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The Genome Integrity Program is dedicated to pioneering basic research with a direct trajectory towards clinical translation, focusing on the substantial role of DNA repair and replication proficiency in cancer susceptibility, treatment responses, neurodegenerative diseases, and the aging process. We are committed to fostering a robust collaborative network that bridges discovery and clinical application, ensuring that every scientific advancement contributes to improving patient care. Central to our efforts is the establishment of the Genome Dynamics Center (GDC), a centralized core facility equipped with state-of-the-art technology and technical expertise. This hub will not only provide a competitive edge but also advance the frontier of genome stability, supporting our pursuit of excellence in research and its translation to therapeutic innovation.