Our Next Noon Seminar

Monday, May 2, 2016 @ 12PM
Michael H. Brodsky, PhD
Assistant Professor, Molecular, Cell and Cancer Biology
Talk Title: “CRISPR-Cas9 Targeting of SNPs and Repeat Sequences in the Huntington’s Disease Gene”


Chair's Message

In House Seminars

Molecular Medicine History

2005 - 2008 - 2012 - 2015

Michael Green Election to the National Academy of Sciences 2014

Nobel Prize Reception

Davis Royal Society Reception

Ambros Lasker Reception

Ambros Silverman Lecture


Victor Ambros - Awarded 2016 March of Dimes prize for co-discorvery of MicroRNAs (announcement)

Katherine Luzuriaga - Elimination of pediatric HIV

Silvia Corvera - UMMS researchers illuminate origins, benefits of ‘beige fat’

Joel Richter named to newly endowed chair - (Article)

Michael Green elected to National Academy of Medicine - (Article)

UMMS scientists identify genes that shut down HIV-1; research published in Nature - (Article)

Discoveries in Luban, Gottlinger labs point to new strategies for disabling viruses - (Article)

Zhao Zhang receives the 2015 Larry Sandler Memorial Award - (Article)

Jeremy Luban and Manuel Garber receive $6.1 Million over 3 years to
establish one of five Genomics of Gene Regulation Programs - (article) 

Victor Ambros awarded 2015 $3M Breakthrough Prize for co-discovery of microRNAs - (Article)

Joel Richter receives $9.3 million over 5 years to establish one of three national Centers for Collaborative Research in Fragile X - (NIH Article)

Victor Ambros named co-recipient of 2014 Gruber Genetics Prize - (Article)

Heinrich Gottlinger, M.D. recipient of 2014 Avant-Garde Award - (Article)

Michael Green elected to National Academy of Sciences - (Article)

Jeremy Luban elected fellow of the American Academy of Microbiology - (Article)

Victor Ambros named recipient of Israel's 2014 Wolf Prize. - (Article)

Thomas Fazzio named one of the nations top scientists - (Article)

Foreign Policy names Luzuriaga a ‘Leading Global Thinker of 2013’ for HIV research - (Article)

Dekker, Sullivan named fellows of prestigious scientific society
American Association for the Advancement of Science fellows announced - (Article)

Roger Davis wins 2013 Steven C. Beering Award - (Article)

Victor Ambros wins Keio Medical Science Prize - (Article)

Katherine Luzuriaga named one of TIME magazine’s TIME 100 - (Article)

Eduardo Torres Named 2013 Searle Scholar - (Article)

Researchers describe first 'functional HIV cure' in an infant (Article)

Bitter taste receptors in airway cells could help treat asthma attacks - (Article)

Roger Davis elected a Fellow of AAAS - (Article)


Recent Molecular Medicine Publications

Structural analyses of the chromatin remodeling enzymes INO80-C and SWR-C

Watanabe S, Tan D, Lakshminarasimhan M, Washburn MP, Hong EJ, Walz T, Peterson CL.  Nat Commun. 2015 May 12;6:7108. doi: 10.1038/ncomms8108.  PMID: 25964121 [PubMed - indexed for MEDLINE]  PMCID:PMC4431590.  (Paper)

Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants.

McManus M, Mick E, Hudson R, Mofenson LM, Sullivan JL, Somasundaran M, Luzuriaga K; PACTG 356 Investigators.  PLoS One. 2016 Apr 22;11(4):e0154391. doi: 10.1371/journal.pone.0154391. eCollection 2016.  PMID: 27104621 [PubMed - as supplied by publisher].  (Paper)

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.

Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA.  Nat Commun. 2016 Apr 21;7:11365. doi: 10.1038/ncomms11365. PMID: 27098609 [PubMed - in process].  (Paper)

Endothelial MAP4K4 is critical for lymphatic vascular development and function.

Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP.   Mol Cell Biol. 2016 Apr 4. pii: MCB.01121-15. [Epub ahead of print].  PMID: 27044870 [PubMed - as supplied by publisher] (Paper)

Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma.

