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Publications 2018

Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh CC, Xing Y, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Strand BL, Rokstad AMA, Lacik I, Langer R, Anderson DG, Oberholzer J. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nat Biomed Eng. 2018;2(11):810-21. Epub 2019/03/16. doi: 10.1038/s41551-018-0275-1. PubMed PMID: 30873298; PMCID: PMC6413527.
https://www.ncbi.nlm.nih.gov/pubmed/30873298   

McManus M, Henderson J, Gautam A, Brody R, Weiss ER, Persaud D, Mick E, Luzuriaga K, Investigators P. Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy. Clin Infect Dis. 2018. Epub 2019/01/23. doi: 10.1093/cid/ciy753. PubMed PMID: 30668843; PMCID: PMC6495016.
https://www.ncbi.nlm.nih.gov/pubmed/30668843    

Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC, 3rd, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA. Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. J Immunol. 2019;202(3):799-804. Epub 2018/12/30. doi: 10.4049/jimmunol.1801085. PubMed PMID: 30593536; PMCID: PMC6344273.
https://www.ncbi.nlm.nih.gov/pubmed/30593536    

Jung SM, Guertin DA. Insulin PACS a Punch in SIRT1 Activity. Mol Cell. 2018;72(6):917-9. Epub 2018/12/24. doi: 10.1016/j.molcel.2018.12.004. PubMed PMID: 30576653. https://www.ncbi.nlm.nih.gov/pubmed/30576653   

Henriques F, Lopes MA, Franco FO, Knobl P, Santos KB, Bueno LL, Correa VA, Bedard AH, Guilherme A, Birbrair A, Peres SB, Farmer SR, Batista ML, Jr. Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome. Sci Rep. 2018;8(1):18024. Epub 2018/12/24. doi: 10.1038/s41598-018-36626-3. PubMed PMID: 30575787; PMCID: PMC6303407.
https://www.ncbi.nlm.nih.gov/pubmed/30575787    

McCauley SM, Kim K, Nowosielska A, Dauphin A, Yurkovetskiy L, Diehl WE, Luban J. Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines. Nat Commun. 2018;9(1):5305. Epub 2018/12/14. doi: 10.1038/s41467-018-07753-2. PubMed PMID: 30546110; PMCID: PMC6294009. https://www.ncbi.nlm.nih.gov/pubmed/30546110   

Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018;9(1):5294. Epub 2018/12/12. doi: 10.1038/s41467-018-07776-9. PubMed PMID: 30531933; PMCID: PMC6288159. https://www.ncbi.nlm.nih.gov/pubmed/30531933  

Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ. NmeCas9 is an intrinsically high-fidelity genome-editing platform. Genome Biol. 2018;19(1):214. Epub 2018/12/07. doi: 10.1186/s13059-018-1591-1. PubMed PMID: 30518407; PMCID: PMC6282386. https://www.ncbi.nlm.nih.gov/pubmed/30518407

Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. MBio. 2018;9(6). Epub 2018/12/06. doi: 10.1128/mBio.02321-18. PubMed PMID: 30514786; PMCID: PMC6282205.
https://www.ncbi.nlm.nih.gov/pubmed/30514786 

Dumas SN, Guo CA, Kim JK, Friedline RH, Ntambi JM. Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver. Biochem Biophys Res Commun. 2019;508(1):87-91. Epub 2018/11/25. doi: 10.1016/j.bbrc.2018.11.083. PubMed PMID: 30470572; PMCID: PMC6309575.
https://www.ncbi.nlm.nih.gov/pubmed/30470572 

Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC. IFN-gamma-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5. Sci Signal. 2018;11(557). Epub 2018/11/22. doi: 10.1126/scisignal.aap9921. PubMed PMID: 30459284. https://www.ncbi.nlm.nih.gov/pubmed/30459284

Swygert SG, Senapati S, Bolukbasi MF, Wolfe SA, Lindsay S, Peterson CL. SIR proteins create compact heterochromatin fibers. Proc Natl Acad Sci U S A. 2018;115(49):12447-52. Epub 2018/11/21. doi: 10.1073/pnas.1810647115. PubMed PMID: 30455303; PMCID: PMC6298083.
https://www.ncbi.nlm.nih.gov/pubmed/30455303 

Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho B, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A. RNAi modulation of placental sFLT1 for the treatment of preeclampsia. Nat Biotechnol. 2018. Epub 2018/11/20. doi: 10.1038/nbt.4297. PubMed PMID: 30451990; PMCID: PMC6526074.
https://www.ncbi.nlm.nih.gov/pubmed/30451990 

Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018;9(1):4856. Epub 2018/11/20. doi: 10.1038/s41467-018-07310-x. PubMed PMID: 30451839; PMCID: PMC6242970. https://www.ncbi.nlm.nih.gov/pubmed/30451839

Quitadamo B, Peters PJ, Koch M, Luzuriaga K, Cheng-Mayer C, Clapham PR, Gonzalez-Perez MP. No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications. Arch Virol. 2019;164(2):473-82. Epub 2018/11/12. doi: 10.1007/s00705-018-4094-1. PubMed PMID: 30415390; PMCID: PMC6369005. https://www.ncbi.nlm.nih.gov/pubmed/30415390

Smith JL, Mou H, Xue W. Understanding and repurposing CRISPR-mediated alternative splicing. Genome Biol. 2018;19(1):184. Epub 2018/11/08. doi: 10.1186/s13059-018-1565-3. PubMed PMID: 30400804; PMCID: PMC6219182.
https://www.ncbi.nlm.nih.gov/pubmed/30400804 

Liu B, Li Y, Stackpole EE, Novak A, Gao Y, Zhao Y, Zhao X, Richter JD. Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation. Proc Natl Acad Sci U S A. 2018;115(48):E11397-E405. Epub 2018/10/31. doi: 10.1073/pnas.1809588115. PubMed PMID: 30373821; PMCID: PMC6275535. https://www.ncbi.nlm.nih.gov/pubmed/30373821

Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018;14(11):1021-31. Epub 2018/10/18. doi: 10.1038/s41589-018-0132-2. PubMed PMID: 30327559; PMCID: PMC6245668.
https://www.ncbi.nlm.nih.gov/pubmed/30327559 

Hamza Z, El-Hashash M, Aly S, Hathout A, Soto E, Sabry B, Ostroff G. Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder. Carbohydr Polym. 2019;203:185-92. Epub 2018/10/16. doi: 10.1016/j.carbpol.2018.08.047. PubMed PMID: 30318202. https://www.ncbi.nlm.nih.gov/pubmed/30318202

Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE, Luban J. Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex. Nat Microbiol. 2018;3(12):1354-61. Epub 2018/10/10. doi: 10.1038/s41564-018-0256-x. PubMed PMID: 30297740; PMCID: PMC6258279.
https://www.ncbi.nlm.nih.gov/pubmed/30297740 

Zhang G, Tu S, Yu T, Zhang XO, Parhad SS, Weng Z, Theurkauf WE. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Cell Rep. 2018;24(13):3413-22 e4. Epub 2018/09/27. doi: 10.1016/j.celrep.2018.08.081. PubMed PMID: 30257203; PMCID: PMC6235161. https://www.ncbi.nlm.nih.gov/pubmed/30257203

Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018;19(1):137. Epub 2018/09/21. doi: 10.1186/s13059-018-1515-0. PubMed PMID: 30231914; PMCID: PMC6146650.
https://www.ncbi.nlm.nih.gov/pubmed/30231914 

Alexander MP, Fiering SN, Ostroff GR, Cramer RA, Mullins DW. Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung. Cancer Immunol Immunother. 2018;67(11):1731-42. Epub 2018/09/01. doi: 10.1007/s00262-018-2234-9. PubMed PMID: 30167860.
https://www.ncbi.nlm.nih.gov/pubmed/30167860 

Zhang XO, Fu Y, Mou H, Xue W, Weng Z. The temporal landscape of recursive splicing during Pol II transcription elongation in human cells. PLoS Genet. 2018;14(8):e1007579. Epub 2018/08/28. doi: 10.1371/journal.pgen.1007579. PubMed PMID: 30148885; PMCID: PMC6110456.
https://www.ncbi.nlm.nih.gov/pubmed/30148885 

