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Michael Brodsky, PhD

Research Focus - Using Gene Editing to Model and Target Huntington’s Disease and Other Human Disease

  • Creation of new human disease models with the Mutagenesis Core Facility
  • Manipulating DNA repair pathways to improve gene editing approaches to correct trinucleotide repeat expansion diseases
  • Allele-specific gene editing of the mutant Huntington’s Disease gene

Representative Publication

Borel F, Sun H, Zeiger M, et al. Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. Proc Natl Acad Sci USA. 2018;115(11):2788-2793.

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