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Jean King, Ph.D.

CCNI Directors Message Large Image

CCNI Directors Message Small GraphicVice Provost for Biomedical Research
Director, Center for Comparative NeuroImaging (CCNI)

Dr. King holds a doctorate in Biology/Neuroscience from New York University and a master’s degree in cell biology from the City University of New York. She is a graduate (magna cum laude) of St. Francis College in New York. She has published over 60 original scientific papers in highly respected international scientific journals, over 10 chapters in books and review articles in major neurophysiology journals, and is an editor of New York Academy of Sciences Publication-Roots of Mental Illness in Children. She has been a scientific consultant for the National Science Foundation and National Institutes of Health as well as the Veterans Administration. Dr. King joined the University Of Massachusetts Medical School (UMass) after teaching at Spelman College in Atlanta and Post- Doctoral training at Emory University, Atlanta GA. At UMass, she rose from Assistant Professor to full Professor, which she was awarded in 2007. Currently, she serves as Vice Chair of Research and the Director of the Center for Comparative NeuroImaging in the Department of Psychiatry at the University of Massachusetts Medical School.

Current Research Interests:
1. Nicotine addiction and co-morbidity with mental health disorders like Attention Deficit Hyperactivity Disorder
2. Animal Models of Neurological disorders like Parkinson disease and Traumatic Brain Injury
3. Role of stress in the etiology of mental health disorders (mood disorders, Post Traumatic Stress Disorder, ADHD etc,)
4. Epigenetic factors impacting emotion and cognition in vulnerable populations (like Autism Spectrum Disorders)
5. Impact of Complementary and Alternative approaches on neuronal plasticity

Research Summary:
The application of functional magnetic resonance imaging (fMRI) to visualize brain regions involved in emotion and cognition has considerably improved our understanding of human neurobiology. Studies in my laboratory use fMRI to identify and monitor neuronal plasticity associated with addiction, ADHD, depression, fearfulness, anxiety, autism and neurological disorders (PD and TBI) in animal models with the hope of finding clues to help us understand these conditions in humans. In recent years our laboratory has shifted to a more translational approach and incorporated a clinical research component to most of our animal studies. The long-term goal of this research is to provide an understanding of the unique features of central mechanisms that regulate emotion and cognition in both resilient and vulnerable populations.

Representative Publications:
Sikoglu EM, Liso Navarro AA, Czerniak SM, McCafferty J, Eisenstock J, Stevenson JH, King JA, Moore CM. (2015) Effects of Recent Concussion on Brain Bioenergetics: A Phosphorus-31 Magnetic Resonance Spectroscopy Study. Cogn Behav Neurol. 2015 Dec; 28(4):181-7. PMID: 26705264.

Li M, Deng W, He Z, Wang Q, Huang C, Jiang L, Gong Q, Ziedonis DM, King JA, Ma X, Zhang N, Li T. (2015) A splitting brain: Imbalanced neural networks in schizophrenia. Psychiatry Res. 232(2):145-53. PMID: 25819347

Huang W, Tam K, Fernando J, Heffernan M, King J, DiFranza JR (2015). Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses. Nicotine Tob Res. [Epub ahead of print]  PMID: 25646348.

Liang Z, King J, Zhang N (2014). Neuroplasticity to a single-episode traumatic stress revealed by resting-state fMRI in awake rats. Neuroimage. 103:485-91. PMID: 25193500.  PMCID: PMC4253640.

Czerniak SM, Sikoglu EM, Liso Navarro AA, McCafferty J, Eisenstock J, Stevenson JH, King JA, Moore CM (2015). A resting state functional magnetic resonance imaging study of concussion in collegiate athletes. Brain Imaging Behav. 9(2):323-32. PMID: 25112544

Huang W, King J, Ursprung WWS, Zheng S, Zhang N, Kennedy DN, Douglas Z, DiFranza JR (2014). “The development and expression of physical nicotine dependence corresponds to structural and functional alterations in the anterior cingulate-precuneus pathway”. Brain and Behavior.  4(3):408-17. PMID: 24944870. PMCID: PMC4055191.

