|Ph.D., 2002, University of Rochester|
|Postdoctoral research: Harvard University|
|Office:||University of Massachusetts Medical School
364 Plantation Street, LRB-409
Worcester, MA 01605
My lab is interested in investigating the signaling mechanisms that underlie organogenesis and tumorigenesis of the gastrointestinal tract. Our work is focused on several key developmental pathways including Hedgehog, Hippo and Wnt signaling. We use a combination of transgenic mouse models and cellular approaches to dissect their roles in stem cell/progenitor self-renewal and differentiation, epithelial-mesenchymal interaction, and understand how dysregulation of these pathways contributes to gastrointestinal tumor initiation and progression.
Rotation project #1: Characterization of YAP/TEAD-mediated oncogenic program in cancer cells
Rotation project #2: Gli-controlled transcriptional network in GI cancer cells.
A postdoctoral position is available to study in this laboratory. Contact Dr. Mao for additional details.