Guangping Gao, PhD

• Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

• Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

• Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration

• Letter to the Editor: mRNA Vaccines in Urological Malignancies

• Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome

• Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery

• WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects

• Direct ITR-to-ITR Nanopore Sequencing of AAV Vector Genomes

• Ocular Drug Delivery: Advancements and Innovations

• Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

• AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy

• Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector

• Evaluating the state of the science for adeno-associated virus integration: An integrated perspective

• Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders

• Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles

• Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

• AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice

• Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity

• Durability of transgene expression after rAAV gene therapy

• Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes

• High concordance of ELISA and neutralization assays allows for the detection of antibodies to individual AAV serotypes

• Proteomic changes of aqueous humor in proliferative diabetic retinopathy patients treated with different intravitreal anti-VEGF agents

• Editorial: "AAV Gene Therapy: Immunology and Immunotherapeutics"

• rAAV-delivered PTEN therapeutics for prostate cancer

• Membranous Bubbles: High-Purity and High-Titer Exosomes as the Potential Solution for Adeno-Associated Viruses to Evade Neutralization?

• Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells

• Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition

• Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo

• AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway

• Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette

• Next-generation strategies for gene-targeted therapies of central nervous system disorders: A workshop summary

• Cellular and Tissue Selectivity of AAV Serotypes for Gene Delivery to Chondrocytes and Cartilage

• Efficacious, safe, and stable inhibition of corneal neovascularization by AAV-vectored anti-VEGF therapeutics

• Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency

• Immune Responses to Recombinant Adenoviruses As Gene Therapy Vectors and COVID-19 Vaccines: A Two-Edged Sword

• rAAV-based and intraprostatically delivered miR-34a therapeutics for efficient inhibition of prostate cancer progression

• Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis

• Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy

• Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?

• It Is Time to Call Anti-Asian Bias What It Is: Racism

• Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

• Single-cell sequencing reveals suppressive transcriptional programs regulated by MIS/AMH in neonatal ovaries

• Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair

• Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

• The NIH Somatic Cell Genome Editing program

• Large-scale molecular epidemiological analysis of AAV in a cancer patient population

• AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies

• Oncolytic Virus Alphavirus M1: A New and Promising Weapon to Fight Cancer

• Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses

• Viral vector platforms within the gene therapy landscape