Liso Navarro, A.A., Sikoglu, E.M., Heinze, C.R., Rogan, R.C. Russell, V.A., King, J.A., Moore, C.M.: (2014) Effect of Diet on Brain Metabolites and Behavior in Spontaneously Hypertensive Rats. Behavioural Brain Research. 270C: 240-247.

Sikoglu, E. M., Heffernan, M. E., Tam, K., Sicard, K. M., Bratane, B. T., Quan, M., Fisher, M., King, J.A.: (2014) Enhancement in Cognitive Function Recovery by Granulocyte-Colony Stimulating Factor in a Rodent Model of Traumatic Brain Injury. Behavioural Brain Research. 259, 354-356.

Huang, W., DiFranza, JR., Kennedy, DN., Zhang, N., Ziedonis, D., Ursprung, S., King, JA., (2013). Progressive Levels of Physical Dependence to Tobacco Coincide with Changes in the Anterior Cingulum Bundle Microstructure. PLoS ONE. 8(7): e67837. Doi: 10.1371/journal.pone.0067837

Liang Z, Li T, King J, Zhang N (2013). Mapping thalamocortical networks in rat brain using resting-state functional connectivity. Neuroimage. 83:237-44. PMID: 23777756. PMCID: PMC3815960.

Heffernan, ME., Huang, W., Sicard, KM., Bratane, BT., Zhang, N., Fisher, M., King, JA., (2013). Multi-modal approach from investigating brain and behavior changes in an animal model of traumatic brain injury. Journal of Neurotrauma. 30:1007-1012.

DiFranza, JA., Huang, W., and King, J., (2012). Neuroadaptation in Nicotine Addiction: Update on the Sensitization-Homeostasis Model. Brain Science. 2, 523-552.

Fulwiler, CF., King JA and Zhang, N., (2012). Amygdala-orbitofrontal resting-state functional connectivity is associated with trait anger. Neuroreport 23(10):606-10.

Liang Z., King J., and Zhang, N., (2012). Anticorrelated resting-state functional connectivity in awake rat brain. Neuroimage. 16;59(2):1190-9.

Rane, P., Shields, J., Heffernan, M., Guo, Y., Akbarian, S., King, J.A., (2012). The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD. Neuropharmacology. 62(7):2408-11.

Huang, W., Heffernan, ME., Li, Z,, Zhang N., Overstreet DH., and King JA., (2012). Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals. Neuroscience Letters, 489:74-78.

Liang Z., King JA., and Zhang N., (2011).  Uncovering Intrinsic Connectional Architecture of Functional Networks in Awake Rat Brain. Journal Neuroscience, 9;31(10) 3776-83.

Rane P., and King J., (2011) Exploring aversion in an animal model of pre-motor stage PD.  Neuroscience. 5;(181) 189-95.

King, J., Huang, W., Chen, W., Heffernan, M., Shields, J., Rane, P., Bircher, R., and DiFranza, J., (2011). A Comparison of brain and behavioral effects of varenicline and nicotine in rats. Behavioral Brain Research 222: 42-47.

Nwosu, BU., Meltzer, B., Maranda, L., Ciccarelli, C., Reynolds, D., Curtis, L., King J, Frazier, JA., and Lee, MM., (2011). A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics. J Pediatr Endocr Met 24(9-10):619–626.

Mary Linton Peters, Paula Ravin, Peter Novak, Anthony M. Burrows, Joan Swearer, Jean King, Sathish Kumar, Dundamadappa, Julie G. Pilitsis., (2010). DBS-implanted Parkinson’s Disease Patients Show Better Olfaction Than Those Treated Medically. Neurological Bull. 2:1-6.

Zhang, N., Rane, P., Huang, W., Liang, Z., Kennedy, D., Frazier, J. and King J., (2010).  Mapping resting-state brain networks in conscious animals. Journal of Neuroscience Methods 189 (2); 186-196.