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William Flavahan, Ph.D.


Assistant Professor Marcus Ruscetti
   

Ph.D.: 2014, Cleveland Clinic Lerner College of Medicine of Case Western  Reserve University

Postdoctoral research:  Massachusetts General Hospital and Harvard Medical School. The Broad Institute of Harvard and MIT

Office: University of Massachusetts Medical School
364 Plantation Street, LRB-515
Worcester, MA 01605
Phone:  
Email: William.Flavahan@umassmed.edu

Research

Research in the Flavahan lab focuses on how defects in the molecular structure of the genome, called chromatin, can affect the expression of cancer related genes.  These defects, including changes in repressive histone marks and the three dimensional structure of the genome, can activate genetically intact oncogenes and lead to tumorigenesis.  By understanding these epigenetic mechanisms, we hope to uncover therapeutic vulnerabilities that can lead to advances in patient care.

Rotation Projects

Rotation projects are available on several topics, including:

Project 1: Characterize chromatin states in tumor models with cryptic genetic driver mutations.

Project 2: Develop and optimize epigenome editing tools to interrogate the effects of chromatin alterations on oncogene expression.

Project 3: Develop and utilize assays for isolation of targeted epigenetic elements, such as insulators and enhancers.


Please contact Dr. Flavahan for more detail.

Positions Available

Positions are available for rotation students, postdocs, and technicians.