Yong-Xu Wang, Ph.D.
|Ph.D., 1999, University of Iowa|
|Postdoctoral research: Salk Institute|
|Office:||University of Massachusetts Medical School
364 Plantation Street, LRB-517
Worcester, MA 01605
Brown fat and white fat have opposite function-energy expenditure and energy storage, respectively. In addition, white fat displays considerable plasticity of switching to brown-like adipocytes under proper stimuli. Both brown and brown-like adipocytes are present in adult humans and have become a potential drug discovery target for obesity and associated metabolic diseases. We are interested in cellular and molecular mechanisms controlling brown fat fate determination and maintenance and whether these mechanisms can be explored to convert white adipocytes to brown-like adipocytes. We particularly focus on transcriptional control, epigenetics, non-coding RNAs, and signaling molecules. We employ an array of tools such as knockout and transgenic mice, deep sequencing, and CRISPR-mediated genome editing in our study.
Rotation projects are available.
Postdoctoral positions are available.