Hung CY, Zhang H, Castro-Lopez N, Ostroff GR, Khoshlenar P, Abraham A, Cole GT, Negron A, Forsthuber T, Peng T, Galgiani JN, Ampel NM, Yu JJ. Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection. Infect Immun. 2018;86(11). Epub 2018/08/15. doi: 10.1128/IAI.00070-18. PubMed PMID: 30104216; PMCID: PMC6204714.
https://www.ncbi.nlm.nih.gov/pubmed/30104216 

Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Nat Biotechnol. 2018;36(9):839-42. Epub 2018/08/14. doi: 10.1038/nbt.4219. PubMed PMID: 30102296; PMCID: PMC6126964.
https://www.ncbi.nlm.nih.gov/pubmed/30102296

Lopes MA, Oliveira Franco F, Henriques F, Peres SB, Batista ML, Jr. LLC tumor cells-derivated factors reduces adipogenesis in co-culture system. Heliyon. 2018;4(7):e00708. Epub 2018/08/11. doi: 10.1016/j.heliyon.2018.e00708. PubMed PMID: 30094378; PMCID: PMC6071679.
https://www.ncbi.nlm.nih.gov/pubmed/30094378 

Landry BD, Leete T, Richards R, Cruz-Gordillo P, Schwartz HR, Honeywell ME, Ren G, Schwartz AD, Peyton SR, Lee MJ. Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells. Mol Syst Biol. 2018;14(8):e8322. Epub 2018/08/08. doi: 10.15252/msb.20188322. PubMed PMID: 30082272; PMCID: PMC6078165.
https://www.ncbi.nlm.nih.gov/pubmed/30082272 

Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ. JNK regulates muscle remodeling via myostatin/SMAD inhibition. Nat Commun. 2018;9(1):3030. Epub 2018/08/04. doi: 10.1038/s41467-018-05439-3. PubMed PMID: 30072727; PMCID: PMC6072737. https://www.ncbi.nlm.nih.gov/pubmed/30072727

Braun MC, Castillo-Ruiz A, Indic P, Jung DY, Kim JK, Brown RH, Jr., Swoap SJ, Schwartz WJ. Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. 2019;311:305-12. Epub 2018/07/22. doi: 10.1016/j.expneurol.2018.07.008. PubMed PMID: 30031021; PMCID: PMC6263852. https://www.ncbi.nlm.nih.gov/pubmed/30031021

Guilherme A, Pedersen DJ, Henriques F, Bedard AH, Henchey E, Kelly M, Morgan DA, Rahmouni K, Czech MP. Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis. Mol Metab. 2018;16:116-25. Epub 2018/07/15. doi: 10.1016/j.molmet.2018.06.014. PubMed PMID: 30005879; PMCID: PMC6157614.
https://www.ncbi.nlm.nih.gov/pubmed/30005879 

Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nat Commun. 2018;9(1):2641. Epub 2018/07/08. doi: 10.1038/s41467-018-05073-z. PubMed PMID: 29980686; PMCID: PMC6035171.
https://www.ncbi.nlm.nih.gov/pubmed/29980686 

Ambros V, Ruvkun G. Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018;209(3):651-73. Epub 2018/07/04. doi: 10.1534/genetics.118.300291. PubMed PMID: 29967059; PMCID: PMC6028246. https://www.ncbi.nlm.nih.gov/pubmed/29967059

Gabriel GC, Pazour GJ, Lo CW. Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes. Front Pediatr. 2018;6:175. Epub 2018/07/03. doi: 10.3389/fped.2018.00175. PubMed PMID: 29963541; PMCID: PMC6013576. https://www.ncbi.nlm.nih.gov/pubmed/29963541

Barutcu SA, Girnius N, Vernia S, Davis RJ. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018;14(9):1586-95. Epub 2018/06/29. doi: 10.1080/15548627.2018.1466013. PubMed PMID: 29950132; PMCID: PMC6135577. https://www.ncbi.nlm.nih.gov/pubmed/29950132

