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World-class Faculty, Cutting-edge Research and Education

Christina Baer

Christina Baer, PhD

Academic Role: Assistant Professor
Focus: Director of the Sanderson Center for Optics Experimentation (SCOPE)

SCOPE Website


Samuel Behar, MD, PhD

Samuel Behar, MD, PhD

Academic Role: Professor
Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.

Lab Page


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Robert Brewster, PhD

Academic Role: Associate Professor
Focus: Quantitative Studies of Transcription and its Regulation

Lab Page


Vanni Bucci, PhD

Academic Role: Associate Professor
Focus: Host-Microbiome Interaction, Computational Biology, Synthetic Biology

Lab Page


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Andres Colubri, PhD

Academic Role: Assistant Professor
Focus: Machine Learning, Digital Epidemiology, Mobile Health, and data visualization

Lab Page


Natasha Durham

Natasha Durham, PhD

Academic Role: Instructor
Focus: Viral Entry, Antibodies & Vaccines, Single Molecule Techniques

Lab Page


Guangping Gao, PhD

Academic Role: Professor
Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease

Lab Page


Rachel Gerstein

Rachel Gerstein, PhD

Academic Role: Professor
Focus: Developmental regulation of V(D)J recombination and B cell development.

Lab Page


He Feng, PhD

Academic Role: Associate Professor
Focus: Post-transcriptional gene regulation in eukaryotes

Lab Page


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Javier E. Irazoqui, PhD

Academic Role: Associate Professor
Focus: Microbiota-Gut-Brain Axis; Mucosal Innate Immunity; Staphylococcus aureus; Transcriptional Regulation of Host Defense; Autophagy; SARS-CoV-2 Interactions with Human Lung Cells

Lab Page


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Allan Jacobson, PhD

Academic Role: Gerald L. Haidak, MD, and Zelda S. Haidak Professor of Cell Biology
Chair and Professor
Focus: Cytoplasmic aspects of post-transcriptional regulation in eukaryotes

Lab Page


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Timothy Kowalik, PhD

Academic Role: Professor
Focus: Cellular and organismal studies of viral infections


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Ping Lu, PhD

Academic Role: Instructor
Focus: Molecular Biology, Bioengineering


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Ana Maldonado-Contreras, PhD

Academic Role: Assistant Professor
Focus: Gastrointestinal Microbiome, Diet-Microbiome Interaction

Lab Page


Elisabet Mandon, PhD

Academic Role: Associate Professor
Focus: Mitochondria and the endoplasmic reticulum

Lab Page


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Beth McCormick, PhD

Academic Role: Professor and Vice Chair; Founder and Director, Program in Microbiome Dynamics
Focus: Mucosal inflammation, host: pathogen interactions, and cancer biology

Lab Page
Program in Microbiome Dynamics


William McDougall

William M McDougall, PhD

Academic Role: Assistant Professor
Focus: Virology and Cell Biology

Lab Page


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Trudy Morrison, PhD

Academic Role: Professor
Focus: Paramyxovirus Membrane Fusion, Assembly of Paramyxoviruses, Virus Vaccines

Lab Page


Manish Muhuri

Manish Muhuri, PhD

Academic Role: Instructor
Focus: RNA Biology, Cancer Biology, Non-coding RNAs


James Munro

James Munro, PhD

Academic Role: Associate Professor
Focus: The Munro laboratory develops and applies quantitative biophysical approaches to visualize virus replication, and probe the functions of the proteins and RNAs involved.

Lab Page


Kenan Murphy, PhD

Kenan Murphy, PhD

Academic Role: Assistant Professor
Focus: Double-stranded DNA break repair in Escherichia coli, Recombineering technology for gene replacement in bacterial pathogens

Lab Page


Kadamba Papavinasasundaram, PhD

Kadambavanasund Papavinasasundaram, PhD

Academic Role: Assistant Professor
Focus: Mycobacterial cell wall synthesis, Mycobacterial genetic manipulation


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Ann R. Rittenhouse, PhD

Academic Role: Associate Professor
Focus: Calcium Channels and Neuronal Plasticity

