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Rachid Skouta, PhD

Research Focus - Probing Diseases with Small Molecules

  • Development of novel small molecules that induce ferroptosis, a form of cell death that is not dependent on caspase enzymes
  • Development of a new class of cancer therapeutics that selectively target RAS mutant tumors by inducing ferroptosis
  • In silico screening of large libraries against a protein of interest for cancer therapy
  • Drug design and creation of highly pure bioactive small molecules
  • In vitro evaluation and mechanism of action of small molecules

Representative Publication

Shimada K, Skouta R, Kaplan A, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016;12(7):497-503.

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