By DoM Communications | Date published: May 20, 2026

Sara Cahill Explores Detection of LPS Under Homeostatic Conditions with F31 Grant 

Sepsis results from over-activation of the immune system following recognition of intracellular LPS, a bacterial component. However, it remains unknown how the detection of LPS is restricted under homeostatic conditions.  

Sara Cahill, a graduate student in the lab of Fiachra Humphries, PhD, received an F31 grant award to explore the role and regulation of a novel LPS decoy receptor, macrophage receptor with collagenous structure (MARCO). The insights gained from her research will provide novel insights into how cellular metabolism and a noncanonical signaling pathway control immune surveillance and pathogenesis of sepsis.