Kernfeld EM, Genga RMJ, Neherin K, Magaletta ME, Xu P, Maehr R. A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation. Immunity. 2018;48(6):1258-70 e6. Epub 2018/06/10. doi: 10.1016/j.immuni.2018.04.015. PubMed PMID: 29884461; PMCID: PMC6013397. https://www.ncbi.nlm.nih.gov/pubmed/29884461

Yu B, Lin YA, Parhad SS, Jin Z, Ma J, Theurkauf WE, Zhang ZZ, Huang Y. Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification. EMBO Rep. 2018;19(7). Epub 2018/06/03. doi: 10.15252/embr.201745418. PubMed PMID: 29858487; PMCID: PMC6030695.
https://www.ncbi.nlm.nih.gov/pubmed/29858487 

Girnius N, Edwards YJ, Garlick DS, Davis RJ. The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. Elife. 2018;7. Epub 2018/06/02. doi: 10.7554/eLife.36389. PubMed PMID: 29856313; PMCID: PMC5984035.
https://www.ncbi.nlm.nih.gov/pubmed/29856313 

Magoulas PL, Shchelochkov OA, Bainbridge MN, Ben-Shachar S, Yatsenko S, Potocki L, Lewis RA, Searby C, Marcogliese AN, Elghetany MT, Zapata G, Hernandez PP, Gadkari M, Einhaus D, Muzny DM, Gibbs RA, Bertuch AA, Scott DA, Corvera S, Franco LM. Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN. Blood. 2018;132(6):658-62. Epub 2018/05/23. doi: 10.1182/blood-2017-12-824433. PubMed PMID: 29784638; PMCID: PMC6085991. https://www.ncbi.nlm.nih.gov/pubmed/29784638

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018;102(8):1223-9. Epub 2018/05/22. doi: 10.1097/TP.0000000000002217. PubMed PMID: 29781950.
https://www.ncbi.nlm.nih.gov/pubmed/29781950 

Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. Structure. 2018;26(7):936-47 e3. Epub 2018/05/22. doi: 10.1016/j.str.2018.04.008. PubMed PMID: 29779790; PMCID: PMC6277972.
https://www.ncbi.nlm.nih.gov/pubmed/29779790 

Hu Y, Miller M, Zhang B, Nguyen TT, Nielsen MK, Aroian RV. In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites. PLoS Negl Trop Dis. 2018;12(5):e0006506. Epub 2018/05/19. doi: 10.1371/journal.pntd.0006506. PubMed PMID: 29775454; PMCID: PMC5979042. https://www.ncbi.nlm.nih.gov/pubmed/29775454

Hu Y, Nguyen TT, Lee ACY, Urban JF, Jr., Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Fujiwara RT, Bowman DD, Ostroff GR, Aroian RV. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. Int J Parasitol Drugs Drug Resist. 2018;8(2):287-94. Epub 2018/05/18. doi: 10.1016/j.ijpddr.2018.05.001. PubMed PMID: 29772478; PMCID: PMC6039361.
https://www.ncbi.nlm.nih.gov/pubmed/29772478 

Tai PWL, Xie J, Fong K, Seetin M, Heiner C, Su Q, Weiand M, Wilmot D, Zapp ML, Gao G. Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras. Mol Ther Methods Clin Dev. 2018;9:130-41. Epub 2018/05/17. doi: 10.1016/j.omtm.2018.02.002. PubMed PMID: 29766023; PMCID: PMC5948225. https://www.ncbi.nlm.nih.gov/pubmed/29766023

Li Q, Nirala NK, Nie Y, Chen HJ, Ostroff G, Mao J, Wang Q, Xu L, Ip YT. Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth. Dev Cell. 2018;45(4):433-49 e6. Epub 2018/05/15. doi: 10.1016/j.devcel.2018.04.014. PubMed PMID: 29754801.
https://www.ncbi.nlm.nih.gov/pubmed/29754801 