Han MS, Barrett T, Brehm MA, Davis RJ.   Cell Rep. 2016 Mar 24. pii: S2211-1247(16)30249-2. doi: 10.1016/j.celrep.2016.03.008. [Epub ahead of print]. PMID: 27052181 [PubMed - as supplied by publisher].  (Paper)

Genetic link between renal birth defects and congenital heart disease.

San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ.  Nat Commun. 2016 Mar 22;7:11103. doi: 10.1038/ncomms11103.  PMID: 27002738. PMCID:PMC4804176  (Paper)

The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation.

Hung HF, Hehnly H, Doxsey S.   Curr Biol. 2016 Mar 2. pii: S0960-9822(16)00075-0. doi: 10.1016/j.cub.2016.01.025. [Epub ahead of print].  PMID: 26948879 [PubMed - as supplied by publisher] (Paper)

Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK.

Vernia S, Cavanagh-Kyros J, Barrett T, Tournier C, Davis RJ.   Cell Rep. 2016 Mar 2. pii: S2211-1247(16)30129-2. doi: 10.1016/j.celrep.2016.02.026. [Epub ahead of print].  PMID: 26947074 [PubMed - as supplied by publisher].  (Paper)

The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.

Tang W, Tu S, Lee HC, Weng Z, Mello CC.   Cell. 2016 Feb 25;164(5):974-84. doi: 10.1016/j.cell.2016.02.008. PMID: 26919432 [PubMed - in process] (Paper)

Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.

Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ.  eLife. 2016 Feb 24;5. pii: e10031. doi: 10.7554/eLife.10031. [Epub ahead of print].  PMID: 26910012 [PubMed - as supplied by publisher]. (Paper)

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.

Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP.  Nat Commun. 2016 Feb 16;7:10686. doi: 10.1038/ncomms10686.  PMID: 26880110[PubMed - in process] (Paper)

TNFα-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38α MAPK Pathway.  

Girnius N, Davis RJ.   Cancer Cell. 2016 Feb 8;29(2):131-3.  doi: 10.1016/j.ccell.2016.01.008.  PMID:26859448 [PubMed - in process] (Paper)

Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.

Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S.   Nat Med. 2016 Jan 25. doi: 10.1038/nm.4031. [Epub ahead of print]. PMID:  26808348.  (Paper)

Highly selective in vivo labeling of subcutaneous white adipocyte precursors with Prx1-Cre.

Sanchez-Gurmaches J, Hsiao WY, Guertin DA.   Stem Cell Reports. 2015 Apr 14;4(4):541-50. doi: 10.1016/j.stemcr.2015.02.008. Epub 2015 Mar 19.  PMID: 25801508.  (Paper)

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.

Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. 
Nat Commun. 2015; 6: 8995.  Published online 2015 Dec 21. doi:  10.1038/ncomms9995. 
PMCID: PMC4703891 (Paper)







Molecular Medicine Awards


Victor Ambros awarded 2016 March of Dimes Prize2015 Breakthrough Prize, 2008 Lasker Prize,  Keio Medical Science Award and the Wolf Prize.


Joel Richter named to newly endowed chair

Gregory Pazour

Gregory Pazour receives Lillian Jean Kaplan International Prize

Craig Mello, Ph.D.

Craig Mello receives 2006 Nobel Prize 

Roger Davis, PhD.

Roger Davis elected to Royal Society of London and EMBO

Michael Green, M.D., Ph.D.

Michael Green elected to National Academy of Sciences and EMBO

Jenn Benanti

 Jennifer Benanti receives 2011 Smith Family Award Program for Excellence in Biomedical Research

Eduardo Torres Eduardo Tores receives 2012 Smith Family Award Program for Excellence in Biomedical Research
Dave Guertin, Ph.D.

David Guertin receives 2010 PEW award

Picture of Katherine Luzuriaga  Katherine Luzuriaga named one of Time's most influential people
Picture of Silvia Corvera Silvia Corvera receives Endowed Chair in Diabetes Research
Thomas Fazzio, Ph.D.

Thomas Fazzio receives 2011 PEW award and the Presidential Early Career Awards for Scientists and Engineers

Jeremy Luban, M.D. Jeremy Luban receives Avant-Garde award



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