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Publications 2020

Batista TM, Dagdeviren S, Carroll SH, Cai W, Melnik VY, Noh HL, Saengnipanthkul S, Kim JK, Kahn CR, Lee RT. Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver. Proc Natl Acad Sci U S A. 2020;117(12):6733-40. Epub 2020/03/12. doi: 10.1073/pnas.1922370117. PubMed PMID: 32156724; PMCID: PMC7104271.

Bose S, Volpatti LR, Thiono D, Yesilyurt V, McGladrigan C, Tang Y, Facklam A, Wang A, Jhunjhunwala S, Veiseh O, Hollister-Lock J, Bhattacharya C, Weir GC, Greiner DL, Langer R, Anderson DG. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nat Biomed Eng. 2020. Epub 2020/04/02. doi: 10.1038/s41551-020-0538-5. PubMed PMID: 32231313. 

Campuzano A, Zhang H, Ostroff GR, Dos Santos Dias L, Wuthrich M, Klein BS, Yu JJ, Lara HH, Lopez-Ribot JL, Hung CY. CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection. J Immunol. 2020;204(12):3296-306. Epub 2020/05/03. doi: 10.4049/jimmunol.1900793. PubMed PMID: 32358020. 

Carreiro S, Marvel-Coen J, Lee R, Chapman B, Ambros V. Circulating microRNA Profiles in Acetaminophen Toxicity. J Med Toxicol. 2020;16(2):177-87. Epub 2019/12/04. doi: 10.1007/s13181-019-00739-6. PubMed PMID: 31792846; PMCID: PMC7099119.

Chauhan G, McClure J, Hekman J, Marsh PW, Bailey JA, Daniels RF, Genereux DP, Karlsson EK. Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution. Front Genet. 2019;10:1322. Epub 2020/02/11. doi: 10.3389/fgene.2019.01322. PubMed PMID: 32038704; PMCID: PMC6985576.

Chen HJ, Li Q, Nirala NK, Ip YT. The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila. Stem Cell Reports. 2020;14(5):828-44. Epub 2020/04/25. doi: 10.1016/j.stemcr.2020.03.021. PubMed PMID: 32330445; PMCID: PMC7220990. 

Corrigan JK, Ramachandran D, He Y, Palmer CJ, Jurczak MJ, Chen R, Li B, Friedline RH, Kim JK, Ramsey JJ, Lantier L, McGuinness OP, Mouse Metabolic Phenotyping Center Energy Balance Working G, Banks AS. A big-data approach to understanding metabolic rate and response to obesity in laboratory mice. Elife. 2020;9. Epub 2020/05/02. doi: 10.7554/eLife.53560. PubMed PMID: 32356724; PMCID: PMC7274785. 

Czech MP. Mechanisms of insulin resistance related to white, beige, and brown adipocytes. Mol Metab. 2020;34:27-42. Epub 2020/03/18. doi: 10.1016/j.molmet.2019.12.014. PubMed PMID: 32180558; PMCID: PMC6997501. 

Damas J, Hughes GM, Keough KC, Painter CA, Persky NS, Corbo M, Hiller M, Koepfli KP, Pfenning AR, Zhao H, Genereux DP, Swofford R, Pollard KS, Ryder OA, Nweeia MT, Lindblad-Toh K, Teeling EC, Karlsson EK, Lewin HA. Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates. bioRxiv. 2020. Epub 2020/06/09. doi: 10.1101/2020.04.16.045302. PubMed PMID: 32511356; PMCID: PMC7263403. 

Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biol. 2020;18(2):e3000626. Epub 2020/02/11. doi: 10.1371/journal.pbio.3000626. PubMed PMID: 32040508; PMCID: PMC7034923. 

Davidson AR, Lu WT, Stanley SY, Wang J, Mejdani M, Trost CN, Hicks BT, Lee J, Sontheimer EJ. Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems. Annu Rev Biochem. 2020;89:309-32. Epub 2020/03/19. doi: 10.1146/annurev-biochem-011420-111224. PubMed PMID: 32186918. 

Desai PB, Stuck MW, Lv B, Pazour GJ. Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling. J Cell Biol. 2020;219(7). Epub 2020/05/22. doi: 10.1083/jcb.201912104. PubMed PMID: 32435793. 

Dobson HE, Dias LDS, Kohn EM, Fites S, Wiesner DL, Dileepan T, Kujoth GC, Abraham A, Ostroff GR, Klein BS, Wuthrich M. Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance. Mucosal Immunol. 2020;13(3):518-29. Epub 2020/01/05. doi: 10.1038/s41385-019-0244-3. PubMed PMID:
31900406; PMCID: PMC7183437. 

Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020;12(1). Epub 2020/01/19. doi: 10.3390/v12010103. PubMed PMID: 31952255; PMCID:

Frantz WT, Ceol CJ. From Tank to Treatment: Modeling Melanoma in Zebrafish. Cells. 2020;9(5). Epub 2020/05/28. doi: 10.3390/cells9051289. PubMed PMID: 32455885; PMCID: PMC7290816. 

Gil A, Kamga L, Chirravuri-Venkata R, Aslan N, Clark F, Ghersi D, Luzuriaga K, Selin LK. Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor alpha and beta Repertoires. mBio. 2020;11(2). Epub 2020/03/19. doi: 10.1128/mBio.00250-20. PubMed PMID: 32184241; PMCID: PMC7078470. 

Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Noh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, Mootha VK. Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 2020. Epub 2020/05/29. doi: 10.1038/s41586-020-2337-2. PubMed PMID: 32461692. 

Guilherme A, Yenilmez B, Bedard AH, Henriques F, Liu D, Lee A, Goldstein L, Kelly M, Nicoloro SM, Chen M, Weinstein L, Collins S, Czech MP. Control of Adipocyte Thermogenesis and Lipogenesis through beta3-Adrenergic and Thyroid Hormone Signal Integration. Cell Rep. 2020;31(5):107598. Epub 2020/05/07. doi: 10.1016/j.celrep.2020.107598. PubMed PMID: 32375048. 

Gupta R, Malvi P, Parajuli KR, Janostiak R, Bugide S, Cai G, Zhu LJ, Green MR, Wajapeyee N. KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity. Proc Natl Acad Sci U S A. 2020;117(22):12341-51. Epub 2020/05/21. doi: 10.1073/pnas.2005156117. PubMed PMID: 32430335; PMCID: PMC7275752. 

Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy B, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu YL, Kuhn B. Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. Dev Cell. 2020;53(1):42-59 e11. Epub 2020/02/29. doi: 10.1016/j.devcel.2020.01.030. PubMed PMID: 32109383. 

Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020;117(6):2751-60. Epub 2020/01/26. doi: 10.1073/pnas.1920004117. PubMed PMID: 31980524; PMCID: PMC7022151. 

Hayden CA, Landrock D, Hung CY, Ostroff G, Fake GM, Walker JH, Kier A, Howard JA. Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone. Vaccines (Basel). 2020;8(1). Epub 2020/01/25. doi: 10.3390/vaccines8010037. PubMed PMID: 31973150; PMCID: PMC7157212. 

Hester MM, Lee CK, Abraham A, Khoshkenar P, Ostroff GR, Levitz SM, Specht CA. Protection of mice against experimental cryptococcosis using glucan particle-based vaccines containing novel recombinant antigens. Vaccine. 2020;38(3):620-6. Epub 2019/11/09. doi: 10.1016/j.vaccine.2019.10.051. PubMed PMID: 31699504; PMCID: PMC6954324. 

Holdorf AD, Higgins DP, Hart AC, Boag PR, Pazour GJ, Walhout AJM, Walker AK. WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data. Genetics. 2020;214(2):279-94. Epub 2019/12/08. doi: 10.1534/genetics.119.302919. PubMed PMID: 31810987; PMCID: PMC7017019. 

Iwanaga R, Truong BT, Hsu JY, Lambert KA, Vyas R, Orlicky D, Shellman YG, Tan AC, Ceol C, Artinger KB. Loss of prdm1a accelerates melanoma onset and progression. Mol Carcinog. 2020. Epub 2020/06/21. doi: 10.1002/mc.23236. PubMed PMID: 32562448. 

Krietenstein N, Abraham S, Venev SV, Abdennur N, Gibcus J, Hsieh TS, Parsi KM, Yang L, Maehr R, Mirny LA, Dekker J, Rando OJ. Ultrastructural Details of Mammalian Chromosome Architecture. Mol Cell. 2020;78(3):554-65 e7. Epub 2020/03/28. doi: 10.1016/j.molcel.2020.03.003. PubMed PMID: 32213324; PMCID: PMC7222625. 

Kwan SY, Sheel A, Song CQ, Zhang XO, Jiang T, Dang H, Cao Y, Ozata DM, Mou H, Yin H, Weng Z, Wang XW, Xue W. Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes. Hepatology. 2020;71(1):275-90. Epub 2019/06/13. doi: 10.1002/hep.30807. PubMed PMID: 31188495; PMCID: PMC6906267. 