Gao XD, Tu LC, Mir A, Rodriguez T, Ding Y, Leszyk J, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ. C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2. Nat Methods. 2018;15(6):433-6. Epub 2018/05/08. doi: 10.1038/s41592-018-0006-2. PubMed PMID: 29735996; PMCID: PMC6202229.
https://www.ncbi.nlm.nih.gov/pubmed/29735996 

Deepe GS, Jr., Buesing WR, Ostroff GR, Abraham A, Specht CA, Huang H, Levitz SM. Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice. Vaccine. 2018;36(23):3359-67. Epub 2018/05/08. doi: 10.1016/j.vaccine.2018.04.047. PubMed PMID: 29729993; PMCID: PMC5960637.
https://www.ncbi.nlm.nih.gov/pubmed/29729993 

Brese RL, Gonzalez-Perez MP, Koch M, O'Connell O, Luzuriaga K, Somasundaran M, Clapham PR, Dollar JJ, Nolan DJ, Rose R, Lamers SL. Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues. J Neurovirol. 2018;24(4):439-53. Epub 2018/04/25. doi: 10.1007/s13365-018-0633-5. PubMed PMID: 29687407.
https://www.ncbi.nlm.nih.gov/pubmed/29687407 

Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A. Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs. Mol Cancer Ther. 2018;17(6):1251-8. Epub 2018/04/15. doi: 10.1158/1535-7163.MCT-17-1144. PubMed PMID: 29654062; PMCID: PMC5984726. https://www.ncbi.nlm.nih.gov/pubmed/29654062

Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018;151:10-7. Epub 2018/04/08. doi: 10.1016/j.mod.2018.04.001. PubMed PMID: 29626631; PMCID: PMC5972074.
https://www.ncbi.nlm.nih.gov/pubmed/29626631 

Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Bluher M, Czech MP, Tabas I. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature. 2018;555(7698):673-7. Epub 2018/03/22. doi: 10.1038/nature26138. PubMed PMID: 29562231; PMCID: PMC6021131. https://www.ncbi.nlm.nih.gov/pubmed/29562231

Morel C, Sherrin T, Kennedy NJ, Forest KH, Avcioglu Barutcu S, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, Benveniste M, Davis RJ, Todorovic C. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018;38(15):3708-28. Epub 2018/03/16. doi: 10.1523/JNEUROSCI.1913-17.2018. PubMed PMID: 29540552; PMCID: PMC5895995.
https://www.ncbi.nlm.nih.gov/pubmed/29540552 

Eguether T, Cordelieres FP, Pazour GJ. Intraflagellar transport is deeply integrated in hedgehog signaling. Mol Biol Cell. 2018;29(10):1178-89. Epub 2018/03/16. doi: 10.1091/mbc.E17-10-0600. PubMed PMID: 29540531; PMCID: PMC5935068. https://www.ncbi.nlm.nih.gov/pubmed/29540531

Huang LH, Melton EM, Li H, Sohn P, Jung D, Tsai CY, Ma T, Sano H, Ha H, Friedline RH, Kim JK, Usherwood E, Chang CCY, Chang TY. Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity. Am J Physiol Endocrinol Metab. 2018;315(3):E340-E56. Epub 2018/03/14. doi: 10.1152/ajpendo.00174.2017. PubMed PMID: 29533741; PMCID: PMC6171008.
https://www.ncbi.nlm.nih.gov/pubmed/29533741 

Girnius N, Edwards YJK, Davis RJ. The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution. Cell Death Differ. 2018;25(9):1702-15. Epub 2018/03/08. doi: 10.1038/s41418-018-0081-z. PubMed PMID: 29511338; PMCID: PMC6143629.
https://www.ncbi.nlm.nih.gov/pubmed/29511338 

Seo Y, Kingsley S, Walker G, Mondoux MA, Tissenbaum HA. Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2018;115(12):E2791-E800. Epub 2018/03/08. doi: 10.1073/pnas.1714178115. PubMed PMID: 29511104; PMCID: PMC5866546. https://www.ncbi.nlm.nih.gov/pubmed/29511104