Lab Page


Christopher Sassetti, PhD

Christopher Sassetti, PhD

Academic Role: Professor
Focus: Pathogenesis of tuberculosis

Lab page


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Carol Schrader, PhD

Academic Role: Associate Professor
Focus: Director of Flow Cytometry Core

Lab Page


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Elizabeth Shank, PhD

Academic Role: Associate Professor
Focus: Chemical and physical interactions of microbes with each other and their hosts

Lab Page

 


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Phillip Tai, PhD

Academic Role: Assistant Professor
Focus: Virology and vectorology of adeno-associated viruses

Lab Page


Michael Volkert, PhD

Michael Volkert, PhD

Academic Role: Professor
Focus: The focus of the lab is to understand the mechanisms of oxidative stress resistance genes and their role in preventing neurodegeneration. We are currently conducting gene therapy experiments to prevent neurodegeneration using an adeno-associated viral vector (AAV) that expresses the human OXR1 gene. Initial experiments demonstrate that elevated expression of OXR1 increases cellular resistance to oxidative stress and AAV8-hOXR1 delays degeneration of the photoreceptor neurons of the retina, a key step leading to blindness in multiple retinal degenerative diseases.

Lab Page



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Doyle Ward, PhD

Academic Role: Associate Professor, Director of Operations, Center for Microbiome Research
Focus:
Microbiome, Bacterial Genomics

Program in Microbiome Dynamics


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Jun Xie, PhD

Academic Role: Associate Professor
Focus: 
AAV vector technology and AAV-mediated miRNA therapeutics


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Ronghua ZhuGe, PhD

Academic Role: Professor
Focus: The ZhuGe lab studies the molecular mechanisms by which Ca2+ signals and ion channels control neurotransmitter release and smooth muscle contractility. We also exploit new physiological functions of bitter taste receptors in extra-oral tissues and organs. We aim to find novel molecular targets for new therapies to manage asthma, fecal incontinence, preterm labor and adenomyosis.

Lab Page


Faculty Emeriti

Michael Bratt, PhD
James Dobson, PhD
H. Maurice Goodman, PhD
Peter Grigg, PhD
Julie Jonassen, PhD
José Lemos, PhD
Janet Stavnezer, PhD
Donald Tipper, PhD
Robert Woodland, PhD
 
   

Affiliated Faculty

Raffi Van Aroian, PhD (Professor)
Karl Dean Bellve, PhD (Assistant Professor)
Sylvain Cecchini, PhD (Associate Professor*)
Jennifer Daly, MD (Professor§)
Richard Ellison, MD (Professor§)
Robert Finberg, MD (Professor§)
Terence Flotte, MD (Professorz)
Kevin Fogarty, MS (Assistant Professor)
Douglas Golenbock, MD (Professor§)
John Haran, MD (Associate Professor)
Michelle Kelliher, PhD (Professor§)
Robert Kotin, PhD (Professor*)
Stuart Levitz, MD (Professor§)
Egil Lien, PhD (Professor§)
Lawrence Lifshitz, PhD (Associate Professor)
Scott Loiler, PhD (Adjunct Assistant Professor*#)
John Mark Madison, MD (Professor§)
Peter Newburger, MD (Professorz)
Erica Ollmann Saphire, PhD (Adjunct Assistant Professor***)
Ann Rothstein, PhD (Professor§)
David Sela, PhD (Adjunct Assistant Professor****)
Neal Silverman, PhD (Professor§)
Marc Uknis, MD (Adjunct Assistant Professorx)
Maria Zapp, PhD (Assistant Professor)

Primary Affiliations

*UMMS Horae Gene Therapy Center https://www.umassmed.edu/gtc/ ; **UMMS Program in Systems Biology https://www.umassmed.edu/psb/; #Voyager Therapeutics Inc. https://www.voyagertherapeutics.com/; ***La Jolla Institute for Immunology https://www.lji.org/labs/saphire/; ****UMass/Amherst  https://www.umass.edu/foodsci/faculty/david-sela; UMMS Program in Molecular Medicine https://www.umassmed.edu/pmm/; §UMMS Department of Medicine https://www.umassmed.edu/medicine/; zUMMS Department of Pediatrics https://www.umassmed.edu/pediatrics/; UMMS Department of Emergency Medicine https://www.umassmed.edu/emed/; &UMMS Department of Molecular, Cell and Cancer Biology https://www.umassmed.edu/mccb/; xGemini Therapeutics Inc. https://geminitherapeutics.com/