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World-Class Diabetes Research and Care 

Research to Prevent and Cure Diabetes at UMass Chan Medical School

 Diabetes Research at UMass Medical School

Under the co-direction of Dale L. Greiner, PhD, and David M. Harlan, MD, the goal of the UMass Diabetes Center of Excellence (DCOE) at UMass Chan Medical School is to prevent and cure diabetes. Our DCOE research faculty is gaining new knowledge of the disease by studying human tissues and human cells inside of our unique biological models, which mimic the human immune system. Understanding what causes diabetes will allow us to develop effective therapies, and ultimately find the cure. 

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Meet the UMass Diabetes Center of Excellence Scientists

 Jamie Kady Diabetes Research

Diabetes Research Laboratories

DCOE News

Total: displaying 5 out of 119 results
  • Monday, November 21, 2022

    Wang Lab Study Finds Early Islet Transcriptional Signature is Associated with Local Inflammation in Type 1 Diabetes

    Viral infections continue to be linked to the development of type 1 diabetes, yet human immune responses to viruses and how that leads to the destruction of insulin-producing beta cells in the pancreas is still unknown.  The laboratory of Jennifer Wang, MD, investigated inflammatory pathways because viruses can trigger inflammation that damages the pancreas.  The research focused on early events leading to autoimmune responses to viruses with the ultimate goal of therapeutics that could target inflammation before T1D manifests.

    Read more
  • Flow Cytometer Donation
    Friday, December 02, 2022

    Generous Donation from the Arthur M. and Martha R. Pappas Foundation Advances UMass Diabetes Research Capabilities

    The Diabetes Center of Excellence at UMass Chan Medical School received a $250,000 donation from the Arthur M. and Martha R. Pappas Foundation.  The funds were used to purchase and maintain a state-of-the-art flow cytometer to characterize cells and their functional and signaling properties.  It provides quantitative data on immune cell and pancreatic islet cell phenotypes to facilitate the analysis of samples and greatly expand our research team’s capacity to rapidly screen experimental samples. 
    FULL STORY & VIDEO ABOUT DR. ARTHUR PAPPAS

    Read more
  • Tzield
    Friday, November 18, 2022

    New Medication Approved by the FDA to Delay Type 1 Diabetes Onset

    Teplizumab (Tzield) was approved by the U.S. Food and Drug Administration to delay the onset of type 1 diabetes when identified in the pre-symptomatic stage. A statement was released by the UMass Memorial Diabetes Center of Excellence regarding the new medication.

    Read more
  • Nuzzy Memorial Foundation Donation 2022
    Tuesday, November 29, 2022

    Joseph Nozzolillo Memorial Foundation Surpassed $85,000 in Fundraising for UMass Chan Diabetes Center of Excellence Research

    The Joseph “Nuzzy” Nozzolillo Memorial Foundation added a $25K donation in 2022 to their ongoing support of the UMass Diabetes Center of Excellence, raising their five-year fundraising total to $85,560. The 5th annual Nuzzy Memorial Golf Tournament and third “Rockin’ for Nuzzy” fundraiser concert were held by Joe's family and friends who are grateful for the care he received and optimistic about the diabetes research taking place at the UMass Chan DCOE.  PHOTOS & VIDEO

    Read more
  • Vitilago Research
    Monday, October 10, 2022

    Diabetes Center of Excellence Immunologist Sally Kent Investigating Autoreactive T Cell Function in Vitiligo

    A five-year grant from the NIH/NIAMS was awarded to John Harris, MD, PhD, Founding Director of the Vitiligo Clinic & Research Center, and Autoimmune Therapeutics Institute at UMass Chan Medical School. The project is entitled Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation. Dr. Kent is leading Project 1, Autoreactive T Cell Function in Vitiligo.

    Read more
  • Adipocyte Signaling Pathway Czech Lab Review
    Monday, September 26, 2022

    The Czech Lab Reviews the Adipocyte Supersystem of Insulin and cAMP Signaling in Trends in Cell Biology

    The Czech lab examined the metabolic regulation of adipocytes by insulin receptor signaling and the cAMP signaling pathway in a review article published in the journal Trends in Cell Biology. The two major signaling networks regulate virtually every organ and/or cell type in the human body.  While the two signaling pathways intercommunicate regularly in fat cells, published data has shown they typically counteract one other in most cellular processes. Their opposite roles are indispensable for adipocyte physiology and metabolic homeostasis. Together they constitute what the Czech lab calls “the adipocyte supersystem.” However, their review highlights a set of genes that are known to promote metabolic health and were activated by both insulin and catecholamines in the same way.  

    Read more
  • Extracellular Vesicles Diabetes Research Kent Lab
    Friday, September 23, 2022

    The Kent Lab is Investigating the Role of Extracellular Vesicles in the Development of Type 1 Diabetes

    Sally Kent, PhD was awarded a Multi-Principal Investigator grant from the NIH/NIDDK entitled Extracellular Vesicle-mediated islet immune cross talk in type 1 diabetes pathogenesis. The project will examine the function of extracellular vesicles originating directly from pancreatic islets in people with  type 1 diabetes. The goal of these studies is to understand their functional role in the autoimmune process and to provide biomarkers for disease development.

    Read more
  • Mark O’Connor UMass Memorial PACE Award
    Wednesday, September 21, 2022

    Endocrinologist Mark O'Connor Awarded Academic Collaboration Prize to Study the Use of Smart Watch Technology to Prevent Dangerous Hypoglycemia

    Dr. O’Connor was co-recipient of the UMass Memorial Medical Group’s Prize for Academic Collaboration and Excellence (PACE) Award. It supports physicians in cutting-edge research and encourages interdepartmental collaboration. His project is studying the benefits of using widely available wearable devices such as smart watches, to protect people who are living with diabetes, from dangerous hypoglycemia. A pilot study of people with type 1 diabetes who are at risk for hypoglycemia will create an optimized algorithm for detecting hypoglycemia based on smart watch data.

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  • Investigating CAR T Cell Therapy
    Tuesday, September 20, 2022

    Investigating CAR T Cell Therapy Targeting Type 1 Diabetes Specific Cells in the Kent and Brehm Labs

    The study aims to generate CAR T cell variants that would target and eliminate islet specific autoreactive T cells in people with type 1 diabetes. A grant from the NIH/NIDDK with Multi-Principal Investigators was awarded to investigate CAR T-cell technology as a potential T1D therapy. 

    Read more
  • Natural Killer Cells
    Thursday, September 08, 2022

    Enhanced Development of Functional Human Natural Killer Cells for Pre-Clinical Study in the Greiner and Brehm Labs

    In a newly published study in the FASEB journal, the laboratories of Michael Brehm, PhD and Dale Greiner, PhD describe a novel humanized mouse model developed with improved Natural Killer (NK) cell acceptance and functionality.  Their data explains the potential for this in vivo model to study human NK cell biology and to test new human-specific immune-therapies that target NK cells. 

    Read more
  • Tammy Nguyen Type 2 Diabetes Wound Healing Research
    Thursday, August 25, 2022

    Tammy Nguyen Receives NIDDK K08 Career Development Award to Investigate and Improve Non-Healing Wounds in People with Type 2 Diabetes

    Vascular surgeon-scientist Tammy Nguyen, MD, PhD, is the recipient of a K08 Clinical Investigator Award from the National Institute of Diabetes and Digestive and Kidney Diseases to advance her independent clinical research. Dr. Nguyen wants to understand why people with diabetes have a difficult time with wound healing, particularly foot ulcers. She’s studying the effect of type 2 diabetes on the development of the immune system, with the goal of designing targeted therapies to combat poor wound healing. As the Medical Director of the Lower Extremity Wound Clinic at UMass Memorial Health, she continues to perform surgeries on people with diabetes who developed uncontrolled infections that led to amputations. 

    Read more
  • Michael Czech Lab Nonalcoholic Steatohepatitis
    Monday, August 22, 2022

    Investigating a Potential Path to Medication for Nonalcoholic Steatohepatitis (NASH) in the Czech Lab

    A significant percentage of people living with type 2 diabetes also have too much fat accumulated in their liver that can develop into a condition called nonalcoholic steatohepatitis (NASH). It’s characterized by severe liver inflammation and fibrosis that can lead to cirrhosis and may require a liver transplantation. Currently, there is no medication for NASH. To better understand how a medicine might be developed, the Czech lab studied fat production in the liver from carbohydrates by disrupting an enzyme that helps to convert blood glucose into fat in obese mice. Results of their research is published in the Journal of Biological Chemistry.