Caracciolo V, Young J, Gonzales D, Ni Y, Flowers SJ, Summer R, Waldman SA, Kim JK, Jung DY, Noh HL, Kim T, Blackshear PJ, O'Connell D, Bauer RC, Kallen CB. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2018;315(4):E676-E93. Epub 2018/03/07. doi: 10.1152/ajpendo.00224.2017. PubMed PMID: 29509432; PMCID: PMC6230714.
https://www.ncbi.nlm.nih.gov/pubmed/29509432 

Edraki A, Sontheimer EJ. CRISPRs from scratch. Nat Microbiol. 2018;3(3):261-2. Epub 2018/02/22. doi: 10.1038/s41564-018-0115-9. PubMed PMID: 29463924. https://www.ncbi.nlm.nih.gov/pubmed/29463924

Donnard E, Vangala P, Afik S, McCauley S, Nowosielska A, Kucukural A, Tabak B, Zhu X, Diehl W, McDonel P, Yosef N, Luban J, Garber M. Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon. Cell Syst. 2018;6(3):381-94 e7. Epub 2018/02/20. doi: 10.1016/j.cels.2018.01.002. PubMed PMID: 29454939; PMCID: PMC5876141.
https://www.ncbi.nlm.nih.gov/pubmed/29454939 

Tran KV, Fitzgibbons T, Min SY, DeSouza T, Corvera S. Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice. Mol Metab. 2018;9:199-206. Epub 2018/02/06. doi: 10.1016/j.molmet.2017.12.014. PubMed PMID: 29396370; PMCID: PMC5869733. https://www.ncbi.nlm.nih.gov/pubmed/29396370

Qaisar N, Jurczyk A, Wang JP. Potential role of type I interferon in the pathogenic process leading to type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2018;25(2):94-100. Epub 2018/01/26. doi: 10.1097/MED.0000000000000399. PubMed PMID: 29369915; PMCID: PMC5836805. https://www.ncbi.nlm.nih.gov/pubmed/29369915

Vertii A, Kaufman PD, Hehnly H, Doxsey S. New dimensions of asymmetric division in vertebrates. Cytoskeleton (Hoboken). 2018;75(3):87-102. Epub 2018/01/24. doi: 10.1002/cm.21434. PubMed PMID: 29360272.
https://www.ncbi.nlm.nih.gov/pubmed/29360272 

Papaiakovou M, Pilotte N, Baumer B, Grant J, Asbjornsdottir K, Schaer F, Hu Y, Aroian R, Walson J, Williams SA. A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen. PLoS Negl Trop Dis. 2018;12(1):e0006130. Epub 2018/01/19. doi: 10.1371/journal.pntd.0006130. PubMed PMID: 29346412; PMCID: PMC5773002. https://www.ncbi.nlm.nih.gov/pubmed/29346412 

Ou J, Wolfe SA, Brodsky MH, Zhu LJ. motifStack for the analysis of transcription factor binding site evolution. Nat Methods. 2018;15(1):8-9. Epub 2018/01/04. doi: 10.1038/nmeth.4555. PubMed PMID: 29298290.
https://www.ncbi.nlm.nih.gov/pubmed/29298290 

Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG. Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors. Structure. 2018;26(1):106-17 e6. Epub 2017/12/26. doi: 10.1016/j.str.2017.11.019. PubMed PMID: 29276036; PMCID: PMC5752578.
https://www.ncbi.nlm.nih.gov/pubmed/29276036 

Owino S, Sanchez-Bretano A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G. Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. J Pineal Res. 2018;64(3). Epub 2017/12/17. doi: 10.1111/jpi.12462. PubMed PMID: 29247541; PMCID: PMC5843510.
https://www.ncbi.nlm.nih.gov/pubmed/29247541 

Kim JH, Lee E, Friedline RH, Suk S, Jung DY, Dagdeviren S, Hu X, Inashima K, Noh HL, Kwon JY, Nambu A, Huh JR, Han MS, Davis RJ, Lee AS, Lee KW, Kim JK. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity. FASEB J. 2018;32(4):2292-304. Epub 2017/12/16. doi: 10.1096/fj.201701017R. PubMed PMID: 29242277; PMCID: PMC6207176. https://www.ncbi.nlm.nih.gov/pubmed/29242277

