|Office:||University of Massachusetts Medical School
364 Plantation Street, LRB-425
Worcester, MA 01605
We study how cells and organisms adapt to mitochondrial dysfunction focusing on a protective stress response known as the mitochondrial UPR. We are interested in the mechanisms by which cells evaluate mitochondrial function and the modes of signal transduction that drive activation of the protective response. We focus on such mechanisms in physiologic scenarios where the UPRmt plays a role such as during aging, infection and cancer.
Current projects focus on how the transcription factor ATFS-1 and the UPRmt are regulated and how it integrates with systems that respond to nutrient or metabolic status. Additional projects include the role of the UPRmt in the propagation of deleterious mitochondrial genomes during aging and in cancer cells, and the role of the UPRmt in detecting and eliminating those pathogens that perturb mitochondrial function. These projects are performed in C. elegans as well as mammalian models.
Multiple positions are available for motivated students, postdoctoral fellows and a technician.