    Read more
  • Lucy Ding Diabetes Clinical Research
    Thursday, August 11, 2022

    Two Clinical Studies Helping Diabetic Patients at UMass Memorial Hospitals

    Meet Clinical Research Assistant Lucy Ding and learn about two studies she's involved with that are designed to help hospitalized patients living with diabetes.  One is a randomized clinical trial that provides continuous glucose monitors to people with diabetes who are currently not using one and arrive at the Emergency Room with high or low blood sugar, or other diabetes related complications. The other study is implementing a carbohydrate counting system for hospitalized inpatients with diabetes throughout the UMass Memorial Health system.

    Read more
  • Bukyung Kim and Jae Hyun Kim
    Wednesday, July 27, 2022

    The Kim Lab Welcomes Visiting Researchers from South Korea to Conduct Type 2 Diabetes Research

    The laboratory of Jason Kim, PhD welcomes two visiting professors from Kosin University College of Medicine in South Korea. Both physician-scientists will be conducting diabetes research at UMass Chan Medical School through 2023.  

    Read more
  • Virtual Diabetes Camp Jason Kim
    Monday, July 11, 2022

    Diabetes Virtual Camp for Future Scientists and Physicians Created by the Family of UMass Diabetes Researcher Jason Kim

    Dr. Kim’s daughters Allison and Lauren are also considering careers in medicine and science. When Lauren’s 2020 summer research internship at Harvard Medical School was canceled due to the COVID-19 pandemic, the family quickly created the Diabetes Virtual Camp to connect students and experts in a virtual internship setting.  

    Read more
  • JDRF Center of Excellence in New England
    Thursday, June 16, 2022

    JDRF Announces the Appointment of David M. Harlan, MD, as Director of their Center of Excellence in New England

    Dr. David Harlan has been named the new director of the JDRF Center of Excellence in New England. For nearly 40 years, Dr. Harlan has been conducting research exploring the pathophysiology underlying diabetes. He also brings years of experience as an endocrinologist with expertise in diabetes and metabolism. A renowned basic and clinical investigator, his current research is focused on beta cell biology and the anti-beta cell immune response. The Center is genetically modifying beta cells with the goal of making them invulnerable to the immune system when infused as a therapy into a person with type 1 diabetes.

    Read more
  • Vascular Cures
    Friday, May 20, 2022

    Vascular Surgeon-Scientist Tammy Nguyen Received the 2022 Wylie Scholar Award For Diabetic Wound Healing Research

    Tammy Nguyen, MD, PhD is a vascular surgeon-scientist who is interested in understanding why people living with diabetes have trouble getting foot wounds to heal. This career development grant will provide $150,000 over the next three years for her project “Exploring How the Diabetic Immune System Contributes to Non-Healing Ulcers.” Dr. Nguyen is studying the effect of type 2 diabetes (T2D) on the development of the immune system to design targeted therapies to combat poor wound healing for people with T2D. She developed a novel method to collect and expand human stem cells directly from the bone marrow of donors both with and without T2D who underwent lower extremity amputation for non-healing wounds.

    Read more
  • Diabetic Homeless Clinic
    Thursday, May 19, 2022

    Fourth Diabetic Foot Clinic Held for Worcester's Homeless and Underserved Population

    The 4th UMass Diabetic Health Clinic for Worcester’s homeless population was a multidisciplinary outreach event with providers from the Diabetes Center of Excellence, vascular surgery, podiatry & more. They volunteered to examine people, provided information & resources and scheduled follow-up appointments if needed. SEE PHOTOS

    Read more
  • Diabetes Coaching Program UMass Memorial
    Friday, April 22, 2022

    Diabetes Coaching Program is Helping Struggling Patients Improve Dangerously High Blood Sugars

    Despite attending an American Diabetes Association-recognized education program at the UMass Memorial Health Diabetes Center of Excellence (DCOE), some people still struggle to keep their blood glucose within a healthy range. The DCOE piloted a Care Coach Program in collaboration with Shields Health Care Group to provide supplemental support to help them manage blood glucose levels. The first participants successfully lowered their A1c and demonstrated a reduction in the distress caused by their diabetes by implementing behavioral, lifestyle, and medication changes, thanks to more frequent contact with a diabetes expert.  

    Read more
  • Diabetes gene study
    Thursday, March 31, 2022

    Endocrinologist Mark O'Connor Identifying Genes Linked to the Risk of Developing Type 2 Diabetes

    Endocrinologist Mark O'Connor, MD, led the largest genome-wide meta-analysis study ever done using a recessive model for Type 2 diabetes.  It identified 51 loci associated with diabetes, including five that were undetected by past additive analyses.  The results were published in the journal Diabetes demonstrating that recessive models can identify new genetic risk factors for T2D, including variants with large effect sizes.  

    Read more
  • Sarah Nicoloro Senior Research Scientist
    Thursday, March 24, 2022

    Genetically Modifying Adipocytes to Increase Fat Burning and Improve Metabolic Function as a Potential Therapy for Type 2 Diabetes

    The Czech Lab is using genetic engineering to investigate a therapeutic approach to Type 2 diabetes.  Senior scientist Sarah Nicoloro's research involves the modification of genes of adipocytes to increase fat burning and improve their metabolic function as a potential therapy.  When she joined the lab in 1998, their focus was to learn about the interactions taking place within adipocytes, particularly insulin signaling and GLUT4 trafficking. She was part of a team of scientists who developed a novel small interfering RNA (siRNA) delivery system. Learn more about Sarah and her research.

    Read more
  • Brown Adipose Tissue
    Wednesday, March 16, 2022

    Guertin Lab Reviews the Multi-omics Era of Adipocyte Insulin Signaling and Metabolism Research in Trends in Biochemical Sciences

    Proteomics and metabolomics are advancing the understanding of insulin signaling focusing on fat cells (white and brown adipocytes).  The Guertin Lab describes how integrating the two ‘omics techniques is critical to clarifying adipocyte insulin action in Type 2 diabetes.  Their article raises questions for future investigation with important implications for understanding and treating insulin resistance, obesity and metabolic diseases such as Type 2 diabetes.  

    Read more
  • Emily and Ben Diabetes Elective
    Tuesday, March 08, 2022

    Two UMass Chan Medical Students Created an Elective Course Teaching In-Depth Diabetes Management and Care

    Two third year medical students at UMass Chan worked with the UMass Diabetes Center of Excellence to launch an elective course called Management and Care of Patients with Type 1 and Type 2 Diabetes. 

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  • Richard Siller, PhD
    Thursday, March 03, 2022

    Type 1 Diabetes Researcher Spotlight: Richard Siller, PhD

    The Maehr Lab is interested in how immune cells are trained by the thymus, which is the organ that educates our body’s immune system to defend against infection.  For some unknown reason, white cells called T lymphocytes or T cells, destroy the insulin-producing beta cells in the pancreas of people with Type 1 diabetes. Richard Siller, PhD, a postdoctoral researcher, is developing functional thymic cells from human stem cells, that will be used to study the role the thymus plays in that autoimmune attack.  Learn more about Richard and his research.

    Read more
  • Insulin Rising Cost
    Thursday, February 24, 2022

    Affordable Insulin Now Act Includes a Monthly Out-Of-Pocket Patient Maximum of $35 for Insulin Prescriptions

    New legislation has been introduced to the United States Senate including a $35 per month insulin co-pay cap for people with Medicare, employer-sponsored coverage, or insurance purchased on the Affordable Care Act marketplace. The Affordable Insulin Now Act also requires commercial insurers to exclude insulin from the deductible. Read reactions to the bill from Dr. Samir Malkani, Clinical Chief of the UMass Diabetes Center of Excellence and Cheryl Barry, RN, Manager of Diabetes Education.  

    Read more
  • Pancreatic Islet
    Friday, February 11, 2022

    The Diabetes Center of Excellence and Worcester Polytechnic Institute Awarded a Grant to Develop Type 1 Diabetes Research Tools

    The Diabetes Center of Excellence received a UMass Center for Clinical and Translational Science pilot grant for a collaborative Type 1 diabetes project with Worcester Polytechnic Institute. A novel tool has been created to improve the removal of individual pancreatic islets from human pancreas slices. Improving the tool will allow our scientists to extract single islets from living pancreas slices for more in-depth investigation of the insulin producing beta cells and immune cells, to better understand the autoimmune attack that occurs in people with Type 1 diabetes.  LEARN MORE

    Read more
  • Emmanouela Tsagkaraki, MD, MSc
    Thursday, February 10, 2022

    Genome Editing for Browning Human Fat Cells as a Potential Therapy for Type 2 Diabetes and Other Metabolic Diseases in the Czech Lab

    The laboratories of Michael Czech, PhD and Silvia Corvera, MD, understand the important role that fat cells play in diabetes development and progression. They’re exploring a cell therapy by manipulating the genome of adipocytes (fat cells) to increase fat burning and improve the metabolic function.  In a newly published study in Nature Communications, Emmanouela Tsagkaraki, MD, PhD, led a team of scientists who removed cell samples from humans, converted white adipocytes into brown-like cells in the lab, reproduced and multiplied those cells, and transplanted them into specialized mice to test the therapeutic approach. The data indicates the process enhanced and improved glucose metabolism.  Learn more about Emmanouela and her research.