Morger D, Zosel F, Buhlmann M, Zuger S, Mittelviefhaus M, Schuler B, Luban J, Grutter MG. The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5alpha. J Virol. 2018;92(5). Epub 2017/12/15. doi: 10.1128/JVI.01541-17. PubMed PMID: 29237846; PMCID: PMC5809731. https://www.ncbi.nlm.nih.gov/pubmed/29237846

Zhang Y, Liu H, Li W, Zhang Z, Zhang S, Teves ME, Stevens C, Foster JA, Campbell GE, Windle JJ, Hess RA, Pazour GJ, Zhang Z. Intraflagellar transporter protein 140 (IFT140), a component of IFT-A complex, is essential for male fertility and spermiogenesis in mice. Cytoskeleton (Hoboken). 2018;75(2):70-84. Epub 2017/12/14. doi: 10.1002/cm.21427. PubMed PMID: 29236364; PMCID: PMC5809318. https://www.ncbi.nlm.nih.gov/pubmed/29236364

Venkatesan AM, Vyas R, Gramann AK, Dresser K, Gujja S, Bhatnagar S, Chhangawala S, Gomes CBF, Xi HS, Lian CG, Houvras Y, Edwards YJK, Deng A, Green M, Ceol CJ. Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. J Clin Invest. 2018;128(1):294-308. Epub 2017/12/05. doi: 10.1172/JCI92513. PubMed PMID: 29202482; PMCID: PMC5749509. https://www.ncbi.nlm.nih.gov/pubmed/29202482

Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA. Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metab. 2018;27(1):195-209 e6. Epub 2017/11/21. doi: 10.1016/j.cmet.2017.10.008. PubMed PMID: 29153407; PMCID: PMC5762420.
https://www.ncbi.nlm.nih.gov/pubmed/29153407 

Bourque DL, Bhuiyan TR, Genereux DP, Rashu R, Ellis CN, Chowdhury F, Khan AI, Alam NH, Paul A, Hossain L, Mayo-Smith LM, Charles RC, Weil AA, LaRocque RC, Calderwood SB, Ryan ET, Karlsson EK, Qadri F, Harris JB. Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways. Infect Immun. 2018;86(2). Epub 2017/11/15. doi: 10.1128/IAI.00594-17. PubMed PMID: 29133347; PMCID: PMC5778365.
https://www.ncbi.nlm.nih.gov/pubmed/29133347 

Quitadamo B, Peters PJ, Repik A, O'Connell O, Mou Z, Koch M, Somasundaran M, Brody R, Luzuriaga K, Wallace A, Wang S, Lu S, McCauley S, Luban J, Duenas-Decamp M, Gonzalez-Perez MP, Clapham PR. HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded. J Virol. 2018;92(2). Epub 2017/11/10. doi: 10.1128/JVI.00841-17. PubMed PMID: 29118121; PMCID: PMC5752949.
https://www.ncbi.nlm.nih.gov/pubmed/29118121 

Weiss ER, Lamers SL, Henderson JL, Melnikov A, Somasundaran M, Garber M, Selin L, Nusbaum C, Luzuriaga K. Early Epstein-Barr Virus Genomic Diversity and Convergence toward the B95.8 Genome in Primary Infection. J Virol. 2018;92(2). Epub 2017/11/03. doi: 10.1128/JVI.01466-17. PubMed PMID: 29093087; PMCID: PMC5752928.
https://www.ncbi.nlm.nih.gov/pubmed/29093087 

Hartwig C, Monis WJ, Chen X, Dickman DK, Pazour GJ, Faundez V. Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes. Dev Neurobiol. 2018;78(3):311-30. Epub 2017/10/08. doi: 10.1002/dneu.22542. PubMed PMID: 28986965; PMCID: PMC5816705. https://www.ncbi.nlm.nih.gov/pubmed/28986965

Neto A, Ceol CJ. Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling. Pigment Cell Melanoma Res. 2018;31(1):115-9. Epub 2017/06/25. doi: 10.1111/pcmr.12610. PubMed PMID: 28646617.
https://www.ncbi.nlm.nih.gov/pubmed/28646617 

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