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Brian Lewis, Ph.D.


Professor
George F. Booth Endowed Chair in the Basic Sciences

   
Ph.D.: 1997, Johns Hopkins University  
Postdoctoral research: NIH and Memorial Sloan-Kettering Cancer Center
   
Office: UMass Chan Medical School
364 Plantation Street, LRB-521
Worcester, MA 01605
Phone: 508-856-4325
Email: Brian.Lewis@umassmed.edu

Research  

Recent advances in oncology have demonstrated the efficacy of targeted therapeutics that inhibit key tumor-driving proteins or processes. Therefore, a primary goal of our laboratory is to elucidate the molecular mechanisms essential for the development and progression of pancreatic and hepatocellular carcinomas, with the goal of informing novel treatment strategies for these malignancies. We perform a combination of in vivo studies utilizing genetically engineered mouse models, cell culture phenotypic assays performed on primary cell cultures and cancer cell lines, and molecular biology and biochemical approaches to address these questions.

View a complete list of Dr. Lewis's published work

Rotation Projects

1. mTORC2 function in pancreatic tumorigenesis

2. Dissection of miR-17~92 and miR-106b~25 in pancreatic tumorigenesis

3. KLF6 target genes involved in hepatocellular carcinoma (HCC) dissemination

4. Involvement of the Notch signaling pathway in HCC metastasis

5. DNPH1 as a therapeutic target in solid tumors

Positions available

same as lab rotations.


 

UMass Chan News Highlights

Getting Results…
  • UMass Chan Early Independence Fellows program aims to develop future top investigators

    UMass Chan Early Independence Fellows program aims to develop future top investigators

    Two new donor-funded fellowships are being launched this year at UMass Chan to recruit recent postdoctoral scientists and, through intensive mentoring and resource support, foster their development as independent investigators. The fellowships align with the vision embodied in The Morningside Foundation’s transformational $175 million gift in 2021.  

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  • UMass Chan High School Health Careers Program preps students for med school journey

    UMass Chan High School Health Careers Program preps students for med school journey

    Nineteen rising high school juniors and seniors spent their summer participating in the immersive 2024 High School Health Careers Program at UMass Chan Medical School.  

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  • UMass Chan delivers fitting tribute to young Worcester scholars

    UMass Chan delivers fitting tribute to young Worcester scholars

    UMass Chan presented “scientist-in-training” lab coats to Lake View Elementary School, one of the 11 North Quadrant schools in Worcester that are part of the UMass Chan North Quadrant Support Services Initiative.

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  • Communicating science: Brian Lewis discusses overcoming therapeutic resistance in pancreatic cancer

    Communicating science: Brian Lewis discusses overcoming therapeutic resistance in pancreatic cancer

    Brian Lewis, PhD, is studying therapeutic resistance in pancreatic cancer cells, hoping to change the grim statistics for patients diagnosed with pancreatic cancer.

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  • Immunology and microbiology PhD candidate aims to use her voice in science policy career

    Immunology and microbiology PhD candidate aims to use her voice in science policy career

    PhD candidate Sarah Cleveland’s mission is to ensure that diverse voices are represented and heard. Cleveland, who studies mechanisms of T cell tolerance, wants to pursue a career in science policy after earning her degree.

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  • David McManus and Brian Lewis named to endowed chairs

    David McManus and Brian Lewis named to endowed chairs

    The University of Massachusetts Board of Trustees approved two “accomplished and visionary” University of Massachusetts faculty as endowed chairs at its April meeting.

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  • Brian Lewis recognized at Biomedical Science Careers Program Evening of Hope 2020

    Brian Lewis recognized at Biomedical Science Careers Program Evening of Hope 2020

    Brian Lewis, PhD, was recognized in the Evening of Hope 2020 Honor Roll during the Biomedical Science Careers Program’s annual fundraising ceremony. He was honored for his commitment to the organization’s mission of closing the equity gap and increasing diversity in science professions.

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