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Horae Gene Therapy Center Faculty

  • Terence  Flotte

    Terence Flotte, MD

    Academic Role: Dean School of Medicine, Provost and Executive Deputy Chancellor, Professor, Pediatrics

    Focus: Recombinant adeno-associated virus (AAV) gene therapy vectors for, cystic fibrosis (CF), alpha-1-antitrypsin deficiency (AAT) and fatty oxidation disorders (FAO).

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  • Guangping Gao

    Guangping Gao, PhD

    Academic Role: Professor Department of Microbiology and Physiological Systems, Director Gene Therapy Center & Vector Core, Scientific Director UMMS-China Translational Research Initiatives

    Focus: Adeno-associated virus vector mediated gene transfer for gene therapy & gene therapy of inherited neurodegenerative Canavan Disease.

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  • Alisha Gruntman

    Alisha Gruntman, DVM, PhD, DACVIM

    Academic Role: Assistant Professor, Department of Pediatrics

    Focus: Gene therapy and neuromodulation for respiratory insufficiency in genetic diseases.  Respiratory physiology and neurophysiology core.

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  • Allison Keeler

    Allison Keeler, PhD

    Academic Role: Assistant Professor, Department of Pediatrics

    Focus: Gene therapy and cell engineering for single gene disorders and novel immunotherapeutics

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  • Chris Mueller

    Chris Mueller, PhD

    Academic Role: Associate Professor, Department of Pediatrics

    Focus: Development of gene therapeuitc approaches for genetic disorders of the lung, liver and central nervous system.

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  • Miguel Sena-Esteves

    Miguel Sena-Esteves, PhD

    Academic Role: Associate Professor, Department of Neurology

    Focus: Gene therapy approaches for the treatment of neurodegenerative lysosomal storage diseases such as GM1-gangliosidosis and GM2-gangliosidoses (Tay-Sachs and Sandhoff diseases).

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  • Phil Tai

    Phil Tai, PhD

    Academic Role: Assistant Professor, Department of Microbiology and Physiological Systems

    Focus: Development of next-gen sequencing methodologies to profile AAV vector genome quality, and discovery and characterization of natural AAV capsid isolates for vectorization and gene therapy.

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  • Dan Wang

    Dan Wang, PhD

    Academic Role: Assistant Professor, RNA Therapeutics Institute

    Focus: AAV-mediated RNA therapeutics and gene editing therapeutics; AAV biology; Gene therapy for rare diseases; Animal modeling.

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  • Jun Xie

    Jun Xie, PhD

    Academic Role: Research Assistant Professor, Department of Microbiology and Physiological Systems

    Focus: AAV vector technology and AAV-mediated miRNA therapeutics.

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