|Office:||University of Massachusetts Medical School
364 Plantation Street, LRB-523
Worcester, MA 01605
Our laboratory focuses on identifying the molecular mechanisms underlying the effects of aneuploidy (an abnormal number of chromosomes) on cellular physiology and on cancer initiation, maintenance and progression. We utilize the yeast Saccharomyces Cerevisiae as a model organism to study cellular responses upon acquiring extra copies of entire chromosomes. Our studies will reveal the conserved basic cellular processes affected by aneuploidy, allowing for the potential to exploit this intrinsic characteristic of most human tumors to development of novel anti-cancer therapies.
A. Study the effects of aneuploidy on cellular metabolism.
B. Study the effects of aneuploidy on protein turnover pathways.
C. Study the mechanisms by which aneuploidy-tolerating mutations improve the fitness of aneuploid cells.
A. Rotations are available in this laboratory. Please contact Dr. Torres for details
B. A postdoctoral fellow position is available for a highly motivated candidate to join us. The Candidates should have a recent Ph.D or M.D/Ph.D degree in Cancer Biology, Genetics, Biochemistry, Cell Biology or related field. They should be highly motivated, have a strong desire to learn and excellent communication skills. Applicants should send their CV, summary of previous research and the name of three references that may be contacted to Dr. Eduardo Torres