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Jeanne Hardy, PhD

Research Focus - Structure and Drug Development for Caspases

  • Identification of allosteric sites in caspases for development of new inhibitors and activators of cancer
  • Small-molecule drug development against caspases
  • Development of fluorescence caspase reporters for activity and observing delivery
  • Delivery of active caspases for cancer therapy (in collaboration with S. Thayumanavan)
  • Co-delivery of caspases and apoptosis modulators

Representative Publication

Dagbay KB, Hardy JA. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proc Natl Acad Sci USA. 2017;114(30):E7977-E7986.

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