|Ph.D., Biology, Massachusetts Institute of Technology|
|Postdoctoral research: Cold Spring Harbor Laboratory|
|Office:||University of Massachusetts Medical School
364 Plantation Street, LRB-506
Worcester, MA 01605
We study proteins that regulate chromosome structure and function. We recently discovered that Chromatin Assembly Factor-1 (CAF-1) regulates protein accumulation and long-range DNA interactions at the nucleolus in human interphase cells. CAF-1 also regulates the protein composition of human mitotic chromosomes. These novel activities are mediated via regulation of the proliferation antigen Ki-67. (Smith et al., Mol. Biol. Cell 25: 2866-2881 (2014); Matheson and Kaufman, Chromosoma 125: 361-71 (2016); Mol. Biol. Cell 28: 21-29 (2017)). We are investigating how these proteins shape the structure of the human cell nucleus, and are also currently performing genome-scale analyses of mouse and human heterochromatin-nucleolar interactions. Ki-67 is particularly interesting not only because of its use as a clinical tumor marker, but because we find that it links cell cycle progression and heterochromatin maintenance in p21 checkpoint-proficient human cells (Sun et al. Mol. Cell. Biol. In press (2017).
Please enquire with Dr. Kaufman
Highly motivated individuals who have first-author publications and are seeking postdoctoral training are encouraged to apply. Contact Dr. Kaufman