Thomas Fazzio, Ph.D.
|Ph.D., 2004, University of Washington and Fred Hutchinson Cancer Research Center|
|Postdoctoral research: chromatin regulation in stem cells at the University of California, San Francisco|
|Office:||University of Massachusetts Medical School
364 Plantation Street, LRB-519
Worcester, MA 01605
We are interested in the mechanisms by which chromatin structure and chromatin regulatory proteins impact gene expression, self-renewal, and differentiation of stem cells. To study these processes, we utilize molecular, cellular, genetic, biochemical and genomics approaches in embryonic stem cell culture, as well as mouse models. Our long-term goal is to understand how chromatin structure and chromatin regulators control transcriptional networks that regulate cell fate, and how these networks are rewired during cellular transitions like differentiation.
Rotation projects are available on any of several main topics being studied in the lab, including the regulation and mechanisms of action of the Tip60-p400 or Mbd3/NuRD chromatin remodeling complexes during embryonic stem cell differentiation, functions of non-coding RNAs in regulation of chromatin structure and ES cell pluripotency, or other topics related to chromatin structure and gene regulation. Rotation projects will usually involve some combination of mammalian cell culture, molecular biology, biochemistry, and genomic approaches.
A postdoctoral position is available to study in this laboratory. Please contact Dr. Fazzio for details