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Translational Oncology

The Translational Oncology (TO) Program bridges scientific discoveries developed at the Cancer Center to the clinic by building tools, preclinical models, and collaborative research programs among basic, translational, and clinical faculty.

Research in the TO Program aims to:

Bring novel cancer treatments and drug delivery approaches from bench to bedside to advance cancer treatment and limit drug resistance
Support clinical trials evaluating innovative anti-cancer therapies through identification of novel biomarkers and prognostic markers.
Develop and utilize advanced preclinical cancer models to test novel therapeutic hypotheses for rapid clinical translation.

Leadership

Getting Results…

Lucio H. Castilla, PhD

Research Focus

Hematopoietic Differentiation and Acute Myeloid Leukemia

Members

Getting Results…

Program Highlights

Getting Results…

Developing a Targeted Therapy for Acute Myeloid Leukemia

With support from the UMass Cancer Pilot Grant Program, Lucio Castilla, PhD, is working on a way to deliver a targeted therapy for inversion(16) acute myeloid leukemia. he is collaborating with S. Thai Thuyamanavan, PhD, an expert in drug delivery, to develop an antibody-nanogel conjugate capable of delivering a small molecule to AML cells and kill them.

Read more

, Translational Oncology,
The Darkest Side of Acute Myeloid Leukemia: The TP53 Mutation

Learn why the TP53 mutation in acute myeloid leukemia is particularly worrisome and what Shyam Patel, MD, PhD is doing about it.

Read more

, Translational Oncology,

Translational Oncology

Leadership

Lucio H. Castilla, PhD

Members

Ali Akalin, MD, PhD

Karim Alavi, MD, MPH

Kathleen Arcaro, PhD

Jennifer A. Baima, MD

Bruce A. Barton, PhD

B. Nicolas Bloch, MD

Alexei A. Bogdanov, Jr., PhD, ScD

Michael Brodsky, PhD

David Cachia, MD

Jan Cerny, MD, PhD

Jennifer L. Clark, MD, PhD

April Deng, MD, PhD

Kate H. Dinh, MD, MS

Todd Emrick, PhD

Thomas J. Fitzgerald, MD

Neil Forbes, PhD

Guangping Gao, PhD

Jonathan M. Gerber, MD

Matthew J. Gounis, PhD

In Memoriam: Michael R. Green, MD, PhD

Gang Han, PhD

Jeanne Hardy, PhD

John E. Harris, MD, PhD

Lloyd M. Hutchinson, PhD

Anastasia Khvorova, PhD

Ashish Kulkarni, PhD

Jennifer LaFemina, MD

Anne C. Larkin, MD

Michael J. Lee, PhD

James M. Lindberg, MD

David Julian McClements, PhD

Beth A. McCormick, PhD

Kriti Mittal, MD

Mathew J. Most, MD

Peter E. Newburger, MD

Shyam A. Patel, MD, PhD

Muthalagu Ramanathan, MD

Vincent M. Rotello, PhD

William Royer, PhD

Miguel Sena-Esteves, PhD

Leili Shahriyari, PhD

Shirin Sioshansi, MD

Rachael Sirianni, PhD

Rachid Skouta, PhD

Govind Srimathveeravalli, PhD

S. "Thai" Thayumanavan, PhD

Paul R. Thompson, PhD

Vijay K. Vanguri, MD

William V. Walsh, MD

Jonathan K. Watts, PhD

Giles F. Whalen, MD

Bruce A. Woda, MD

Scot A. Wolfe, PhD

Michelle Yang, MD, PhD

Jennifer Yates, MD

Susan Zweizig, MD

Developing a Targeted Therapy for Acute Myeloid Leukemia

The Darkest Side of Acute Myeloid Leukemia: The TP53 Mutation

Research Programs