rev Biochem. 2020 Mar 18. doi: 10.1146/annurev-biochem-011420-111224. PMID: 32186918

February 4, 2020 - New publication from the Zamore & Gao LabsEffective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold. Xie J, Tai PWL, Brown A, Gong S, Zhu S, Wang Y, Li C, Colpan C, Su Q, He R, Ma H, Li J, Ye H, Ko J, Zamore PD, Gao G. Mol Ther. 2020 Feb 5;28(2):422-430. doi: 10.1016/j.ymthe.2019.11.018. Epub 2019 Nov 27.

January 13, 2020 - New review from the Watts Lab. RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease.  Watts JK, Ockene IS. Nucleic Acid Ther. 2020 Jan 13. doi: 10.1089/nat.2019.0835. PMID: 31928497