    Read more
  • Maehr Nature Communications
    Thursday, February 03, 2022

    Identifying Genes and Signaling Pathways to Develop Thymus Cells to Explore the Root Cause of Type 1 Diabetes in the Maehr Lab

    The Maehr laboratory is focused on the thymus, the major organ involved in educating the immune system.  They're using human pluripotent stem cells to develop functional thymic epithelial cells that will be used to study the role the organ plays in the Type 1 diabetes autoimmune attack. A newly published study in Nature Communications examined changes in gene expression & cellular behaviors that occur during the development of several organ domains including the thymus.  

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  • Diabetes Insulin Pump and CGM
    Monday, June 27, 2022

    The Latest Blood Glucose Management Tools and Products

    New insulin pumps, infusion devices, continuous glucose monitors, glucagon delivery devices and new smartphone apps continue to become available to help with diabetes management. Learn about the latest technology and tools providing improved self-care options for people living with both type 1 diabetes and type 2 diabetes.   

    Read more
  • Adipose Tissue Gene Analysis
    Monday, January 03, 2022

    Gene Analysis Research Uncovered a Physiological Brake Protecting Thermogenesis in Fat Tissue

    A recently published gene analysis study from the laboratory of Yong-Xu Wang, PhD, uncovered a physiological brake to protect the thermogenesis process in adipose tissue, providing new insights into mechanisms that sustain whole-body energy balance and tissue stability.  Their research is investigating cellular and molecular mechanisms to convert white adipocytes into brown-like adipocytes, as a potential Type 2 diabetes therapy.   

    Read more
  • Human Type 1 Diabetes Research
    Monday, December 20, 2021

    Modeling and Studying the Autoimmune Processes of Human Type 1 Diabetes Using Human Cells and Tissue

    Animal models of Type 1 diabetes (T1D) have provided valuable insights for decades, however rodent experiments have not provided an understanding of the root cause of how the disease develops in humans. The research team at the UMass Diabetes Center of Excellence continues to gain new knowledge of the disease by recreating human immune systems inside of unique “humanized” mice to investigate human cells and tissues. A newly published manuscript in Molecular Metabolism emphasizes the concept that T1D pathogenesis is far more heterogeneous than has previously been widely appreciated by the broad diabetes research community.  

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  • Continuous Glucose Monitor Nancy Sidhom
    Tuesday, December 14, 2021

    Diabetes Nurse Practitioner Nancy Sidhom Describes the Benefits of Continuous Glucose Monitors

    In an article featured in Worcester Medicine, UMass DCOE Nurse Practitioner Nancy Sidhom describes the benefits of continuous glucose monitors (CGM) and how the constantly improving technology is helping people living with diabetes like never before. From a nursing perspective, education is the center point of every patient encounter. CGM use has led many patients to reduce insulin use, revamp dietary choices, create exercise habits and effectively instill long-sought behavior change. Historically, CGM therapy was reserved for patients with Type 1 diabetes. Fortunately, CGM therapy is now widely covered for patients with Type 1 and Type 2 diabetes. 

     
    Read more
  • Molecular Therapy Nonalcoholic steatohepatitis
    Thursday, December 09, 2021

    Identifying Therapeutic Targets Using RNAi Technology to Treat Non-alcoholic Steatohepatitis (NASH) in the Czech Lab

    The Czech Lab is targeting genes that promote fatty liver and inflammation in obesity and diabetes with short-interfering RNA (siRNA)-induced RNAi as a potential therapy for nonalcoholic steatohepatitis (NASH).  It's a severe liver disorder characterized by accumulating triglycerides and severe inflammation.  In a newly published study in the scientific journal Molecular Therapy, Batuhan Yenilmez, PhD, led preclinical studies using “humanized mice” from the Brehm Lab. The humanized model was used to show that their compound can successfully target human mRNA in vivo.  

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  • Adilson Guilherme, PhD
    Tuesday, November 09, 2021

    Type 2 Diabetes Researcher Spotlight: Adilson Guilherme, PhD

    Dr. Guilherme is approaching his 27th anniversary working in the laboratory of Michael Czech, PhD at UMass Chan Medical School.  One of his career highlights thus far was his involvement in the development of small interfering RNA (siRNA) screens as a therapeutic tool to address cellular and molecular mechanisms of inflammation, obesity and diabetes. Another was the Czech Lab's discovery of a molecular motor they found to be essential for insulin stimulation of glucose transport into fat cells.  He's excited for future research to determine what additional hormones adipocytes are secreting, then studying those to determine if mutating or deleting them may offer therapeutic potential for people struggling with obesity, diabetes or cardiovascular disease.  Learn more about Adilson and his research.

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  • Jennifer Wang Type 1 Diabetes Immuno Horizons
    Thursday, October 28, 2021

    The Wang Lab Sheds New Light on the Relationship Between Viral Infections and Type 1 Diabetes

    Newly published research conducted in the laboratory of Jennifer Wang, MD, investigated the relationship between viral infections and type 1 diabetes (T1D). A significant number of viruses have been associated with T1D, including enteroviruses, such as Coxsackievirus.  The Wang Lab conducts extensive research using a unique rat model of T1D to study viruses as a possible trigger of the disease. The study defined how deleting components of the innate immune antiviral response alters immune cells to protect against autoimmunity.

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  • Dale Greiner, Diabetes research, Humanized Mouse
    Friday, October 22, 2021

    Greiner Lab Helping to Improve a Macroencapsulation Device to Advance the Development of Beta Cell Replacement Technology

    A collaborative research team including UMass Diabetes Center of Excellence co-director Dale Greiner, PhD, developed and tested an enhanced microencapsulation device intended to protect transplanted human islets into people with Type 1 diabetes.  This newly published study showed proof-of-concept by providing a glucose-sensing, insulin-secreting encapsulation device that holds more cells and demonstrated greater cell survival than previous MEDs.  It also provided enhanced nutrient transport that ultimately led to a rapid reduction of hyperglycemia.  

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  • Sam Redick Type 1 Diabetes Research UMass Medical School
    Wednesday, October 06, 2021

    Type 1 Diabetes Researcher Spotlight: Sambra Redick, PhD

    Dr. Redick is a senior research scientist in the laboratory of Dr. David Harlan.  She's developing techniques to remove and study single islets from slices of human pancreas that we receive as members of the Network for Pancreatic Organ Donors with Diabetes (nPOD).  Her research helped put to rest a decades old debate about beta cells.  She has also worked closely with Worcester Polytechnic Institute (WPI) engineers to develop a novel tool to improve the removal of individual islets from human pancreas slices to better investigate them.  Learn more about Sam and her research

    Read more
  • Mason Tarpley Diabetes Research
    Thursday, September 16, 2021

    Bioinformatician Mason Tarpley Named Cammett Scholar in Type 1 Diabetes Research

    Mason Tarpley was named the Cammett Scholar for Type 1 Diabetes Research at UMass Chan Medical School’s Diabetes Center of Excellence. His role as a bioinformatician is to analyze the immense amount of data generated in the laboratories of David Harlan, MD, Sally Kent, PhD, and Jennifer Wang, MD. 
    Meet Mason and learn about his work

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  • Mello Award
    Friday, September 10, 2021

    Mello Scholar Awards Recognize Molecular Research, including Type 2 Diabetes Studies at UMass Chan Medical School

    The 2021 Mello Scholar awards were presented to four graduate students at UMass Chan Medical School, including two who are conducting type 2 diabetes research.  The award is presented annually by its namesake, Nobel Laureate Craig Mello, PhD.  Kate Korobkina is a PhD candidate who works in the Guertin Lab. Kate is studying mechanisms of nutrient sensing in cells and tissues focusing in mTORC2 regulation and thermogenesis pathways.  Chandler Friend is PhD candidate in the Davis Lab where she's conducting metabolism studies.  Chadler is investigating endothelial cells, which form the barrier between tissues and circulating blood.  Learn more about the award and this year's recipients.

