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David M. Harlan, MD

William and Doris Krupp Professor of Medicine and Co-Director of the Diabetes Center of Excellence at the UMass Chan Medical School, Investigator at the JDRF Center of Excellence in New England 

Dr. Harlan is internationally acclaimed as a diabetes investigator and physician. He's the William and Doris Krupp Professor of Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School, and treats patients at UMass Memorial. For more than three decades, Dr. Harlan has conducted basic and clinical research exploring the pathophysiology underlying diabetes. His clinical trials test new therapies and explain human biology as it relates to diabetes and its treatment. Current research focuses on exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.

Video: Type 1 Diabetes Pathogenesis: Lessons Learned, Lessons Forgotten & Open Questions

David Harlan Type 1 Diabetes Pathogenesis

Scott Soleimanpour, MD - Exiting from the Silos: Understanding the emerging spectrum of diabetes pathogenesis  

March 2024 UMass Endocrine Grand Rounds

David Harlan, MD - Research to Develop Treatments to Prevent or Cure Type 1 Diabetes

February 2024 UMass Endocrine Grand Rounds

February 2023 UMass Endocrine Grand Rounds

Deborah Schlossman MD - Treatment of Diabetic Retinopathy

December 2023 UMass Endocrine Grand Rounds

Lyle Mitzner, MD - Challenges in Managing In-Patient Diabetes

November 2023 UMass Endocrine Grand Rounds

Mirjam Christ-Crain, PhD - Update in Name, Def and dg of Diabetes Insipidus AVP Deficiency and Resistance (AVP-D and AVP-R) 

October 2023 UMass Endocrine Grand Rounds

Silvia Corvera, MD - "Therapeutic Potential of Adipose Tissue"

September 2023 UMass Endocrine Grand Rounds

Wura Arowosegbe - "Inflammatory Cell Recruitment in Autoimmune Diabetes: Lessons from rats"

June 2023 UMass Fellows Endocrine Research Conference

Héctor Pérez - "Removing Barriers in Gender-Affirming Healthcare"

June 2023 UMass Endocrine Grand Rounds

David M. Harlan, MD - "Moving Forward Despite Unplanned Sharp Turns"

Rachmiel Levine Award lecture from the 2023 Levine-Riggs Diabetes Research Symposium repeated for UMass Memorial colleagues via Zoom.

R. Michael Tuttle, MD - "Active Surveillance in Low-Risk Papillary Thyroid Cancer"

May 2023 UMass Endocrine Grand Rounds

Michael Jensen, MD - "Update on Adipose Tissue Metabolism in Human Obesity"

April 2023 UMass Endocrine Grand Rounds

Michael Brodsky, PhD - "Treatment of Human Disease by In Vivo Gene Editing"

April 2023 UMass Fellows Endocrine Research Conference

M. Furkan Burak, MD - "Fat Talks & the Body Listens: Can we improve insulin sensitivity & lipogenesis by the lipokine"

March 2023 UMass Endocrine Grand Rounds

Accalia Fu, PhD - "Metabolic Licensing of Pancreatic Beta Cell Survival in Inflammation"

December 2022 UMass Fellows Endocrine Research Conference 

Louis Philipson, MD, PhD - "Importance of Making a Diagnosis: Monogenic Diabetes & Personalized Medicine"

October 2022 UMass Endocrine Grand Rounds

David Ludwig, MD, PhD - "Competing Paradigms of Obesity: Energy balance versus carbohydrate-insulin models"

September 2022 UMass Endocrine Grand Rounds

Jaime Moore, MD, MPH - "Toward Defining Standardized (and Personalized) Care for Adolescents and Young Adults After Bariatric Surgery"

June 2022 UMass Endocrine Grand Rounds

Tammy Nguyen, MD, PhD - "Dissecting the Human Diabetic Bone Marrow Niche"

May 2022 UMass Fellows Endocrine Research Conference 

Carmella Evans-Molina, PhD, MD - "The Ailing and Diabetic Beta Cell in Type 1 Diabetes: Insights from a Trip to the ER"

May 2022 UMass Endocrine Grand Rounds

Michael Weiss, MD, PhD - "Mechanism-Based Design of a Unimolecular Glucose-Responsive Insulin"

4/26/22 UMass Endocrine Grand Rounds

Deborah Wexler, MD, MSc - "The Paradigm Shift in Type 2 Diabetes Management"

4/12/22 UMass Endocrine Grand Rounds

Eric Westman, MD, MHS - "Reversing Type 2 Diabetes with Obesity Medicine"

