Brian Lewis, Ph.D.
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Professor |
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| Ph.D.: 1997, Johns Hopkins University | ||
| Postdoctoral research: NIH and Memorial Sloan-Kettering Cancer Center | ||
| Office: | UMass Chan Medical School 364 Plantation Street, LRB-521 Worcester, MA 01605 |
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| Phone: | 508-856-4325 | |
| Email: | Brian.Lewis@umassmed.edu | |
Research
Recent advances in oncology have demonstrated the efficacy of targeted therapeutics that inhibit key tumor-driving proteins or processes. Therefore, a primary goal of our laboratory is to elucidate the molecular mechanisms essential for the development and progression of pancreatic and hepatocellular carcinomas, with the goal of informing novel treatment strategies for these malignancies. We perform a combination of in vivo studies utilizing genetically engineered mouse models, cell culture phenotypic assays performed on primary cell cultures and cancer cell lines, and molecular biology and biochemical approaches to address these questions.
View a complete list of Dr. Lewis's published work
Rotation Projects
1. mTORC2 function in pancreatic tumorigenesis
2. Dissection of miR-17~92 and miR-106b~25 in pancreatic tumorigenesis
3. KLF6 target genes involved in hepatocellular carcinoma (HCC) dissemination
4. Involvement of the Notch signaling pathway in HCC metastasis
5. DNPH1 as a therapeutic target in solid tumors
Positions available
same as lab rotations.
UMass Chan News Highlights
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UMass Chan High School Health Careers Program preps students for med school journey
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UMass Chan delivers fitting tribute to young Worcester scholars
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Communicating science: Brian Lewis discusses overcoming therapeutic resistance in pancreatic cancer
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Immunology and microbiology PhD candidate aims to use her voice in science policy career
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David McManus and Brian Lewis named to endowed chairs
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Brian Lewis recognized at Biomedical Science Careers Program Evening of Hope 2020
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