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Publications 2010-2006

Karp, X., Ambros, V. The developmental timing regulator hbl-1 modulates the dauer formation decision in Caenorhabditis elegans. Genetics. 2011, Jan;187(1):345-53. doi: 10.1534/genetics. 110.123992. Epub 2010 Oct 26. PMID: 20980238. PMCID: PMC3018311.  (Paper)

Zheng G, Ambros V, Li WH. Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent. Silence. 2010 Apr 1;1(1):9.PMID: 20359322. PMCID:PMC2864223. (Paper)

Ambros, V. MicroRNAs: genetically sensitized worms reveal new secrets. Curr Biol. 2010, July 27;20(14): R598-600.  (Paper)

Hammell, C.M., Karp, X. and Ambros, V. A feedback circuit involving let-7-Family miRNAs and DAF-12 integrates environmental signals and developmental timing in C. elegans. Proc Natl Acad Sci USA. 2009, Oct 13. PMID: 19828440. PMCID: PMC2774035.  (Paper)

Hong, X., Hammell, M., Ambros, V., and Cohen, S.M. Imunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci USA. 2009, Sep 1;106(35):15085-90. PMID: 19706460. PMCID: PMC2728611. (Paper)

Zhang, L., Hammell, M., Kudlow, B.A., Ambros, V. and Han, M. Systematic analysis of dynamic miRNA- target interactions during C. elegans development. Development. 2009, Sep;136(18):3043-55.PMID: 19675127. PMCID: PMC2730362.  (Paper)

Hammell, C.M., Lubin, I., Boag, P.R., Blackwell, K.T., Ambros, V. nhl-2 modulates miRNA activity in Caenorhabditis elegans. Cell. 2009, Mar 6;136(5):926-38. PMID: 19269369. PMCID: PMC2670343.  (Paper)

Ambros, V. pRB/CKI pathways at the interface of cell cycle and development. Cell Cycle. 2009 Nov 16; 8(21). PMID: 19823011. (Paper)

Ambros V. The evolution of our thinking about microRNAs. Nat Med. 2008, Oct 14:10:1036-40. PMID: 18841144.  (Paper)

Ow MC, Martinez NJ, Olsen PH, Silverman HS, Barrasa MI, Conradt B, Walhout AJ, Ambros V. The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans. Genes Dev. 2008, Sep 15;22(18):2520-34. PMID:. 18794349. PMCID: PMC2546698.  (Paper)

Martinez, N. J., Ow, M. C., Barrasa, M. I., Hammell, M., Sequerra, R., Doucette-Stamm, L., Roth, F. P., Ambros, V. R., Walhout, A.J.M.  A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. Genes and Dev. 2008, Sep 15;22(18):2535-49.PMID: 18794350. PMCID: PMC2546694.  (Paper)

Hammell, M., Long, D., Zhang, L., Lee, A., Carmack, C. S., Han, M., Ding, Y. and Ambros, V. mirWIP: microRNA target prediction based on miRNA-containing ribonucleoprotein-enriched transcripts. Nat Methods. 2008, Sep: 5(9): 813-819. PMID: 19160516. PMCID: PMC3092588.  (Paper)

Sokol NS, Xu P, Jan YN, Ambros V. Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis. Genes Dev. 2008, Jun 15;22(12):1591-6. PMID: 18559475. PMCID: PMC2428057.  (Paper)

Martinez, N. J., Ow, M. C., Reece-Hoyes, J., Barrasa, M. I, Ambros, V. R., Walhout, A.J.M.  Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity. Genome Res.2008, Dec;18(12):2005-15. PMID: 18981266. PMCID: PMC2593583.  (Paper)

Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V.R. and Horvitz, H. R. (2007) Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet. 2007, Dec 14;3(12):e215. PMID: 18085825. PMCID: PMC2134938.  (Paper)

Gaur, A.B. , Jewell, D.A., Liang, Y., Ridzon, D. , Moore, J.H. Chen, C., Ambros,V. R. and Israel, M. A.  Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res. 2007, Mar 15;67 (6); 2456-68. PMID: 17363563.  (Paper)

Long, D., Lee, R., Williams, P., Chan, C.Y., Ambros,V. and Ding, Y.  Potent effect of target structure in microRNA function. Nature Struct. Mol Biol. 2007, Apr 14(4); 287-294. PMID: 17401373. (Paper)

Hinas, A, Reimegård, J. Wagner, E.G.H., Nellen, W., Ambros, V.R. and Söderbom, F. The small RNA repertoire of Dictyostelium discoideum and its regulation by components of the RNAi pathway. Nucleic Acids Res. 2007;35(20):6714-26. PMID: 17916577. PMCID: PMC2175303.  (Paper)

Ambros V. The 2007 George W. Beadle Medal, Robert K. Herman. Genetics. 2007 ,Feb;175(2):465-6. PMID: 17322351. PMCID: PMC1800618.  (Paper)

Lee RC, Hammell CM, Ambros V. Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans. RNA. 2006, Apr;12(4):589-97. PMID:16489184, PMCID: PMC1421084. (Paper)

Ambros, V. and Chen, C. The Regulation of Genes and Genomes by Small RNAs. Development. 2007 May: 1 34(9):1635-41. PMID: 17409118.  (Paper)