    Read more
  • Brown Adipose Tissue
    Thursday, September 09, 2021

    Type 2 Diabetes Research in the Guertin Lab Tracked and Discovered New Functions of Glucose in Brown Fat

    Brown adipose tissue (BAT), commonly known as brown fat, is a type of body fat that is activated in cold conditions.  Its main function is to turn the energy from fat storage and food into heat that helps maintain body temperature in the cold.  In a new study published in Cell Reports, the Guertin Lab learned that BAT uses glucose not only for fuel, but for many other metabolic pathways that support thermogenesis.  This discovery was possible through adapting a new technique and strategy to track how brown fat uses the individual atoms of glucose as they are consumed by the brown fat tissue.
    LEARN MORE

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  • Carrie Zammitti Brehm Lab Type 1 Diabetes Research
    Wednesday, September 08, 2021

    Researcher Spotlight: Carey Zammitti

    Carey Zammitti is a Research Associate in the UMass Diabetes Center of Excellence laboratory of Michael Brehm, PhD.  Some of the projects she’s involved with include testing pig islets in the Brehm Lab’s unique “humanized” mouse models of type 1 diabetes to study their potential for transplantation as a possible therapeutic treatment.  She’s also working with microscopic encapsulation devices to test their functionality to protect insulin-producing beta cells and islets from being recognized and attacked by immune cells.  MEET CAREY

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  • Diabetic Foot Ulcers Healing
    Wednesday, September 01, 2021

    Investigating Leptin Regulation of the Human Diabetic Immune System in Nonhealing Diabetic Foot Ulcers

    Approximately a third of all people with diabetes develop diabetic foot ulcers.  While current treatment is effective for some patients, about half of diabetic foot ulcers become nonhealing and result in amputation.  A team of scientists at the UMass Diabetes Center of Excellence believe that can be avoided. 
    LEARN MORE

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  • type-1diabetes-covid-pandemic
    Tuesday, August 17, 2021

    The COVID-19 Pandemic and Pediatric Type 1 Diabetes

    A recent study led by Benjamin Udoka Nwosu, MD, explored whether the pandemic lockdown had an effect on the blood sugar control of U.S. children and adolescents living with type 1 diabetes (T1D).  Published in Frontiers in Endocrinology, the research found no significant change in glucose control between March 15, 2020, when schools throughout Massachusetts first closed due to COVID-19, through July 6, 2020. 

    Read more
  • Insulin Biosimilar Approved by FDA
    Friday, July 30, 2021

    FDA Approves Interchangeable Biosimilar Insulin to Potentially Reduce Cost for People to Treat Diabetes

    The FDA has approved the first interchangeable biosimilar insulin for the treatment of diabetes.  It can be substituted by pharmacies without the intervention of the prescribing physician. Will this help to lower insulin prices for people who require this life-saving medication?  Dr. Samir Malkani, Interim Chief of Diabetes at UMass Memorial Health & UMass Diabetes Center of Excellence Education Manager Cheryl Barry, RN, CDCES, offered their thoughts on the matter. LEARN MORE

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  • T Cells in T1D
    Monday, July 19, 2021

    Means, Motive, and Opportunity: Investigating the Role of Immune Cells in the Development of Type 1 Diabetes

    Sally Kent, PhD, conducts extensive research at UMass Medical School to understand how and why immune cells in people with type 1 diabetes attack their own beta cells.  A newly published article in the scientific journal Frontiers in Immunology specifically investigates the role of T cells at the “scene of the crime,” where the autoimmune attack occurs.  Dr. Kent collaborated with eight other scientists from the United States, Germany, France, and Sweden to co-author “Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?”   
    FULL STORY

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  • Diabetic Foot Clinic
    Friday, July 02, 2021

    Diabetes Screenings at UMass Memorial Health Clinic for People Experiencing Homelessness

    The second UMass Diabetic Health Clinic for Worcester’s homeless population was a multidisciplinary outreach event with providers from the Diabetes Center of Excellence, vascular surgery, wound care, podiatry & more. They volunteered to examine people, provided information & resources and scheduled follow-up appointments as necessary.  PHOTOS & ARTICLE

    Read more
  • John Mordes Type 1 Diabetes Research UMass Medical School
    Thursday, June 17, 2021

    Dr. John Mordes is Studying Genes to Predict Type 1 Diabetes Susceptibility in a Unique Rat Model of T1D

    Recently published data involving the development of a unique rat model provides new insight as to how type 1 diabetes may develop in humans. The collaborative research led by Dr. John Mordes, a physician-scientist at UMass Chan Medical School and UMass Memorial Health, studied the relationship between a couple of genes which have previously been determined to increase the likelihood of a person developing T1D. They also investigated a protein coding gene, that when removed, has prevented diabetes in the rats. 

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  • Commander of the Air Force Medical Readiness Agency
    Friday, May 21, 2021

    UMass Diabetes Nurse Practitioner Sean Collins Appointed Commander of the Air Force Medical Readiness Agency

    UMass Memorial Diabetes Center of Excellence nurse practitioner and United States Air Force Brigadier General Sean Collins, has once again been called to active duty in Washington, DC.  He’s now serving a leadership role as Commander of the Air Force Medical Readiness Agency.  Learn about his decorated military career and how he balances it with his role as a valued member of our our diabetes care team. 
    FULL STORY

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  • Roger Davis Academy of Arts and Sciences
    Friday, April 30, 2021

    Roger Davis Elected to The American Academy of Arts & Sciences

    Dr. Davis was elected to the American Academy of Arts & Sciences.  His research on stress signaling pathways are connected to diabetes, heart disease, stroke and cancer.  His work has led to the discovery of new genes that contribute to the development of these devastating diseases.  His impressive resume includes investigator of the Howard Hughes Medical Institute, fellow of the American Academy of Microbiology and the American Association for the Advancement of Science, member of the National Academy of Inventors and the National Academy of Sciences. The Davis Lab is investigating the molecular mechanism by which inflammation contributes to diabetes and working on the design of novel therapeutic strategies.  FULL STORY

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  • Diabetes Proinsulin
    Thursday, April 29, 2021

    Sally Kent Contributed to a Newly Published Study of Proinsulin

    Newly published research in the scientific journal Frontiers in Endocrinology investigates potential immunotherapies for type 1 diabetes using a protein called proinsulin. The UMass Diabetes Center of Excellence laboratory of Sally Kent, PhD, provided essential information and materials.  LEARN MORE

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  • Cell Metabolism Insulin 100 Years
    Friday, April 16, 2021

    UMass Diabetes Center of Excellence Researchers Recognized in Cell Metabolism's 100 Years of Insulin Issue

    As we approach the 100th anniversary of the discovery of insulin in 1921, the scientific journal Cell Metabolism shared stories of scientists and clinicians whose research has advanced our understanding of insulin, islet biology, insulin resistance and diabetes. Two UMass Diabetes Center of Excellence researchers reflected on the privilege of studying insulin.  FULL STORY   

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  • Livongo Study at Umass Memorial
    Friday, March 19, 2021

    Clinical Study Evaluates a Remote Glucose Monitoring Program to Help People With Poorly Controlled Type 2 Diabetes

    Newly published data of a randomized crossover trial evaluated a remote monitoring program for people with poorly controlled type 2 diabetes within the UMass Memorial Health system. Patients were provided with coaching from diabetes educators who monitored readings of patients’ blood glucose each time they tested and contacted them if their blood glucose was dangerously high or low. LEARN MORE

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  • Researcher Spotlight: Sushobhana Bandyopadhyay, PhD
    Wednesday, March 03, 2021

    Researcher Spotlight: Sushobhana Bandyopadhyay, PhD

    Dr. Bandyopadhyay is a postdoc in the Brehm Lab. She's studying how and why the autoimmune attack occurs in people with type 1 diabetes. They've started transplanting human cells that were derived from stem cells, into their unique "humanized" mouse models. She conducts experiments to observe interactions between insulin-producing beta cells and immune cells from the same T1D patients.  VIDEO & STORY

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  • JDRF Stem Cell Research
    Tuesday, February 23, 2021

    Genetically Engineering & Testing Human Insulin-Producing Cells as a Potential Therapeutic Cure for Type 1 Diabetes

    The newly funded JDRF Center of Excellence in New England research collaborative brings together leading scientists who are striving to cure type 1 diabetes. Three simultaneous projects are working in harmony to create a stem cell-derived beta cell replacement therapy that would be invisible to the immune system, and provide insulin independence for people living with T1D. 
    VIDEO

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  • David Harlan, MD - Insulin's 100th Birthday
    Friday, February 19, 2021

    Dr. David Harlan Celebrates 100 Years Since the Initial Purification & Use of Insulin in Diabetes Therapy with "The Noble and Often Nobel Role of Insulin-Related Research"