Leech CM, Flynn MJ, Arsenault HE, Ou J, Liu H, Zhu LJ, Benanti JA. The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network. PLoS Genet. 2020;16(4):e1008600. Epub 2020/04/29. doi: 10.1371/journal.pgen.1008600. PubMed PMID: 32343701; PMCID: PMC7209309. 

Li Q, Sun Y, Jarugumilli GK, Liu S, Dang K, Cotton JL, Xiol J, Chan PY, DeRan M, Ma L, Li R, Zhu LJ, Li JH, Leiter AB, Ip YT, Camargo FD, Luo X, Johnson RL, Wu X, Mao J. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell. 2020;26(5):675-92 e8. Epub 2020/04/08. doi: 10.1016/j.stem.2020.03.002. PubMed PMID: 32259481; PMCID: PMC7310193. 

Lin AE, Diehl WE, Cai Y, Finch CL, Akusobi C, Kirchdoerfer RN, Bollinger L, Schaffner SF, Brown EA, Saphire EO, Andersen KG, Kuhn JH, Luban J, Sabeti PC. Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111. Viruses. 2020;12(1). Epub 2020/01/19. doi: 10.3390/v12010105. PubMed PMID: 31952352; PMCID: PMC7019320. 

Magaletta ME, Siller R, Maehr R. Differentiation of human pluripotent stem cells toward pharyngeal endoderm derivatives: Current status and potential. Curr Top Dev Biol. 2020;138:175-208. Epub 2020/03/30. doi: 10.1016/bs.ctdb.2020.01.004. PubMed PMID: 32220297. 

Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villen J, Wellen KE, Guertin DA. mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis. Nat Commun. 2020;11(1):575. Epub 2020/01/31. doi: 10.1038/s41467-020-14430-w. PubMed PMID: 31996678; PMCID: PMC6989638. 

McManus M, Karalius B, Patel K, Persaud D, Luzuriaga K, Pediatric HIVACS. Quantitative HIV-1-specific antibodies as predictors of peripheral blood cell-associated HIV-1 DNA concentrations. AIDS. 2020;34(8):1117-26. Epub 2020/04/15. doi: 10.1097/QAD.0000000000002525. PubMed PMID: 32287055. 

Nyalwidhe JO, Jurczyk A, Satish B, Redick S, Qaisar N, Trombly MI, Vangala P, Racicot R, Bortell R, Harlan DM, Greiner DL, Brehm MA, Nadler JL, Wang JP. Proteomic and Transcriptional Profiles of Human Stem Cell-Derived beta Cells Following Enteroviral Challenge. Microorganisms. 2020;8(2). Epub 2020/02/26. doi: 10.3390/microorganisms8020295. PubMed PMID: 32093375; PMCID: PMC7074978. 

Ohainle M, Kim K, Komurlu Keceli S, Felton A, Campbell E, Luban J, Emerman M. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner. PLoS Pathog. 2020;16(4):e1008507. Epub 2020/04/14. doi: 10.1371/journal.ppat.1008507. PubMed PMID: 32282853; PMCID: PMC7179944. 

Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K. The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV. Lancet HIV. 2020;7(5):e359-e65. Epub 2020/05/11. doi: 10.1016/S2352-3018(20)30100-4. PubMed PMID: 32386722. 

Parhad SS, Yu T, Zhang G, Rice NP, Weng Z, Theurkauf WE. Adaptive Evolution Targets a piRNA Precursor Transcription Network. Cell Rep. 2020;30(8):2672-85 e5. Epub 2020/02/27. doi: 10.1016/j.celrep.2020.01.109. PubMed PMID: 32101744; PMCID: PMC7061269. 

Pazour GJ, Quarmby L, Smith AO, Desai PB, Schmidts M. Cilia in cystic kidney and other diseases. Cell Signal. 2020;69:109519. Epub 2019/12/28. doi: 10.1016/j.cellsig.2019.109519. PubMed PMID: 31881326; PMCID: PMC6953175. 

Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A. Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice. FASEB J. 2020;34(1):1901-11. Epub 2020/01/10. doi: 10.1096/fj.201901022RR. PubMed PMID: 31914605; PMCID: PMC6972551. 

Richards R, Schwartz HR, Honeywell ME, Stewart MS, Cruz-Gordillo P, Joyce AJ, Landry BD, Lee MJ. Drug antagonism and single-agent dominance result from differences in death kinetics. Nat Chem Biol. 2020;16(7):791-800. Epub 2020/04/07. doi: 10.1038/s41589-020-0510-4. PubMed PMID: 32251407; PMCID: PMC7311243. 

Ruiz CF, Montal ED, Haley JA, Bott AJ, Haley JD. SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC. FASEB J. 2020. Epub 2020/06/23. doi: 10.1096/fj.202000052R. PubMed PMID: 32568455. 

