Mica Microhub

User-friendly, all-in-one imaging platform from Leica 

Designed to simplify advanced fluorescence microscopy while expanding access to high-quality imaging for researchers of all experience levels. Unlike traditional microscope systems that require users to move samples between instruments, Mica integrates widefield, confocal, live-cell incubation, and computational image enhancement.

The Mica is equipped with multiple objectives from an overview 1.6x 0.05NA to a high resolution 63x 1.2NA water immersion. Mica combines widefield and confocal imaging modalities, allowing users to seamlessly switch between fast sample overviews and high-resolution confocal imaging without disturbing the sample. Its patented FluoSync™ technology enables simultaneous acquisition of up to four fluorescent labels, reducing imaging time while preserving spatial and temporal relationships between signals.

The system features integrated LED illumination for widefield imaging and optional 405, 488, 561, and 638 nm laser lines for confocal imaging. A 5 MP CMOS detector supports widefield imaging, while Leica’s HyD detector is used for confocal acquisition. Automated focus control, sample finding, objective collision prevention, and OneTouch image optimization streamline workflow.

For live-cell applications, Mica offers environmental control with temperature regulation up to 45°C, CO₂ control from 0–10%, and humidity regulation. The platform also includes THUNDER computational clearing for widefield and LIGHTNING deconvolution for confocal. 

The Leica Mica Microhub is available for use by all trained internal and external users. 

SCOPE training procedures can be found here. 

Leica Mica Specific Training videos can be found here.