    Dr. Harlan kicked off the Stanford Diabetes Research Center Symposium celebrating the 100th anniversary of the purification & use of insulin as a life-saving diabetes treatment. His thorough retrospective describes important roles played by various scientists, including Nobel laureates. Four major themes in his presentation are: good ideas vs. brilliance; the roles that serendipity and persistence played; and unforeseen consequences of these incredible research accomplishments. VIEW VIDEO  

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  • Tammy Nguyen UMass Medical School Wound Healing
    Tuesday, January 26, 2021

    Tammy Nguyen Received a Vascular and Endovascular Surgery Society Award to Investigate Diabetic Wound Healing Problems

    Tammy Nguyen, MD, PhD, is analyzing bone marrow to learn why diabetes patients with foot ulcers have a difficult time healing. She received the Vascular and Endovascular Surgery Society’s 2021 Early Career Faculty Research Grant designed to help new vascular surgical investigators initiate projects that will lead to additional funding. She's comparing immune cells from people with diabetes who have had amputations with nondiabetic patients who have had amputations for other reasons.  FULL STORY

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  • Virtual Diabetes Camp Jason Kim
    Friday, January 15, 2021

    Diabetes Virtual Camp for Future Scientists and Physicians Created by the Family of UMass Diabetes Researcher Jason Kim

    Dr. Kim’s daughters Allison and Lauren are also considering careers in medicine and science. When Lauren’s summer research internship at Harvard Medical School was canceled due to the COVID-19 pandemic last year, the family quickly created the Diabetes Virtual Camp to connect students and experts in a virtual internship setting. After successful summer and fall sessions, they teamed up with the American Diabetes Association to support diabetes research, education and care. LEARN MORE

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  • Sean Collins Soldiers Home
    Thursday, January 14, 2021

    UMass Diabetes Nurse Practitioner, Brig. Gen. Sean Collins Was Appointed to Board of Trustees for the Holyoke Soldiers’ Home

    In addition to being a nurse practitioner for the Diabetes Center of Excellence at UMass Memorial Medical Center, Sean Collins, PhD, NP, is also has a decorated military career. Air National Guard Brigadier General Sean Collins has been named a member of the Board of Trustees for the Soldiers’ Home in Holyoke. He recently served three months at the Pentagon addressing COVID issues in the early days of the pandemic.  FULL STORY

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  • Myoung Sook Han diabetes research
    Tuesday, January 05, 2021

    Davis Lab Investigating a Potential Hormone Therapy for Type 2 Diabetes

    Newly published research from the Davis Lab at the UMass Diabetes Center of Excellence explains a discovery that could lead to a potential therapy for type 2 diabetes and other metabolic diseases. LEARN MORE

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  • Silvia Corvera UMass Diabetes
    Monday, November 30, 2020

    Protein Commonly Screened For During Pregnancy is Linked to Gestational Diabetes

    Research at UMass Chan Medical School showed low levels of a protein commonly seen in screening tests during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes in pregnant women. The study, published in Science Translational Medicine, outlines a new role for pregnancy-associated plasma protein A, known as PAPPA, in gestational diabetes, with translational potential as both a diagnostic tool and therapeutic target.  

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  • Messina Lab Wound Healing Research
    Wednesday, November 18, 2020

    Messina Lab Developing a Treatment for Previously Non-Healing Wounds in People with Diabetes

    The laboratory of Louis M. Messina, MD, has received grant funding from the National Institutes of Health to test a novel therapy they’ve developed to treat wounds in older adults living with type 2 diabetes.  The Messina Lab already developed and patented a biotherapeutic, which they're now testing in our unique humanized mouse models.   

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  • Micheal Czech and Silvia Corvera
    Thursday, October 29, 2020

    Re-engineering “Bad Fat” into “Good Fat” as a Therapeutic Approach to Type 2 Diabetes in the Czech & Corvera Labs

    Scientists in the Czech Lab and Corvera Lab at UMass Chan Medical School are using the gene editing tool CRISPR to alter DNA and modify gene function - and developing new methods to modify human fat cells in vitro, then transplanting them as a potential therapy for type 2 diabetes and obesity.  LEARN MORE

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  • Cell Reports Guertin Lab Type 2 Research
    Saturday, October 10, 2020

    Studying Fat Cell Function in the Guertin Lab in an Effort to Develop & Test Therapies for Type 2 Diabetes

    Newly published research in the Guertin Lab at the UMass Diabetes Center of Excellence knocks out a gene, specifically in a precursor cell population, that gives rise to new fat cells, to understand how to make a healthy fat cell. They're studying a signaling pathway called mTOR Complex 2 (mTORC2). A key regulatory input was discovered that helps to establish not only insulin sensitivity, but the ability of fat tissue to use insulin to take up and store energy as lipids. For the first time, this data establishes mTORC2 as a key regulator of a developing fat cell.  FULL STORY

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  • Silvia Corvera Type 2 Diabetes Research
    Saturday, October 17, 2020

    The Corvera Lab is Examining How Different Body Fat Plays a Role in Type 2 Diabetes

    People with extra fat around their belly are more at risk of developing type 2 diabetes than those who have fat in the lower body. The Corvera Lab is studying how the development and function of fat cells differ in people with and without diabetes. They examine human fat from different locations in the body to study cells which become fat cells. Understanding the differences in genes expressed in these cells from abdominal fat or gluteal fat and how they become different types of fat cells will help elucidate how different fat depots form, and if they vary between people with and without type 2 diabetes. It will also help explain why lower body fat is beneficial, and maybe recapitulate these beneficial effects in ways that can improve health.  LEARN MORE

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  • Kyounghee Min
    Saturday, October 03, 2020

    Mello Scholars Recognized for Molecular Research at UMass Medical School in Pursuit of the Advancement of Human Health

    Nobel Laureate Craig Mello presented the annual Mello Scholars awards at a socially distanced ceremony at UMass Medical School. The event recognizes graduate students in the Program in Molecular Medicine with outstanding track records and bright futures. The award comes with one year of funding. One of this year’s recipients is a member of the Czech Lab at the UMass Diabetes Center of Excellence. Learn more about this year's honorees here.

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  • Silvia Corvera Clinical Trial
    Wednesday, August 26, 2020

    Corvera Lab Leading a Clinical Study to Investigate the Relationship Between Fat, Diabetes and Obesity

    The location of body fat varies in people and too much fat in the belly area is a risk factor for diabetes. The purpose of this research is to characterize how fat cells from the abdomen and buttock regions are different and to study how these cells are different in people with type 2 diabetes.  

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  • Cell Metabolism Type 2 Diabetes Research
    Wednesday, August 19, 2020

    The Kim Lab Participated in Newly Published Collaborative Type 2 Diabetes Research That Identified a Potential Oral Treatment

    Type 2 diabetes research in the laboratory of Dr. Jason Kim at the UMass Diabetes Center of Excellence, in a collaborative project led by Dr. Anath Shalev at the University of Alabama at Birmingham and her research team who had discovered a small molecule SRI-37330, have unveiled an exciting new process by which this compound effectively rescues mice from obesity-induced diabetes.  Compared to currently available therapies it could provide an effective new approach to treating type 2 diabetes.  LEARN MORE

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  • Diabetes Prevention Program
    Thursday, July 30, 2020

    Research Project by Medical Students Looks at Improving Prediabetes and Diabetes in Primary Health Care

    Prior to completing their studies at University of Massachusetts Medical School, Dr. Ashley Millette Cote and Dr. Alexandria Capozza completed a capstone research project which analyzed the effectiveness of Diabetes Prevention Programs in Massachusetts.  They also developed an elective class at the medical school to teach future students about the best care available for people living with prediabetes and type 2 diabetes.  FULL STORY

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  • Cell Reports July 2020
    Friday, July 24, 2020

    Modeling Type 1 Diabetes Using Human Stem Cells in the Brehm and Greiner Labs

    Scientists at the UMass Diabetes Center of Excellence continue to gain new knowledge of type 1 diabetes by studying human tissues and human cells, to recreate the disease in our unique humanized animal models.  Newly published research describes our collaboration with the Melton Lab at The Harvard Stem Cell Institute.  Scientists were recently able to model type 1 diabetes autoimmunity using patient’s blood and stem cell derived beta cells.  LEARN MORE

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  • Sally Kent Diabetes Journal Article
    Thursday, July 09, 2020

    UMass DCOE Scientist Sally Kent Contributed to a Published Article About the Autoimmune Process of Type 1 Diabetes

    UMass Diabetes Center of Excellence scientist Sally Kent's lab is credited with uncovering new information about how autoreactive T cells target beta cells in pancreatic islets. Dr. Kent is encouraged her breakthrough will contribute to the design of therapies for people living with type 1 diabetes. She's one of the authors of a published Perspective article in the July 2020 journal Diabetes which updates and reappraises what scientists have found over the past 30 years examining autoreactive T cell response in T1D.  FULL STORY