3/22/22 UMass Endocrine Grand Rounds

Sushobhana Bandyopadhyay, PhD - "Immunogenicity of Human Pancreatic Beta Cells Derived From Pluripotent Stem Cells"

3/8/22 UMass Fellows Endocrine Research Conference 

Gregory W. Randolph, MD - "Advanced Thyroid Cancer Management - New Tools 2022"

2/22/22 UMass Endocrine Grand Rounds

Alan Malabanan, MD - "Evaluation of Isolated Hyperparathyroidism"

2/8/22 UMass Endocrine Grand Rounds

Gary Taubes - "Energy Balance, Fat-Shaming and the Questionable Science of Obesity: The History of a Bad Idea"

1/11/22 UMass Endocrine Grand Rounds

Sana Hasan, DO & Kelly Mason, MD - "Effect of CFTR Modulators on Cystic Fibrosis-Related Diabetes & CFRD from the Patient Perspective"

12/14/21 UMass Endocrine Grand Rounds

John Mordes, MD - "T1D Genetics Research at UMass"

11/9/21 UMass Fellows Endocrine Research Conference 

Suzanne K. Freitag, MD - “Thyroid Eye Disease: Overview and Update on Management”

10/26/21 UMass Endocrine Grand Rounds

Christos S. Mantzoros, MD, DSc, PhD - "NASH as a Prevalent Metabolic Condition: Diagnosis & Emerging Management Options"

10/12/21 UMass Endocrine Grand Rounds

Michael Lewiecki, MD, FACP, FACE - “Rare Bone Diseases You Should Never Miss”

9/28/21 UMass Endocrine Grand Rounds

Michael McClung, MD, FACP, FACE, FASBMR - "When & How to Use Osteoanabolic Therapies"

9/14/21 UMass Endocrine Grand Rounds

"100 Years of Insulin - A Medical Marvel: The Past, Present & Future" Drs. David Harlan, Robert Gabbay and Michael Weiss

Featured webinar during the 2021 American Diabetes Association's Scientific Sessions

David M. Harlan, MD - "The Noble and Often Nobel Role of Insulin-Related Research"

This talk is from the 2021 Stanford Diabetes Research Center Symposium celebrating 100 years since Banting & Best isolated human insulin

Mark Schuta, MD - “Improving Diabetes Care in the United States: Identifying the Major Problems and Proposed First Steps”

6/8/21 UMass Endocrine Grand Rounds

Tiffany A. Moore Simas, MD, MPH, MEd, FACOG & Silvia Corvera, MD - "Gestational Diabetes: Conversations Between the Placenta and Adipose Tissue"

5/25/21 UMass Endocrine Grand Rounds

Mark Reitman, MD, PhD - "Understanding Regulation of Metabolic Rate and Body Temperature to Understand Obesity”

5/11/21 UMass Endocrine Grand Rounds

Jonathan Krakoff, MD - "Does Energy Expenditure Mediate Weight Gain?"

4/27/21 UMass Endocrine Grand Rounds

Neil B. Marya, MD - “Endoscopic Management of Weight Regain Following Bariatric Surgery”

4/13/21 UMass Endocrine Grand Rounds

Katharine Garvey MD, MPH - “Health Care Transition in Young Adults with Type 1 Diabetes: Challenges and Opportunities”

3/23/21 UMass Endocrine Grand Rounds

David M. Harlan, MD - "Type 1 Diabetes Pathogenesis: Lessons Learned, Lessons Forgotten & Open Questions"

3/9/21 Fellows' Endocrine Research Conference talk 

Jack A. Yanovski, MD, PhD - "Genetics of Obesity”

1/12/21 UMass Endocrine Grand Rounds

Anthony Ferrante, Jr., MD, PhD - "Immune Function in Adipose Tissue Homeostasis”

12/9/20 UMass Endocrine Grand Rounds

Desmond Schatz, MD - “Personalizing Therapies for the Prevention of Type 1 Diabetes: Searching for Endotypes”

11/10/20 UMass Endocrine Grand Rounds 

Kevin Hall, PhD “Calories, Carbs, or Quality: What Matters Most for Body Weight?”

10/13/20 UMass Endocrine Grand Rounds 

Clifford Rosen, MD - "A New Counter-Regulatory Hormone During Exercise: The Story of Irisin"

9/22/20 UMass Endocrine Grand Rounds 

Ezio Bonifacio, PhD - “Auto Antibodies as Predictors of Type 1 Diabetes”

UMass Diabetes Day 2019

Anette-Gabriele Ziegler, MD, PhD “Clinical Trials Related to Type 1 Diabetes and its Treatment”

UMass Diabetes Day 2019