Shah S, Molinaro G, Liu B, Wang R, Huber KM, Richter JD. FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism. Cell Rep. 2020;30(13):4459-72 e6. Epub 2020/04/03. doi: 10.1016/j.celrep.2020.02.076. PubMed PMID: 32234480; PMCID: PMC7179797. 

Shih DJH, Nayyar N, Bihun I, Dagogo-Jack I, Gill CM, Aquilanti E, Bertalan M, Kaplan A, D'Andrea MR, Chukwueke U, Ippen FM, Alvarez-Breckenridge C, Camarda ND, Lastrapes M, McCabe D, Kuter B, Kaufman B, Strickland MR, Martinez-Gutierrez JC, Nagabhushan D, De Sauvage M, White MD, Castro BA, Hoang K, Kaneb A, Batchelor ED, Paek SH, Park SH, Martinez-Lage M, Berghoff AS, Merrill P, Gerstner ER, Batchelor TT, Frosch MP, Frazier RP, Borger DR, Iafrate AJ, Johnson BE, Santagata S, Preusser M, Cahill DP, Carter SL, Brastianos PK. Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma. Nat Genet. 2020;52(4):371-7. Epub 2020/03/24. doi: 10.1038/s41588-020-0592-7. PubMed PMID: 32203465; PMCID: PMC7136154. 

Sissaoui S, Yu J, Yan A, Li R, Yukselen O, Kucukural A, Zhu LJ, Lawson ND. Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression. Circ Res. 2020;126(7):875-88. Epub 2020/02/18. doi: 10.1161/CIRCRESAHA.119.316075. PubMed PMID: 32065070;
PMCID: PMC7212523. 

Smith JL, Rodriguez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Weng Z, Sontheimer EJ, Xue W. YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells. Hepatology. 2020. Epub 2020/05/27. doi: 10.1002/hep.31389. PubMed PMID: 32452550. 

Stanney W, 3rd, Ladam F, Donaldson IJ, Parsons TJ, Maehr R, Bobola N, Sagerstrom CG. Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish. Dev Biol. 2020;459(2):161-80. Epub 2019/12/22. doi: 10.1016/j.ydbio.2019.12.003. PubMed PMID: 31862379; PMCID: PMC7080602.

Struck MW, Pazour GJ, Lambright DG. X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease. Structure. 2020;28(4):385-7. Epub 2020/04/09. doi: 10.1016/j.str.2020.03.005. PubMed PMID: 32268075. 

Tran KV, Brown EL, DeSouza T, Jespersen NZ, Nandrup-Bus C, Yang Q, Yang Z, Desai A, Min SY, Rojas-Rodriguez R, Lundh M, Feizi A, Willenbrock H, Larsen TJ, Severinsen MCK, Malka K, Mozzicato AM, Deshmukh AS, Emanuelli B, Pedersen BK, Fitzgibbons T, Scheele C, Corvera S, Nielsen S. Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473. Nat Metab. 2020;2(5):397-412. Epub 2020/05/23. doi: 10.1038/s42255-020-0205-x. PubMed PMID: 32440655; PMCID: PMC7241442. 

Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice. Sci Rep. 2020;10(1):4561. Epub 2020/03/14. doi: 10.1038/s41598-020-61443-y. PubMed PMID: 32165710; PMCID: PMC7067781. 

Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020;21(3):274-86. Epub 2020/02/19. doi: 10.1038/s41590-020-0593-9. PubMed PMID: 32066947; PMCID: PMC7044076. 

Wang Z, Shi Y, Ma S, Huang Q, Yap YT, Shi L, Zhang S, Zhou T, Li W, Hu B, Zhang L, Krawetz SA, Pazour GJ, Hess RA, Zhang Z. Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice. Am J Physiol Cell Physiol. 2020;318(1):C174-C90. Epub 2019/10/03. doi: 10.1152/ajpcell.00517.2018. PubMed PMID: 31577511; PMCID: PMC6985835. 

Wu SS, Li QC, Yin CQ, Xue W, Song CQ. Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases. Theranostics. 2020;10(10):4374-82. Epub 2020/04/16. doi: 10.7150/thno.43360. PubMed PMID: 32292501; PMCID: PMC7150498.  

Yukselen O, Turkyilmaz O, Ozturk AR, Garber M, Kucukural A. DolphinNext: a distributed data processing platform for high throughput genomics. BMC Genomics. 2020;21(1):310. Epub 2020/04/21. doi: 10.1186/s12864-020-6714-x. PubMed PMID: 32306927; PMCID: PMC7168977.