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  • Diabetes Camp Study UMass Memorial
    Wednesday, July 01, 2020

    A Study by Dr. Amy Darukhanavala Compared Blood Sugar Control and Treatment Satisfaction Between Diabetes Camp vs. Home

    Amy Darukhanavala, MD, a pediatric diabetes physician at UMass Memorial’s Diabetes Center of Excellence, led a study comparing the success of continuous glucose monitoring at diabetes summer camp versus at home prior to camp. The research examined blood sugar data and quality of life, based on how the children felt about their diabetes in both settings.  STUDY RESULTS

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  • Jennifer Wang UMass Diabetes research
    Wednesday, June 17, 2020

    Physician-Scientist Jennifer Wang Uses Stem-Cell Derived Beta Cells to Study the Effects of Viral Infections on Type 1 Diabetes Development

    Enteroviruses encompass a group of viruses that give rise to infectious illnesses which are usually mild. However, if enteroviruses such as coxsackievirus infect the central nervous system or heart, they can cause serious illness. Enteroviral infections are also associated with T1D, but how they contribute to this disease is not well understood. Jennifer Wang's lab is using stem-cell derived beta cells to study virus-driven immunology and beta cell dysfunction, with the ultimate goal of new treatments.  FULL STORY

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  • Diabetes Telehealth
    Tuesday, May 19, 2020

    Telehealth May Become the New Normal in Diabetes Care

    Virtual telemedicine has been considered by many over the years to be well-suited for diabetes care. A recent study shows better A1c reduction in people who received telehealth care compared with typical in-person appointments. UMass Memorial patients who have received remote diabetes care during the coronavirus pandemic have been overwhelmingly positive about the process. Another published study claims people with type 1 diabetes have combined telehealth and technology with proper blood glucose management and monitoring to achieve better outcomes during the pandemic, as patients avoid in-person visits.
    FULL STORY

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  • Type 1 Diabetes Pancreas Study
    Thursday, May 14, 2020

    Dr. David Harlan Collaborated on a Newly Published Study Investigating Smaller Pancreases in People with Type 1 Diabetes

    UMass Diabetes Center of Excellence co-director David Harlan, MD, participated in newly published research that further characterized pancreases from adult donors with type 1 diabetes compared with similarly aged donors without diabetes. The study found the pancreases from those with both longstanding and recent-onset T1D to be approximately 45% smaller than pancreases from donors without diabetes.  To learn more about the study and its other findings, check out the FULL STORY

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  • Beige Fat Study in Cell Reports
    Tuesday, May 05, 2020

    Type 2 Diabetes Research in the Czech Lab Investigating Beige Fat to Potentially Increase Metabolism

    Type 2 diabetes research in the UMass Diabetes Center of Excellence laboratory of Michael Czech, PhD, is investigating the behavior and function of various fat cells, with the goal of improving metabolism for a potential obesity therapy.  New data from a recent study was published in the journal Cell ReportsFULL STORY

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  • COVID-19 CGM
    Friday, April 24, 2020

    Continuous Glucose Monitors Now Permitted at UMass Memorial to Monitor Diabetes Patients and Protect Hospital Workers During the COVID-19 Pandemic

    The Food and Drug Administration agreed to allow continuous glucose monitors to be used in hospitals during the pandemic to help health care workers monitor diabetes patients while reducing their own exposure to the coronavirus. UMass Memorial began using them to monitor the blood sugar of UMass Memorial's patients with diabetes. In recent years, the UMass Diabetes Center of Excellence has revolutionized blood glucose management for all people living with diabetes who are admitted to Worcester’s UMass Memorial hospitals.  

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  • Alan Derr Diabetes Research
    Tuesday, April 14, 2020

    Alan Derr Named Cammett Scholar in Type 1 Diabetes Research at UMass Medical School

    Alan Derr was named the Cammett Scholar for type 1 diabetes research, supported by a generous gift from UMass Diabetes Center of Excellence Visiting Advocacy Committee member John Cammett. Alan's role as a bioinformatician is to analyze the vast volume of data generated during the study of human insulin producing beta cells and the immune cells that attack human islets in people living with diabetes.

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  • Guertin Lab Published New Data About mTORC2 Signaling in Brown Adipocytes
    Thursday, April 02, 2020

    Guertin Lab Published New Data About mTORC2 Signaling in Brown Adipocytes

    Type 2 diabetes metabolism research in the Guertin Lab examined time dependent changes in the mTORC2 signaling pathway in mature brown adipocytes.

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  • Daniel Amante and Adarsha Bajracharya
    Tuesday, February 18, 2020

    ID PLUS Care program developed to help at-risk type 2 diabetes patients within UMass Memorial receive the care they need

    A new program within the UMass Diabetes Center of Excellence is tracking patients at-risk for negative outcomes due to gaps in care by identifying their difficulties and guiding them towards available services and resources to control their diabetes. The ultimate goal is to prevent or reduce the risk of complications, lower healthcare costs, and improve quality of life by encouraging self-care diabetes management. 

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  • Richard A. Siller, PhD  UMass Medical Diabetes
    Friday, February 07, 2020

    Glass Family Fellowship in Diabetes Research Established at the UMass Medical School Diabetes Center of Excellence

    The UMass Diabetes Center of Excellence established The Glass Family Fellowship in Diabetes Research, through a gift from Scott and Patricia Glass. It was awarded to Richard A. Siller, PhD, a postdoctoral research fellow in the Maehr Lab. He's eager to collaborate with his fellow lab members to work toward creating a fully functional human thymus over the the next two years at the University of Massachusetts Medical School.   

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  • Davis Lab Sheds Light on Complications From High Blood Glucose and Excess Body Fat Which Lead to Type 2 Diabetes
    Friday, February 07, 2020

    Davis Lab Sheds Light on Complications From High Blood Glucose and Excess Body Fat Which Lead to Type 2 Diabetes

    A new study in the Davis Lab on causes of metabolic syndrome was published in The Proceedings of the National Academy of Sciences, the official journal of the National Academy of Sciences. Data obtained from this research provides insight into some type 2 diabetes risk factors including high blood glucose and obesity.  

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  • Guertin Lab mTORC2 Signaling Study Published in Nature Communications
    Monday, February 03, 2020

    Guertin Lab mTORC2 Signaling Study Published in Nature Communications

    A study by Camila Martinez Calejman, PhD, published in the journal Nature Communications revealed an unexpected link between mTOR signaling and the synthesis of Acetyl-CoA, a molecule with critical roles in carbohydrate and lipid metabolism and the epigenetic control of gene expression.  It describes the importance of this link in brown adipose tissue, but the implications may extend to understanding other aspects of type 2 diabetes and cancer.   

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  • Rene Maher Type 1 Diabetes
    Wednesday, January 29, 2020

    Developing a Thymus in the Maehr Lab to Improve Type 1 Diabetes Research

    The Maehr Lab is developing human thymus glands using stem cells from the blood of volunteer participants. They'll be inserted into our humanized immune systems, along with insulin producing beta cells and immune cells created from the stem cells of those same blood donors. This will allow our scientists to study the interaction between an individual’s own cells, to investigate how and why the autoimmune attack is taking place. Once it’s determined what’s causing type 1 diabetes, we can then begin to test therapies within our humanized immune models.  

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  • FACEB Journal Harlan Lab
    Tuesday, January 21, 2020

    The Harlan and Greiner Labs Developed a Method to Study Human Cells and Tissue That Improves Type 1 Diabetes Research

    A new technique to study human cells and tissues was recently developed at the UMass Diabetes Center of Excellence. It’s another step forward in the continued effort to examine the insulin producing beta cells of humans living with type 1 diabetes and to learn more about the autoimmune attack associated with the disease. The new method allows our scientists to recover and further examine sufficient amounts of living human cells that they previously transplanted into our novel human immune models.   

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  • Michael Czech UMass Diabetes
    Friday, January 17, 2020

    Using RNA Interference to Study Behaviors and Function Cells Within Adipose Fat Tissue and the Effect on Blood Glucose Metabolism

    Type 2 diabetes research in the laboratory of Michael Czech, PhD, includes studying the behavior and function of the various cells that make up adipose tissue, with a goal of improving systemic metabolism in obesity.  They contributed some of their lab's RNAi technology to a study published in The Journal of Immunology.  

