Punzo Lab News

  • Jun 27, 2017 IRRF 2016 annual report features Marina's research on Cover

    IRRF 2016 annual report features Marina's research on Cover

    The Internationa Retinal Research Foundation (IRRF) highlights Marina's research on thier 2016 Cover. The research shows that altering cell metabolism in rods and cones in a cell autonomouse manner inmproves photoreceptor survival in a model of age-related macular degeneration that lacks retinal pigmented epithelium (RPE) cells due to sodium iodate administration. Interetsingly, the model shows that rod survival does not affect cone survival when the RPE is missing. The report also introduces the Punzo Lab.

  • Jun 12, 2017 Rods and Cones compete for AAV access

    Rods and Cones compete for AAV access

    Lolita Petit et al., show how development of photoreceptor outer segments influence AAV infectivity of rods. The data indicates that rods and cones compete for AAV access. Furthermore, the data indicates that the presence of an outer segemnt for rods greatly increases AAV infectivity. Her work was featured on the cover, which shows a 3D-rendering of the outer nuclear layer 21 days post infection with AAV5-CMV-H2BGFP-IRES-Cre after subretinal injection at postnatal day 1 into the Ai9 tdTomato Cre-reporter line. Blue shows viral nuclear H2BGFP; green shows tdTomato expressions in transduced cells reporting viral Cre; red shows cones expressing cone arrestin and white shows nuclear DAPI. 

  • Aug 18, 2016 How to stop Cone death in Retinitis Pigmentosa

    How to stop Cone death in Retinitis Pigmentosa

    Erika Camacho, Claudio Punzo and Stephen Wirkus show with a mathematical model that cone death can be halted at any time during the disease progression by increasing nutrient availability to cones in a recent article entitled "Quantifying the metabolic contribution to photoreceptor death in retinitis pigmentosa via a mathematical model" and published in the Journal of Theoretical Biology.

  • Jun 22, 2016 Lolita Petit: Press Release of review

    Lolita Petit: Press Release of review

    Lolita Petit, Hemant Khanna, and Claudio Punzo, University of Massachusetts Medical School, Worcester, coauthored the article "Advances in Gene Therapy for Diseases of the Eye."

  • Jun 22, 2016 IRRF highlights Marina's research on Webpage

    IRRF highlights Marina's research on Webpage

    Iternational Retinal Research Foundation (IRRF) Reporst on Marina's research.
    "Age-related macular degeneration (AMD) is characterized by malfunction and loss of retinal-pigmented epithelium (RPE) cells."

  • Jun 5, 2016 Aditya: Class Speaker 2016

    Aditya: Class Speaker 2016

    Graduate School of Biomedical Sciences Class of 2016 speaker Aditya Venkatesh will reflect on his path to science when he takes the stage at the 43rdUMass Medical School Commencement on Sunday, June 5. As a child growing up in India, he said he was fascinated by biology and dreamed of becoming a doctor.

  • Mar 24, 2015 Authors take on the role of mTORC1 in cone survival.

    Authors take on the role of mTORC1 in cone survival.

    Aditya and Claudio comment on their approach to significantly prolong cone survival in Retinitis Pigmentosa by activating mTORC1 in cones.

  • Mar 23, 2015 Jean Bennett comments on mTORC1

    Jean Bennett comments on mTORC1

    The use of gene therapy for blinding disease shows growing promise; however, due to an ever-expanding list of disease-causing genes and mutations, the identification of a generic gene-based treatment is urgently needed. In this issue of the JCI, Venkatesh et al. and Xiong et al. exploit two different pathways to promote cone cell survival.....

  • Jan 21, 2014 UMMS experts: New gene therapy success holds promise for retinal diseases

    UMMS experts: New gene therapy success holds promise for retinal diseases

    Gene therapy researchers at UMass Medical School focused on degenerative retinal diseases are calling a promising new study out of the University of Oxford the “future” of gene therapy, after clinical trial participants with a rare eye disease experienced significant improvement in their vision.

  • May 13, 2013 Aditya: Mentoring Award

    Aditya: Mentoring Award

    Outstanding Mentoring Awards to Aditya Venkatesh for mentoring in a lab setting, Artem Kutikov for mentoring in a lab setting and Lauren Clancy for mentoring in a classroom setting.

  • Jun 7, 2012 Aditya: Science fair judge

    Aditya: Science fair judge

    Drawing more than 300 young competitors from across Massachusetts, the science fair was held Saturday, June 3, at Worcester Technical High School.

  • Dec 6, 2009 Cone Starvation in Retinitis Pigmentosa

    Cone Starvation in Retinitis Pigmentosa

    Even when a person experiences starvation, he doesn't think to start eating himself. But that's exactly what cells do when they are starved. Now, Howard Hughes Medical Institute researchers report that one of the reasons that the cells responsible for color vision die off in people with retinitis pigmentosa may be that the cells nibble themselves to death....

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