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Publications 2015-2011

Zinovyeva AY, Veksler-Lublinsky I, Vashisht AA, Wohlschlegel JA, Ambros VR. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5271-80. doi: 10.1073/pnas.1506576112. Epub 2015 Sep 8.PMID:26351692. PMCID:PMC4586838.  (Paper)

Burke SL, Hammell M, Ambros V. Robust distal tip cell pathfinding in the face of temperature stress is ensured by two conserved microRNAS in caenorhabditis elegans. Genetics. 2015, Aug;200(4):1201-18. doi: 10.1534/genetics.115.179184. Epub 2015 Jun 15. PMID:26078280. PMCID:PMC4574240. (Paper)

Bala S, Csak T, Momen-Heravi F, Lippai D, Kodys K, Catalano D, Satishchandran A, Ambros V, Szabo G. Biodistribution and function of extracellular miRNA-155 in mice. Sci Rep. 2015, May 29;5:10721. doi: 10.1038/srep10721.PMID: 26024046. PMCID:PMC4448655. (Paper)

Ren Z, Ambros VR. Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress. Proc Natl Acad Sci USA. 2015, May 5;112(18):E2366-75. doi: 10.1073/pnas.1422858112. Epub 2015 Apr 20. PMID:25897023.  PMCID: PMC4426397.  (Paper)

Harandi OF, Ambros VR. Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans. Proc Natl Acad Sci USA. 2015, Jan 20;112(3):E287-96. doi: 10.1073/pnas.1422852112. Epub 2015 Jan 5. PMID: 25561544.PMCID:PMC4311799. (Paper)

Nelson C, Ambros V, Baehrecke EH. miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. Mol Cell. 2014, Nov 6;56(3):376-88. doi: 10.1016/j.molcel.2014.09.011. Epub 2014 Oct 9. PMID:25306920. PMCID:PMC4252298.  (Paper)

McJunkin K, Ambros V. The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in C. elegans. G3 (Bethesda). 2014, Jul 21;4(9):1747-54. doi: 10.1534/g3.114.011973. PMID:25053708. PMCID:PMC4169167. (Paper)

Ward J, Kanchagar C, Veksler-Lublinsky I, Lee R, McGill M, Jaeschke H, Curry S, Ambros V.  Circulating MicroRNA Profiles in Human Patients with Acetaminophen Hepatotoxicity or Ischemic Hepatitis. Proc Natl Acad Sci USA. 2014, Aug 19;111(33):12169-74. doi: 10.1073/pnas.1412608111. Epub 2014 Aug 4. PMID: 25092309. PMCID: PMC4143020.

Sterling C, Veksler-Lublinsky I, Ambros V. An efficient and sensitive method for preparing cDNAlibraries from scarce biological samples. Nucleic Acids Res. 2015 Jan;43(1):e1. doi: 10.1093/nar/gku637. Epub 2014, Jul 23. PMID:25056322. PMCID:PMC4288208.  (Paper)

Zinovyeva, AY, Bouasker S, Simard MJ, Hammell CM and Ambros V. Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression. PLoS Genet. 2014, Apr 24;10(4):e1004286. eCollection. 2014. PMID: 24763381. PMCID: PMC3998888.  (Paper)

Ward JA, Esa N, Pidikiti R, Freedman JE, Keaney JF, Tanriverdi K, Vitseva O, Ambros V, Lee R, McManus DD. Circulating Cell and Plasma microRNA Profiles Differ Between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction. Fam Med Med Sci Res. 2013, Oct 1;2(2):108. PubMed PMID: 24432306. PMCID: PMC3890357.  (Paper)

Bossé GD, Rüegger S, Ow MC, Vasquez-Rifo A, Rondeau EL, Ambros VR, Großhans H, and Simard MJ. The Decapping Scavenger Enzyme DCS-1 Controls MicroRNA Levels in Caenorhabditis elegans. Mol Cell. 2013, Apr 25;50(2):281-7. doi: 10.1016/j.molcel.2013.02.023. Epub 2013 Mar 28.  PMID: 23541767. PMCID: PMC4624197. (Paper)

Zou Y, Chiu H, Zinovyeva A, Ambros V, Chuang C-F, Chang C. Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science. 2013, Apr 19;340(6130):372-6. PMID: 23599497. PMCID: PMC4074024. (Paper)

Karp X, Ambros V. Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans. Development. 2012, Jun; 139(12):2177-86. PMID: 22619389. PMCID: PMC3357911. (Paper)

McManus DD, Ambros V. Circulating MicroRNAs in cardiovascular disease. Circulation. 2011, Nov. 1;124(18):1908-10. PMID: 22042926. PMCID: PMC3951832.  (Paper)

Ambros V. MicroRNAs and developmental timing. Curr Opin Genet Dev. 2011, Apr 28. PMID: 21530229. PMCID: PMC3149784. (Paper)  

Karp, X., Hammell, M., Ow, M.C., and Ambros, V. Effect of life history on microRNA expression during C. elegans development. RNA. 2011, Apr;17(4):639- PMID: 21343388 PMCID: PMC3062175.  (Paper)