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  • Wally Gilbert and David Harlan
    Tuesday, February 25, 2020

    David Harlan Interviews Nobel Laureate Wally Gilbert About His Pioneering Work in DNA Sequencing That Led to the Creation of the First Genetically Engineered Human Insulin

    David Harlan, MD, interviewed Nobel Prize laureate Wally Gilbert, PhD, 40 years after the first human insulin for diabetes treatment was genetically engineered, thanks in part to his pioneering work in DNA sequencing. Dr. Gilbert is now an accomplished artist and after the interview they toured his impressive art studio in Boston. VIDEO

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  • Sally Kent Type 1 Diabetes Research
    Wednesday, December 11, 2019

    Sally Kent Named Fuller Foundation Term Chair in Diabetes

    Sally C. Kent, PhD, has been named the George F. and Sybil H. Fuller Foundation Term Chair in Diabetes. Dr. Kent studies autoimmune response in type 1 diabetes. Her lab is credited with uncovering new information on how autoreactive T cells target beta cells in islets, a breakthrough that will contribute to the design of therapies for people with type 1 diabetes.  FULL STORY

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  • Current Diabetes Report Adyposite
    Tuesday, November 26, 2019

    Guertin Lab review on the metabolism of fat cells in type 2 diabetes published in Current Diabetes Reports

    Guertin Lab graduate student Wen-Yu Hsiao presents an interesting perspective based on recent findings about what makes a fat cell “healthy” and why.  Their research examines how the metabolism of adipocytes impacts blood glucose and insulin resistance especially in people living with obesity and/or type 2 diabetes.  READ MORE

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  • Conversation Maps for Diabetes Education
    Wednesday, October 16, 2019

    Mapping your plan to control blood glucose with the help of diabetes education

    UMass Memorial Diabetes Center of Excellence education workshops use Conversation Maps® to teach a variety of diabetes topics to help people make lifestyle changes as part of their self-management.   

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  • Carl H. June, MD, pioneer of CAR T Cell Immunotherapy
    Friday, September 27, 2019

    Carl H. June, MD, pioneer of CAR T Cell Immunotherapy

    Dr. David Harlan welcomed his longtime friend and fellow distinguished physician/scientist, Carl H. June, MD, to speak at the UMass Chan Medical School Department of Medicine Grand Rounds. They worked closely throughout the 1990's when they led the U.S. Navy’s “Immune Cell Biology Program." Dr. June is director of the Center for Cellular Immunotherapies at the University of Pennsylvania Medical School, and is best known for his pioneering work developing CAR T-cell therapy for the treatment of leukemia. FULL VIDEO

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  • Jinglian Yan UMass Diabetes Wound Healing Research
    Thursday, September 26, 2019

    The Messina Lab is Developing Blood Stem Cell Approaches to Impaired Diabetic Wound Healing

    The Messina lab is studying impaired wound healing resulting from type 2 diabetes. They've found that diabetes impairs wound healing by causing an injury to blood stem cells that affects a particular white blood cell which is the most important cell in the body’s response to a diabetic ulcer.  Loss of limbs is a major fear of people with uncontrolled blood sugars. This research is exploring a blood stem cell-based therapeutic approach to reverse what is one of the most feared complications of diabetes.  FULL STORY 

        

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  • Silvia Corvera Adipocyte Research
    Friday, September 20, 2019

    New research in the Corvera lab discovered new fat cells with specialized functions in the metabolism of the human body

    Dr. Corvera’s laboratory determined that there are more types of fat cells in the human body than originally thought. Prior research had shown two types of fat cells, white and beige. This new research uncovered at least five types of human fat cells which play different roles in how they affect metabolism.  They're now investigating human cell therapy, which consists of using the body’s own cells to increase metabolism, as a possible treatment for type 2 diabetes or its complications.  FULL STORY

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  • Brehm lab islet encapsulation device research
    Thursday, September 05, 2019

    Brehm and Greiner laboratories testing islet encapsulation device in collaboration with Lockheed Martin & JDRF Research

    The goal of this research is to create an implantable cell replacement device to be used as a therapy for people living with type 1 diabetes. Insulin-producing beta cells would be encapsulated in the device to protect the cells from the autoimmune attack, while also allowing those protected cells to survive and function.  FULL STORY

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  • Diabetes CGM Article
    Saturday, August 24, 2019

    Continuous Glucose Monitors and Children with Type 1 Diabetes

    Parents of young children living with type 1 diabetes were asked about the pros and cons of using continuous glucose monitors.  They described the benefits and the challenges.  We asked members of our pediatric diabetes care team their thoughts. 

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  • David Harlan Endocrine Society
    Saturday, June 22, 2019

    Dr. David Harlan Presents "Going Beyond Insulin in Type 1 Diabetes" at the Endocrine Society's Annual Fellows Conference

    Dr. Harlan was invited to speak at the Endocrine Society's Fellows Series: Type 1 Diabetes Care and Management.  His talk titled "Going Beyond Insulin: Emerging Options for T1D" presented options beyond insulin therapy for people living with diabetes, including GLP-1 and SGLT use.  LEARN MORE

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  • Grant Awarded to Improve Inpatient Diabetes Care at UMass Memorial Hospitals
    Wednesday, June 05, 2019

    Grant Awarded to Improve Inpatient Diabetes Care at UMass Memorial Hospitals

    The second annual Herman G. Berkman Diabetes Clinical Innovation Fund grant has been awarded to Leslie J. Domalik, MD and co-investigator Asem Ali, MD.  Read about their project, intended to improve blood glucose control for all patients admitted to UMass Memorial hospitals who are living with diabetes.  FULL STORY

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  • Harlan and Kent Labs resolved a 30 year debate by locating beta cells in people with T1D which express important immune pathway gene products
    Friday, March 29, 2019

    Harlan and Kent Labs resolved a 30 year debate by locating beta cells in people with T1D which express important immune pathway gene products

    Studying the islets of people with type 1 diabetes, the laboratories of David Harlan, MD and Sally Kent, PhD definitively put to rest a three decades old debate about whether beta cells express important immune genes called “human leukocyte antigen class II” (HLA Class II).  LEARN MORE 

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  • Nicole Gray Certified Child Life Specialist
    Friday, February 22, 2019

    The Role of a Certified Child Life Specialist in a Diabetes Care Clinic

    The Certified Child Life Specialist at the UMass Memorial Diabetes Center of Excellence supports children and families beginning at the very first office appointment. She works closely with the pediatric diabetes care team to provide age appropriate support and interventions. 

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  • Silvia Corvera Lab Adipocyte studies
    Friday, February 01, 2019

    Corvera Lab is Creating "Good Fat" as a Potential Therapy for Type 2 Diabetes

    The laboratory of Silvia Corvera, MD, was featured on WCVB-TV/ABC in Boston and WJAR-TV/NBC of Providence about their research in which they are transforming white fat into beige fat, to harness its ability to burn energy, accelerate metabolism and fight disease.  VIDEO 

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  • Research in the Brehm and Davis Laboratories Uncovered New Memory T Cells Data
    Monday, February 04, 2019

    Research in the Brehm and Davis Laboratories Uncovered New Memory T Cells Data

    Apoptosis of CD8 T cells is an essential mechanism that maintains immune system homeostasis, prevents autoimmunity, and reduces immunopathology.  Research from the Brehm, Greiner and Davis laboratories at the UMass Diabetes Center of Excellence, was published in The Journal of ImmunologyFULL STORY

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  • Rachel Stamateris diabetes beta cell research
    Thursday, January 10, 2019

    MD/PhD Candidate Rachel Stamateris Named Ruth L. Kirschstein Fellow

    Rachel Stamateris, an MD/PhD candidate at University of Massachusetts Medical School, was awarded a prestigious Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship for dual-doctoral degree students, from the National Institute of Diabetes and Digestive and Kidney Diseases. Her fellowship experience is intended to enhance Rachel’s integrated research and clinical training as predoctoral student. Over the next four years, this award will help to sponsor her research and promote her development into a productive, independent physician/clinician-scientist.  READ MORE

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  • Research in the Harlan lab discovered a rare genetic defect that affects human beta cell function
    Tuesday, December 18, 2018

    Research in the Harlan lab discovered a rare genetic defect that affects human beta cell function

    Isolating donated islets from a young man who had been treated for 17 years for presumed T1D, scientists found a rare genetic defect had caused his beta cells to function improperly.  Findings were published in The Journal of Clinical Investigation.  LEARN MORE

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  • UMass Diabetes Center of Excellence Receives a $10.5K Gift From a Grateful Family
    Friday, November 02, 2018

    UMass Diabetes Center of Excellence Receives a $10.5K Gift From a Grateful Family

    The First Annual Joe “Nuzzy” Memorial Golf Tournament raised $10,500, which was generously donated to the UMass Memorial Diabetes Center of Excellence (DCOE), to be used for continued patient care.  The family wants the money to help others being treated for diabetes at UMass Memorial.  They recently toured our research laboratories, and were impressed with what they saw.   
    FULL STORY

