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Rigor and Transparency in NIH Grant and Career Development Applications

Effective January 2016, NIH established critical changes to grant applications that are intended to enhance the reproducibility of research findings (Notice Numbers: NOT-OD-16-011, NOT-OD-16-012 and NOT-OD-17-068).

Beginning with applications due on January 25, 2019 the application instructions and review criteria will be clarified to replace the term “scientific premise” with the term "rigor of the prior research". Applicants will also be instructed to describe plans to address any weaknesses in the rigor of prior research within the Research Strategy. For additional details, see NOT-OD-18-228 and NOT-OD-18-229. These new instructions and revised review criteria focus on the following four areas deemed important for enhancing rigor and transparency:

  1. The rigor of the prior research

  2. Rigorous experimental design for robust and unbiased results

  3. Consideration of relevant biological variables

  4. Authentication of key biological and/or chemical resources

There are a number of good resources on the web to help you. Some of our favorites include:

UMass Chan recently received an administrative supplement to redesign our rigor and reproducibility curriculum for trainees. Read more here.

Rigor & Reproducibility Seminar Series Videos               Fundamentals of Clinical Research Mini Course Videos

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Rigor and Reproducibility Seminar: "Industry Influence on the DSM 5 TR: Prolonged Grief Disorder and Treatment Resistant Depression"

Presented by Lisa Cosgrove-Berman, PhD, Department of counseling and School Psychology, UMass Boston

 

Slide Presentation

Seminar Transcript

Flyer

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Fundamentals of Clinical Research - Mini Course #1  "Everything you need to know about the IRB and then some" 

Presented by Heather Strom Tessier, MA

This lecture series is designed for students in training, residents, post-doctoral fellows, and junior faculty who are interested in learning about the most commonly employed study designs used in clinical and public health research and about the IRB review process. Additional Supporting Documents:

  1. PQHI Fundamentals IRB Powerpoint Presentation
  2. PQHS Fundamental Course IRB Links
  3. RMS Job Aid Clinical and Other External User Log In
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Rigor and Reproducibility Seminar: "Sharing Confidential and Sensitive Data”                                 

Presented by: George Alter, PhD, Research Professor Emeritus, Institute for Social Research, University of Michigan 

Special Seminar Flyer

Powerpoint Presentation

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Fundamentals of Clinical Research  - Mini course #2 "Observational Studies Used in Clinical Research"

Presented by Rob Goldberg, PhD 

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Rigor and Reproducibility Seminar: “Are Predatory Journals Bad Hombres?”

Presented by David Moher, PhD, MSc, BA, Professor, Senior Scientist, Clinical Epidemiology Program Ottawa Hospital Research Institute

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Fundamentals of Clinical Research - Mini Course #3

"Randomized Clinical Trials: Introduction and Theory"

Presented by Bruce Barton, PhD

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Rigor & Reprodcuibility Seminar: "Intro to Reproducibility Crisis"

Presented by David Jensen, PhD, Director of Knowledge Discovery Laboratory, Manning College of Information & Computer Science, UMass Amherst

Reproducibility Talk PDF

Dr. Jensen Bio

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Fundamentals of Clinical Research - Mini Course #4

"Randomized Clinical Trials: Implementation and Conduct"

Presented by Bruce Barton, PhD

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Rigor and Reproducibility Seminar: "Rigor, Transperancy and NIH Grants Review"

Presented By Devon Crawford, PhD, Program Director, Office of Research Quality, National Institute of Neurological Disorders and Stroke (NINDS)

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Fundamentals of Clinical Research - Mini Course #5

"Randomized Clinical Trials - Analysis and Publication" 

Presented by Bruce Barton, PhD