Preclinical: Rat - Modality: functional connectivity
Segregation of the whole-brain network of the awake rat brain. a, The global functional network constructed based on significant intercomponent connections. Each colored box represents an ICA component labeled with its corresponding anatomy and the ICA number. Each line represents a significant connection between two components. Nodes within the same module are displayed in the same color (red, green, and yellow). Three modules were obtained by the spectral partitioning algorithm. B, Bilateral; L, left; R, right; AMG, amygdala; INS, insula; NAcc, nucleus accumbens; MO, motor cortex; HC, hippocampus; HY, hypothalamus; OB, olfactory bulb; Pir, piriform cortex; PTL, parietal cortex; S, septum; TE, temporal cortex; TH, thalamus; VIS, visual cortex. b–d, Community structures of the whole-brain network revealed by spectral partitioning. b, The first module is dominated by cortical ribbon. c, The second module is highlighted by the olfactory pathway and its interaction with PFC, and the integration of other sensory input, cognitive processing, and output in cortical and subcortical regions like thalamus and hippocampus. d, The third module includes regions important for emotional and autonomic functions such as amygdala, insular cortex, PFC, and hypothalamus. The same colors are used in b, c, and d as those in a. Distance to bregma (in millimeters) is labeled at the bottom of each image.