Leslie Shaw, Ph.D.
|Office:||University of Massachusetts Medical School
364 Plantation Street, LRB-409
Worcester, MA 01605
The Shaw lab is interested in signaling pathways that regulate tumor progression and metastasis. We utilize both in vitro and in vivo approaches to investigate the mechanisms by which tumor cells acquire the ability to metastasize to secondary organs and how they survive and grow in these foreign microenvironments. Our focus is to identify molecules or signaling pathways that play an essential role in the acquisition of a metastatic phenotype and to understand their mechanism of action. From a translational perspective, the goal of our work is to develop novel targets to predict or to treat metastatic cancer.
1)Structure/function analysis of IRS-1 and IRS-2; 2) Feedback regulation of IRS function; 3) Regulation of IRS intracellular localization and the importance for breast carcinoma cell function; 4) Regulation of IGF-1R trafficking; 5) Role of the IRS proteins in the tumor microenvironment; 6) Mechanism of Beclin 1 regulation of tumor cell invasion and metabolism. Basic cell biology, biochemistry and molecular biology techniques will be used. In addition, we have both transgenic and orthotopic mouse models of breast cancer established in the lab for studying metastasis.