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Recent Publications

Sutiwisesak R, Hicks ND, Boyce S, Murphy KC, Papavinasasundaram K, Carpenter SM, Boucau J, Joshi N, Le Gall S, Fortune SM, Sassetti CM, Behar SM. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. PLoS Pathog. 2020 Oct;16(10):e1009000. doi: 10.1371/journal.ppat.1009000.  PMID: 33075106; PMCID: PMC7597557.

Lee J, Boyce S, Powers J, Baer C, Sassetti CM, Behar SM. CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis. PLoS Pathog. 2020 Jun;16(6):e1008621. doi: 10.1371/journal.ppat.1008621. PMID: 32544188; PMCID: PMC7319360. 

Ogongo P, Steyn AJ, Karim F, Dullabh KJ, Awala I, Madansein R, Leslie A, Behar SM. Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs. J Clin Invest. 2020 Jan 2;130(1):214-230. doi: 10.1172/JCI130711.  PMID: 31763997; PMCID: PMC6934215. 

Patankar YR, Sutiwisesak R, Boyce S, Lai R, Lindestam Arlehamn CS, Sette A, Behar SM. Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice. Mucosal Immunol. 2020 Jan;13(1):140-148. doi: 10.1038/s41385-019-0217-6. Epub 2019 Oct 21.  PMID: 31636345; PMCID: PMC7161428. 

Behar SM, Sassetti C. Tuberculosis vaccine finds an improved route. Nature. 2020 Jan;577(7788):31-32. doi: 10.1038/d41586-019-03597-y.  PMID: 31894152. 

Smith CM, Proulx MK, Lai R, Kiritsy MC, Bell TA, Hock P, Pardo-Manuel de Villena F, Ferris MT, Baker RE, Behar SM, Sassetti CM. Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice. mBio. 2019 Nov 26;10(6). doi: 10.1128/mBio.02791-19.  PMID: 31772048; PMCID: PMC6879725. 

Behar SM, Briken V. Apoptosis inhibition by intracellular bacteria and its consequence on host immunity. Curr Opin Immunol. 2019 Oct;60:103-110. doi: 10.1016/j.coi.2019.05.007. Epub 2019 Jun 19. Review.  PMID: 31228759; PMCID: PMC6800630. 

Yang JD, Mott D, Sutiwisesak R, Lu YJ, Raso F, Stowell B, Babunovic GH, Lee J, Carpenter SM, Way SS, Fortune SM, Behar SM. Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages. PLoS Pathog. 2018 Feb;14(5):e1007060. doi: 10.1371/journal.ppat.1007060.  PMID: 29782535; PMCID: PMC6013218. 

Carpenter SM, Behar SM. A new vaccine for tuberculosis in rhesus macaques. Nat Med. 2018 Feb 7;24(2):124-126. doi: 10.1038/nm.4488.  PMID: 29414932. 

Carpenter SM, Yang JD, Lee J, Barreira-Silva P, Behar SM. Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis. PLoS Pathog. 2017 Nov;13(11):e1006704. doi: 10.1371/journal.ppat.1006704. PMID: 29176787; PMCID: PMC5720822. 

Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. mBio. 2017 Oct 24;8(5). doi: 10.1128/mBio.01514-17.  PMID: 29066547; PMCID: PMC5654932.