Cole Haynes, Ph.D.

Professor
Ph.D.:  2003, University of Missouri-Kansas City
Postdoctoral research: New York University School of Medicine
Office:	UMass Chan Medical School 364 Plantation Street, LRB-425 Worcester, MA 01605
Phone:	508-856-
Email:	Cole.Haynes@umassmed.edu

Research

We study how cells and organisms adapt to mitochondrial dysfunction focusing on a protective stress response known as the mitochondrial UPR. We are interested in the mechanisms by which cells evaluate mitochondrial function and the modes of signal transduction that drive activation of the protective response. We focus on such mechanisms in physiologic scenarios where the UPR^mt plays a role such as during aging, infection and cancer.

View a complete list of Dr. Haynes's published work

Visit the Haynes Lab website

Rotation Projects

Current projects focus on how the transcription factor ATFS-1 and the UPR^mt are regulated and how it integrates with systems that respond to nutrient or metabolic status. Additional projects include the role of the UPR^mt in the propagation of deleterious mitochondrial genomes during aging and in cancer cells, and the role of the UPR^mt in detecting and eliminating those pathogens that perturb mitochondrial function. These projects are performed in C. elegans as well as mammalian models.

Positions Available

Multiple positions are available for motivated students, postdoctoral fellows and a technician.