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Cancer Nexus Blog

Read up on the Center's latest developments in cancer research, screening and prevention, as well as innovations in cancer detection and treatment.

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    Putting Alveolar Soft Part Sarcoma in the (Therapeutic) Crosshairs

    By diving into the mechanistic underpinnings of alveolar soft part sarcoma (ASPS), Matthew Hemming, MD, PhD, and team revealed a targetable vulnerability ready for translation.

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    Developing a Targeted Therapy for Acute Myeloid Leukemia

    With support from the UMass Cancer Pilot Grant Program, Lucio Castilla, PhD, is working on a way to deliver a targeted therapy for inversion(16) acute myeloid leukemia. he is collaborating with S. Thai Thuyamanavan, PhD, an expert in drug delivery, to develop an antibody-nanogel conjugate capable of delivering a small molecule to AML cells and kill them.

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    Toward Healing Both the Cancer Patient and Their Caregiver: A Conversation with Timothy Sannes, PhD

    A cancer diagnosis impacts more than the patient. Timothy Sannes, PhD, tells us about how he helps patient caregivers as well.

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    The Darkest Side of Acute Myeloid Leukemia: The TP53 Mutation

    Learn why the TP53 mutation in acute myeloid leukemia is particularly worrisome and what Shyam Patel, MD, PhD is doing about it.

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    Unlocking the Potential of Immunotherapy in Melanoma: Converting Cold Tumors to Hot

    John Harris, MD, PhD, and team are using their UMass BRIDGE funds to perfect their self-delivering drug that enhances the immune system in melanoma. They are optimizing the drug to ensure durability, efficacy and efficiency to help bring the drug forward to clinical trials.

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    UMass Cancer Research Office Receives Certificate for Full Commendation from ECOG-ACRIN

    For the fifth consecutive year the UMass Cancer Research Office received commendations from ECOG-ACRIN. To top it off, this year they received FULL commendation for the first time!

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    Clogging the Drain: Poisoning Cancer Cells from the Inside

    Dohoon Kim, PhD, and team are poisoning cancer cells from the inside. With the help of a UMass Chan Bridge Fund, they aim to develop a drug that blocks a detoxifying enzyme from neutralizing a dangerous metabolite within cancer cells. Without this detoxifying enzyme, the cancer cells will die.

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    Reprogramming the Innate Immune System in Cancer

    With the help of a UMass Chan BRIDGE Fund, Fiachra Humphries, PhD, and team are designing a way to reawaken the innate immune system. They are developing a nanobody to turn off a receptor and enable immune cells to infiltrate and kill tumors.

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    Michael Green Memorial

    Michael R. Green, MD, PhD, Memorial website pages.

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    Bringing Drugs to the Brain Takes Ingenuity: A Conversation with Rachael Sirianni, PhD

    Rachael Sirianni, PhD, is working on ways to deliver drugs directly to the brain. Her research has broad implications for treating brain cancer and neurodegenerative disorders.

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    Reviving the Immune Response in Pancreatic Cancer

    Marcus Ruscetti, PhD, and Loretah Chibaya, PhD, explain how they successfully activated the immune system in a pancreatic cancer model.

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    Next Generation Science Meets Next Generation Scientists: Neuroblastoma, Nanoparticles and Immunotherapy

    This summer, Prabhani Atukorale, PhD, and Jason Shohet, MD, PhD, will work with a visiting student, on developing an immunotherapy for neuroblastoma.

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    An Inside Look at Pancreatic Tumor Cells: A Conversation with Jason Pitarresi, PhD

    Jason Pitarresi, PhD, tells us about his research path and the tools he is using to better understand pancreatic cancer.

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    Fighting Back Against Gastrointestinal Stromal Tumors

    Matthew Hemming, MD, PhD, is developing new therapies for gastrointestinal stromal tumors and other sarcomas. He is also identifying new biomarkers for assessing risk of tumor recurrence.

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    How Mitochondria Survive in Cancer Cells: A Conversation with Jessica Spinelli, PhD

    Jessica Spinelli, PhD, explains how tumor cells can survive without oxygen

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    Pushing Back on Glioblastoma

    Samantha Sarli and Jonathan Watts, PhD are working on a novel drug to treat glioblastoma.

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    Accolades Once Again for the Cancer Research Office

    The Cancer Research Office is commended for their outstanding performance — once again!

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    Stopping Blood Cancer Before It Starts

    Shyam Patel, MD, PhD, explains a new method for detecting blood cancer before it takes root.

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    It’s All about the Gaps: Why Chemotherapy Works on Some Cells but Not Others

    Sharon Cantor, PhD, explains why chemotherapy for hereditary breast and ovarian cancer doesn't always work as expected.

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    A Translational Approach to T cells: A Conversation with Jillian Richmond, PhD

    Jillian Richmond, PhD, discusses her T cell research and its application to diagnostics and therapies for lymphoma.

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    UMass Chan is attending major cancer conference to share advances in cancer research

    Follow Our Research Presentations at the AACR Annual Meeting 2022

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    Simulated Emergencies to the Rescue

    UMass thoracic surgeons perform simulated surgery using a robotic platform to train for an emergency conversion to an open procedure.

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    Paving the Path for Neuro-Oncology Translational Research: A Conversation with David Cachia, MD

    David Cachia, MD talks about future neuro-oncology clinical trials at UMass Chan

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    Adapt2YourMood: A Mood-tailored Intervention for Smoking Cessation

    A pilot study to develop new bioinformatic tools to identify fusion circRNAs in cancer has received funding from the UMass Cancer Center and PQHS

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    Using Single-Cell Profiling to Uncover Vulnerabilities in Breast Cancer

    A study on the epigenetic vulnerabilities of metastatic breast cancer has received funding from the UMass Cancer Center

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