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  • Micheal Czech and Silvia Corvera
    Monday, October 29, 2018

    Michael Czech and Silvia Corvera receive $2.5 million grant to advance potential therapy for type 2 diabetes

    Silvia Corvera, MD, and Michael Czech, PhD, are investigating whether technologies developed in their labs will harness beige fat’s ability to burn energy and accelerate metabolism in order to improve the body’s response to sugar and lower blood glucose levels.  READ MORE

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  • Unexpected cell population slows down fat cells
    Tuesday, August 07, 2018

    Unexpected cell population slows down fat cells

    Fat tissue has a remarkable capacity for growth. David A. Guertin, PhD, explains why his latest research of a fat-precursor cell which unexpectedly functions to suppress adipocyte production, is exciting to the future of combating obesity.  READ MORE

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  • How virus triggers type 1 diabetes
    Tuesday, August 28, 2018

    Jennifer Wang Receives Funding Grant to Continue Studying How Viruses Trigger Type 1 Diabetes

    Infectious disease and immunology expert Jennifer Wang, MD hopes to move closer to better understanding type 1 diabetes by working with a new animal model to identify pathways which could be stopped in order to prevent the disease from developing.  FULL STORY

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  • Kristin MacGregor Umass Memorial Diabetes
    Thursday, July 12, 2018

    Why Language is Important in Diabetes Management

    Words used to describe something shapes the way others perceive and value that thing. The culture in diabetes tends to be the disease defines the person. Changing language can make a world of difference, according to Kristin L. MacGregor, PhD, a former behavioral psychologist at the UMass Diabetes Center of Excellence. 

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  • Cheryl Barry, RN Diabetes Education
    Monday, July 09, 2018

    Diabetes Education Offers Many Benefits

    Diabetes education has been shown to lower A1c by as much as 1%, which is similar to adding a medication but without side effects. Research has shown people who received diabetes education are more likely to utilize primary care and preventative services, take medications as prescribed and control their blood glucose, blood pressure and cholesterol levels. As a result, those people have lower health costs.  The UMass Memorial Diabetes Center of Excellence offers an extensive education program covering a variety of topics. Both one-on-one sessions and group workshops are available.  

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  • René Maehr, PhD thymus development research
    Wednesday, June 20, 2018

    The Maehr Lab's Thymus Development Study Featured as the Cover Story in Immunity

    Thymus development research in the lab of René Maehr, PhD was featured as the cover story in Immunity.  Single-cell RNA sequencing was used to illustrate a framework for biological discovery and molecular analysis of thymus organogenesis (the production and development of the organ).  READ MORE 

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  • Christine Hoogasian, Diabetes UMass Memorial
    Monday, May 09, 2022

    The Important Role of a Nurse Practitioner in Diabetes Care

    Many patients do not understand the role and capabilities of a nurse practitioner (NP) when it comes to diabetes care.  NPs are taught both the medical model and the nursing model of care.  The scope of practice of a nurse practitioner varies from state to state. Meet Christine and learn how she provides care to patients at the UMass Memorial Diabetes Center of Excellence.   

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  • Roger Davis UMass medical school
    Thursday, May 03, 2018

    Roger Davis Elected into the National Academy of Sciences

    Roger J. Davis, PhD was elected into the National Academy of Sciences.  Membership in the NAS is one of the highest honors bestowed upon a scientist in the United States.  He joins four UMass Medical School colleagues who have received membership in recognition of their for outstanding contributions to original research.  His work to explain the molecular mechanism by which inflammation contributes to diabetes, cancer and stroke has been among the most important in this field for more than two decades.  READ MORE

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  • Low Carb with Type 1 Diabetes
    Monday, May 07, 2018

    The New York Times Asked Dr. David Harlan About Eating a Low-Carbohydrate & High Protein Diet with Type 1 Diabetes

    David Harlan, MD, co-director of the UMass Diabetes Center of Excellence, was quoted in a New York Times article about a new study published in the journal Pediatrics.  The research found children and adults with type 1 diabetes who followed a low-carbohydrate and high-protein diet, combined with smaller insulin doses than typically required with a normal diet, experienced “exceptional” blood sugar control and few complications.  FULL ARTICLE

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  • Diabetes Center of Excellence
    Wednesday, March 14, 2018

    Dr. David Harlan and Colleagues Nationwide Provided a Framework for Developing a Successful Diabetes Center of Excellence

    Although diabetes research centers are well defined by National Institutes of Health, there is no clear definition for clinical Diabetes Centers of Excellence (DCOE).  Dr. David Harlan, co-director, UMass Diabetes Center of Excellence collaborated on an article published in The Journal of Clinical Endocrinology & Metabolism, in which they propose a framework to guide advancement for DCOE.  

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  • Nancy Morris UMass Diabetes
    Wednesday, March 07, 2018

    Nancy Morris Receives Excellence in Nursing Education Award from American Nursing Association Massachusetts

    Nancy Morris, Adult Nurse Practitioner in the UMass Diabetes Center of Excellence, was awarded the Excellence in Nursing Education Award from The American Nursing Association of Massachusetts.  It honors nurse educators for teaching, research and practice, recognizing innovative approaches to facilitate learning and professional development.  

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  • Sally Kent nPOD award
    Wednesday, February 28, 2018

    Sally Kent receives Pioneer Award from the Network for Pancreatic Organ Donors with Diabetes (nPod)

    Sally Kent, PhD, a scientist at the UMass Diabetes Center of Excellence, was recognized by the Network for Pancreatic Organ Donors with Diabetes with a Pioneer Award for her "continued dedication to create a world free of type 1 diabetes.”  Jenny Aurielle Babon, PhD, a postdoc in the Kent Lab, presented some of their latest research during nPOD's Annual Scientific Meeting.   

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  • Silvia Corvera Adipocyte Research
    Wednesday, February 03, 2016

    The Corvera Lab Sheds Light on Beige Fat as a Potential Therapy for Type 2 Diabetes

    The Corvera Lab at UMass Chan Medical School's Diabetes Center of Excellence shed light on the benefits of beige fat. Our body's fat has the ability to generate beige fat, which could potentially be deployed within ourselves to treat diabetes, obesity and cardiovascular disease.

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  • Sean Collins Diabetes Air Force
    Monday, November 14, 2016

    Diabetes Nurse Practitioner Sean Collins Joins the U.S. Defense Health Agency with Promotion to Air Force Brigadier General

    Distinguished UMass Diabetes nurse practitioner, Sean Collins, PhD, has been promoted to U.S. Army Reserves Brigadier General and will serve as a principal advisor to the Pentagon’s Director of Health Affairs on Guard and Reserve matters. BG Collins has served on the forefront of the diabetes epidemic for more than 30 years.  

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  • Diabetes Research at UMass Medical School
    Monday, October 31, 2016

    The Kent and Harlan Labs Isolated Immune Cells from Islets of Donors with Type 1 Diabetes

    Sally C. Kent, PhD, and Jenny Aurielle B. Babon, PhD, have isolated and characterized a large bank of live islet-infiltrating T cells directly from the islets of tissue donors with type 1 diabetes. The findings, published in Nature Medicine, have direct implications for the design of therapies and preventative strategies for people with type 1 diabetes and those at risk for developing it. 

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  • UMass Medical School hosts American Diabetes Association Step Out Walk to Stop Diabetes
    Monday, September 26, 2016

    UMass Medical School hosts American Diabetes Association Step Out Walk to Stop Diabetes

    The UMass Diabetes Diabetes Center of Excellence once again hosted the Central MA Step Out Walk to Stop Diabetes. The signature fundraising event for the American Diabetes Association takes place on the UMass Medical School campus. This year, more than 1000 people participated, including DCOE faculty, staff & families. Entertainment included representatives from the Red Sox, Patriots, New England Revolution, Worcester Bravehearts & Worcester Railers.  PHOTOS 

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Patient Wall of Honor

nan-hilton-type-two-diabetic

Nan was diagnosed with Type 2 diabetes at 23 years old. During a difficult pregnancy, Nan developed severe diabetic retinopathy that required invasive surgery and painful injections. After giving birth she committed to make necessary changes. After years of taking medications & insulin, she made lifestyle modifications and lost 90 pounds and no longer takes any diabetes medications. Meet Nan 

deborah-okeefe-type-1-diabetes.jpg

Taylor’s A1c reached 15% in 2011 and remained elevated until 2016. That’s when she made a personal commitment to her health and started 2022 with an all-time low A1c of 6.4%. Her inspiring story proves it’s never too late to take control of diabetes. In addition to improved health, she went to nursing school and today she’s a UMass Memorial Health Nurse and plans to become a Diabetes Educator.
Meet Taylor

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