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Shyam A. Patel, MD, PhD

Research Focus - Clinico-genomic Profiling and Clonal Dynamic Modeling of Myelodysplastic Syndrome and Acute Myeloid Leukemia

  • Focusing on genomics of acute myeloid leukemia and tracking of clones with therapy over time, including determining how subsets of leukemia cells respond to therapy and how the subclonal structure of acute myeloid leukemia evolves
  • Investigating genomics of myelodysplastic syndrome as they relate to clonal evolution to acute myeloid leukemia
  • Understanding clonal hematopoiesis—how different mutations confer variable risk of progression towards acute myeloid leukemia
  • Modeling clonal dynamics of myeloid malignancies in mutation-specific cohorts, with the goal of designing better therapies for acute leukemia

Representative Publication

Patel SA, Cerny J, Gerber WK, et al. Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with TP53 disruptions. EJHaem. 2023;4(4):1059-1070. 

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