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Research Collaborations

We believe in strength in numbers, and our work is underpinned by a spirit of collaboration and consultation.

The Health Systems Science (HSS) division leverages the research capabilities of a collective network of organizations committed to advancing clinical practice through quality research.

Examples of our ongoing collaborative partnerships:


The Health Care Systems Research Network (HCSRN) brings together the research departments of some of the nation's best and most innovative health care systems. Collectively, the HCSRN represents more than 1,900 scientists and research staff with methodological and content expertise from an array of disciplines such as epidemiology, economics, disparities, outcomes and quality assessment, trials, and genomics. The mission of the HCSRN is to improve individual and population health through research that connects the resources and capabilities of learning health care systems.The Health Care Systems Research Network, formerly known as the HMO Research Network, is the nation’s preeminent source of population-based research that measurably improves health and health care.
HSS Lead/Contact: Mara Epstein, ScD, ScM

The All of Us Research Program is funded and managed by the National Institute of Health (NIH) with the goal of advancing precision medicine.  Precision medicine takes into account individual differences in factors like where you live (environment), what you do (lifestyle), and your family health history (genetics) to tailor healthcare around the individual - a contrast to the current healthcare system that applies a "one size fits all" approach when treating patients.  The All of Us Research Program aims to collect data to allow researchers to determine whether these differences may influence the type of treatment that would work best for an individual.  The Program's goal is to recruit at least one million participants from diverse backgrounds across the United States.  By harnessing information from over one million people over a period of ten years, researchers will be able to investigate more effective way to treat disease and change the face of medicine.
HSS Lead/Contact: Mara M. Epstein, ScD


The AGING Initiative was funded in 2014 by the National Institute on Aging (1R24 AG045050), and is now funded by the National Institute on Aging R33 (AG057806) as of 2018.The HCSRN-OAICs AGING Initiative is an exciting opportunity to build upon the collective and complementary knowledge, resources, and capabilities of the HCSRN and the OAICs to develop an interdisciplinary research agenda focused on older adults with multiple chronic conditions under a new HCSRN-OAICs AGING (“Advancing Geriatrics Infrastructure & Network Growth”) Initiative. The goal of the AGING Initiative is to bridge the Health Care Systems Research Network (HCSRN) with the Claude D. Pepper Older Americans Independence Centers (OAIC) to create a national resource to nurture and advance an interdisciplinary research agenda focused on older adults with multiple chronic conditions (MCCs). These efforts will lay the foundation to address the knowledge gaps that exist regarding the health and healthcare of these understudied patients.

In related work, the American Geriatrics Society and the AGING Initiative have partnered to create an AGS/AGING Learning, Educating, and Researching National Initiative in Geriatrics ("LEARNING") Collaborative that will fill educational and training gaps in multiple chronic conditions research. The overarching goal of the AGS/AGING LEARNING Collaborative is to develop a national self-directed learning curriculum focused on the science of MCCs. These efforts will ultimately foster research that will translate into the delivery of higher quality care for the growing population of Americans with MCCs. 
HSS Lead/Contact: Jerry H. Gurwitz, MD