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Research Labs in MaPS


Behar
We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.

shapeimage_4.png Brewster
We are interested in quantitative studies of transcription and its regulation. Our primary aim is to dissect and understand the implications of resource sharing (for instance, transcription factors, polymerases, etc.) to cellular decision making.

Bucci
The Bucci Lab seek to understand mechanisms responsible for the temporal and spatial dynamics of complex biological systems such as the human microbiome and to develop tools to predict and engineer them.

Colubri
The Colubri Lab (CoLabo) conducts research at the interface between genetics, epidemiology, machine learning, and data visualization. The goal is to create new tools that integrate heterogenous data sources (ranging from genome sequences to environmental factors) with applications not only in infectious disease prediction but also in science outreach and STEM education.

shapeimage_4.png Durham
Research Summary

shapeimage_4.png Gerstein
Research Summary

shapeimage_4.png He

Control of eukaryotic mRNA translation and decay.


Irazoqui
Host-Microbe Interactions, including pathogenic bacteria, viruses, and microbiome. Brain-gut-microbiota axis in health and disease. SARS-CoV-2 cellular pathogenesis.

Jacobson
Cytoplasmic aspects of post-transcriptional regulation in eukaryotes.

shapeimage_4.png Kowalik
Cellular and organismal studies of viral infections.

shapeimage_4.png Maldonado-Contreras
We investigate how manipulation of the gut microbiota through diet can improve clinical outcomes in patients with chronic diseases.


McCormick
We investigate epithelial barrier function in the intestine and mucosal inflammation during enteric bacterial pathogen infection and inflammatory bowel diseases.

shapeimage_4.png McDougall
Research Summary

shapeimage_4.png Morrison
We study basic mechanisms of infection of enveloped, RNA viruses as well as vaccine development.

Munro
We are devoted to the development and application of quantitative, biophysical approaches to studying a variety viral pathogens, including HIV, influenza, Ebola, Lassa, and SARS-CoV-2.

Murphy
My lab focuses on recombineering technologies for the modification of mycobacterial genes, identification of new antibiotics for tuberculosis, and the molecular mechanisms of mycobacterial DNA mismatch repair.

shapeimage_4.png Papavinasasundaram
Research Summary

shapeimage_4.png Rittenhouse
The Rittenhouse laboratory is exploring the role that voltage-gated Ca2+ channel (VGCC) subunits play in the body.

Sassetti
The development of transformational new interventions for tuberculosis relies on understanding the fundamental biology that determines the outcome of an infection.  The Sassetti lab applies a combination of mammalian and bacterial genetic strategies to understand the intricate interactions between phenotypically diverse host and pathogen influence pathogenesis and the response to therapy.

shapeimage_4.png Schrader
B cell immunology focusing on antibody diversification mechanisms of class switch recombination and somatic hypermutation. 

Tai
The Tai lab works towares the development the next-generation of rAAVs and other therapeutic platforms.

Volkert
The focus of the lab is to understand the mechanisms of oxidative stress resistance genes and their role in preventing neurodegeneration. We are currently conducting gene therapy experiments to prevent neurodegeneration using an adeno-associated viral vector (AAV) that expresses the human OXR1 gene. Initial experiments demonstrate that elevated expression of OXR1 increases cellular resistance to oxidative stress and AAV8-hOXR1 delays degeneration of the photoreceptor neurons of the retina, a key step leading to blindness in multiple retinal degenerative diseases.

shapeimage_4.png Ward
Our group applies microbial genomic and metagenomic approaches to understand the how bacteria contribute to human heath and infectious disease, focusing on the transmission of pathogenic strains both in the hospital and in the community.

Zhuge
The ZhuGe lab studies the molecular mechanisms by which Ca2+ signals and ion channels control neurotransmitter release and smooth muscle contractility. We also exploit new physiological functions of bitter taste receptors in extra-oral tissues and organs.