Our lab focuses on developing gene therapies targeting mitochondria. We are interested in mitochondria because they are not only the powerhouses of the cell, but also regulate metabolism, stress responses, and other critical functions of every cell types. Their dysfunction can lead to many rare diseases, as well as common diseases, such as Type II diabetes and Parkinson's disease. Currently, our research focuses on rare diseases including Leigh syndrome, a primary mitochondrial disease, and NF2-related schwannomatosis. We are addressing genetic mutations from both nuclear DNA and mitochondrial DNA-encoded genes. To develop precise, efficient, and safe gene therapies, we integrate cutting-edge experimental approaches with bioinformatics tools to accelerate discovery and translation. 

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