Molecular Medicine Special Seminar

Guangshuo Ou, PhD

School for Life Sciences Tsinghua and Peking Universities
Beijing, China

“Intraflagellar Transport in
C. elegans Sensory Neurons

Friday, March 22, 2019 @10:00am

Host: Victor R. Ambros, PhD

Molecular Medicine Seminar Room
3rd Floor, Biotech Two
373 Plantation Street
Worcester, MA 01605

Molecular Medicine In-House Seminar Series

Thomas Fazzio, PhD
Associate Professor Molecular, Cell and Cancer Biology
UMass Medical School

“Roles of chromatin remodeling factors in cell fate and development”

Monday, April 1, 2019 @12:00 pm

Host: Roger J. Davis, PhD

Molecular Medicine Seminar Room
3rd Floor, Biotech Two
373 Plantation Street
Worcester, MA 01605

Pioneers in Molecular Medicine Distinguished Lecture

Michael Rosbash, Ph.D.
Howard Hughes Medical Institute
Departments of Biology &
Brandeis University

“Circadian Rhythms and Gene Expressionin Discrete Neurons” 

Thursday, April 4, 2019 @4:00pm

 Host: Roger J. Davis, Ph.D.

Molecular Medicine Seminar Room
rd Floor, Biotech Two

373 Plantation Street, Worcester, MA 01605

 Chair's Message

In-House Seminar Series


2005 - 2008 - 2012 - 2015


Roger Davis Election to the National Academy of Sciences 2018

Michael Green Election to the National Academy of Sciences 2014

Nobel Prize Reception

Davis Royal Society Reception

Ambros Lasker Reception

Ambros Silverman Lecture


Caterina Strambio De Castillia named Imaging Scientist by Chan Zuckerberg Initiative (article)

Roger Davis to chair Program in Molecular Medicine (announcement)


Silvia Corvera - Transforming white fat into beige to harness its ability to burn energy, accelerate metabolism and fight disease. (Article) {Video}

UMMS scientists receive $1.6M in NIH funding to improve genome editing techniques.
Guangping Gao, PhD, and Erik Sontheimer, PhD, will lead the research teams. (Article)

Jeremy Luban - UMMS study identifies potential on/off switch for HIV-1.
Discovery points to a new strategy for eliminating latent HIV-1 reservoirs.  (article)

Paul Greer - Smelling the Cheese
using the mouse olfactory system to explore how sensory input gets translated into action. (video)

Craig Peterson receives $4.5 million outstanding investigator award
from NIH MIRA program encourages investigators to embark on ‘long-term projects of unusual potential’ (announcement)

Additional Announcements



Recent Molecular Medicine Publications


Brown fat organogenesis and maintenance requires AKT1 and AKT2.
Sanchez-Gurmaches J, Martinez Calejman C, Jung SM, Li H, Guertin DA.  Mol Metab. 2019 Feb 20. pii: S2212-8778(18)30060-7. doi: 10.1016/j.molmet.2019.02.004. [Epub ahead of print] PMID: 30833219. (Paper)

Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity.
Nelson C, Ambros V.  Development. 2019 Feb 15. pii: dev.172031. doi: 10.1242/dev.172031. [Epub ahead of print].  PMID: 30770392  (Paper)

The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis.
Choi S, Ambros V.  Development. 2019 Feb 11. pii: dev.164293. doi: 10.1242/dev.164293. [Epub ahead of print] PMID: 30745431.  (Paper)


Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines. 
McCauley SM, Kim K, Nowosielska A, Dauphin A, Yurkovetskiy L, Diehl WE, Luban J. Nat Commun. 2018 Dec 13;9(1):5305. doi: 10.1038/s41467-018-07753-2. PMID: 30546110 [PubMed - indexed for MEDLINE] (Paper)

Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans. 
Dokshin GA, Ghanta KS, Piscopo KM, Mello CC.  Genetics. 2018 Nov;210(3):781-787. doi: 10.1534/genetics.118.301532. Epub 2018 Sep 13.  PMID: 30213854. (Paper)

Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine.
Ding W, Higgins DP, Yadav DK, Godbole AA, Pukkila-Worley R, Walker AK. PLoS Genet. 2018 Nov 28;14(11):e1007812. doi: 10.1371/journal.pgen.1007812. [Epub ahead of print] PMID: 30485261 [PubMed - as supplied by publisher].  (Paper)

SIR proteins create compact heterochromatin fibers.  
Swygert SG, Senapati S, Bolukbasi MF, Wolfe SA, Lindsay S, Peterson CL. Proc Natl Acad Sci U S A. 2018 Nov 19. pii: 201810647. doi: 10.1073/pnas.1810647115. [Epub ahead of print].   PMID: 30455303 [PubMed - as supplied by publisher] (Paper)

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains. 
Oudelaar AM, Davies JOJ, Hanssen LLP, Telenius JM, Schwessinger R, Liu Y, Brown JM, Downes DJ, Chiariello AM, Bianco S, Nicodemi M, Buckle VJ, Dekker J, Higgs DR, Hughes JR.
Nat Genet. 2018 Oct 29. doi: 10.1038/s41588-018-0253-2. [Epub ahead of print] PMID: 30374068 [PubMed - as supplied by publisher] (Paper)

Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.
Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE, Luban J.  Nat Microbiol. 2018 Oct 8. doi: 10.1038/s41564-018-0256-x. [Epub ahead of print].  PMID: 30297740.  (Paper)

CRISPR delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure.
Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP.  J Biol Chem. 2018 Sep 6. pii: jbc.RA118.004554. doi: 10.1074/jbc.RA118.004554. [Epub ahead of print].  PMID: 30190322.  (Paper)

Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs.
Ambros, V, Ruvkun, G.  Genetics. 2018 Jul;209(3):651-673. doi: 10.1534/genetics.118.300291.   PMID:29967059 (Paper)

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing.
Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ.  Nat Commun. 2018 Jul 6;9(1):2641. PMID: 29980686, PMCID: PMC6035171.  (Paper)

Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis.
Guilherme A, Pedersen DJ, Henriques F, Bedard AH, Henchey E, Kelly M, Morgan DA, Rahmouni K, Czech MP. Mol Metab. 2018 Jun 27. pii: S2212-8778(18)30518-0. doi: 10.1016/j.molmet.2018.06.014. [Epub ahead of print] PMID: 30005879.  (Paper)

Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth.
Li Q, Nirala NK, Nie Y, Chen HJ, Ostroff G, Mao J, Wang Q, Xu L, Ip YT.  Dev Cell. 2018 May 21;45(4):433-449.e6. doi: 10.1016. PMID: 29754801.  (Paper)

Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.
Neto A, Ceol CJ. Pigment Cell Melanoma Res. 2018 Jan;31(1):115-119. doi: 10.1111/pcmr.12610. Epub 2017 Oct 23. PMID: 28646617 [PubMed - indexed for MEDLINE].  (Paper)

Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.
Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG. Structure. 2018 Jan 2;26(1):106-117.e6. doi: 10.1016/j.str.2017.11.019. Epub 2017 Dec 21. PMID: 29276036.  (Paper)

 Additional Publications