HIV-1

Research in the Gottlinger laboratory focuses on interactions between HIV-1, the virus that causes AIDS, and the host cell in which it propagates. One major goal is to understand the role of a cellular membrane fission machinery in the assembly and release of infectious HIV-1 particles from the cell surface. Another area of interest are cellular factors that are potentially involved in the organization of the viral RNA genome and its uptake into HIV-1 particles. Furthermore, the Gottlinger laboratory investigates the function of an accessory HIV-1 protein called Nef, which is not essential for the virus to multiply, but for unknown reasons is crucial for its ability to cause disease.

Dr. Heinrich Gottlinger
Heinrich.Gottlinger@umassmed.edu

For more information, please visit Dr. Heinrich Gottlinger Faculty Profile.